Amino acid dipepetide frequency for Flavobacterium columnare (strain ATCC 49512 / CIP 103533 / TG 44/87)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.102AlaAla: 3.102 ± 0.094	0.558AlaCys: 0.558 ± 0.027	2.788AlaAsp: 2.788 ± 0.062	3.702AlaGlu: 3.702 ± 0.12	3.03AlaPhe: 3.03 ± 0.057	3.632AlaGly: 3.632 ± 0.09	1.05AlaHis: 1.05 ± 0.039	5.06AlaIle: 5.06 ± 0.083	4.987AlaLys: 4.987 ± 0.126	5.695AlaLeu: 5.695 ± 0.103	1.333AlaMet: 1.333 ± 0.046	3.405AlaAsn: 3.405 ± 0.079	1.807AlaPro: 1.807 ± 0.065	2.449AlaGln: 2.449 ± 0.056	1.796AlaArg: 1.796 ± 0.056	3.754AlaSer: 3.754 ± 0.072	3.513AlaThr: 3.513 ± 0.102	3.532AlaVal: 3.532 ± 0.074	0.488AlaTrp: 0.488 ± 0.023	2.244AlaTyr: 2.244 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.445CysAla: 0.445 ± 0.023	0.096CysCys: 0.096 ± 0.01	0.418CysAsp: 0.418 ± 0.024	0.51CysGlu: 0.51 ± 0.029	0.504CysPhe: 0.504 ± 0.022	0.565CysGly: 0.565 ± 0.027	0.208CysHis: 0.208 ± 0.017	0.692CysIle: 0.692 ± 0.028	0.633CysLys: 0.633 ± 0.032	0.667CysLeu: 0.667 ± 0.027	0.168CysMet: 0.168 ± 0.016	0.502CysAsn: 0.502 ± 0.033	0.348CysPro: 0.348 ± 0.023	0.3CysGln: 0.3 ± 0.02	0.245CysArg: 0.245 ± 0.019	0.595CysSer: 0.595 ± 0.028	0.516CysThr: 0.516 ± 0.041	0.48CysVal: 0.48 ± 0.023	0.061CysTrp: 0.061 ± 0.009	0.349CysTyr: 0.349 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.096AspAla: 3.096 ± 0.073	0.412AspCys: 0.412 ± 0.022	2.298AspAsp: 2.298 ± 0.066	3.257AspGlu: 3.257 ± 0.076	3.633AspPhe: 3.633 ± 0.066	2.806AspGly: 2.806 ± 0.071	0.891AspHis: 0.891 ± 0.03	4.068AspIle: 4.068 ± 0.069	4.372AspLys: 4.372 ± 0.081	5.27AspLeu: 5.27 ± 0.083	0.957AspMet: 0.957 ± 0.037	2.767AspAsn: 2.767 ± 0.064	1.602AspPro: 1.602 ± 0.053	1.606AspGln: 1.606 ± 0.049	1.709AspArg: 1.709 ± 0.045	2.859AspSer: 2.859 ± 0.063	2.576AspThr: 2.576 ± 0.052	2.972AspVal: 2.972 ± 0.067	0.57AspTrp: 0.57 ± 0.023	2.694AspTyr: 2.694 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.07GluAla: 4.07 ± 0.122	0.402GluCys: 0.402 ± 0.022	3.066GluAsp: 3.066 ± 0.069	5.229GluGlu: 5.229 ± 0.111	2.987GluPhe: 2.987 ± 0.061	3.779GluGly: 3.779 ± 0.066	1.054GluHis: 1.054 ± 0.036	6.271GluIle: 6.271 ± 0.089	6.937GluLys: 6.937 ± 0.144	6.319GluLeu: 6.319 ± 0.102	1.541GluMet: 1.541 ± 0.044	4.881GluAsn: 4.881 ± 0.086	1.47GluPro: 1.47 ± 0.044	2.345GluGln: 2.345 ± 0.055	2.389GluArg: 2.389 ± 0.07	3.295GluSer: 3.295 ± 0.073	3.628GluThr: 3.628 ± 0.058	4.099GluVal: 4.099 ± 0.08	0.597GluTrp: 0.597 ± 0.026	2.626GluTyr: 2.626 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.719PheAla: 2.719 ± 0.055	0.533PheCys: 0.533 ± 0.025	3.212PheAsp: 3.212 ± 0.066	3.585PheGlu: 3.585 ± 0.072	3.11PhePhe: 3.11 ± 0.093	3.345PheGly: 3.345 ± 0.074	0.873PheHis: 0.873 ± 0.03	4.243PheIle: 4.243 ± 0.094	4.055PheLys: 4.055 ± 0.073	5.168PheLeu: 5.168 ± 0.105	1.162PheMet: 1.162 ± 0.042	3.371PheAsn: 3.371 ± 0.075	1.721PhePro: 1.721 ± 0.041	1.771PheGln: 1.771 ± 0.043	1.562PheArg: 1.562 ± 0.046	3.98PheSer: 3.98 ± 0.089	3.064PheThr: 3.064 ± 0.06	3.111PheVal: 3.111 ± 0.065	0.557PheTrp: 0.557 ± 0.025	2.413PheTyr: 2.413 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	3.709GlyAla: 3.709 ± 0.087	0.62GlyCys: 0.62 ± 0.034	2.727GlyAsp: 2.727 ± 0.062	3.387GlyGlu: 3.387 ± 0.067	3.469GlyPhe: 3.469 ± 0.064	4.222GlyGly: 4.222 ± 0.105	1.109GlyHis: 1.109 ± 0.041	5.421GlyIle: 5.421 ± 0.095	5.302GlyLys: 5.302 ± 0.07	5.443GlyLeu: 5.443 ± 0.085	1.525GlyMet: 1.525 ± 0.041	3.65GlyAsn: 3.65 ± 0.092	1.144GlyPro: 1.144 ± 0.041	1.835GlyGln: 1.835 ± 0.047	1.931GlyArg: 1.931 ± 0.049	3.635GlySer: 3.635 ± 0.077	3.856GlyThr: 3.856 ± 0.115	4.056GlyVal: 4.056 ± 0.084	0.627GlyTrp: 0.627 ± 0.028	2.772GlyTyr: 2.772 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.89HisAla: 0.89 ± 0.036	0.19HisCys: 0.19 ± 0.016	0.801HisAsp: 0.801 ± 0.032	0.945HisGlu: 0.945 ± 0.03	1.26HisPhe: 1.26 ± 0.046	0.973HisGly: 0.973 ± 0.039	0.435HisHis: 0.435 ± 0.027	1.564HisIle: 1.564 ± 0.043	1.288HisLys: 1.288 ± 0.04	1.848HisLeu: 1.848 ± 0.048	0.253HisMet: 0.253 ± 0.018	1.018HisAsn: 1.018 ± 0.031	0.854HisPro: 0.854 ± 0.031	0.778HisGln: 0.778 ± 0.033	0.628HisArg: 0.628 ± 0.027	1.063HisSer: 1.063 ± 0.035	1.042HisThr: 1.042 ± 0.037	0.755HisVal: 0.755 ± 0.034	0.198HisTrp: 0.198 ± 0.017	0.91HisTyr: 0.91 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.306IleAla: 5.306 ± 0.086	0.74IleCys: 0.74 ± 0.032	4.864IleAsp: 4.864 ± 0.074	6.087IleGlu: 6.087 ± 0.109	3.851IlePhe: 3.851 ± 0.082	5.209IleGly: 5.209 ± 0.088	1.593IleHis: 1.593 ± 0.049	7.003IleIle: 7.003 ± 0.128	7.152IleLys: 7.152 ± 0.101	7.517IleLeu: 7.517 ± 0.134	1.403IleMet: 1.403 ± 0.041	5.582IleAsn: 5.582 ± 0.08	3.449IlePro: 3.449 ± 0.072	3.24IleGln: 3.24 ± 0.07	2.632IleArg: 2.632 ± 0.059	5.648IleSer: 5.648 ± 0.102	5.085IleThr: 5.085 ± 0.097	4.942IleVal: 4.942 ± 0.084	0.704IleTrp: 0.704 ± 0.029	3.144IleTyr: 3.144 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	4.97LysAla: 4.97 ± 0.14	0.471LysCys: 0.471 ± 0.024	4.422LysAsp: 4.422 ± 0.084	7.314LysGlu: 7.314 ± 0.112	3.204LysPhe: 3.204 ± 0.072	4.968LysGly: 4.968 ± 0.073	1.333LysHis: 1.333 ± 0.039	8.165LysIle: 8.165 ± 0.106	8.505LysLys: 8.505 ± 0.136	6.823LysLeu: 6.823 ± 0.104	2.353LysMet: 2.353 ± 0.056	6.356LysAsn: 6.356 ± 0.095	2.623LysPro: 2.623 ± 0.057	3.032LysGln: 3.032 ± 0.071	2.857LysArg: 2.857 ± 0.066	4.758LysSer: 4.758 ± 0.08	5.151LysThr: 5.151 ± 0.088	4.81LysVal: 4.81 ± 0.078	0.838LysTrp: 0.838 ± 0.032	3.51LysTyr: 3.51 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.616LeuAla: 5.616 ± 0.121	0.728LeuCys: 0.728 ± 0.03	4.842LeuAsp: 4.842 ± 0.08	6.361LeuGlu: 6.361 ± 0.114	5.115LeuPhe: 5.115 ± 0.1	5.774LeuGly: 5.774 ± 0.089	1.568LeuHis: 1.568 ± 0.05	7.389LeuIle: 7.389 ± 0.095	8.294LeuLys: 8.294 ± 0.12	8.747LeuLeu: 8.747 ± 0.155	1.944LeuMet: 1.944 ± 0.049	6.046LeuAsn: 6.046 ± 0.096	3.474LeuPro: 3.474 ± 0.066	3.446LeuGln: 3.446 ± 0.069	2.966LeuArg: 2.966 ± 0.061	6.278LeuSer: 6.278 ± 0.091	5.197LeuThr: 5.197 ± 0.088	5.263LeuVal: 5.263 ± 0.089	0.767LeuTrp: 0.767 ± 0.031	3.493LeuTyr: 3.493 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.447MetAla: 1.447 ± 0.047	0.165MetCys: 0.165 ± 0.014	1.033MetAsp: 1.033 ± 0.038	1.248MetGlu: 1.248 ± 0.045	0.853MetPhe: 0.853 ± 0.034	1.33MetGly: 1.33 ± 0.041	0.31MetHis: 0.31 ± 0.02	1.718MetIle: 1.718 ± 0.043	2.065MetLys: 2.065 ± 0.047	1.829MetLeu: 1.829 ± 0.051	0.552MetMet: 0.552 ± 0.027	1.431MetAsn: 1.431 ± 0.042	0.828MetPro: 0.828 ± 0.035	0.836MetGln: 0.836 ± 0.034	0.868MetArg: 0.868 ± 0.034	1.406MetSer: 1.406 ± 0.041	1.17MetThr: 1.17 ± 0.041	1.203MetVal: 1.203 ± 0.038	0.16MetTrp: 0.16 ± 0.013	0.744MetTyr: 0.744 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.66AsnAla: 3.66 ± 0.071	0.598AsnCys: 0.598 ± 0.033	3.199AsnAsp: 3.199 ± 0.064	4.186AsnGlu: 4.186 ± 0.078	3.385AsnPhe: 3.385 ± 0.071	3.923AsnGly: 3.923 ± 0.109	1.282AsnHis: 1.282 ± 0.043	5.196AsnIle: 5.196 ± 0.091	5.346AsnLys: 5.346 ± 0.088	5.989AsnLeu: 5.989 ± 0.096	1.185AsnMet: 1.185 ± 0.037	4.357AsnAsn: 4.357 ± 0.092	2.952AsnPro: 2.952 ± 0.066	2.777AsnGln: 2.777 ± 0.059	2.034AsnArg: 2.034 ± 0.049	4.02AsnSer: 4.02 ± 0.098	4.155AsnThr: 4.155 ± 0.11	3.333AsnVal: 3.333 ± 0.07	0.794AsnTrp: 0.794 ± 0.03	3.122AsnTyr: 3.122 ± 0.078	0.0AsnXaa: 0.0 ± 0.0
Pro	1.757ProAla: 1.757 ± 0.061	0.227ProCys: 0.227 ± 0.017	1.699ProAsp: 1.699 ± 0.044	2.603ProGlu: 2.603 ± 0.047	1.957ProPhe: 1.957 ± 0.051	1.568ProGly: 1.568 ± 0.053	0.592ProHis: 0.592 ± 0.025	2.985ProIle: 2.985 ± 0.063	2.692ProLys: 2.692 ± 0.056	2.953ProLeu: 2.953 ± 0.054	0.65ProMet: 0.65 ± 0.031	2.501ProAsn: 2.501 ± 0.069	0.712ProPro: 0.712 ± 0.028	1.141ProGln: 1.141 ± 0.035	0.88ProArg: 0.88 ± 0.036	2.188ProSer: 2.188 ± 0.05	2.079ProThr: 2.079 ± 0.067	2.2ProVal: 2.2 ± 0.061	0.29ProTrp: 0.29 ± 0.019	1.46ProTyr: 1.46 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.032GlnAla: 2.032 ± 0.057	0.218GlnCys: 0.218 ± 0.023	1.577GlnAsp: 1.577 ± 0.043	2.654GlnGlu: 2.654 ± 0.061	1.767GlnPhe: 1.767 ± 0.043	1.831GlnGly: 1.831 ± 0.047	0.605GlnHis: 0.605 ± 0.028	3.172GlnIle: 3.172 ± 0.061	3.636GlnLys: 3.636 ± 0.067	3.619GlnLeu: 3.619 ± 0.072	0.848GlnMet: 0.848 ± 0.032	2.647GlnAsn: 2.647 ± 0.057	1.091GlnPro: 1.091 ± 0.034	1.35GlnGln: 1.35 ± 0.055	1.109GlnArg: 1.109 ± 0.034	2.014GlnSer: 2.014 ± 0.048	2.034GlnThr: 2.034 ± 0.052	2.039GlnVal: 2.039 ± 0.053	0.412GlnTrp: 0.412 ± 0.024	1.56GlnTyr: 1.56 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	1.796ArgAla: 1.796 ± 0.044	0.207ArgCys: 0.207 ± 0.016	1.454ArgAsp: 1.454 ± 0.04	2.074ArgGlu: 2.074 ± 0.055	1.831ArgPhe: 1.831 ± 0.051	1.803ArgGly: 1.803 ± 0.047	0.549ArgHis: 0.549 ± 0.03	2.882ArgIle: 2.882 ± 0.056	2.845ArgLys: 2.845 ± 0.054	3.158ArgLeu: 3.158 ± 0.07	0.881ArgMet: 0.881 ± 0.033	2.093ArgAsn: 2.093 ± 0.051	0.962ArgPro: 0.962 ± 0.036	1.016ArgGln: 1.016 ± 0.036	1.125ArgArg: 1.125 ± 0.042	1.712ArgSer: 1.712 ± 0.051	1.741ArgThr: 1.741 ± 0.043	2.001ArgVal: 2.001 ± 0.056	0.337ArgTrp: 0.337 ± 0.021	1.399ArgTyr: 1.399 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.261SerAla: 3.261 ± 0.067	0.685SerCys: 0.685 ± 0.031	2.98SerAsp: 2.98 ± 0.058	3.609SerGlu: 3.609 ± 0.078	3.911SerPhe: 3.911 ± 0.077	4.28SerGly: 4.28 ± 0.092	1.054SerHis: 1.054 ± 0.037	5.54SerIle: 5.54 ± 0.096	5.279SerLys: 5.279 ± 0.089	5.822SerLeu: 5.822 ± 0.097	1.204SerMet: 1.204 ± 0.037	3.965SerAsn: 3.965 ± 0.085	1.901SerPro: 1.901 ± 0.052	2.164SerGln: 2.164 ± 0.051	1.848SerArg: 1.848 ± 0.046	4.151SerSer: 4.151 ± 0.096	3.611SerThr: 3.611 ± 0.076	3.727SerVal: 3.727 ± 0.065	0.649SerTrp: 0.649 ± 0.031	2.726SerTyr: 2.726 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	3.448ThrAla: 3.448 ± 0.095	0.38ThrCys: 0.38 ± 0.03	3.02ThrAsp: 3.02 ± 0.068	3.41ThrGlu: 3.41 ± 0.071	3.15ThrPhe: 3.15 ± 0.065	3.869ThrGly: 3.869 ± 0.097	1.167ThrHis: 1.167 ± 0.038	5.337ThrIle: 5.337 ± 0.099	4.361ThrLys: 4.361 ± 0.074	5.473ThrLeu: 5.473 ± 0.08	0.933ThrMet: 0.933 ± 0.038	3.782ThrAsn: 3.782 ± 0.113	2.574ThrPro: 2.574 ± 0.081	2.136ThrGln: 2.136 ± 0.057	1.654ThrArg: 1.654 ± 0.041	3.821ThrSer: 3.821 ± 0.086	3.813ThrThr: 3.813 ± 0.104	3.464ThrVal: 3.464 ± 0.098	0.52ThrTrp: 0.52 ± 0.026	2.405ThrTyr: 2.405 ± 0.069	0.0ThrXaa: 0.0 ± 0.0
Val	3.776ValAla: 3.776 ± 0.089	0.576ValCys: 0.576 ± 0.026	3.128ValAsp: 3.128 ± 0.061	3.734ValGlu: 3.734 ± 0.069	3.363ValPhe: 3.363 ± 0.067	3.412ValGly: 3.412 ± 0.079	0.934ValHis: 0.934 ± 0.034	4.585ValIle: 4.585 ± 0.074	4.439ValLys: 4.439 ± 0.071	5.87ValLeu: 5.87 ± 0.086	1.237ValMet: 1.237 ± 0.033	3.516ValAsn: 3.516 ± 0.081	1.951ValPro: 1.951 ± 0.053	1.868ValGln: 1.868 ± 0.047	1.829ValArg: 1.829 ± 0.049	4.026ValSer: 4.026 ± 0.074	3.381ValThr: 3.381 ± 0.12	3.941ValVal: 3.941 ± 0.087	0.519ValTrp: 0.519 ± 0.025	2.48ValTyr: 2.48 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.546TrpAla: 0.546 ± 0.031	0.102TrpCys: 0.102 ± 0.011	0.544TrpAsp: 0.544 ± 0.026	0.602TrpGlu: 0.602 ± 0.026	0.556TrpPhe: 0.556 ± 0.029	0.58TrpGly: 0.58 ± 0.028	0.2TrpHis: 0.2 ± 0.017	0.808TrpIle: 0.808 ± 0.035	0.818TrpLys: 0.818 ± 0.032	0.926TrpLeu: 0.926 ± 0.037	0.296TrpMet: 0.296 ± 0.017	0.713TrpAsn: 0.713 ± 0.034	0.166TrpPro: 0.166 ± 0.015	0.352TrpGln: 0.352 ± 0.02	0.322TrpArg: 0.322 ± 0.015	0.54TrpSer: 0.54 ± 0.027	0.503TrpThr: 0.503 ± 0.027	0.553TrpVal: 0.553 ± 0.023	0.124TrpTrp: 0.124 ± 0.011	0.425TrpTyr: 0.425 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.28TyrAla: 2.28 ± 0.049	0.393TyrCys: 0.393 ± 0.02	2.343TyrAsp: 2.343 ± 0.062	2.491TyrGlu: 2.491 ± 0.063	2.62TyrPhe: 2.62 ± 0.064	2.572TyrGly: 2.572 ± 0.055	0.885TyrHis: 0.885 ± 0.033	3.052TyrIle: 3.052 ± 0.067	3.456TyrLys: 3.456 ± 0.063	4.175TyrLeu: 4.175 ± 0.083	0.768TyrMet: 0.768 ± 0.03	2.909TyrAsn: 2.909 ± 0.063	1.506TyrPro: 1.506 ± 0.043	1.773TyrGln: 1.773 ± 0.048	1.483TyrArg: 1.483 ± 0.042	2.624TyrSer: 2.624 ± 0.063	2.599TyrThr: 2.599 ± 0.085	2.083TyrVal: 2.083 ± 0.053	0.465TyrTrp: 0.465 ± 0.026	2.06TyrTyr: 2.06 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2617 proteins (888968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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