Amino acid dipepetide frequency for Psychromonas ingrahamii (strain 37)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.472AlaAla: 7.472 ± 0.192	0.974AlaCys: 0.974 ± 0.031	4.525AlaAsp: 4.525 ± 0.077	5.185AlaGlu: 5.185 ± 0.1	3.407AlaPhe: 3.407 ± 0.059	5.913AlaGly: 5.913 ± 0.118	1.524AlaHis: 1.524 ± 0.033	6.271AlaIle: 6.271 ± 0.084	4.885AlaLys: 4.885 ± 0.068	9.517AlaLeu: 9.517 ± 0.125	2.289AlaMet: 2.289 ± 0.046	3.594AlaAsn: 3.594 ± 0.066	2.464AlaPro: 2.464 ± 0.061	3.775AlaGln: 3.775 ± 0.066	3.119AlaArg: 3.119 ± 0.064	4.998AlaSer: 4.998 ± 0.083	4.377AlaThr: 4.377 ± 0.101	5.721AlaVal: 5.721 ± 0.084	0.861AlaTrp: 0.861 ± 0.028	2.34AlaTyr: 2.34 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.03	0.19CysCys: 0.19 ± 0.014	0.633CysAsp: 0.633 ± 0.026	0.641CysGlu: 0.641 ± 0.025	0.479CysPhe: 0.479 ± 0.021	0.904CysGly: 0.904 ± 0.03	0.367CysHis: 0.367 ± 0.019	0.732CysIle: 0.732 ± 0.023	0.503CysLys: 0.503 ± 0.024	1.158CysLeu: 1.158 ± 0.034	0.23CysMet: 0.23 ± 0.015	0.418CysAsn: 0.418 ± 0.02	0.469CysPro: 0.469 ± 0.02	0.455CysGln: 0.455 ± 0.019	0.47CysArg: 0.47 ± 0.023	0.771CysSer: 0.771 ± 0.028	0.489CysThr: 0.489 ± 0.02	0.616CysVal: 0.616 ± 0.023	0.143CysTrp: 0.143 ± 0.012	0.395CysTyr: 0.395 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.013AspAla: 4.013 ± 0.065	0.569AspCys: 0.569 ± 0.025	2.817AspAsp: 2.817 ± 0.064	3.067AspGlu: 3.067 ± 0.064	2.647AspPhe: 2.647 ± 0.054	3.356AspGly: 3.356 ± 0.084	1.088AspHis: 1.088 ± 0.038	4.322AspIle: 4.322 ± 0.07	3.714AspLys: 3.714 ± 0.064	5.628AspLeu: 5.628 ± 0.081	1.22AspMet: 1.22 ± 0.036	2.902AspAsn: 2.902 ± 0.07	2.023AspPro: 2.023 ± 0.049	2.326AspGln: 2.326 ± 0.046	1.979AspArg: 1.979 ± 0.05	3.388AspSer: 3.388 ± 0.052	2.538AspThr: 2.538 ± 0.089	3.2AspVal: 3.2 ± 0.07	0.78AspTrp: 0.78 ± 0.028	2.016AspTyr: 2.016 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.431GluAla: 4.431 ± 0.085	0.51GluCys: 0.51 ± 0.027	2.503GluAsp: 2.503 ± 0.052	3.14GluGlu: 3.14 ± 0.07	2.424GluPhe: 2.424 ± 0.051	3.286GluGly: 3.286 ± 0.061	1.353GluHis: 1.353 ± 0.038	4.504GluIle: 4.504 ± 0.068	4.449GluLys: 4.449 ± 0.084	6.631GluLeu: 6.631 ± 0.088	1.674GluMet: 1.674 ± 0.043	3.279GluAsn: 3.279 ± 0.061	1.667GluPro: 1.667 ± 0.04	3.569GluGln: 3.569 ± 0.065	2.524GluArg: 2.524 ± 0.057	3.595GluSer: 3.595 ± 0.063	2.937GluThr: 2.937 ± 0.071	3.792GluVal: 3.792 ± 0.074	0.67GluTrp: 0.67 ± 0.027	1.724GluTyr: 1.724 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.531PheAla: 3.531 ± 0.058	0.577PheCys: 0.577 ± 0.024	2.742PheAsp: 2.742 ± 0.055	2.434PheGlu: 2.434 ± 0.049	2.079PhePhe: 2.079 ± 0.06	2.838PheGly: 2.838 ± 0.061	0.825PheHis: 0.825 ± 0.028	3.503PheIle: 3.503 ± 0.055	2.476PheLys: 2.476 ± 0.045	3.897PheLeu: 3.897 ± 0.066	1.003PheMet: 1.003 ± 0.03	2.458PheAsn: 2.458 ± 0.056	1.538PhePro: 1.538 ± 0.034	1.325PheGln: 1.325 ± 0.036	1.356PheArg: 1.356 ± 0.036	3.911PheSer: 3.911 ± 0.063	2.529PheThr: 2.529 ± 0.069	2.769PheVal: 2.769 ± 0.055	0.497PheTrp: 0.497 ± 0.024	1.471PheTyr: 1.471 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.983GlyAla: 4.983 ± 0.093	0.907GlyCys: 0.907 ± 0.029	3.506GlyAsp: 3.506 ± 0.07	3.959GlyGlu: 3.959 ± 0.064	3.247GlyPhe: 3.247 ± 0.06	4.463GlyGly: 4.463 ± 0.081	1.443GlyHis: 1.443 ± 0.036	5.086GlyIle: 5.086 ± 0.08	4.101GlyLys: 4.101 ± 0.066	7.071GlyLeu: 7.071 ± 0.103	1.8GlyMet: 1.8 ± 0.053	2.677GlyAsn: 2.677 ± 0.077	1.537GlyPro: 1.537 ± 0.039	2.625GlyGln: 2.625 ± 0.047	2.711GlyArg: 2.711 ± 0.053	4.223GlySer: 4.223 ± 0.119	3.332GlyThr: 3.332 ± 0.118	4.498GlyVal: 4.498 ± 0.084	0.837GlyTrp: 0.837 ± 0.03	2.449GlyTyr: 2.449 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.475HisAla: 1.475 ± 0.04	0.335HisCys: 0.335 ± 0.015	0.938HisAsp: 0.938 ± 0.027	1.024HisGlu: 1.024 ± 0.025	1.205HisPhe: 1.205 ± 0.036	1.29HisGly: 1.29 ± 0.029	0.639HisHis: 0.639 ± 0.025	1.466HisIle: 1.466 ± 0.036	1.184HisLys: 1.184 ± 0.035	2.324HisLeu: 2.324 ± 0.048	0.453HisMet: 0.453 ± 0.021	0.931HisAsn: 0.931 ± 0.028	1.044HisPro: 1.044 ± 0.031	1.107HisGln: 1.107 ± 0.031	0.893HisArg: 0.893 ± 0.033	1.435HisSer: 1.435 ± 0.042	0.912HisThr: 0.912 ± 0.028	1.004HisVal: 1.004 ± 0.029	0.316HisTrp: 0.316 ± 0.016	0.879HisTyr: 0.879 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.817IleAla: 6.817 ± 0.092	0.858IleCys: 0.858 ± 0.029	4.767IleAsp: 4.767 ± 0.058	5.004IleGlu: 5.004 ± 0.075	2.943IlePhe: 2.943 ± 0.062	4.868IleGly: 4.868 ± 0.065	1.287IleHis: 1.287 ± 0.033	5.247IleIle: 5.247 ± 0.073	4.936IleLys: 4.936 ± 0.085	6.564IleLeu: 6.564 ± 0.081	1.465IleMet: 1.465 ± 0.041	4.123IleAsn: 4.123 ± 0.065	2.883IlePro: 2.883 ± 0.056	2.301IleGln: 2.301 ± 0.049	2.718IleArg: 2.718 ± 0.06	5.445IleSer: 5.445 ± 0.074	4.386IleThr: 4.386 ± 0.095	4.312IleVal: 4.312 ± 0.07	0.66IleTrp: 0.66 ± 0.024	2.157IleTyr: 2.157 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.89LysAla: 4.89 ± 0.08	0.423LysCys: 0.423 ± 0.019	2.884LysAsp: 2.884 ± 0.054	3.903LysGlu: 3.903 ± 0.072	1.826LysPhe: 1.826 ± 0.046	3.592LysGly: 3.592 ± 0.064	1.288LysHis: 1.288 ± 0.036	4.593LysIle: 4.593 ± 0.072	4.634LysLys: 4.634 ± 0.087	6.07LysLeu: 6.07 ± 0.088	1.758LysMet: 1.758 ± 0.038	3.45LysAsn: 3.45 ± 0.068	2.158LysPro: 2.158 ± 0.045	3.266LysGln: 3.266 ± 0.064	2.786LysArg: 2.786 ± 0.054	3.949LysSer: 3.949 ± 0.069	3.5LysThr: 3.5 ± 0.063	4.004LysVal: 4.004 ± 0.068	0.611LysTrp: 0.611 ± 0.023	1.631LysTyr: 1.631 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.601LeuAla: 9.601 ± 0.102	1.114LeuCys: 1.114 ± 0.035	5.587LeuAsp: 5.587 ± 0.075	5.663LeuGlu: 5.663 ± 0.086	4.957LeuPhe: 4.957 ± 0.083	6.715LeuGly: 6.715 ± 0.097	2.061LeuHis: 2.061 ± 0.041	7.587LeuIle: 7.587 ± 0.105	6.343LeuLys: 6.343 ± 0.089	11.998LeuLeu: 11.998 ± 0.164	2.606LeuMet: 2.606 ± 0.055	5.186LeuAsn: 5.186 ± 0.078	4.603LeuPro: 4.603 ± 0.067	4.322LeuGln: 4.322 ± 0.068	4.126LeuArg: 4.126 ± 0.069	8.351LeuSer: 8.351 ± 0.093	6.343LeuThr: 6.343 ± 0.12	6.505LeuVal: 6.505 ± 0.09	1.043LeuTrp: 1.043 ± 0.033	2.848LeuTyr: 2.848 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.194MetAla: 2.194 ± 0.052	0.204MetCys: 0.204 ± 0.014	1.217MetAsp: 1.217 ± 0.034	1.186MetGlu: 1.186 ± 0.037	0.825MetPhe: 0.825 ± 0.026	1.669MetGly: 1.669 ± 0.045	0.469MetHis: 0.469 ± 0.024	1.673MetIle: 1.673 ± 0.043	1.458MetLys: 1.458 ± 0.037	2.676MetLeu: 2.676 ± 0.055	0.693MetMet: 0.693 ± 0.029	1.17MetAsn: 1.17 ± 0.031	1.136MetPro: 1.136 ± 0.031	1.113MetGln: 1.113 ± 0.033	1.049MetArg: 1.049 ± 0.03	1.808MetSer: 1.808 ± 0.036	1.533MetThr: 1.533 ± 0.038	1.574MetVal: 1.574 ± 0.037	0.181MetTrp: 0.181 ± 0.014	0.497MetTyr: 0.497 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.775AsnAla: 3.775 ± 0.058	0.492AsnCys: 0.492 ± 0.022	2.625AsnAsp: 2.625 ± 0.078	2.786AsnGlu: 2.786 ± 0.052	2.032AsnPhe: 2.032 ± 0.047	2.96AsnGly: 2.96 ± 0.086	0.992AsnHis: 0.992 ± 0.033	3.881AsnIle: 3.881 ± 0.072	3.464AsnLys: 3.464 ± 0.067	4.626AsnLeu: 4.626 ± 0.066	1.088AsnMet: 1.088 ± 0.033	2.918AsnAsn: 2.918 ± 0.075	2.048AsnPro: 2.048 ± 0.044	2.085AsnGln: 2.085 ± 0.049	1.921AsnArg: 1.921 ± 0.043	3.104AsnSer: 3.104 ± 0.061	2.475AsnThr: 2.475 ± 0.062	2.718AsnVal: 2.718 ± 0.06	0.662AsnTrp: 0.662 ± 0.025	1.584AsnTyr: 1.584 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.013ProAla: 3.013 ± 0.055	0.331ProCys: 0.331 ± 0.019	2.121ProAsp: 2.121 ± 0.051	2.898ProGlu: 2.898 ± 0.057	1.695ProPhe: 1.695 ± 0.039	2.133ProGly: 2.133 ± 0.046	0.707ProHis: 0.707 ± 0.027	2.648ProIle: 2.648 ± 0.055	1.954ProLys: 1.954 ± 0.047	4.001ProLeu: 4.001 ± 0.071	0.866ProMet: 0.866 ± 0.029	1.539ProAsn: 1.539 ± 0.038	1.069ProPro: 1.069 ± 0.03	1.454ProGln: 1.454 ± 0.04	1.159ProArg: 1.159 ± 0.038	2.299ProSer: 2.299 ± 0.042	1.998ProThr: 1.998 ± 0.06	2.846ProVal: 2.846 ± 0.05	0.429ProTrp: 0.429 ± 0.02	1.163ProTyr: 1.163 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.172GlnAla: 4.172 ± 0.074	0.413GlnCys: 0.413 ± 0.021	1.944GlnAsp: 1.944 ± 0.042	2.288GlnGlu: 2.288 ± 0.047	1.715GlnPhe: 1.715 ± 0.039	2.939GlnGly: 2.939 ± 0.054	1.062GlnHis: 1.062 ± 0.031	2.929GlnIle: 2.929 ± 0.062	2.708GlnLys: 2.708 ± 0.058	5.284GlnLeu: 5.284 ± 0.095	0.972GlnMet: 0.972 ± 0.03	1.8GlnAsn: 1.8 ± 0.04	1.514GlnPro: 1.514 ± 0.044	3.019GlnGln: 3.019 ± 0.089	2.111GlnArg: 2.111 ± 0.048	2.637GlnSer: 2.637 ± 0.051	2.152GlnThr: 2.152 ± 0.043	2.842GlnVal: 2.842 ± 0.057	0.587GlnTrp: 0.587 ± 0.024	1.373GlnTyr: 1.373 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.925ArgAla: 2.925 ± 0.057	0.458ArgCys: 0.458 ± 0.021	2.092ArgAsp: 2.092 ± 0.049	2.393ArgGlu: 2.393 ± 0.055	2.051ArgPhe: 2.051 ± 0.044	2.29ArgGly: 2.29 ± 0.052	0.986ArgHis: 0.986 ± 0.031	2.986ArgIle: 2.986 ± 0.053	2.309ArgLys: 2.309 ± 0.059	4.684ArgLeu: 4.684 ± 0.069	0.975ArgMet: 0.975 ± 0.033	1.744ArgAsn: 1.744 ± 0.042	1.4ArgPro: 1.4 ± 0.037	1.826ArgGln: 1.826 ± 0.049	1.918ArgArg: 1.918 ± 0.048	2.362ArgSer: 2.362 ± 0.044	1.913ArgThr: 1.913 ± 0.046	2.642ArgVal: 2.642 ± 0.06	0.507ArgTrp: 0.507 ± 0.021	1.495ArgTyr: 1.495 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.655SerAla: 5.655 ± 0.069	0.73SerCys: 0.73 ± 0.025	3.732SerAsp: 3.732 ± 0.071	4.023SerGlu: 4.023 ± 0.065	3.101SerPhe: 3.101 ± 0.053	5.21SerGly: 5.21 ± 0.104	1.446SerHis: 1.446 ± 0.036	4.849SerIle: 4.849 ± 0.074	3.606SerLys: 3.606 ± 0.061	7.371SerLeu: 7.371 ± 0.101	1.593SerMet: 1.593 ± 0.039	2.903SerAsn: 2.903 ± 0.063	2.431SerPro: 2.431 ± 0.054	2.712SerGln: 2.712 ± 0.052	2.644SerArg: 2.644 ± 0.05	4.482SerSer: 4.482 ± 0.069	3.455SerThr: 3.455 ± 0.072	4.544SerVal: 4.544 ± 0.084	0.772SerTrp: 0.772 ± 0.025	2.126SerTyr: 2.126 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.729ThrAla: 4.729 ± 0.163	0.505ThrCys: 0.505 ± 0.02	2.99ThrAsp: 2.99 ± 0.094	3.267ThrGlu: 3.267 ± 0.064	2.227ThrPhe: 2.227 ± 0.06	4.218ThrGly: 4.218 ± 0.118	1.095ThrHis: 1.095 ± 0.031	3.658ThrIle: 3.658 ± 0.069	2.648ThrLys: 2.648 ± 0.048	6.446ThrLeu: 6.446 ± 0.087	1.094ThrMet: 1.094 ± 0.033	2.104ThrAsn: 2.104 ± 0.06	2.45ThrPro: 2.45 ± 0.051	2.217ThrGln: 2.217 ± 0.043	2.0ThrArg: 2.0 ± 0.039	3.181ThrSer: 3.181 ± 0.059	3.039ThrThr: 3.039 ± 0.102	3.855ThrVal: 3.855 ± 0.119	0.556ThrTrp: 0.556 ± 0.024	1.521ThrTyr: 1.521 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.61ValAla: 5.61 ± 0.106	0.718ValCys: 0.718 ± 0.028	3.821ValAsp: 3.821 ± 0.07	3.828ValGlu: 3.828 ± 0.071	2.803ValPhe: 2.803 ± 0.054	4.125ValGly: 4.125 ± 0.07	1.141ValHis: 1.141 ± 0.032	5.085ValIle: 5.085 ± 0.072	3.662ValLys: 3.662 ± 0.077	6.414ValLeu: 6.414 ± 0.087	1.676ValMet: 1.676 ± 0.044	3.292ValAsn: 3.292 ± 0.078	2.169ValPro: 2.169 ± 0.048	2.152ValGln: 2.152 ± 0.058	2.42ValArg: 2.42 ± 0.054	4.466ValSer: 4.466 ± 0.07	3.905ValThr: 3.905 ± 0.128	4.487ValVal: 4.487 ± 0.083	0.661ValTrp: 0.661 ± 0.022	1.795ValTyr: 1.795 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.779TrpAla: 0.779 ± 0.028	0.158TrpCys: 0.158 ± 0.014	0.543TrpAsp: 0.543 ± 0.023	0.494TrpGlu: 0.494 ± 0.021	0.553TrpPhe: 0.553 ± 0.023	0.707TrpGly: 0.707 ± 0.027	0.308TrpHis: 0.308 ± 0.015	0.744TrpIle: 0.744 ± 0.027	0.55TrpLys: 0.55 ± 0.022	1.594TrpLeu: 1.594 ± 0.04	0.282TrpMet: 0.282 ± 0.014	0.448TrpAsn: 0.448 ± 0.023	0.423TrpPro: 0.423 ± 0.02	0.792TrpGln: 0.792 ± 0.025	0.548TrpArg: 0.548 ± 0.021	0.77TrpSer: 0.77 ± 0.026	0.463TrpThr: 0.463 ± 0.023	0.718TrpVal: 0.718 ± 0.026	0.172TrpTrp: 0.172 ± 0.013	0.336TrpTyr: 0.336 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.292TyrAla: 2.292 ± 0.051	0.451TyrCys: 0.451 ± 0.021	1.606TyrAsp: 1.606 ± 0.052	1.48TyrGlu: 1.48 ± 0.04	1.544TyrPhe: 1.544 ± 0.044	1.978TyrGly: 1.978 ± 0.044	0.774TyrHis: 0.774 ± 0.023	1.979TyrIle: 1.979 ± 0.041	1.633TyrLys: 1.633 ± 0.04	3.604TyrLeu: 3.604 ± 0.059	0.586TyrMet: 0.586 ± 0.025	1.299TyrAsn: 1.299 ± 0.037	1.302TyrPro: 1.302 ± 0.033	2.02TyrGln: 2.02 ± 0.043	1.505TyrArg: 1.505 ± 0.04	2.209TyrSer: 2.209 ± 0.052	1.52TyrThr: 1.52 ± 0.059	1.58TyrVal: 1.58 ± 0.04	0.437TyrTrp: 0.437 ± 0.021	1.135TyrTyr: 1.135 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3530 proteins (1173915 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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