Amino acid dipepetide frequency for Moraxella phage Mcat21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.607AlaAla: 6.607 ± 1.359
0.881AlaCys: 0.881 ± 0.524
3.964AlaAsp: 3.964 ± 0.699
6.46AlaGlu: 6.46 ± 1.171
2.643AlaPhe: 2.643 ± 0.703
5.286AlaGly: 5.286 ± 1.028
2.202AlaHis: 2.202 ± 0.413
4.992AlaIle: 4.992 ± 0.835
7.782AlaLys: 7.782 ± 1.277
9.837AlaLeu: 9.837 ± 1.549
1.909AlaMet: 1.909 ± 0.704
4.845AlaAsn: 4.845 ± 0.798
2.055AlaPro: 2.055 ± 0.355
4.845AlaGln: 4.845 ± 0.888
4.405AlaArg: 4.405 ± 0.913
7.635AlaSer: 7.635 ± 1.139
7.047AlaThr: 7.047 ± 1.62
5.286AlaVal: 5.286 ± 0.868
0.587AlaTrp: 0.587 ± 0.456
2.936AlaTyr: 2.936 ± 0.687
0.0AlaXaa: 0.0 ± 0.0
Cys
0.294CysAla: 0.294 ± 0.296
0.147CysCys: 0.147 ± 0.148
0.44CysAsp: 0.44 ± 0.258
0.294CysGlu: 0.294 ± 0.173
0.294CysPhe: 0.294 ± 0.208
0.147CysGly: 0.147 ± 0.147
0.147CysHis: 0.147 ± 0.148
0.294CysIle: 0.294 ± 0.207
0.734CysLys: 0.734 ± 0.432
0.734CysLeu: 0.734 ± 0.329
0.294CysMet: 0.294 ± 0.236
0.44CysAsn: 0.44 ± 0.261
0.44CysPro: 0.44 ± 0.259
0.44CysGln: 0.44 ± 0.26
0.734CysArg: 0.734 ± 0.378
0.734CysSer: 0.734 ± 0.452
0.44CysThr: 0.44 ± 0.319
0.294CysVal: 0.294 ± 0.21
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.286AspAla: 5.286 ± 0.872
0.44AspCys: 0.44 ± 0.25
4.405AspAsp: 4.405 ± 1.051
5.579AspGlu: 5.579 ± 1.087
2.496AspPhe: 2.496 ± 0.786
6.166AspGly: 6.166 ± 0.657
0.881AspHis: 0.881 ± 0.454
3.964AspIle: 3.964 ± 0.637
3.671AspLys: 3.671 ± 0.651
4.551AspLeu: 4.551 ± 0.623
1.615AspMet: 1.615 ± 0.413
3.524AspAsn: 3.524 ± 0.66
1.762AspPro: 1.762 ± 0.612
1.615AspGln: 1.615 ± 0.705
2.496AspArg: 2.496 ± 0.816
3.083AspSer: 3.083 ± 0.537
3.23AspThr: 3.23 ± 0.676
3.23AspVal: 3.23 ± 0.56
1.175AspTrp: 1.175 ± 0.352
1.468AspTyr: 1.468 ± 0.458
0.0AspXaa: 0.0 ± 0.0
Glu
3.817GluAla: 3.817 ± 0.854
0.294GluCys: 0.294 ± 0.193
3.671GluAsp: 3.671 ± 0.953
3.377GluGlu: 3.377 ± 1.013
3.524GluPhe: 3.524 ± 0.645
2.055GluGly: 2.055 ± 0.595
2.055GluHis: 2.055 ± 0.589
4.258GluIle: 4.258 ± 0.766
4.258GluLys: 4.258 ± 1.079
7.488GluLeu: 7.488 ± 1.276
1.468GluMet: 1.468 ± 0.529
3.964GluAsn: 3.964 ± 0.64
1.909GluPro: 1.909 ± 0.817
4.111GluGln: 4.111 ± 0.827
4.111GluArg: 4.111 ± 1.166
2.643GluSer: 2.643 ± 0.676
1.909GluThr: 1.909 ± 0.515
3.671GluVal: 3.671 ± 0.715
0.44GluTrp: 0.44 ± 0.242
3.524GluTyr: 3.524 ± 0.541
0.0GluXaa: 0.0 ± 0.0
Phe
4.258PheAla: 4.258 ± 0.936
0.734PheCys: 0.734 ± 0.355
3.671PheAsp: 3.671 ± 0.808
2.936PheGlu: 2.936 ± 0.788
0.881PhePhe: 0.881 ± 0.399
3.377PheGly: 3.377 ± 0.879
0.294PheHis: 0.294 ± 0.22
2.496PheIle: 2.496 ± 0.555
2.055PheLys: 2.055 ± 0.617
2.349PheLeu: 2.349 ± 0.613
0.44PheMet: 0.44 ± 0.255
1.615PheAsn: 1.615 ± 0.492
0.294PhePro: 0.294 ± 0.23
0.294PheGln: 0.294 ± 0.223
1.468PheArg: 1.468 ± 0.541
1.468PheSer: 1.468 ± 0.476
2.496PheThr: 2.496 ± 0.605
3.671PheVal: 3.671 ± 0.677
0.44PheTrp: 0.44 ± 0.252
1.615PheTyr: 1.615 ± 0.525
0.0PheXaa: 0.0 ± 0.0
Gly
4.845GlyAla: 4.845 ± 1.369
0.294GlyCys: 0.294 ± 0.193
4.111GlyAsp: 4.111 ± 0.838
4.405GlyGlu: 4.405 ± 0.894
2.79GlyPhe: 2.79 ± 0.781
6.46GlyGly: 6.46 ± 1.597
0.881GlyHis: 0.881 ± 0.346
4.698GlyIle: 4.698 ± 0.832
6.754GlyLys: 6.754 ± 0.797
5.873GlyLeu: 5.873 ± 0.864
1.762GlyMet: 1.762 ± 0.7
3.377GlyAsn: 3.377 ± 0.533
0.294GlyPro: 0.294 ± 0.268
1.762GlyGln: 1.762 ± 0.388
2.936GlyArg: 2.936 ± 0.635
3.671GlySer: 3.671 ± 0.694
3.964GlyThr: 3.964 ± 1.04
3.817GlyVal: 3.817 ± 0.8
0.587GlyTrp: 0.587 ± 0.278
1.175GlyTyr: 1.175 ± 0.424
0.0GlyXaa: 0.0 ± 0.0
His
1.468HisAla: 1.468 ± 0.477
0.147HisCys: 0.147 ± 0.152
1.468HisAsp: 1.468 ± 0.472
1.321HisGlu: 1.321 ± 0.401
0.734HisPhe: 0.734 ± 0.311
1.321HisGly: 1.321 ± 0.585
0.44HisHis: 0.44 ± 0.244
0.881HisIle: 0.881 ± 0.404
1.028HisLys: 1.028 ± 0.41
2.936HisLeu: 2.936 ± 0.651
0.44HisMet: 0.44 ± 0.248
1.321HisAsn: 1.321 ± 0.469
0.734HisPro: 0.734 ± 0.248
0.881HisGln: 0.881 ± 0.33
0.44HisArg: 0.44 ± 0.219
0.734HisSer: 0.734 ± 0.315
1.615HisThr: 1.615 ± 0.521
0.147HisVal: 0.147 ± 0.148
0.587HisTrp: 0.587 ± 0.351
1.321HisTyr: 1.321 ± 0.45
0.0HisXaa: 0.0 ± 0.0
Ile
5.139IleAla: 5.139 ± 0.788
0.294IleCys: 0.294 ± 0.204
5.139IleAsp: 5.139 ± 0.722
3.377IleGlu: 3.377 ± 0.85
1.909IlePhe: 1.909 ± 0.581
4.405IleGly: 4.405 ± 0.646
0.734IleHis: 0.734 ± 0.41
5.286IleIle: 5.286 ± 0.923
5.432IleLys: 5.432 ± 1.053
4.551IleLeu: 4.551 ± 0.729
2.055IleMet: 2.055 ± 0.521
3.671IleAsn: 3.671 ± 0.645
1.028IlePro: 1.028 ± 0.355
2.643IleGln: 2.643 ± 0.75
2.643IleArg: 2.643 ± 0.777
3.964IleSer: 3.964 ± 0.74
5.286IleThr: 5.286 ± 0.901
2.055IleVal: 2.055 ± 0.398
0.294IleTrp: 0.294 ± 0.195
2.202IleTyr: 2.202 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
9.984LysAla: 9.984 ± 1.719
0.147LysCys: 0.147 ± 0.153
3.817LysAsp: 3.817 ± 0.981
3.23LysGlu: 3.23 ± 0.643
2.643LysPhe: 2.643 ± 0.653
4.698LysGly: 4.698 ± 0.713
1.468LysHis: 1.468 ± 0.59
3.671LysIle: 3.671 ± 0.792
7.047LysLys: 7.047 ± 1.406
6.607LysLeu: 6.607 ± 1.087
2.496LysMet: 2.496 ± 0.576
4.551LysAsn: 4.551 ± 0.763
2.643LysPro: 2.643 ± 0.715
3.083LysGln: 3.083 ± 0.587
3.377LysArg: 3.377 ± 0.696
6.02LysSer: 6.02 ± 1.196
4.551LysThr: 4.551 ± 0.906
2.79LysVal: 2.79 ± 0.701
0.587LysTrp: 0.587 ± 0.436
2.349LysTyr: 2.349 ± 0.497
0.0LysXaa: 0.0 ± 0.0
Leu
8.809LeuAla: 8.809 ± 1.19
0.44LeuCys: 0.44 ± 0.246
6.607LeuAsp: 6.607 ± 0.799
5.579LeuGlu: 5.579 ± 1.078
3.083LeuPhe: 3.083 ± 0.619
4.405LeuGly: 4.405 ± 0.969
1.468LeuHis: 1.468 ± 0.556
5.286LeuIle: 5.286 ± 0.766
7.488LeuLys: 7.488 ± 1.161
6.607LeuLeu: 6.607 ± 1.418
1.615LeuMet: 1.615 ± 0.603
5.579LeuAsn: 5.579 ± 0.679
3.083LeuPro: 3.083 ± 0.732
3.377LeuGln: 3.377 ± 0.795
4.111LeuArg: 4.111 ± 0.556
6.754LeuSer: 6.754 ± 0.9
5.579LeuThr: 5.579 ± 1.182
5.579LeuVal: 5.579 ± 0.946
1.321LeuTrp: 1.321 ± 0.322
2.496LeuTyr: 2.496 ± 0.576
0.0LeuXaa: 0.0 ± 0.0
Met
2.055MetAla: 2.055 ± 0.503
0.0MetCys: 0.0 ± 0.0
1.321MetAsp: 1.321 ± 0.532
1.175MetGlu: 1.175 ± 0.439
1.909MetPhe: 1.909 ± 0.544
1.909MetGly: 1.909 ± 0.56
0.734MetHis: 0.734 ± 0.318
1.321MetIle: 1.321 ± 0.316
2.055MetLys: 2.055 ± 0.533
1.762MetLeu: 1.762 ± 0.477
0.881MetMet: 0.881 ± 0.439
1.028MetAsn: 1.028 ± 0.478
1.321MetPro: 1.321 ± 0.314
1.321MetGln: 1.321 ± 0.525
0.44MetArg: 0.44 ± 0.268
2.643MetSer: 2.643 ± 0.599
1.909MetThr: 1.909 ± 0.471
2.349MetVal: 2.349 ± 0.94
0.294MetTrp: 0.294 ± 0.248
0.294MetTyr: 0.294 ± 0.242
0.0MetXaa: 0.0 ± 0.0
Asn
5.286AsnAla: 5.286 ± 0.919
0.147AsnCys: 0.147 ± 0.153
2.496AsnAsp: 2.496 ± 0.852
2.936AsnGlu: 2.936 ± 1.132
2.349AsnPhe: 2.349 ± 0.657
2.79AsnGly: 2.79 ± 0.7
1.175AsnHis: 1.175 ± 0.431
3.671AsnIle: 3.671 ± 0.736
3.817AsnLys: 3.817 ± 0.798
4.845AsnLeu: 4.845 ± 0.939
2.055AsnMet: 2.055 ± 0.809
2.936AsnAsn: 2.936 ± 0.862
2.936AsnPro: 2.936 ± 0.789
2.055AsnGln: 2.055 ± 0.611
2.496AsnArg: 2.496 ± 0.636
4.111AsnSer: 4.111 ± 1.164
2.055AsnThr: 2.055 ± 0.502
2.202AsnVal: 2.202 ± 0.539
0.294AsnTrp: 0.294 ± 0.176
2.496AsnTyr: 2.496 ± 0.597
0.0AsnXaa: 0.0 ± 0.0
Pro
1.468ProAla: 1.468 ± 0.575
0.44ProCys: 0.44 ± 0.249
1.615ProAsp: 1.615 ± 0.569
2.349ProGlu: 2.349 ± 0.549
2.055ProPhe: 2.055 ± 0.642
0.881ProGly: 0.881 ± 0.391
0.44ProHis: 0.44 ± 0.22
2.79ProIle: 2.79 ± 0.669
2.202ProLys: 2.202 ± 0.536
1.909ProLeu: 1.909 ± 0.534
1.175ProMet: 1.175 ± 0.305
1.909ProAsn: 1.909 ± 0.62
1.615ProPro: 1.615 ± 0.555
1.028ProGln: 1.028 ± 0.408
0.734ProArg: 0.734 ± 0.402
3.083ProSer: 3.083 ± 0.818
1.468ProThr: 1.468 ± 0.468
1.468ProVal: 1.468 ± 0.444
0.44ProTrp: 0.44 ± 0.295
0.734ProTyr: 0.734 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
6.02GlnAla: 6.02 ± 0.775
0.147GlnCys: 0.147 ± 0.186
2.643GlnAsp: 2.643 ± 0.701
2.79GlnGlu: 2.79 ± 0.542
1.175GlnPhe: 1.175 ± 0.422
1.321GlnGly: 1.321 ± 0.311
0.587GlnHis: 0.587 ± 0.267
3.671GlnIle: 3.671 ± 0.807
4.111GlnLys: 4.111 ± 0.612
3.964GlnLeu: 3.964 ± 0.707
0.881GlnMet: 0.881 ± 0.385
2.055GlnAsn: 2.055 ± 0.498
1.468GlnPro: 1.468 ± 0.462
1.909GlnGln: 1.909 ± 0.617
2.496GlnArg: 2.496 ± 0.724
2.496GlnSer: 2.496 ± 0.584
2.936GlnThr: 2.936 ± 0.577
1.909GlnVal: 1.909 ± 0.617
0.147GlnTrp: 0.147 ± 0.157
1.762GlnTyr: 1.762 ± 0.553
0.0GlnXaa: 0.0 ± 0.0
Arg
4.551ArgAla: 4.551 ± 0.591
0.294ArgCys: 0.294 ± 0.218
2.202ArgAsp: 2.202 ± 0.435
3.23ArgGlu: 3.23 ± 0.782
2.349ArgPhe: 2.349 ± 0.554
2.643ArgGly: 2.643 ± 0.616
0.734ArgHis: 0.734 ± 0.274
2.349ArgIle: 2.349 ± 0.601
2.055ArgLys: 2.055 ± 0.483
5.286ArgLeu: 5.286 ± 1.098
1.028ArgMet: 1.028 ± 0.37
2.202ArgAsn: 2.202 ± 0.488
1.762ArgPro: 1.762 ± 0.398
2.936ArgGln: 2.936 ± 0.797
2.496ArgArg: 2.496 ± 0.841
2.643ArgSer: 2.643 ± 0.735
3.083ArgThr: 3.083 ± 0.918
2.496ArgVal: 2.496 ± 0.607
0.734ArgTrp: 0.734 ± 0.305
2.936ArgTyr: 2.936 ± 0.695
0.0ArgXaa: 0.0 ± 0.0
Ser
6.46SerAla: 6.46 ± 1.045
0.44SerCys: 0.44 ± 0.23
3.083SerAsp: 3.083 ± 0.771
4.698SerGlu: 4.698 ± 0.698
2.496SerPhe: 2.496 ± 0.664
3.964SerGly: 3.964 ± 0.557
2.349SerHis: 2.349 ± 0.402
3.671SerIle: 3.671 ± 0.965
5.579SerLys: 5.579 ± 0.867
5.726SerLeu: 5.726 ± 1.022
1.615SerMet: 1.615 ± 0.475
3.083SerAsn: 3.083 ± 0.641
1.468SerPro: 1.468 ± 0.664
3.377SerGln: 3.377 ± 1.104
3.964SerArg: 3.964 ± 0.76
2.496SerSer: 2.496 ± 0.664
2.79SerThr: 2.79 ± 0.814
5.432SerVal: 5.432 ± 0.896
0.294SerTrp: 0.294 ± 0.195
1.615SerTyr: 1.615 ± 0.417
0.0SerXaa: 0.0 ± 0.0
Thr
6.607ThrAla: 6.607 ± 1.586
0.147ThrCys: 0.147 ± 0.14
3.23ThrAsp: 3.23 ± 0.8
3.377ThrGlu: 3.377 ± 0.643
1.028ThrPhe: 1.028 ± 0.457
5.139ThrGly: 5.139 ± 0.954
0.734ThrHis: 0.734 ± 0.386
3.23ThrIle: 3.23 ± 0.72
4.405ThrLys: 4.405 ± 1.175
4.845ThrLeu: 4.845 ± 0.694
1.909ThrMet: 1.909 ± 0.495
2.936ThrAsn: 2.936 ± 0.852
2.496ThrPro: 2.496 ± 0.591
3.23ThrGln: 3.23 ± 0.582
2.643ThrArg: 2.643 ± 0.668
2.349ThrSer: 2.349 ± 0.807
4.258ThrThr: 4.258 ± 0.903
4.551ThrVal: 4.551 ± 0.968
0.734ThrTrp: 0.734 ± 0.324
1.762ThrTyr: 1.762 ± 0.395
0.0ThrXaa: 0.0 ± 0.0
Val
5.139ValAla: 5.139 ± 0.965
1.175ValCys: 1.175 ± 0.517
3.377ValAsp: 3.377 ± 0.881
3.377ValGlu: 3.377 ± 0.693
1.175ValPhe: 1.175 ± 0.291
3.671ValGly: 3.671 ± 0.931
1.321ValHis: 1.321 ± 0.414
3.524ValIle: 3.524 ± 0.579
3.083ValLys: 3.083 ± 0.816
4.992ValLeu: 4.992 ± 0.769
1.762ValMet: 1.762 ± 0.529
2.79ValAsn: 2.79 ± 0.53
1.468ValPro: 1.468 ± 0.337
2.936ValGln: 2.936 ± 0.632
2.936ValArg: 2.936 ± 0.705
4.111ValSer: 4.111 ± 0.662
2.79ValThr: 2.79 ± 0.616
3.671ValVal: 3.671 ± 0.676
1.028ValTrp: 1.028 ± 0.389
2.349ValTyr: 2.349 ± 0.597
0.0ValXaa: 0.0 ± 0.0
Trp
1.028TrpAla: 1.028 ± 0.481
0.44TrpCys: 0.44 ± 0.28
0.587TrpAsp: 0.587 ± 0.185
0.734TrpGlu: 0.734 ± 0.365
0.0TrpPhe: 0.0 ± 0.0
0.734TrpGly: 0.734 ± 0.298
0.147TrpHis: 0.147 ± 0.132
0.44TrpIle: 0.44 ± 0.26
0.294TrpLys: 0.294 ± 0.212
0.881TrpLeu: 0.881 ± 0.416
0.147TrpMet: 0.147 ± 0.193
0.44TrpAsn: 0.44 ± 0.323
0.147TrpPro: 0.147 ± 0.14
1.321TrpGln: 1.321 ± 0.592
0.587TrpArg: 0.587 ± 0.318
0.881TrpSer: 0.881 ± 0.351
0.587TrpThr: 0.587 ± 0.327
0.587TrpVal: 0.587 ± 0.257
0.147TrpTrp: 0.147 ± 0.139
0.44TrpTyr: 0.44 ± 0.283
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.23TyrAla: 3.23 ± 0.96
0.294TyrCys: 0.294 ± 0.234
2.79TyrAsp: 2.79 ± 0.528
1.321TyrGlu: 1.321 ± 0.506
1.321TyrPhe: 1.321 ± 0.358
3.083TyrGly: 3.083 ± 0.597
1.175TyrHis: 1.175 ± 0.486
1.615TyrIle: 1.615 ± 0.453
1.909TyrLys: 1.909 ± 0.589
3.524TyrLeu: 3.524 ± 0.96
1.028TyrMet: 1.028 ± 0.435
0.881TyrAsn: 0.881 ± 0.328
0.881TyrPro: 0.881 ± 0.446
1.321TyrGln: 1.321 ± 0.432
2.496TyrArg: 2.496 ± 0.54
3.083TyrSer: 3.083 ± 0.612
1.615TyrThr: 1.615 ± 0.439
1.468TyrVal: 1.468 ± 0.499
0.44TyrTrp: 0.44 ± 0.217
1.762TyrTyr: 1.762 ± 0.545
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 33 proteins (6812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski