Amino acid dipepetide frequency for Lentzea sp. FXJ1.1311

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.8AlaAla: 17.8 ± 0.128
1.111AlaCys: 1.111 ± 0.023
7.822AlaAsp: 7.822 ± 0.07
8.143AlaGlu: 8.143 ± 0.072
3.566AlaPhe: 3.566 ± 0.039
11.328AlaGly: 11.328 ± 0.088
2.715AlaHis: 2.715 ± 0.035
4.118AlaIle: 4.118 ± 0.043
3.088AlaLys: 3.088 ± 0.05
13.899AlaLeu: 13.899 ± 0.1
2.459AlaMet: 2.459 ± 0.028
2.476AlaAsn: 2.476 ± 0.039
5.743AlaPro: 5.743 ± 0.069
3.764AlaGln: 3.764 ± 0.045
8.93AlaArg: 8.93 ± 0.075
6.243AlaSer: 6.243 ± 0.052
6.716AlaThr: 6.716 ± 0.052
11.733AlaVal: 11.733 ± 0.074
1.853AlaTrp: 1.853 ± 0.027
2.229AlaTyr: 2.229 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
1.145CysAla: 1.145 ± 0.024
0.1CysCys: 0.1 ± 0.007
0.532CysAsp: 0.532 ± 0.016
0.427CysGlu: 0.427 ± 0.012
0.25CysPhe: 0.25 ± 0.01
1.023CysGly: 1.023 ± 0.019
0.203CysHis: 0.203 ± 0.008
0.184CysIle: 0.184 ± 0.009
0.129CysLys: 0.129 ± 0.007
0.787CysLeu: 0.787 ± 0.019
0.143CysMet: 0.143 ± 0.007
0.16CysAsn: 0.16 ± 0.008
0.496CysPro: 0.496 ± 0.014
0.23CysGln: 0.23 ± 0.009
0.634CysArg: 0.634 ± 0.015
0.536CysSer: 0.536 ± 0.014
0.537CysThr: 0.537 ± 0.014
0.723CysVal: 0.723 ± 0.019
0.15CysTrp: 0.15 ± 0.008
0.188CysTyr: 0.188 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.296AspAla: 7.296 ± 0.071
0.446AspCys: 0.446 ± 0.013
3.771AspAsp: 3.771 ± 0.043
4.26AspGlu: 4.26 ± 0.048
1.771AspPhe: 1.771 ± 0.025
6.138AspGly: 6.138 ± 0.059
1.49AspHis: 1.49 ± 0.025
1.85AspIle: 1.85 ± 0.027
1.254AspLys: 1.254 ± 0.028
6.569AspLeu: 6.569 ± 0.058
0.831AspMet: 0.831 ± 0.017
1.201AspAsn: 1.201 ± 0.021
4.021AspPro: 4.021 ± 0.036
1.874AspGln: 1.874 ± 0.027
4.653AspArg: 4.653 ± 0.049
2.578AspSer: 2.578 ± 0.03
2.912AspThr: 2.912 ± 0.039
5.983AspVal: 5.983 ± 0.049
0.978AspTrp: 0.978 ± 0.02
1.168AspTyr: 1.168 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
6.336GluAla: 6.336 ± 0.057
0.429GluCys: 0.429 ± 0.013
2.583GluAsp: 2.583 ± 0.033
2.901GluGlu: 2.901 ± 0.041
1.787GluPhe: 1.787 ± 0.027
3.374GluGly: 3.374 ± 0.041
1.732GluHis: 1.732 ± 0.025
2.54GluIle: 2.54 ± 0.032
1.388GluLys: 1.388 ± 0.027
7.596GluLeu: 7.596 ± 0.076
0.972GluMet: 0.972 ± 0.021
1.206GluAsn: 1.206 ± 0.023
3.147GluPro: 3.147 ± 0.041
2.474GluGln: 2.474 ± 0.03
4.834GluArg: 4.834 ± 0.047
2.612GluSer: 2.612 ± 0.034
2.632GluThr: 2.632 ± 0.032
5.071GluVal: 5.071 ± 0.047
0.862GluTrp: 0.862 ± 0.02
1.076GluTyr: 1.076 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
3.916PheAla: 3.916 ± 0.04
0.281PheCys: 0.281 ± 0.01
2.286PheAsp: 2.286 ± 0.034
1.547PheGlu: 1.547 ± 0.026
0.947PhePhe: 0.947 ± 0.025
3.355PheGly: 3.355 ± 0.038
0.686PheHis: 0.686 ± 0.017
0.761PheIle: 0.761 ± 0.019
0.541PheLys: 0.541 ± 0.015
2.686PheLeu: 2.686 ± 0.04
0.417PheMet: 0.417 ± 0.012
0.653PheAsn: 0.653 ± 0.018
1.428PhePro: 1.428 ± 0.022
0.786PheGln: 0.786 ± 0.018
1.936PheArg: 1.936 ± 0.028
1.713PheSer: 1.713 ± 0.024
2.159PheThr: 2.159 ± 0.031
2.723PheVal: 2.723 ± 0.029
0.438PheTrp: 0.438 ± 0.013
0.644PheTyr: 0.644 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
9.486GlyAla: 9.486 ± 0.077
0.845GlyCys: 0.845 ± 0.02
5.2GlyAsp: 5.2 ± 0.054
4.841GlyGlu: 4.841 ± 0.049
3.042GlyPhe: 3.042 ± 0.036
7.681GlyGly: 7.681 ± 0.076
2.13GlyHis: 2.13 ± 0.029
3.4GlyIle: 3.4 ± 0.038
2.746GlyLys: 2.746 ± 0.04
8.836GlyLeu: 8.836 ± 0.072
1.899GlyMet: 1.899 ± 0.027
2.035GlyAsn: 2.035 ± 0.038
4.261GlyPro: 4.261 ± 0.044
2.794GlyGln: 2.794 ± 0.034
6.502GlyArg: 6.502 ± 0.06
5.043GlySer: 5.043 ± 0.044
5.561GlyThr: 5.561 ± 0.055
8.174GlyVal: 8.174 ± 0.069
1.717GlyTrp: 1.717 ± 0.026
2.301GlyTyr: 2.301 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
2.696HisAla: 2.696 ± 0.036
0.231HisCys: 0.231 ± 0.009
1.496HisAsp: 1.496 ± 0.026
1.329HisGlu: 1.329 ± 0.025
0.664HisPhe: 0.664 ± 0.017
2.244HisGly: 2.244 ± 0.033
0.722HisHis: 0.722 ± 0.019
0.648HisIle: 0.648 ± 0.016
0.357HisLys: 0.357 ± 0.012
2.446HisLeu: 2.446 ± 0.033
0.318HisMet: 0.318 ± 0.011
0.481HisAsn: 0.481 ± 0.013
1.62HisPro: 1.62 ± 0.028
0.714HisGln: 0.714 ± 0.018
2.053HisArg: 2.053 ± 0.027
1.083HisSer: 1.083 ± 0.023
1.236HisThr: 1.236 ± 0.025
2.122HisVal: 2.122 ± 0.029
0.373HisTrp: 0.373 ± 0.011
0.503HisTyr: 0.503 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
5.261IleAla: 5.261 ± 0.049
0.294IleCys: 0.294 ± 0.011
2.503IleAsp: 2.503 ± 0.036
2.131IleGlu: 2.131 ± 0.031
0.763IlePhe: 0.763 ± 0.018
3.885IleGly: 3.885 ± 0.044
0.619IleHis: 0.619 ± 0.016
1.011IleIle: 1.011 ± 0.021
0.873IleLys: 0.873 ± 0.02
2.174IleLeu: 2.174 ± 0.031
0.496IleMet: 0.496 ± 0.014
0.886IleAsn: 0.886 ± 0.018
1.821IlePro: 1.821 ± 0.027
0.783IleGln: 0.783 ± 0.019
2.344IleArg: 2.344 ± 0.03
2.051IleSer: 2.051 ± 0.026
2.631IleThr: 2.631 ± 0.036
2.997IleVal: 2.997 ± 0.037
0.422IleTrp: 0.422 ± 0.013
0.615IleTyr: 0.615 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
2.882LysAla: 2.882 ± 0.036
0.149LysCys: 0.149 ± 0.008
1.232LysAsp: 1.232 ± 0.027
1.061LysGlu: 1.061 ± 0.026
0.653LysPhe: 0.653 ± 0.016
1.652LysGly: 1.652 ± 0.031
0.543LysHis: 0.543 ± 0.015
1.068LysIle: 1.068 ± 0.025
0.739LysLys: 0.739 ± 0.021
2.548LysLeu: 2.548 ± 0.036
0.415LysMet: 0.415 ± 0.013
0.573LysAsn: 0.573 ± 0.016
1.623LysPro: 1.623 ± 0.029
0.806LysGln: 0.806 ± 0.018
1.627LysArg: 1.627 ± 0.029
1.269LysSer: 1.269 ± 0.027
1.411LysThr: 1.411 ± 0.027
2.235LysVal: 2.235 ± 0.037
0.372LysTrp: 0.372 ± 0.011
0.488LysTyr: 0.488 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
14.598LeuAla: 14.598 ± 0.102
0.909LeuCys: 0.909 ± 0.02
6.969LeuAsp: 6.969 ± 0.059
4.876LeuGlu: 4.876 ± 0.053
2.82LeuPhe: 2.82 ± 0.038
9.21LeuGly: 9.21 ± 0.075
2.426LeuHis: 2.426 ± 0.039
3.42LeuIle: 3.42 ± 0.042
2.103LeuLys: 2.103 ± 0.035
11.094LeuLeu: 11.094 ± 0.098
1.638LeuMet: 1.638 ± 0.027
2.002LeuAsn: 2.002 ± 0.027
6.151LeuPro: 6.151 ± 0.054
2.312LeuGln: 2.312 ± 0.03
8.792LeuArg: 8.792 ± 0.066
5.803LeuSer: 5.803 ± 0.056
6.565LeuThr: 6.565 ± 0.055
10.16LeuVal: 10.16 ± 0.073
1.353LeuTrp: 1.353 ± 0.026
1.702LeuTyr: 1.702 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
2.121MetAla: 2.121 ± 0.026
0.136MetCys: 0.136 ± 0.008
0.89MetAsp: 0.89 ± 0.017
0.671MetGlu: 0.671 ± 0.016
0.537MetPhe: 0.537 ± 0.015
1.24MetGly: 1.24 ± 0.025
0.388MetHis: 0.388 ± 0.013
0.772MetIle: 0.772 ± 0.018
0.466MetLys: 0.466 ± 0.013
1.827MetLeu: 1.827 ± 0.029
0.303MetMet: 0.303 ± 0.011
0.431MetAsn: 0.431 ± 0.013
1.043MetPro: 1.043 ± 0.019
0.441MetGln: 0.441 ± 0.015
1.648MetArg: 1.648 ± 0.023
1.36MetSer: 1.36 ± 0.022
1.481MetThr: 1.481 ± 0.025
1.415MetVal: 1.415 ± 0.025
0.239MetTrp: 0.239 ± 0.01
0.303MetTyr: 0.303 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.556AsnAla: 2.556 ± 0.034
0.216AsnCys: 0.216 ± 0.009
1.198AsnAsp: 1.198 ± 0.026
0.997AsnGlu: 0.997 ± 0.02
0.597AsnPhe: 0.597 ± 0.017
2.391AsnGly: 2.391 ± 0.041
0.449AsnHis: 0.449 ± 0.013
0.723AsnIle: 0.723 ± 0.021
0.507AsnLys: 0.507 ± 0.016
2.021AsnLeu: 2.021 ± 0.035
0.317AsnMet: 0.317 ± 0.01
0.603AsnAsn: 0.603 ± 0.019
1.64AsnPro: 1.64 ± 0.03
0.672AsnGln: 0.672 ± 0.02
1.543AsnArg: 1.543 ± 0.025
1.154AsnSer: 1.154 ± 0.024
1.304AsnThr: 1.304 ± 0.026
1.735AsnVal: 1.735 ± 0.028
0.369AsnTrp: 0.369 ± 0.013
0.495AsnTyr: 0.495 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
7.093ProAla: 7.093 ± 0.073
0.379ProCys: 0.379 ± 0.014
4.407ProAsp: 4.407 ± 0.048
3.774ProGlu: 3.774 ± 0.042
1.607ProPhe: 1.607 ± 0.023
5.552ProGly: 5.552 ± 0.061
1.25ProHis: 1.25 ± 0.026
1.698ProIle: 1.698 ± 0.022
1.336ProLys: 1.336 ± 0.026
5.027ProLeu: 5.027 ± 0.047
1.027ProMet: 1.027 ± 0.019
1.275ProAsn: 1.275 ± 0.03
3.262ProPro: 3.262 ± 0.06
1.616ProGln: 1.616 ± 0.028
3.506ProArg: 3.506 ± 0.043
3.309ProSer: 3.309 ± 0.042
2.962ProThr: 2.962 ± 0.036
5.474ProVal: 5.474 ± 0.049
0.89ProTrp: 0.89 ± 0.018
1.008ProTyr: 1.008 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
3.741GlnAla: 3.741 ± 0.042
0.206GlnCys: 0.206 ± 0.011
1.371GlnAsp: 1.371 ± 0.024
1.397GlnGlu: 1.397 ± 0.023
0.839GlnPhe: 0.839 ± 0.017
2.054GlnGly: 2.054 ± 0.03
0.811GlnHis: 0.811 ± 0.018
1.177GlnIle: 1.177 ± 0.023
0.666GlnLys: 0.666 ± 0.016
3.514GlnLeu: 3.514 ± 0.037
0.47GlnMet: 0.47 ± 0.013
0.625GlnAsn: 0.625 ± 0.018
1.827GlnPro: 1.827 ± 0.031
1.38GlnGln: 1.38 ± 0.027
2.699GlnArg: 2.699 ± 0.036
1.342GlnSer: 1.342 ± 0.027
1.388GlnThr: 1.388 ± 0.023
2.877GlnVal: 2.877 ± 0.041
0.51GlnTrp: 0.51 ± 0.016
0.586GlnTyr: 0.586 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
8.848ArgAla: 8.848 ± 0.08
0.696ArgCys: 0.696 ± 0.017
4.302ArgAsp: 4.302 ± 0.043
4.352ArgGlu: 4.352 ± 0.04
2.576ArgPhe: 2.576 ± 0.032
5.569ArgGly: 5.569 ± 0.047
1.87ArgHis: 1.87 ± 0.03
3.109ArgIle: 3.109 ± 0.033
1.905ArgLys: 1.905 ± 0.027
8.243ArgLeu: 8.243 ± 0.079
1.856ArgMet: 1.856 ± 0.027
1.606ArgAsn: 1.606 ± 0.024
4.179ArgPro: 4.179 ± 0.047
2.433ArgGln: 2.433 ± 0.03
6.731ArgArg: 6.731 ± 0.067
4.14ArgSer: 4.14 ± 0.042
4.838ArgThr: 4.838 ± 0.047
6.15ArgVal: 6.15 ± 0.049
1.408ArgTrp: 1.408 ± 0.025
1.778ArgTyr: 1.778 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.896SerAla: 6.896 ± 0.06
0.494SerCys: 0.494 ± 0.016
2.939SerAsp: 2.939 ± 0.033
2.533SerGlu: 2.533 ± 0.033
1.745SerPhe: 1.745 ± 0.029
5.951SerGly: 5.951 ± 0.051
1.036SerHis: 1.036 ± 0.017
1.788SerIle: 1.788 ± 0.029
1.137SerLys: 1.137 ± 0.023
5.263SerLeu: 5.263 ± 0.048
1.198SerMet: 1.198 ± 0.021
1.149SerAsn: 1.149 ± 0.023
3.122SerPro: 3.122 ± 0.035
1.354SerGln: 1.354 ± 0.023
3.894SerArg: 3.894 ± 0.039
3.413SerSer: 3.413 ± 0.05
3.512SerThr: 3.512 ± 0.039
4.769SerVal: 4.769 ± 0.044
1.058SerTrp: 1.058 ± 0.021
1.205SerTyr: 1.205 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
7.717ThrAla: 7.717 ± 0.065
0.517ThrCys: 0.517 ± 0.015
3.369ThrAsp: 3.369 ± 0.036
3.156ThrGlu: 3.156 ± 0.039
1.803ThrPhe: 1.803 ± 0.026
6.1ThrGly: 6.1 ± 0.058
1.191ThrHis: 1.191 ± 0.023
2.102ThrIle: 2.102 ± 0.029
1.439ThrLys: 1.439 ± 0.028
5.303ThrLeu: 5.303 ± 0.047
1.046ThrMet: 1.046 ± 0.019
1.325ThrAsn: 1.325 ± 0.028
3.862ThrPro: 3.862 ± 0.05
1.366ThrGln: 1.366 ± 0.025
3.83ThrArg: 3.83 ± 0.038
3.684ThrSer: 3.684 ± 0.043
4.166ThrThr: 4.166 ± 0.057
5.692ThrVal: 5.692 ± 0.058
1.005ThrTrp: 1.005 ± 0.022
1.244ThrTyr: 1.244 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
11.419ValAla: 11.419 ± 0.074
0.782ValCys: 0.782 ± 0.019
6.037ValAsp: 6.037 ± 0.055
5.354ValGlu: 5.354 ± 0.051
2.664ValPhe: 2.664 ± 0.036
6.799ValGly: 6.799 ± 0.06
2.222ValHis: 2.222 ± 0.03
3.219ValIle: 3.219 ± 0.034
1.913ValLys: 1.913 ± 0.033
10.939ValLeu: 10.939 ± 0.076
1.353ValMet: 1.353 ± 0.024
1.934ValAsn: 1.934 ± 0.036
5.334ValPro: 5.334 ± 0.048
2.345ValGln: 2.345 ± 0.03
7.196ValArg: 7.196 ± 0.061
5.014ValSer: 5.014 ± 0.052
5.734ValThr: 5.734 ± 0.053
9.749ValVal: 9.749 ± 0.082
1.194ValTrp: 1.194 ± 0.025
1.499ValTyr: 1.499 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
1.608TrpAla: 1.608 ± 0.025
0.163TrpCys: 0.163 ± 0.008
0.856TrpAsp: 0.856 ± 0.021
0.74TrpGlu: 0.74 ± 0.019
0.592TrpPhe: 0.592 ± 0.014
1.071TrpGly: 1.071 ± 0.022
0.438TrpHis: 0.438 ± 0.012
0.561TrpIle: 0.561 ± 0.016
0.366TrpLys: 0.366 ± 0.011
1.93TrpLeu: 1.93 ± 0.028
0.317TrpMet: 0.317 ± 0.01
0.44TrpAsn: 0.44 ± 0.013
0.834TrpPro: 0.834 ± 0.014
0.667TrpGln: 0.667 ± 0.016
1.401TrpArg: 1.401 ± 0.03
1.02TrpSer: 1.02 ± 0.019
1.058TrpThr: 1.058 ± 0.02
1.179TrpVal: 1.179 ± 0.024
0.36TrpTrp: 0.36 ± 0.013
0.33TrpTyr: 0.33 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.318TyrAla: 2.318 ± 0.031
0.193TyrCys: 0.193 ± 0.007
1.283TyrAsp: 1.283 ± 0.022
1.059TyrGlu: 1.059 ± 0.02
0.682TyrPhe: 0.682 ± 0.017
1.875TyrGly: 1.875 ± 0.03
0.415TyrHis: 0.415 ± 0.013
0.413TyrIle: 0.413 ± 0.012
0.391TyrLys: 0.391 ± 0.013
2.205TyrLeu: 2.205 ± 0.03
0.237TyrMet: 0.237 ± 0.009
0.428TyrAsn: 0.428 ± 0.015
1.036TyrPro: 1.036 ± 0.02
0.668TyrGln: 0.668 ± 0.016
1.838TyrArg: 1.838 ± 0.028
1.09TyrSer: 1.09 ± 0.021
1.115TyrThr: 1.115 ± 0.025
1.74TyrVal: 1.74 ± 0.028
0.377TyrTrp: 0.377 ± 0.013
0.47TyrTyr: 0.47 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8306 proteins (2773018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski