Amino acid dipepetide frequency for Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.734AlaAla: 3.734 ± 0.06
0.598AlaCys: 0.598 ± 0.017
2.65AlaAsp: 2.65 ± 0.034
2.927AlaGlu: 2.927 ± 0.044
2.12AlaPhe: 2.12 ± 0.033
2.683AlaGly: 2.683 ± 0.046
1.02AlaHis: 1.02 ± 0.02
3.534AlaIle: 3.534 ± 0.034
3.754AlaLys: 3.754 ± 0.043
5.062AlaLeu: 5.062 ± 0.05
1.242AlaMet: 1.242 ± 0.019
2.934AlaAsn: 2.934 ± 0.032
2.232AlaPro: 2.232 ± 0.039
1.99AlaGln: 1.99 ± 0.032
2.212AlaArg: 2.212 ± 0.03
4.53AlaSer: 4.53 ± 0.05
3.795AlaThr: 3.795 ± 0.044
2.916AlaVal: 2.916 ± 0.037
0.469AlaTrp: 0.469 ± 0.014
1.566AlaTyr: 1.566 ± 0.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.558CysAla: 0.558 ± 0.015
0.268CysCys: 0.268 ± 0.011
0.624CysAsp: 0.624 ± 0.014
0.57CysGlu: 0.57 ± 0.016
0.628CysPhe: 0.628 ± 0.017
0.747CysGly: 0.747 ± 0.019
0.304CysHis: 0.304 ± 0.011
0.907CysIle: 0.907 ± 0.017
0.713CysLys: 0.713 ± 0.018
1.246CysLeu: 1.246 ± 0.025
0.262CysMet: 0.262 ± 0.011
0.6CysAsn: 0.6 ± 0.018
0.474CysPro: 0.474 ± 0.015
0.457CysGln: 0.457 ± 0.013
0.451CysArg: 0.451 ± 0.013
0.956CysSer: 0.956 ± 0.021
0.611CysThr: 0.611 ± 0.016
0.721CysVal: 0.721 ± 0.019
0.135CysTrp: 0.135 ± 0.007
0.471CysTyr: 0.471 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.058AspAla: 3.058 ± 0.034
0.611AspCys: 0.611 ± 0.014
4.892AspAsp: 4.892 ± 0.073
5.279AspGlu: 5.279 ± 0.051
2.633AspPhe: 2.633 ± 0.034
2.866AspGly: 2.866 ± 0.039
1.117AspHis: 1.117 ± 0.02
4.343AspIle: 4.343 ± 0.038
3.646AspLys: 3.646 ± 0.04
5.76AspLeu: 5.76 ± 0.042
1.281AspMet: 1.281 ± 0.022
3.365AspAsn: 3.365 ± 0.038
2.558AspPro: 2.558 ± 0.031
1.931AspGln: 1.931 ± 0.025
2.011AspArg: 2.011 ± 0.026
4.758AspSer: 4.758 ± 0.041
3.235AspThr: 3.235 ± 0.035
3.492AspVal: 3.492 ± 0.044
0.632AspTrp: 0.632 ± 0.019
2.082AspTyr: 2.082 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
3.225GluAla: 3.225 ± 0.038
0.629GluCys: 0.629 ± 0.018
4.512GluAsp: 4.512 ± 0.048
6.543GluGlu: 6.543 ± 0.102
2.752GluPhe: 2.752 ± 0.027
2.751GluGly: 2.751 ± 0.039
1.261GluHis: 1.261 ± 0.022
4.364GluIle: 4.364 ± 0.05
5.432GluLys: 5.432 ± 0.058
6.679GluLeu: 6.679 ± 0.07
1.517GluMet: 1.517 ± 0.026
4.42GluAsn: 4.42 ± 0.042
2.26GluPro: 2.26 ± 0.036
2.887GluGln: 2.887 ± 0.039
3.031GluArg: 3.031 ± 0.035
4.827GluSer: 4.827 ± 0.046
4.036GluThr: 4.036 ± 0.045
3.33GluVal: 3.33 ± 0.04
0.662GluTrp: 0.662 ± 0.018
2.244GluTyr: 2.244 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
2.307PheAla: 2.307 ± 0.032
0.528PheCys: 0.528 ± 0.015
2.792PheAsp: 2.792 ± 0.037
2.807PheGlu: 2.807 ± 0.034
2.037PhePhe: 2.037 ± 0.032
2.501PheGly: 2.501 ± 0.044
1.062PheHis: 1.062 ± 0.022
3.174PheIle: 3.174 ± 0.037
3.177PheLys: 3.177 ± 0.035
4.042PheLeu: 4.042 ± 0.037
0.917PheMet: 0.917 ± 0.018
2.749PheAsn: 2.749 ± 0.032
1.853PhePro: 1.853 ± 0.027
2.046PheGln: 2.046 ± 0.024
1.509PheArg: 1.509 ± 0.024
3.399PheSer: 3.399 ± 0.047
2.52PheThr: 2.52 ± 0.033
2.467PheVal: 2.467 ± 0.032
0.509PheTrp: 0.509 ± 0.015
1.531PheTyr: 1.531 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
2.69GlyAla: 2.69 ± 0.042
0.703GlyCys: 0.703 ± 0.015
2.646GlyAsp: 2.646 ± 0.033
2.806GlyGlu: 2.806 ± 0.035
2.306GlyPhe: 2.306 ± 0.036
3.058GlyGly: 3.058 ± 0.048
1.0GlyHis: 1.0 ± 0.022
3.495GlyIle: 3.495 ± 0.044
3.602GlyLys: 3.602 ± 0.039
4.343GlyLeu: 4.343 ± 0.048
1.052GlyMet: 1.052 ± 0.024
2.845GlyAsn: 2.845 ± 0.036
1.621GlyPro: 1.621 ± 0.029
1.575GlyGln: 1.575 ± 0.029
2.066GlyArg: 2.066 ± 0.033
4.328GlySer: 4.328 ± 0.043
3.124GlyThr: 3.124 ± 0.039
2.94GlyVal: 2.94 ± 0.045
0.576GlyTrp: 0.576 ± 0.017
1.746GlyTyr: 1.746 ± 0.028
0.0GlyXaa: 0.0 ± 0.0
His
0.906HisAla: 0.906 ± 0.019
0.3HisCys: 0.3 ± 0.011
1.214HisAsp: 1.214 ± 0.024
1.263HisGlu: 1.263 ± 0.021
1.004HisPhe: 1.004 ± 0.02
1.063HisGly: 1.063 ± 0.021
0.731HisHis: 0.731 ± 0.021
1.432HisIle: 1.432 ± 0.022
1.21HisLys: 1.21 ± 0.022
2.172HisLeu: 2.172 ± 0.031
0.442HisMet: 0.442 ± 0.013
1.122HisAsn: 1.122 ± 0.021
1.129HisPro: 1.129 ± 0.023
0.815HisGln: 0.815 ± 0.017
0.946HisArg: 0.946 ± 0.019
1.882HisSer: 1.882 ± 0.033
1.103HisThr: 1.103 ± 0.021
1.131HisVal: 1.131 ± 0.02
0.247HisTrp: 0.247 ± 0.01
0.779HisTyr: 0.779 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
3.536IleAla: 3.536 ± 0.041
0.886IleCys: 0.886 ± 0.019
4.259IleAsp: 4.259 ± 0.044
4.252IleGlu: 4.252 ± 0.046
3.05IlePhe: 3.05 ± 0.036
3.049IleGly: 3.049 ± 0.037
1.448IleHis: 1.448 ± 0.024
4.671IleIle: 4.671 ± 0.046
4.683IleLys: 4.683 ± 0.042
6.634IleLeu: 6.634 ± 0.059
1.449IleMet: 1.449 ± 0.025
4.092IleAsn: 4.092 ± 0.045
3.667IlePro: 3.667 ± 0.04
2.587IleGln: 2.587 ± 0.03
2.821IleArg: 2.821 ± 0.034
5.866IleSer: 5.866 ± 0.058
4.025IleThr: 4.025 ± 0.048
3.74IleVal: 3.74 ± 0.039
0.729IleTrp: 0.729 ± 0.018
2.132IleTyr: 2.132 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.313LysAla: 3.313 ± 0.04
0.794LysCys: 0.794 ± 0.016
4.298LysAsp: 4.298 ± 0.049
5.547LysGlu: 5.547 ± 0.059
3.192LysPhe: 3.192 ± 0.035
2.962LysGly: 2.962 ± 0.035
1.498LysHis: 1.498 ± 0.025
4.884LysIle: 4.884 ± 0.05
6.8LysLys: 6.8 ± 0.078
7.296LysLeu: 7.296 ± 0.068
1.632LysMet: 1.632 ± 0.024
4.501LysAsn: 4.501 ± 0.049
2.887LysPro: 2.887 ± 0.037
2.915LysGln: 2.915 ± 0.035
3.903LysArg: 3.903 ± 0.043
5.259LysSer: 5.259 ± 0.052
3.998LysThr: 3.998 ± 0.039
3.855LysVal: 3.855 ± 0.04
0.773LysTrp: 0.773 ± 0.018
2.713LysTyr: 2.713 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
5.019LeuAla: 5.019 ± 0.059
1.216LeuCys: 1.216 ± 0.025
5.438LeuAsp: 5.438 ± 0.05
6.327LeuGlu: 6.327 ± 0.068
4.207LeuPhe: 4.207 ± 0.05
4.382LeuGly: 4.382 ± 0.044
2.012LeuHis: 2.012 ± 0.027
6.044LeuIle: 6.044 ± 0.057
7.646LeuLys: 7.646 ± 0.065
9.741LeuLeu: 9.741 ± 0.096
2.017LeuMet: 2.017 ± 0.027
6.065LeuAsn: 6.065 ± 0.056
4.742LeuPro: 4.742 ± 0.043
4.473LeuGln: 4.473 ± 0.048
4.432LeuArg: 4.432 ± 0.043
8.145LeuSer: 8.145 ± 0.065
5.673LeuThr: 5.673 ± 0.051
4.881LeuVal: 4.881 ± 0.049
0.893LeuTrp: 0.893 ± 0.019
2.997LeuTyr: 2.997 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.419MetAla: 1.419 ± 0.022
0.231MetCys: 0.231 ± 0.01
1.491MetAsp: 1.491 ± 0.026
1.535MetGlu: 1.535 ± 0.026
0.913MetPhe: 0.913 ± 0.02
1.258MetGly: 1.258 ± 0.023
0.362MetHis: 0.362 ± 0.012
1.36MetIle: 1.36 ± 0.024
1.627MetLys: 1.627 ± 0.025
1.899MetLeu: 1.899 ± 0.026
0.542MetMet: 0.542 ± 0.017
1.527MetAsn: 1.527 ± 0.03
0.792MetPro: 0.792 ± 0.02
0.738MetGln: 0.738 ± 0.018
0.853MetArg: 0.853 ± 0.019
2.007MetSer: 2.007 ± 0.027
1.364MetThr: 1.364 ± 0.028
1.269MetVal: 1.269 ± 0.022
0.192MetTrp: 0.192 ± 0.008
0.572MetTyr: 0.572 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.118AsnAla: 3.118 ± 0.038
0.639AsnCys: 0.639 ± 0.017
4.232AsnAsp: 4.232 ± 0.046
4.549AsnGlu: 4.549 ± 0.048
2.499AsnPhe: 2.499 ± 0.028
3.34AsnGly: 3.34 ± 0.042
1.179AsnHis: 1.179 ± 0.022
4.288AsnIle: 4.288 ± 0.049
4.343AsnLys: 4.343 ± 0.051
5.341AsnLeu: 5.341 ± 0.052
1.354AsnMet: 1.354 ± 0.024
5.26AsnAsn: 5.26 ± 0.105
2.616AsnPro: 2.616 ± 0.039
2.189AsnGln: 2.189 ± 0.037
2.183AsnArg: 2.183 ± 0.029
5.435AsnSer: 5.435 ± 0.069
3.68AsnThr: 3.68 ± 0.042
3.573AsnVal: 3.573 ± 0.036
0.657AsnTrp: 0.657 ± 0.015
1.974AsnTyr: 1.974 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
2.205ProAla: 2.205 ± 0.034
0.351ProCys: 0.351 ± 0.014
2.179ProAsp: 2.179 ± 0.031
2.918ProGlu: 2.918 ± 0.035
1.927ProPhe: 1.927 ± 0.031
1.836ProGly: 1.836 ± 0.031
0.921ProHis: 0.921 ± 0.02
3.164ProIle: 3.164 ± 0.036
2.896ProLys: 2.896 ± 0.042
4.202ProLeu: 4.202 ± 0.043
0.966ProMet: 0.966 ± 0.02
2.633ProAsn: 2.633 ± 0.035
2.617ProPro: 2.617 ± 0.059
1.964ProGln: 1.964 ± 0.039
1.705ProArg: 1.705 ± 0.029
4.175ProSer: 4.175 ± 0.051
3.28ProThr: 3.28 ± 0.039
2.563ProVal: 2.563 ± 0.036
0.438ProTrp: 0.438 ± 0.011
1.434ProTyr: 1.434 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
1.844GlnAla: 1.844 ± 0.031
0.462GlnCys: 0.462 ± 0.013
2.2GlnAsp: 2.2 ± 0.03
2.893GlnGlu: 2.893 ± 0.031
1.834GlnPhe: 1.834 ± 0.025
1.705GlnGly: 1.705 ± 0.03
0.853GlnHis: 0.853 ± 0.02
2.528GlnIle: 2.528 ± 0.033
2.611GlnLys: 2.611 ± 0.04
4.371GlnLeu: 4.371 ± 0.045
0.912GlnMet: 0.912 ± 0.019
2.362GlnAsn: 2.362 ± 0.036
1.734GlnPro: 1.734 ± 0.037
3.099GlnGln: 3.099 ± 0.117
2.039GlnArg: 2.039 ± 0.027
2.853GlnSer: 2.853 ± 0.041
2.204GlnThr: 2.204 ± 0.031
2.049GlnVal: 2.049 ± 0.027
0.441GlnTrp: 0.441 ± 0.012
1.478GlnTyr: 1.478 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.153ArgAla: 2.153 ± 0.032
0.527ArgCys: 0.527 ± 0.015
2.414ArgAsp: 2.414 ± 0.032
2.825ArgGlu: 2.825 ± 0.03
1.839ArgPhe: 1.839 ± 0.025
2.081ArgGly: 2.081 ± 0.034
0.958ArgHis: 0.958 ± 0.019
2.905ArgIle: 2.905 ± 0.034
3.557ArgLys: 3.557 ± 0.047
4.033ArgLeu: 4.033 ± 0.042
0.915ArgMet: 0.915 ± 0.017
2.591ArgAsn: 2.591 ± 0.036
1.585ArgPro: 1.585 ± 0.029
1.671ArgGln: 1.671 ± 0.027
2.873ArgArg: 2.873 ± 0.041
3.46ArgSer: 3.46 ± 0.038
2.517ArgThr: 2.517 ± 0.034
2.158ArgVal: 2.158 ± 0.024
0.466ArgTrp: 0.466 ± 0.015
1.55ArgTyr: 1.55 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
4.084SerAla: 4.084 ± 0.07
0.867SerCys: 0.867 ± 0.02
4.336SerAsp: 4.336 ± 0.047
4.516SerGlu: 4.516 ± 0.053
3.717SerPhe: 3.717 ± 0.041
3.952SerGly: 3.952 ± 0.051
1.849SerHis: 1.849 ± 0.028
5.898SerIle: 5.898 ± 0.062
6.146SerLys: 6.146 ± 0.052
8.24SerLeu: 8.24 ± 0.059
2.005SerMet: 2.005 ± 0.028
5.858SerAsn: 5.858 ± 0.062
3.792SerPro: 3.792 ± 0.052
3.275SerGln: 3.275 ± 0.04
3.547SerArg: 3.547 ± 0.041
10.257SerSer: 10.257 ± 0.195
6.279SerThr: 6.279 ± 0.081
4.377SerVal: 4.377 ± 0.045
0.807SerTrp: 0.807 ± 0.017
2.526SerTyr: 2.526 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
3.401ThrAla: 3.401 ± 0.043
0.643ThrCys: 0.643 ± 0.017
3.239ThrAsp: 3.239 ± 0.04
3.578ThrGlu: 3.578 ± 0.044
2.705ThrPhe: 2.705 ± 0.033
3.196ThrGly: 3.196 ± 0.044
1.226ThrHis: 1.226 ± 0.021
4.286ThrIle: 4.286 ± 0.039
4.287ThrLys: 4.287 ± 0.044
5.905ThrLeu: 5.905 ± 0.059
1.33ThrMet: 1.33 ± 0.021
3.889ThrAsn: 3.889 ± 0.044
3.266ThrPro: 3.266 ± 0.041
2.098ThrGln: 2.098 ± 0.028
2.4ThrArg: 2.4 ± 0.03
5.945ThrSer: 5.945 ± 0.08
5.087ThrThr: 5.087 ± 0.088
3.566ThrVal: 3.566 ± 0.037
0.556ThrTrp: 0.556 ± 0.015
1.742ThrTyr: 1.742 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
3.269ValAla: 3.269 ± 0.043
0.719ValCys: 0.719 ± 0.017
3.425ValAsp: 3.425 ± 0.043
3.651ValGlu: 3.651 ± 0.046
2.408ValPhe: 2.408 ± 0.037
2.749ValGly: 2.749 ± 0.038
1.089ValHis: 1.089 ± 0.019
3.574ValIle: 3.574 ± 0.038
3.846ValLys: 3.846 ± 0.038
5.059ValLeu: 5.059 ± 0.05
1.139ValMet: 1.139 ± 0.022
2.982ValAsn: 2.982 ± 0.032
2.807ValPro: 2.807 ± 0.038
1.952ValGln: 1.952 ± 0.027
2.232ValArg: 2.232 ± 0.028
4.761ValSer: 4.761 ± 0.059
3.468ValThr: 3.468 ± 0.038
3.4ValVal: 3.4 ± 0.049
0.559ValTrp: 0.559 ± 0.013
1.705ValTyr: 1.705 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
0.525TrpAla: 0.525 ± 0.016
0.222TrpCys: 0.222 ± 0.009
0.69TrpAsp: 0.69 ± 0.02
0.629TrpGlu: 0.629 ± 0.015
0.493TrpPhe: 0.493 ± 0.013
0.512TrpGly: 0.512 ± 0.016
0.199TrpHis: 0.199 ± 0.008
0.657TrpIle: 0.657 ± 0.017
0.877TrpLys: 0.877 ± 0.018
0.941TrpLeu: 0.941 ± 0.02
0.216TrpMet: 0.216 ± 0.01
0.706TrpAsn: 0.706 ± 0.016
0.283TrpPro: 0.283 ± 0.01
0.366TrpGln: 0.366 ± 0.013
0.493TrpArg: 0.493 ± 0.014
0.806TrpSer: 0.806 ± 0.019
0.553TrpThr: 0.553 ± 0.013
0.559TrpVal: 0.559 ± 0.014
0.15TrpTrp: 0.15 ± 0.007
0.396TrpTyr: 0.396 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.605TyrAla: 1.605 ± 0.028
0.508TyrCys: 0.508 ± 0.015
2.022TyrAsp: 2.022 ± 0.032
1.951TyrGlu: 1.951 ± 0.026
1.663TyrPhe: 1.663 ± 0.026
1.831TyrGly: 1.831 ± 0.031
0.8TyrHis: 0.8 ± 0.017
2.069TyrIle: 2.069 ± 0.025
2.166TyrLys: 2.166 ± 0.027
3.385TyrLeu: 3.385 ± 0.039
0.762TyrMet: 0.762 ± 0.017
1.946TyrAsn: 1.946 ± 0.032
1.459TyrPro: 1.459 ± 0.022
1.444TyrGln: 1.444 ± 0.024
1.371TyrArg: 1.371 ± 0.02
2.68TyrSer: 2.68 ± 0.036
1.79TyrThr: 1.79 ± 0.028
1.806TyrVal: 1.806 ± 0.027
0.38TyrTrp: 0.38 ± 0.014
1.426TyrTyr: 1.426 ± 0.027
0.001TyrXaa: 0.001 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 5565 proteins (2764192 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski