Amino acid dipepetide frequency for Variovorax sp. WDL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.769AlaAla: 18.769 ± 0.123
1.35AlaCys: 1.35 ± 0.025
6.37AlaAsp: 6.37 ± 0.056
7.266AlaGlu: 7.266 ± 0.066
4.171AlaPhe: 4.171 ± 0.045
11.231AlaGly: 11.231 ± 0.089
2.755AlaHis: 2.755 ± 0.038
5.272AlaIle: 5.272 ± 0.055
3.931AlaLys: 3.931 ± 0.052
14.797AlaLeu: 14.797 ± 0.104
3.666AlaMet: 3.666 ± 0.041
2.786AlaAsn: 2.786 ± 0.04
6.613AlaPro: 6.613 ± 0.076
5.692AlaGln: 5.692 ± 0.051
10.018AlaArg: 10.018 ± 0.078
7.08AlaSer: 7.08 ± 0.067
6.04AlaThr: 6.04 ± 0.055
9.108AlaVal: 9.108 ± 0.076
1.937AlaTrp: 1.937 ± 0.036
2.434AlaTyr: 2.434 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
1.256CysAla: 1.256 ± 0.026
0.146CysCys: 0.146 ± 0.01
0.543CysAsp: 0.543 ± 0.018
0.571CysGlu: 0.571 ± 0.015
0.325CysPhe: 0.325 ± 0.011
0.997CysGly: 0.997 ± 0.023
0.259CysHis: 0.259 ± 0.011
0.432CysIle: 0.432 ± 0.015
0.257CysLys: 0.257 ± 0.011
0.834CysLeu: 0.834 ± 0.022
0.225CysMet: 0.225 ± 0.01
0.241CysAsn: 0.241 ± 0.01
0.483CysPro: 0.483 ± 0.017
0.247CysGln: 0.247 ± 0.012
0.684CysArg: 0.684 ± 0.018
0.528CysSer: 0.528 ± 0.016
0.491CysThr: 0.491 ± 0.015
0.693CysVal: 0.693 ± 0.016
0.133CysTrp: 0.133 ± 0.009
0.187CysTyr: 0.187 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.359AspAla: 7.359 ± 0.066
0.495AspCys: 0.495 ± 0.013
2.766AspAsp: 2.766 ± 0.039
3.318AspGlu: 3.318 ± 0.044
2.052AspPhe: 2.052 ± 0.031
4.659AspGly: 4.659 ± 0.053
1.099AspHis: 1.099 ± 0.024
2.298AspIle: 2.298 ± 0.032
1.587AspLys: 1.587 ± 0.029
5.229AspLeu: 5.229 ± 0.049
1.166AspMet: 1.166 ± 0.021
1.103AspAsn: 1.103 ± 0.021
3.043AspPro: 3.043 ± 0.039
1.536AspGln: 1.536 ± 0.028
3.611AspArg: 3.611 ± 0.043
2.262AspSer: 2.262 ± 0.031
2.333AspThr: 2.333 ± 0.034
3.888AspVal: 3.888 ± 0.048
0.908AspTrp: 0.908 ± 0.019
1.296AspTyr: 1.296 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.615GluAla: 7.615 ± 0.064
0.454GluCys: 0.454 ± 0.016
2.433GluAsp: 2.433 ± 0.032
2.899GluGlu: 2.899 ± 0.041
1.833GluPhe: 1.833 ± 0.027
4.289GluGly: 4.289 ± 0.048
1.467GluHis: 1.467 ± 0.025
2.687GluIle: 2.687 ± 0.042
1.88GluLys: 1.88 ± 0.036
6.332GluLeu: 6.332 ± 0.06
1.36GluMet: 1.36 ± 0.024
1.25GluAsn: 1.25 ± 0.024
2.715GluPro: 2.715 ± 0.037
2.565GluGln: 2.565 ± 0.033
5.191GluArg: 5.191 ± 0.043
2.715GluSer: 2.715 ± 0.035
2.498GluThr: 2.498 ± 0.033
4.254GluVal: 4.254 ± 0.045
0.759GluTrp: 0.759 ± 0.02
1.013GluTyr: 1.013 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
4.33PheAla: 4.33 ± 0.05
0.389PheCys: 0.389 ± 0.015
2.516PheAsp: 2.516 ± 0.032
2.22PheGlu: 2.22 ± 0.036
1.243PhePhe: 1.243 ± 0.027
3.334PheGly: 3.334 ± 0.04
0.744PheHis: 0.744 ± 0.018
1.391PheIle: 1.391 ± 0.027
1.149PheLys: 1.149 ± 0.026
3.02PheLeu: 3.02 ± 0.042
0.757PheMet: 0.757 ± 0.018
1.014PheAsn: 1.014 ± 0.022
1.494PhePro: 1.494 ± 0.027
0.996PheGln: 0.996 ± 0.019
2.013PheArg: 2.013 ± 0.028
2.086PheSer: 2.086 ± 0.03
1.743PheThr: 1.743 ± 0.027
2.778PheVal: 2.778 ± 0.034
0.464PheTrp: 0.464 ± 0.014
0.776PheTyr: 0.776 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
9.67GlyAla: 9.67 ± 0.069
0.875GlyCys: 0.875 ± 0.021
4.056GlyAsp: 4.056 ± 0.054
4.817GlyGlu: 4.817 ± 0.047
3.227GlyPhe: 3.227 ± 0.042
7.165GlyGly: 7.165 ± 0.095
2.0GlyHis: 2.0 ± 0.032
3.98GlyIle: 3.98 ± 0.053
3.145GlyLys: 3.145 ± 0.041
8.739GlyLeu: 8.739 ± 0.076
2.278GlyMet: 2.278 ± 0.033
2.137GlyAsn: 2.137 ± 0.037
3.381GlyPro: 3.381 ± 0.041
3.179GlyGln: 3.179 ± 0.041
6.15GlyArg: 6.15 ± 0.072
4.779GlySer: 4.779 ± 0.057
4.636GlyThr: 4.636 ± 0.063
6.417GlyVal: 6.417 ± 0.059
1.417GlyTrp: 1.417 ± 0.024
2.248GlyTyr: 2.248 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
3.06HisAla: 3.06 ± 0.039
0.306HisCys: 0.306 ± 0.012
1.205HisAsp: 1.205 ± 0.022
1.26HisGlu: 1.26 ± 0.026
0.848HisPhe: 0.848 ± 0.019
2.221HisGly: 2.221 ± 0.038
0.628HisHis: 0.628 ± 0.02
0.871HisIle: 0.871 ± 0.02
0.574HisLys: 0.574 ± 0.016
2.257HisLeu: 2.257 ± 0.033
0.509HisMet: 0.509 ± 0.014
0.487HisAsn: 0.487 ± 0.014
1.522HisPro: 1.522 ± 0.027
0.757HisGln: 0.757 ± 0.021
1.759HisArg: 1.759 ± 0.039
1.022HisSer: 1.022 ± 0.024
0.941HisThr: 0.941 ± 0.021
1.75HisVal: 1.75 ± 0.029
0.399HisTrp: 0.399 ± 0.012
0.565HisTyr: 0.565 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.18IleAla: 6.18 ± 0.065
0.421IleCys: 0.421 ± 0.015
3.076IleAsp: 3.076 ± 0.04
3.246IleGlu: 3.246 ± 0.039
1.193IlePhe: 1.193 ± 0.023
4.146IleGly: 4.146 ± 0.052
0.838IleHis: 0.838 ± 0.02
1.337IleIle: 1.337 ± 0.026
1.322IleLys: 1.322 ± 0.029
3.057IleLeu: 3.057 ± 0.041
0.659IleMet: 0.659 ± 0.017
1.202IleAsn: 1.202 ± 0.027
2.009IlePro: 2.009 ± 0.03
1.219IleGln: 1.219 ± 0.024
2.678IleArg: 2.678 ± 0.033
2.206IleSer: 2.206 ± 0.033
2.167IleThr: 2.167 ± 0.029
3.558IleVal: 3.558 ± 0.042
0.444IleTrp: 0.444 ± 0.016
0.921IleTyr: 0.921 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.107LysAla: 4.107 ± 0.051
0.178LysCys: 0.178 ± 0.009
1.604LysAsp: 1.604 ± 0.033
1.63LysGlu: 1.63 ± 0.033
0.918LysPhe: 0.918 ± 0.021
2.403LysGly: 2.403 ± 0.036
0.651LysHis: 0.651 ± 0.018
1.342LysIle: 1.342 ± 0.024
1.315LysLys: 1.315 ± 0.032
3.557LysLeu: 3.557 ± 0.052
0.72LysMet: 0.72 ± 0.02
0.865LysAsn: 0.865 ± 0.021
2.079LysPro: 2.079 ± 0.031
1.11LysGln: 1.11 ± 0.023
2.302LysArg: 2.302 ± 0.03
1.765LysSer: 1.765 ± 0.028
1.887LysThr: 1.887 ± 0.03
2.439LysVal: 2.439 ± 0.043
0.369LysTrp: 0.369 ± 0.013
0.633LysTyr: 0.633 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.047LeuAla: 15.047 ± 0.105
1.033LeuCys: 1.033 ± 0.024
5.832LeuAsp: 5.832 ± 0.051
5.481LeuGlu: 5.481 ± 0.054
3.288LeuPhe: 3.288 ± 0.044
8.706LeuGly: 8.706 ± 0.073
2.462LeuHis: 2.462 ± 0.032
4.028LeuIle: 4.028 ± 0.048
3.438LeuLys: 3.438 ± 0.046
10.933LeuLeu: 10.933 ± 0.101
2.442LeuMet: 2.442 ± 0.037
2.499LeuAsn: 2.499 ± 0.036
6.036LeuPro: 6.036 ± 0.062
3.949LeuGln: 3.949 ± 0.044
8.145LeuArg: 8.145 ± 0.064
5.962LeuSer: 5.962 ± 0.057
4.837LeuThr: 4.837 ± 0.046
7.897LeuVal: 7.897 ± 0.068
1.241LeuTrp: 1.241 ± 0.028
2.01LeuTyr: 2.01 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.036MetAla: 3.036 ± 0.041
0.179MetCys: 0.179 ± 0.009
1.067MetAsp: 1.067 ± 0.024
1.112MetGlu: 1.112 ± 0.024
0.705MetPhe: 0.705 ± 0.018
1.767MetGly: 1.767 ± 0.029
0.565MetHis: 0.565 ± 0.017
0.898MetIle: 0.898 ± 0.022
1.058MetLys: 1.058 ± 0.022
2.682MetLeu: 2.682 ± 0.038
0.553MetMet: 0.553 ± 0.016
0.837MetAsn: 0.837 ± 0.02
1.562MetPro: 1.562 ± 0.026
1.074MetGln: 1.074 ± 0.021
1.874MetArg: 1.874 ± 0.029
1.575MetSer: 1.575 ± 0.025
1.529MetThr: 1.529 ± 0.026
1.699MetVal: 1.699 ± 0.026
0.209MetTrp: 0.209 ± 0.01
0.354MetTyr: 0.354 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.115AsnAla: 3.115 ± 0.042
0.258AsnCys: 0.258 ± 0.01
1.244AsnAsp: 1.244 ± 0.028
1.235AsnGlu: 1.235 ± 0.021
0.879AsnPhe: 0.879 ± 0.021
2.16AsnGly: 2.16 ± 0.038
0.481AsnHis: 0.481 ± 0.015
1.104AsnIle: 1.104 ± 0.024
0.79AsnLys: 0.79 ± 0.02
2.415AsnLeu: 2.415 ± 0.037
0.551AsnMet: 0.551 ± 0.017
0.679AsnAsn: 0.679 ± 0.019
1.738AsnPro: 1.738 ± 0.029
0.783AsnGln: 0.783 ± 0.022
1.621AsnArg: 1.621 ± 0.025
1.175AsnSer: 1.175 ± 0.025
1.28AsnThr: 1.28 ± 0.03
1.846AsnVal: 1.846 ± 0.03
0.395AsnTrp: 0.395 ± 0.011
0.636AsnTyr: 0.636 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.527ProAla: 7.527 ± 0.078
0.406ProCys: 0.406 ± 0.011
3.139ProAsp: 3.139 ± 0.037
3.52ProGlu: 3.52 ± 0.042
1.814ProPhe: 1.814 ± 0.027
4.93ProGly: 4.93 ± 0.047
1.202ProHis: 1.202 ± 0.024
1.953ProIle: 1.953 ± 0.036
1.584ProLys: 1.584 ± 0.031
5.128ProLeu: 5.128 ± 0.051
1.406ProMet: 1.406 ± 0.026
1.234ProAsn: 1.234 ± 0.026
3.011ProPro: 3.011 ± 0.063
1.986ProGln: 1.986 ± 0.024
3.371ProArg: 3.371 ± 0.041
3.012ProSer: 3.012 ± 0.04
2.629ProThr: 2.629 ± 0.039
4.291ProVal: 4.291 ± 0.039
0.786ProTrp: 0.786 ± 0.021
1.2ProTyr: 1.2 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.349GlnAla: 5.349 ± 0.058
0.321GlnCys: 0.321 ± 0.014
1.529GlnAsp: 1.529 ± 0.029
1.682GlnGlu: 1.682 ± 0.03
1.215GlnPhe: 1.215 ± 0.022
2.92GlnGly: 2.92 ± 0.035
0.913GlnHis: 0.913 ± 0.022
1.604GlnIle: 1.604 ± 0.026
1.081GlnLys: 1.081 ± 0.026
4.119GlnLeu: 4.119 ± 0.049
0.905GlnMet: 0.905 ± 0.021
0.747GlnAsn: 0.747 ± 0.019
2.227GlnPro: 2.227 ± 0.031
1.834GlnGln: 1.834 ± 0.041
3.585GlnArg: 3.585 ± 0.052
1.803GlnSer: 1.803 ± 0.03
1.711GlnThr: 1.711 ± 0.027
2.894GlnVal: 2.894 ± 0.039
0.598GlnTrp: 0.598 ± 0.018
0.715GlnTyr: 0.715 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.682ArgAla: 8.682 ± 0.075
0.709ArgCys: 0.709 ± 0.019
3.761ArgAsp: 3.761 ± 0.041
4.721ArgGlu: 4.721 ± 0.048
2.916ArgPhe: 2.916 ± 0.041
5.247ArgGly: 5.247 ± 0.065
2.068ArgHis: 2.068 ± 0.04
3.71ArgIle: 3.71 ± 0.044
2.286ArgLys: 2.286 ± 0.032
8.199ArgLeu: 8.199 ± 0.07
2.036ArgMet: 2.036 ± 0.029
1.852ArgAsn: 1.852 ± 0.026
3.62ArgPro: 3.62 ± 0.039
2.998ArgGln: 2.998 ± 0.037
6.047ArgArg: 6.047 ± 0.064
3.95ArgSer: 3.95 ± 0.046
3.562ArgThr: 3.562 ± 0.042
5.364ArgVal: 5.364 ± 0.062
1.245ArgTrp: 1.245 ± 0.025
1.85ArgTyr: 1.85 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.632SerAla: 6.632 ± 0.06
0.486SerCys: 0.486 ± 0.016
2.618SerAsp: 2.618 ± 0.039
2.687SerGlu: 2.687 ± 0.037
2.137SerPhe: 2.137 ± 0.032
5.119SerGly: 5.119 ± 0.057
1.177SerHis: 1.177 ± 0.024
2.356SerIle: 2.356 ± 0.038
1.603SerLys: 1.603 ± 0.031
5.509SerLeu: 5.509 ± 0.057
1.391SerMet: 1.391 ± 0.025
1.367SerAsn: 1.367 ± 0.03
3.049SerPro: 3.049 ± 0.039
1.851SerGln: 1.851 ± 0.026
3.799SerArg: 3.799 ± 0.047
3.203SerSer: 3.203 ± 0.042
2.942SerThr: 2.942 ± 0.041
3.881SerVal: 3.881 ± 0.045
0.758SerTrp: 0.758 ± 0.019
1.239SerTyr: 1.239 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
5.882ThrAla: 5.882 ± 0.062
0.409ThrCys: 0.409 ± 0.016
2.35ThrAsp: 2.35 ± 0.037
2.371ThrGlu: 2.371 ± 0.029
1.648ThrPhe: 1.648 ± 0.027
4.574ThrGly: 4.574 ± 0.058
1.122ThrHis: 1.122 ± 0.022
2.012ThrIle: 2.012 ± 0.031
1.281ThrLys: 1.281 ± 0.026
5.935ThrLeu: 5.935 ± 0.051
1.124ThrMet: 1.124 ± 0.023
1.131ThrAsn: 1.131 ± 0.025
3.42ThrPro: 3.42 ± 0.044
1.796ThrGln: 1.796 ± 0.03
3.412ThrArg: 3.412 ± 0.037
2.685ThrSer: 2.685 ± 0.039
2.686ThrThr: 2.686 ± 0.043
4.04ThrVal: 4.04 ± 0.05
0.666ThrTrp: 0.666 ± 0.018
1.023ThrTyr: 1.023 ± 0.022
0.0ThrXaa: 0.0 ± 0.0
Val
9.724ValAla: 9.724 ± 0.082
0.705ValCys: 0.705 ± 0.019
4.108ValAsp: 4.108 ± 0.049
4.396ValGlu: 4.396 ± 0.052
2.637ValPhe: 2.637 ± 0.042
5.558ValGly: 5.558 ± 0.068
1.71ValHis: 1.71 ± 0.03
3.218ValIle: 3.218 ± 0.042
2.418ValLys: 2.418 ± 0.035
8.295ValLeu: 8.295 ± 0.068
1.779ValMet: 1.779 ± 0.026
1.973ValAsn: 1.973 ± 0.036
4.305ValPro: 4.305 ± 0.043
2.757ValGln: 2.757 ± 0.038
5.543ValArg: 5.543 ± 0.047
4.046ValSer: 4.046 ± 0.042
3.803ValThr: 3.803 ± 0.043
6.332ValVal: 6.332 ± 0.059
0.946ValTrp: 0.946 ± 0.021
1.465ValTyr: 1.465 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.336TrpAla: 1.336 ± 0.025
0.163TrpCys: 0.163 ± 0.009
0.6TrpAsp: 0.6 ± 0.015
0.602TrpGlu: 0.602 ± 0.016
0.539TrpPhe: 0.539 ± 0.017
0.941TrpGly: 0.941 ± 0.02
0.385TrpHis: 0.385 ± 0.014
0.638TrpIle: 0.638 ± 0.018
0.502TrpLys: 0.502 ± 0.015
1.94TrpLeu: 1.94 ± 0.035
0.398TrpMet: 0.398 ± 0.013
0.428TrpAsn: 0.428 ± 0.014
0.734TrpPro: 0.734 ± 0.018
0.681TrpGln: 0.681 ± 0.017
1.306TrpArg: 1.306 ± 0.025
0.827TrpSer: 0.827 ± 0.019
0.747TrpThr: 0.747 ± 0.02
0.963TrpVal: 0.963 ± 0.021
0.262TrpTrp: 0.262 ± 0.011
0.311TrpTyr: 0.311 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.61TyrAla: 2.61 ± 0.034
0.247TyrCys: 0.247 ± 0.01
1.188TyrAsp: 1.188 ± 0.028
1.175TyrGlu: 1.175 ± 0.024
0.869TyrPhe: 0.869 ± 0.02
1.929TyrGly: 1.929 ± 0.031
0.419TyrHis: 0.419 ± 0.014
0.748TyrIle: 0.748 ± 0.017
0.672TyrLys: 0.672 ± 0.017
2.287TyrLeu: 2.287 ± 0.032
0.41TyrMet: 0.41 ± 0.014
0.555TyrAsn: 0.555 ± 0.017
1.093TyrPro: 1.093 ± 0.021
0.744TyrGln: 0.744 ± 0.02
1.711TyrArg: 1.711 ± 0.03
1.125TyrSer: 1.125 ± 0.023
1.104TyrThr: 1.104 ± 0.023
1.624TyrVal: 1.624 ± 0.026
0.368TyrTrp: 0.368 ± 0.015
0.546TyrTyr: 0.546 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7754 proteins (2270876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski