Amino acid dipepetide frequency for Propionispora sp. 2/2-37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.267AlaAla: 10.267 ± 0.144	1.059AlaCys: 1.059 ± 0.033	4.573AlaAsp: 4.573 ± 0.066	5.846AlaGlu: 5.846 ± 0.076	3.192AlaPhe: 3.192 ± 0.063	8.054AlaGly: 8.054 ± 0.113	1.43AlaHis: 1.43 ± 0.031	6.09AlaIle: 6.09 ± 0.087	4.986AlaLys: 4.986 ± 0.074	8.63AlaLeu: 8.63 ± 0.092	2.515AlaMet: 2.515 ± 0.046	3.083AlaAsn: 3.083 ± 0.061	2.362AlaPro: 2.362 ± 0.047	3.096AlaGln: 3.096 ± 0.049	3.994AlaArg: 3.994 ± 0.066	4.195AlaSer: 4.195 ± 0.06	4.052AlaThr: 4.052 ± 0.06	8.088AlaVal: 8.088 ± 0.095	0.738AlaTrp: 0.738 ± 0.031	2.632AlaTyr: 2.632 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.832CysAla: 0.832 ± 0.028	0.217CysCys: 0.217 ± 0.015	0.537CysAsp: 0.537 ± 0.022	0.601CysGlu: 0.601 ± 0.024	0.471CysPhe: 0.471 ± 0.02	1.127CysGly: 1.127 ± 0.035	0.288CysHis: 0.288 ± 0.017	0.788CysIle: 0.788 ± 0.027	0.57CysLys: 0.57 ± 0.024	1.087CysLeu: 1.087 ± 0.032	0.331CysMet: 0.331 ± 0.017	0.441CysAsn: 0.441 ± 0.021	0.595CysPro: 0.595 ± 0.023	0.468CysGln: 0.468 ± 0.024	0.753CysArg: 0.753 ± 0.029	0.82CysSer: 0.82 ± 0.03	0.59CysThr: 0.59 ± 0.026	0.703CysVal: 0.703 ± 0.022	0.125CysTrp: 0.125 ± 0.011	0.378CysTyr: 0.378 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.652AspAla: 3.652 ± 0.056	0.632AspCys: 0.632 ± 0.02	2.082AspAsp: 2.082 ± 0.05	3.27AspGlu: 3.27 ± 0.061	2.249AspPhe: 2.249 ± 0.045	3.502AspGly: 3.502 ± 0.065	0.935AspHis: 0.935 ± 0.031	4.456AspIle: 4.456 ± 0.071	3.102AspLys: 3.102 ± 0.055	4.431AspLeu: 4.431 ± 0.063	1.563AspMet: 1.563 ± 0.034	2.085AspAsn: 2.085 ± 0.049	1.803AspPro: 1.803 ± 0.041	1.524AspGln: 1.524 ± 0.034	2.483AspArg: 2.483 ± 0.05	2.638AspSer: 2.638 ± 0.052	2.585AspThr: 2.585 ± 0.05	3.515AspVal: 3.515 ± 0.057	0.557AspTrp: 0.557 ± 0.023	1.982AspTyr: 1.982 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.543GluAla: 5.543 ± 0.078	0.615GluCys: 0.615 ± 0.025	2.806GluAsp: 2.806 ± 0.055	4.906GluGlu: 4.906 ± 0.083	2.293GluPhe: 2.293 ± 0.047	3.593GluGly: 3.593 ± 0.057	1.265GluHis: 1.265 ± 0.036	4.985GluIle: 4.985 ± 0.072	4.878GluLys: 4.878 ± 0.071	6.459GluLeu: 6.459 ± 0.082	1.933GluMet: 1.933 ± 0.04	2.982GluAsn: 2.982 ± 0.051	1.87GluPro: 1.87 ± 0.041	3.158GluGln: 3.158 ± 0.06	3.534GluArg: 3.534 ± 0.061	2.722GluSer: 2.722 ± 0.049	3.222GluThr: 3.222 ± 0.059	4.451GluVal: 4.451 ± 0.076	0.627GluTrp: 0.627 ± 0.023	2.24GluTyr: 2.24 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.403PheAla: 3.403 ± 0.061	0.528PheCys: 0.528 ± 0.024	2.042PheAsp: 2.042 ± 0.042	1.933PheGlu: 1.933 ± 0.038	1.97PhePhe: 1.97 ± 0.05	3.102PheGly: 3.102 ± 0.052	0.78PheHis: 0.78 ± 0.027	3.01PheIle: 3.01 ± 0.052	1.88PheLys: 1.88 ± 0.046	3.853PheLeu: 3.853 ± 0.067	1.06PheMet: 1.06 ± 0.032	1.585PheAsn: 1.585 ± 0.039	1.5PhePro: 1.5 ± 0.039	1.286PheGln: 1.286 ± 0.033	1.652PheArg: 1.652 ± 0.039	2.895PheSer: 2.895 ± 0.053	2.301PheThr: 2.301 ± 0.048	2.693PheVal: 2.693 ± 0.053	0.453PheTrp: 0.453 ± 0.021	1.38PheTyr: 1.38 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.662GlyAla: 5.662 ± 0.081	1.039GlyCys: 1.039 ± 0.032	3.329GlyAsp: 3.329 ± 0.056	4.289GlyGlu: 4.289 ± 0.063	3.118GlyPhe: 3.118 ± 0.057	5.473GlyGly: 5.473 ± 0.099	1.467GlyHis: 1.467 ± 0.042	6.57GlyIle: 6.57 ± 0.064	5.107GlyLys: 5.107 ± 0.061	7.259GlyLeu: 7.259 ± 0.079	2.429GlyMet: 2.429 ± 0.044	2.917GlyAsn: 2.917 ± 0.058	1.969GlyPro: 1.969 ± 0.042	2.808GlyGln: 2.808 ± 0.058	3.72GlyArg: 3.72 ± 0.058	4.26GlySer: 4.26 ± 0.075	4.156GlyThr: 4.156 ± 0.074	5.656GlyVal: 5.656 ± 0.079	0.794GlyTrp: 0.794 ± 0.029	2.886GlyTyr: 2.886 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.463HisAla: 1.463 ± 0.035	0.335HisCys: 0.335 ± 0.017	0.927HisAsp: 0.927 ± 0.029	1.015HisGlu: 1.015 ± 0.028	0.854HisPhe: 0.854 ± 0.026	1.513HisGly: 1.513 ± 0.037	0.505HisHis: 0.505 ± 0.027	1.649HisIle: 1.649 ± 0.036	0.959HisLys: 0.959 ± 0.03	1.868HisLeu: 1.868 ± 0.04	0.489HisMet: 0.489 ± 0.019	0.791HisAsn: 0.791 ± 0.024	0.992HisPro: 0.992 ± 0.031	0.669HisGln: 0.669 ± 0.025	0.927HisArg: 0.927 ± 0.028	1.208HisSer: 1.208 ± 0.037	1.134HisThr: 1.134 ± 0.032	1.249HisVal: 1.249 ± 0.031	0.228HisTrp: 0.228 ± 0.015	0.748HisTyr: 0.748 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.116IleAla: 7.116 ± 0.084	0.908IleCys: 0.908 ± 0.03	3.92IleAsp: 3.92 ± 0.06	4.257IleGlu: 4.257 ± 0.067	2.688IlePhe: 2.688 ± 0.053	5.761IleGly: 5.761 ± 0.079	1.562IleHis: 1.562 ± 0.039	5.308IleIle: 5.308 ± 0.08	4.162IleLys: 4.162 ± 0.062	6.854IleLeu: 6.854 ± 0.08	1.8IleMet: 1.8 ± 0.043	3.067IleAsn: 3.067 ± 0.056	3.438IlePro: 3.438 ± 0.054	2.518IleGln: 2.518 ± 0.052	3.573IleArg: 3.573 ± 0.054	4.56IleSer: 4.56 ± 0.068	4.384IleThr: 4.384 ± 0.067	5.366IleVal: 5.366 ± 0.069	0.593IleTrp: 0.593 ± 0.031	2.105IleTyr: 2.105 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.97LysAla: 4.97 ± 0.067	0.453LysCys: 0.453 ± 0.021	2.753LysAsp: 2.753 ± 0.053	4.417LysGlu: 4.417 ± 0.063	1.677LysPhe: 1.677 ± 0.036	3.504LysGly: 3.504 ± 0.052	1.078LysHis: 1.078 ± 0.028	4.562LysIle: 4.562 ± 0.067	4.213LysLys: 4.213 ± 0.061	5.469LysLeu: 5.469 ± 0.069	1.759LysMet: 1.759 ± 0.041	2.803LysAsn: 2.803 ± 0.052	2.256LysPro: 2.256 ± 0.044	2.753LysGln: 2.753 ± 0.05	2.922LysArg: 2.922 ± 0.051	2.861LysSer: 2.861 ± 0.049	3.307LysThr: 3.307 ± 0.058	4.336LysVal: 4.336 ± 0.062	0.542LysTrp: 0.542 ± 0.024	1.968LysTyr: 1.968 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.798LeuAla: 9.798 ± 0.115	1.151LeuCys: 1.151 ± 0.033	4.793LeuAsp: 4.793 ± 0.064	6.143LeuGlu: 6.143 ± 0.084	3.945LeuPhe: 3.945 ± 0.07	7.046LeuGly: 7.046 ± 0.085	1.909LeuHis: 1.909 ± 0.043	6.216LeuIle: 6.216 ± 0.071	5.642LeuLys: 5.642 ± 0.072	10.419LeuLeu: 10.419 ± 0.133	2.399LeuMet: 2.399 ± 0.05	3.75LeuAsn: 3.75 ± 0.063	4.477LeuPro: 4.477 ± 0.07	4.073LeuGln: 4.073 ± 0.067	4.451LeuArg: 4.451 ± 0.065	6.436LeuSer: 6.436 ± 0.08	5.725LeuThr: 5.725 ± 0.071	6.585LeuVal: 6.585 ± 0.08	0.884LeuTrp: 0.884 ± 0.028	2.932LeuTyr: 2.932 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.674MetAla: 2.674 ± 0.052	0.2MetCys: 0.2 ± 0.013	1.424MetAsp: 1.424 ± 0.034	1.834MetGlu: 1.834 ± 0.042	0.922MetPhe: 0.922 ± 0.027	1.989MetGly: 1.989 ± 0.043	0.456MetHis: 0.456 ± 0.02	2.027MetIle: 2.027 ± 0.043	1.769MetLys: 1.769 ± 0.041	2.911MetLeu: 2.911 ± 0.057	0.739MetMet: 0.739 ± 0.026	1.216MetAsn: 1.216 ± 0.031	1.174MetPro: 1.174 ± 0.032	1.082MetGln: 1.082 ± 0.028	1.256MetArg: 1.256 ± 0.036	1.593MetSer: 1.593 ± 0.034	1.489MetThr: 1.489 ± 0.034	2.102MetVal: 2.102 ± 0.041	0.181MetTrp: 0.181 ± 0.012	0.665MetTyr: 0.665 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.982AsnAla: 2.982 ± 0.057	0.485AsnCys: 0.485 ± 0.021	1.827AsnAsp: 1.827 ± 0.042	2.319AsnGlu: 2.319 ± 0.047	1.531AsnPhe: 1.531 ± 0.04	2.929AsnGly: 2.929 ± 0.052	0.886AsnHis: 0.886 ± 0.022	3.38AsnIle: 3.38 ± 0.059	2.379AsnLys: 2.379 ± 0.045	3.83AsnLeu: 3.83 ± 0.048	1.194AsnMet: 1.194 ± 0.033	1.629AsnAsn: 1.629 ± 0.041	2.122AsnPro: 2.122 ± 0.042	1.529AsnGln: 1.529 ± 0.042	2.085AsnArg: 2.085 ± 0.045	2.263AsnSer: 2.263 ± 0.049	2.266AsnThr: 2.266 ± 0.05	2.67AsnVal: 2.67 ± 0.055	0.478AsnTrp: 0.478 ± 0.022	1.475AsnTyr: 1.475 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.519ProAla: 3.519 ± 0.055	0.428ProCys: 0.428 ± 0.022	2.356ProAsp: 2.356 ± 0.044	3.248ProGlu: 3.248 ± 0.056	1.584ProPhe: 1.584 ± 0.043	3.203ProGly: 3.203 ± 0.053	0.838ProHis: 0.838 ± 0.028	2.167ProIle: 2.167 ± 0.049	1.612ProLys: 1.612 ± 0.039	3.753ProLeu: 3.753 ± 0.058	0.891ProMet: 0.891 ± 0.032	1.319ProAsn: 1.319 ± 0.036	1.37ProPro: 1.37 ± 0.036	1.415ProGln: 1.415 ± 0.033	1.498ProArg: 1.498 ± 0.039	1.891ProSer: 1.891 ± 0.044	1.622ProThr: 1.622 ± 0.035	3.769ProVal: 3.769 ± 0.064	0.418ProTrp: 0.418 ± 0.02	1.399ProTyr: 1.399 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.908GlnAla: 3.908 ± 0.061	0.368GlnCys: 0.368 ± 0.019	1.863GlnAsp: 1.863 ± 0.042	3.034GlnGlu: 3.034 ± 0.059	1.302GlnPhe: 1.302 ± 0.032	2.626GlnGly: 2.626 ± 0.053	0.766GlnHis: 0.766 ± 0.025	2.605GlnIle: 2.605 ± 0.051	2.354GlnLys: 2.354 ± 0.044	3.678GlnLeu: 3.678 ± 0.065	1.127GlnMet: 1.127 ± 0.035	1.604GlnAsn: 1.604 ± 0.038	1.43GlnPro: 1.43 ± 0.036	2.071GlnGln: 2.071 ± 0.05	1.802GlnArg: 1.802 ± 0.042	2.076GlnSer: 2.076 ± 0.046	1.969GlnThr: 1.969 ± 0.045	2.795GlnVal: 2.795 ± 0.05	0.364GlnTrp: 0.364 ± 0.017	1.42GlnTyr: 1.42 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.261ArgAla: 3.261 ± 0.054	0.527ArgCys: 0.527 ± 0.02	2.343ArgAsp: 2.343 ± 0.046	3.858ArgGlu: 3.858 ± 0.073	1.942ArgPhe: 1.942 ± 0.042	2.944ArgGly: 2.944 ± 0.048	1.022ArgHis: 1.022 ± 0.03	3.686ArgIle: 3.686 ± 0.054	3.001ArgLys: 3.001 ± 0.05	5.047ArgLeu: 5.047 ± 0.074	1.531ArgMet: 1.531 ± 0.042	1.978ArgAsn: 1.978 ± 0.04	1.688ArgPro: 1.688 ± 0.038	2.502ArgGln: 2.502 ± 0.055	2.716ArgArg: 2.716 ± 0.051	2.428ArgSer: 2.428 ± 0.047	2.323ArgThr: 2.323 ± 0.041	3.139ArgVal: 3.139 ± 0.06	0.483ArgTrp: 0.483 ± 0.024	1.875ArgTyr: 1.875 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.536SerAla: 4.536 ± 0.068	0.658SerCys: 0.658 ± 0.035	2.536SerAsp: 2.536 ± 0.049	3.165SerGlu: 3.165 ± 0.063	2.587SerPhe: 2.587 ± 0.046	5.171SerGly: 5.171 ± 0.079	1.097SerHis: 1.097 ± 0.032	4.017SerIle: 4.017 ± 0.062	2.769SerLys: 2.769 ± 0.057	5.921SerLeu: 5.921 ± 0.074	1.595SerMet: 1.595 ± 0.041	2.012SerAsn: 2.012 ± 0.045	2.166SerPro: 2.166 ± 0.041	2.113SerGln: 2.113 ± 0.041	2.915SerArg: 2.915 ± 0.056	3.422SerSer: 3.422 ± 0.061	2.869SerThr: 2.869 ± 0.054	4.038SerVal: 4.038 ± 0.06	0.613SerTrp: 0.613 ± 0.023	1.944SerTyr: 1.944 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.427ThrAla: 5.427 ± 0.075	0.527ThrCys: 0.527 ± 0.021	2.763ThrAsp: 2.763 ± 0.052	3.081ThrGlu: 3.081 ± 0.047	2.039ThrPhe: 2.039 ± 0.044	4.985ThrGly: 4.985 ± 0.072	0.943ThrHis: 0.943 ± 0.03	3.903ThrIle: 3.903 ± 0.061	2.541ThrLys: 2.541 ± 0.045	5.264ThrLeu: 5.264 ± 0.063	1.318ThrMet: 1.318 ± 0.032	1.96ThrAsn: 1.96 ± 0.043	2.37ThrPro: 2.37 ± 0.051	1.664ThrGln: 1.664 ± 0.039	2.165ThrArg: 2.165 ± 0.042	2.661ThrSer: 2.661 ± 0.057	2.841ThrThr: 2.841 ± 0.062	4.838ThrVal: 4.838 ± 0.069	0.456ThrTrp: 0.456 ± 0.021	1.671ThrTyr: 1.671 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.698ValAla: 6.698 ± 0.082	0.953ValCys: 0.953 ± 0.033	3.827ValAsp: 3.827 ± 0.064	4.4ValGlu: 4.4 ± 0.069	2.991ValPhe: 2.991 ± 0.058	5.043ValGly: 5.043 ± 0.057	1.254ValHis: 1.254 ± 0.033	5.593ValIle: 5.593 ± 0.064	4.457ValLys: 4.457 ± 0.069	7.454ValLeu: 7.454 ± 0.083	2.034ValMet: 2.034 ± 0.046	3.168ValAsn: 3.168 ± 0.06	2.946ValPro: 2.946 ± 0.05	2.362ValGln: 2.362 ± 0.048	3.447ValArg: 3.447 ± 0.062	4.673ValSer: 4.673 ± 0.066	4.318ValThr: 4.318 ± 0.067	5.7ValVal: 5.7 ± 0.089	0.705ValTrp: 0.705 ± 0.023	2.387ValTyr: 2.387 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.658TrpAla: 0.658 ± 0.025	0.119TrpCys: 0.119 ± 0.01	0.498TrpAsp: 0.498 ± 0.02	0.565TrpGlu: 0.565 ± 0.021	0.416TrpPhe: 0.416 ± 0.023	0.745TrpGly: 0.745 ± 0.028	0.221TrpHis: 0.221 ± 0.013	0.595TrpIle: 0.595 ± 0.022	0.518TrpLys: 0.518 ± 0.022	1.185TrpLeu: 1.185 ± 0.039	0.259TrpMet: 0.259 ± 0.016	0.455TrpAsn: 0.455 ± 0.022	0.356TrpPro: 0.356 ± 0.017	0.59TrpGln: 0.59 ± 0.022	0.526TrpArg: 0.526 ± 0.024	0.563TrpSer: 0.563 ± 0.026	0.432TrpThr: 0.432 ± 0.019	0.596TrpVal: 0.596 ± 0.023	0.122TrpTrp: 0.122 ± 0.011	0.329TrpTyr: 0.329 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.511TyrAla: 2.511 ± 0.051	0.521TyrCys: 0.521 ± 0.019	1.848TyrAsp: 1.848 ± 0.038	1.896TyrGlu: 1.896 ± 0.046	1.536TyrPhe: 1.536 ± 0.035	2.598TyrGly: 2.598 ± 0.043	0.821TyrHis: 0.821 ± 0.026	2.333TyrIle: 2.333 ± 0.041	1.705TyrLys: 1.705 ± 0.04	3.402TyrLeu: 3.402 ± 0.053	0.737TyrMet: 0.737 ± 0.024	1.414TyrAsn: 1.414 ± 0.039	1.417TyrPro: 1.417 ± 0.035	1.478TyrGln: 1.478 ± 0.034	1.877TyrArg: 1.877 ± 0.039	1.982TyrSer: 1.982 ± 0.049	1.832TyrThr: 1.832 ± 0.043	2.119TyrVal: 2.119 ± 0.042	0.389TyrTrp: 0.389 ± 0.019	1.377TyrTyr: 1.377 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3949 proteins (1189072 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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