Amino acid dipepetide frequency for Callorhinus ursinus (Northern fur seal)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.21AlaAla: 7.21 ± 0.044	1.409AlaCys: 1.409 ± 0.01	2.946AlaAsp: 2.946 ± 0.013	4.905AlaGlu: 4.905 ± 0.024	2.602AlaPhe: 2.602 ± 0.015	4.907AlaGly: 4.907 ± 0.026	1.563AlaHis: 1.563 ± 0.01	2.616AlaIle: 2.616 ± 0.013	3.344AlaLys: 3.344 ± 0.015	7.301AlaLeu: 7.301 ± 0.032	1.443AlaMet: 1.443 ± 0.009	1.964AlaAsn: 1.964 ± 0.011	4.605AlaPro: 4.605 ± 0.03	3.37AlaGln: 3.37 ± 0.017	3.859AlaArg: 3.859 ± 0.018	6.007AlaSer: 6.007 ± 0.025	3.536AlaThr: 3.536 ± 0.016	4.662AlaVal: 4.662 ± 0.019	0.791AlaTrp: 0.791 ± 0.007	1.46AlaTyr: 1.46 ± 0.01	0.004AlaXaa: 0.004 ± 0.0
Cys	1.246CysAla: 1.246 ± 0.01	0.59CysCys: 0.59 ± 0.008	0.968CysAsp: 0.968 ± 0.009	1.254CysGlu: 1.254 ± 0.011	0.802CysPhe: 0.802 ± 0.007	1.803CysGly: 1.803 ± 0.018	0.652CysHis: 0.652 ± 0.007	0.895CysIle: 0.895 ± 0.009	1.106CysLys: 1.106 ± 0.009	2.124CysLeu: 2.124 ± 0.014	0.392CysMet: 0.392 ± 0.005	0.768CysAsn: 0.768 ± 0.008	1.359CysPro: 1.359 ± 0.011	1.048CysGln: 1.048 ± 0.01	1.287CysArg: 1.287 ± 0.01	1.972CysSer: 1.972 ± 0.013	1.055CysThr: 1.055 ± 0.009	1.251CysVal: 1.251 ± 0.01	0.28CysTrp: 0.28 ± 0.004	0.558CysTyr: 0.558 ± 0.005	0.002CysXaa: 0.002 ± 0.0
Asp	2.835AspAla: 2.835 ± 0.013	1.03AspCys: 1.03 ± 0.009	2.607AspAsp: 2.607 ± 0.016	3.422AspGlu: 3.422 ± 0.018	2.091AspPhe: 2.091 ± 0.011	3.237AspGly: 3.237 ± 0.018	1.126AspHis: 1.126 ± 0.007	2.493AspIle: 2.493 ± 0.015	2.485AspLys: 2.485 ± 0.015	5.025AspLeu: 5.025 ± 0.018	1.08AspMet: 1.08 ± 0.007	1.625AspAsn: 1.625 ± 0.011	2.961AspPro: 2.961 ± 0.012	1.846AspGln: 1.846 ± 0.01	2.442AspArg: 2.442 ± 0.013	4.217AspSer: 4.217 ± 0.019	2.418AspThr: 2.418 ± 0.011	2.992AspVal: 2.992 ± 0.017	0.604AspTrp: 0.604 ± 0.006	1.426AspTyr: 1.426 ± 0.009	0.002AspXaa: 0.002 ± 0.0
Glu	5.375GluAla: 5.375 ± 0.026	1.471GluCys: 1.471 ± 0.017	4.402GluAsp: 4.402 ± 0.021	8.165GluGlu: 8.165 ± 0.045	1.998GluPhe: 1.998 ± 0.01	4.29GluGly: 4.29 ± 0.018	1.517GluHis: 1.517 ± 0.009	3.071GluIle: 3.071 ± 0.018	5.535GluLys: 5.535 ± 0.03	6.542GluLeu: 6.542 ± 0.029	1.675GluMet: 1.675 ± 0.009	3.11GluAsn: 3.11 ± 0.017	3.394GluPro: 3.394 ± 0.018	3.262GluGln: 3.262 ± 0.018	4.209GluArg: 4.209 ± 0.021	4.552GluSer: 4.552 ± 0.019	3.369GluThr: 3.369 ± 0.017	4.172GluVal: 4.172 ± 0.017	0.676GluTrp: 0.676 ± 0.006	1.523GluTyr: 1.523 ± 0.011	0.003GluXaa: 0.003 ± 0.0
Phe	1.91PheAla: 1.91 ± 0.011	0.914PheCys: 0.914 ± 0.006	1.627PheAsp: 1.627 ± 0.009	1.972PheGlu: 1.972 ± 0.01	1.527PhePhe: 1.527 ± 0.01	2.154PheGly: 2.154 ± 0.016	1.013PheHis: 1.013 ± 0.007	1.749PheIle: 1.749 ± 0.013	1.709PheLys: 1.709 ± 0.012	3.963PheLeu: 3.963 ± 0.017	0.754PheMet: 0.754 ± 0.007	1.286PheAsn: 1.286 ± 0.009	2.014PhePro: 2.014 ± 0.012	1.776PheGln: 1.776 ± 0.009	1.944PheArg: 1.944 ± 0.011	3.405PheSer: 3.405 ± 0.016	1.962PheThr: 1.962 ± 0.012	2.026PheVal: 2.026 ± 0.012	0.471PheTrp: 0.471 ± 0.005	1.12PheTyr: 1.12 ± 0.007	0.003PheXaa: 0.003 ± 0.0
Gly	4.725GlyAla: 4.725 ± 0.022	1.253GlyCys: 1.253 ± 0.01	3.103GlyAsp: 3.103 ± 0.016	4.168GlyGlu: 4.168 ± 0.022	2.33GlyPhe: 2.33 ± 0.014	5.3GlyGly: 5.3 ± 0.035	1.709GlyHis: 1.709 ± 0.011	2.619GlyIle: 2.619 ± 0.013	3.799GlyLys: 3.799 ± 0.016	5.885GlyLeu: 5.885 ± 0.022	1.29GlyMet: 1.29 ± 0.01	2.292GlyAsn: 2.292 ± 0.013	4.565GlyPro: 4.565 ± 0.041	2.861GlyGln: 2.861 ± 0.016	3.936GlyArg: 3.936 ± 0.02	5.972GlySer: 5.972 ± 0.027	3.561GlyThr: 3.561 ± 0.017	3.496GlyVal: 3.496 ± 0.016	0.784GlyTrp: 0.784 ± 0.007	1.619GlyTyr: 1.619 ± 0.012	0.006GlyXaa: 0.006 ± 0.001
His	1.338HisAla: 1.338 ± 0.008	0.696HisCys: 0.696 ± 0.007	0.872HisAsp: 0.872 ± 0.007	1.33HisGlu: 1.33 ± 0.009	1.058HisPhe: 1.058 ± 0.007	1.563HisGly: 1.563 ± 0.01	0.916HisHis: 0.916 ± 0.009	1.215HisIle: 1.215 ± 0.007	1.259HisLys: 1.259 ± 0.01	2.957HisLeu: 2.957 ± 0.013	0.572HisMet: 0.572 ± 0.006	0.837HisAsn: 0.837 ± 0.007	1.708HisPro: 1.708 ± 0.009	1.448HisGln: 1.448 ± 0.013	1.655HisArg: 1.655 ± 0.011	2.329HisSer: 2.329 ± 0.013	1.559HisThr: 1.559 ± 0.013	1.479HisVal: 1.479 ± 0.008	0.348HisTrp: 0.348 ± 0.004	0.78HisTyr: 0.78 ± 0.007	0.002HisXaa: 0.002 ± 0.0
Ile	2.458IleAla: 2.458 ± 0.013	1.024IleCys: 1.024 ± 0.008	1.927IleAsp: 1.927 ± 0.011	2.503IleGlu: 2.503 ± 0.014	1.789IlePhe: 1.789 ± 0.012	2.106IleGly: 2.106 ± 0.012	1.334IleHis: 1.334 ± 0.01	2.248IleIle: 2.248 ± 0.016	2.545IleLys: 2.545 ± 0.015	4.403IleLeu: 4.403 ± 0.018	0.962IleMet: 0.962 ± 0.008	1.722IleAsn: 1.722 ± 0.01	2.54IlePro: 2.54 ± 0.014	2.283IleGln: 2.283 ± 0.012	2.288IleArg: 2.288 ± 0.012	3.593IleSer: 3.593 ± 0.017	2.471IleThr: 2.471 ± 0.016	2.344IleVal: 2.344 ± 0.013	0.488IleTrp: 0.488 ± 0.005	1.301IleTyr: 1.301 ± 0.01	0.002IleXaa: 0.002 ± 0.0
Lys	3.995LysAla: 3.995 ± 0.019	1.104LysCys: 1.104 ± 0.01	3.109LysAsp: 3.109 ± 0.017	5.201LysGlu: 5.201 ± 0.027	1.669LysPhe: 1.669 ± 0.012	3.153LysGly: 3.153 ± 0.02	1.398LysHis: 1.398 ± 0.01	2.694LysIle: 2.694 ± 0.018	4.694LysLys: 4.694 ± 0.031	5.17LysLeu: 5.17 ± 0.021	1.457LysMet: 1.457 ± 0.012	2.339LysAsn: 2.339 ± 0.014	3.202LysPro: 3.202 ± 0.022	2.681LysGln: 2.681 ± 0.014	3.313LysArg: 3.313 ± 0.015	4.019LysSer: 4.019 ± 0.019	3.116LysThr: 3.116 ± 0.017	3.391LysVal: 3.391 ± 0.016	0.583LysTrp: 0.583 ± 0.005	1.488LysTyr: 1.488 ± 0.01	0.002LysXaa: 0.002 ± 0.0
Leu	6.856LeuAla: 6.856 ± 0.027	2.132LeuCys: 2.132 ± 0.013	4.699LeuAsp: 4.699 ± 0.021	7.356LeuGlu: 7.356 ± 0.029	3.286LeuPhe: 3.286 ± 0.017	5.949LeuGly: 5.949 ± 0.026	2.731LeuHis: 2.731 ± 0.013	3.741LeuIle: 3.741 ± 0.017	5.789LeuLys: 5.789 ± 0.027	10.767LeuLeu: 10.767 ± 0.041	1.981LeuMet: 1.981 ± 0.009	3.435LeuAsn: 3.435 ± 0.016	6.172LeuPro: 6.172 ± 0.027	5.92LeuGln: 5.92 ± 0.026	6.071LeuArg: 6.071 ± 0.022	8.083LeuSer: 8.083 ± 0.023	5.047LeuThr: 5.047 ± 0.017	5.431LeuVal: 5.431 ± 0.019	1.118LeuTrp: 1.118 ± 0.008	2.42LeuTyr: 2.42 ± 0.012	0.006LeuXaa: 0.006 ± 0.001
Met	1.883MetAla: 1.883 ± 0.01	0.399MetCys: 0.399 ± 0.005	1.246MetAsp: 1.246 ± 0.007	1.854MetGlu: 1.854 ± 0.01	0.702MetPhe: 0.702 ± 0.007	1.261MetGly: 1.261 ± 0.009	0.472MetHis: 0.472 ± 0.005	0.783MetIle: 0.783 ± 0.006	1.426MetLys: 1.426 ± 0.009	1.96MetLeu: 1.96 ± 0.012	0.557MetMet: 0.557 ± 0.006	0.883MetAsn: 0.883 ± 0.007	1.106MetPro: 1.106 ± 0.012	0.945MetGln: 0.945 ± 0.007	1.038MetArg: 1.038 ± 0.007	1.557MetSer: 1.557 ± 0.01	1.098MetThr: 1.098 ± 0.008	1.35MetVal: 1.35 ± 0.009	0.241MetTrp: 0.241 ± 0.004	0.561MetTyr: 0.561 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	1.98AsnAla: 1.98 ± 0.01	0.8AsnCys: 0.8 ± 0.007	1.449AsnAsp: 1.449 ± 0.01	2.169AsnGlu: 2.169 ± 0.013	1.419AsnPhe: 1.419 ± 0.009	2.334AsnGly: 2.334 ± 0.015	0.941AsnHis: 0.941 ± 0.007	2.026AsnIle: 2.026 ± 0.013	2.168AsnLys: 2.168 ± 0.012	3.636AsnLeu: 3.636 ± 0.016	0.904AsnMet: 0.904 ± 0.007	1.44AsnAsn: 1.44 ± 0.01	2.14AsnPro: 2.14 ± 0.012	1.686AsnGln: 1.686 ± 0.01	1.814AsnArg: 1.814 ± 0.01	3.128AsnSer: 3.128 ± 0.015	1.909AsnThr: 1.909 ± 0.01	2.106AsnVal: 2.106 ± 0.011	0.432AsnTrp: 0.432 ± 0.005	1.053AsnTyr: 1.053 ± 0.007	0.002AsnXaa: 0.002 ± 0.0
Pro	5.296ProAla: 5.296 ± 0.032	1.14ProCys: 1.14 ± 0.011	2.84ProAsp: 2.84 ± 0.016	4.629ProGlu: 4.629 ± 0.023	1.931ProPhe: 1.931 ± 0.011	5.538ProGly: 5.538 ± 0.052	1.509ProHis: 1.509 ± 0.01	1.824ProIle: 1.824 ± 0.012	2.833ProLys: 2.833 ± 0.019	5.411ProLeu: 5.411 ± 0.021	1.071ProMet: 1.071 ± 0.008	1.795ProAsn: 1.795 ± 0.011	6.643ProPro: 6.643 ± 0.052	3.021ProGln: 3.021 ± 0.018	3.643ProArg: 3.643 ± 0.018	6.022ProSer: 6.022 ± 0.029	3.147ProThr: 3.147 ± 0.015	3.929ProVal: 3.929 ± 0.018	0.704ProTrp: 0.704 ± 0.007	1.553ProTyr: 1.553 ± 0.013	0.005ProXaa: 0.005 ± 0.001
Gln	3.653GlnAla: 3.653 ± 0.019	0.926GlnCys: 0.926 ± 0.009	2.349GlnAsp: 2.349 ± 0.012	4.049GlnGlu: 4.049 ± 0.021	1.326GlnPhe: 1.326 ± 0.008	2.923GlnGly: 2.923 ± 0.015	1.358GlnHis: 1.358 ± 0.01	1.975GlnIle: 1.975 ± 0.011	3.057GlnLys: 3.057 ± 0.017	4.854GlnLeu: 4.854 ± 0.022	1.151GlnMet: 1.151 ± 0.008	1.856GlnAsn: 1.856 ± 0.01	2.956GlnPro: 2.956 ± 0.019	3.194GlnGln: 3.194 ± 0.026	3.152GlnArg: 3.152 ± 0.016	3.255GlnSer: 3.255 ± 0.017	2.347GlnThr: 2.347 ± 0.013	2.841GlnVal: 2.841 ± 0.014	0.528GlnTrp: 0.528 ± 0.005	1.123GlnTyr: 1.123 ± 0.007	0.003GlnXaa: 0.003 ± 0.0
Arg	4.095ArgAla: 4.095 ± 0.021	1.189ArgCys: 1.189 ± 0.011	2.782ArgAsp: 2.782 ± 0.013	4.197ArgGlu: 4.197 ± 0.019	1.813ArgPhe: 1.813 ± 0.011	3.759ArgGly: 3.759 ± 0.021	1.59ArgHis: 1.59 ± 0.01	2.417ArgIle: 2.417 ± 0.01	3.732ArgLys: 3.732 ± 0.015	5.525ArgLeu: 5.525 ± 0.024	1.188ArgMet: 1.188 ± 0.007	2.072ArgAsn: 2.072 ± 0.011	3.501ArgPro: 3.501 ± 0.019	2.727ArgGln: 2.727 ± 0.016	4.636ArgArg: 4.636 ± 0.027	4.525ArgSer: 4.525 ± 0.031	2.855ArgThr: 2.855 ± 0.015	3.148ArgVal: 3.148 ± 0.015	0.684ArgTrp: 0.684 ± 0.007	1.415ArgTyr: 1.415 ± 0.008	0.004ArgXaa: 0.004 ± 0.0
Ser	5.506SerAla: 5.506 ± 0.02	1.805SerCys: 1.805 ± 0.011	3.931SerAsp: 3.931 ± 0.021	5.368SerGlu: 5.368 ± 0.024	3.015SerPhe: 3.015 ± 0.017	5.768SerGly: 5.768 ± 0.023	2.144SerHis: 2.144 ± 0.011	3.109SerIle: 3.109 ± 0.016	4.174SerLys: 4.174 ± 0.022	8.358SerLeu: 8.358 ± 0.027	1.606SerMet: 1.606 ± 0.009	2.675SerAsn: 2.675 ± 0.013	6.412SerPro: 6.412 ± 0.037	4.027SerGln: 4.027 ± 0.019	4.754SerArg: 4.754 ± 0.029	9.793SerSer: 9.793 ± 0.047	4.554SerThr: 4.554 ± 0.022	4.919SerVal: 4.919 ± 0.015	1.075SerTrp: 1.075 ± 0.008	1.987SerTyr: 1.987 ± 0.011	0.005SerXaa: 0.005 ± 0.001
Thr	3.765ThrAla: 3.765 ± 0.016	1.23ThrCys: 1.23 ± 0.012	2.408ThrAsp: 2.408 ± 0.014	3.507ThrGlu: 3.507 ± 0.017	2.068ThrPhe: 2.068 ± 0.01	3.561ThrGly: 3.561 ± 0.017	1.311ThrHis: 1.311 ± 0.011	2.265ThrIle: 2.265 ± 0.013	2.6ThrLys: 2.6 ± 0.015	5.218ThrLeu: 5.218 ± 0.016	1.086ThrMet: 1.086 ± 0.007	1.669ThrAsn: 1.669 ± 0.01	3.669ThrPro: 3.669 ± 0.023	2.299ThrGln: 2.299 ± 0.012	2.496ThrArg: 2.496 ± 0.012	4.708ThrSer: 4.708 ± 0.021	2.927ThrThr: 2.927 ± 0.021	3.771ThrVal: 3.771 ± 0.019	0.66ThrTrp: 0.66 ± 0.007	1.35ThrTyr: 1.35 ± 0.01	0.004ThrXaa: 0.004 ± 0.0
Val	4.234ValAla: 4.234 ± 0.018	1.399ValCys: 1.399 ± 0.009	2.845ValAsp: 2.845 ± 0.016	3.794ValGlu: 3.794 ± 0.017	2.286ValPhe: 2.286 ± 0.013	3.335ValGly: 3.335 ± 0.016	1.598ValHis: 1.598 ± 0.01	2.773ValIle: 2.773 ± 0.012	3.332ValLys: 3.332 ± 0.018	6.157ValLeu: 6.157 ± 0.024	1.295ValMet: 1.295 ± 0.008	2.196ValAsn: 2.196 ± 0.011	3.736ValPro: 3.736 ± 0.018	2.733ValGln: 2.733 ± 0.013	3.045ValArg: 3.045 ± 0.013	4.868ValSer: 4.868 ± 0.019	3.607ValThr: 3.607 ± 0.018	3.898ValVal: 3.898 ± 0.017	0.688ValTrp: 0.688 ± 0.006	1.542ValTyr: 1.542 ± 0.009	0.003ValXaa: 0.003 ± 0.0
Trp	0.793TrpAla: 0.793 ± 0.007	0.25TrpCys: 0.25 ± 0.004	0.635TrpAsp: 0.635 ± 0.006	0.798TrpGlu: 0.798 ± 0.008	0.429TrpPhe: 0.429 ± 0.005	0.734TrpGly: 0.734 ± 0.008	0.298TrpHis: 0.298 ± 0.004	0.52TrpIle: 0.52 ± 0.007	0.779TrpLys: 0.779 ± 0.007	1.169TrpLeu: 1.169 ± 0.008	0.294TrpMet: 0.294 ± 0.004	0.532TrpAsn: 0.532 ± 0.005	0.54TrpPro: 0.54 ± 0.006	0.517TrpGln: 0.517 ± 0.005	0.728TrpArg: 0.728 ± 0.006	0.851TrpSer: 0.851 ± 0.007	0.641TrpThr: 0.641 ± 0.005	0.664TrpVal: 0.664 ± 0.007	0.175TrpTrp: 0.175 ± 0.004	0.319TrpTyr: 0.319 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.344TyrAla: 1.344 ± 0.009	0.649TyrCys: 0.649 ± 0.006	1.217TyrAsp: 1.217 ± 0.009	1.665TyrGlu: 1.665 ± 0.01	1.155TyrPhe: 1.155 ± 0.008	1.592TyrGly: 1.592 ± 0.012	0.739TyrHis: 0.739 ± 0.006	1.294TyrIle: 1.294 ± 0.009	1.412TyrLys: 1.412 ± 0.012	2.558TyrLeu: 2.558 ± 0.012	0.564TyrMet: 0.564 ± 0.005	1.04TyrAsn: 1.04 ± 0.007	1.255TyrPro: 1.255 ± 0.008	1.231TyrGln: 1.231 ± 0.009	1.546TyrArg: 1.546 ± 0.01	2.122TyrSer: 2.122 ± 0.012	1.389TyrThr: 1.389 ± 0.01	1.491TyrVal: 1.491 ± 0.01	0.335TyrTrp: 0.335 ± 0.005	0.892TyrTyr: 0.892 ± 0.008	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.004XaaGlu: 0.004 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.005XaaGly: 0.005 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.006XaaLeu: 0.006 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.005XaaPro: 0.005 ± 0.0	0.003XaaGln: 0.003 ± 0.0	0.003XaaArg: 0.003 ± 0.0	0.004XaaSer: 0.004 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.005XaaVal: 0.005 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.012XaaXaa: 0.012 ± 0.002

Statistics based on 35454 proteins (22677905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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