Amino acid dipepetide frequency for Streptococcus pneumoniae 2070335

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.283AlaAla: 5.283 ± 0.117	0.544AlaCys: 0.544 ± 0.032	4.06AlaAsp: 4.06 ± 0.109	5.204AlaGlu: 5.204 ± 0.102	3.348AlaPhe: 3.348 ± 0.09	5.496AlaGly: 5.496 ± 0.097	1.34AlaHis: 1.34 ± 0.05	5.541AlaIle: 5.541 ± 0.107	4.992AlaLys: 4.992 ± 0.099	7.342AlaLeu: 7.342 ± 0.129	1.889AlaMet: 1.889 ± 0.055	2.957AlaAsn: 2.957 ± 0.075	2.237AlaPro: 2.237 ± 0.067	3.047AlaGln: 3.047 ± 0.086	2.901AlaArg: 2.901 ± 0.078	4.674AlaSer: 4.674 ± 0.138	4.211AlaThr: 4.211 ± 0.083	5.131AlaVal: 5.131 ± 0.103	0.666AlaTrp: 0.666 ± 0.033	2.714AlaTyr: 2.714 ± 0.073	0.002AlaXaa: 0.002 ± 0.002
Cys	0.322CysAla: 0.322 ± 0.023	0.075CysCys: 0.075 ± 0.01	0.338CysAsp: 0.338 ± 0.027	0.274CysGlu: 0.274 ± 0.021	0.367CysPhe: 0.367 ± 0.027	0.551CysGly: 0.551 ± 0.034	0.18CysHis: 0.18 ± 0.017	0.359CysIle: 0.359 ± 0.023	0.326CysLys: 0.326 ± 0.023	0.731CysLeu: 0.731 ± 0.037	0.228CysMet: 0.228 ± 0.019	0.23CysAsn: 0.23 ± 0.019	0.23CysPro: 0.23 ± 0.02	0.319CysGln: 0.319 ± 0.023	0.266CysArg: 0.266 ± 0.02	0.46CysSer: 0.46 ± 0.031	0.211CysThr: 0.211 ± 0.019	0.374CysVal: 0.374 ± 0.024	0.081CysTrp: 0.081 ± 0.014	0.269CysTyr: 0.269 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.649AspAla: 3.649 ± 0.091	0.331AspCys: 0.331 ± 0.023	2.551AspAsp: 2.551 ± 0.072	3.918AspGlu: 3.918 ± 0.086	3.287AspPhe: 3.287 ± 0.074	3.997AspGly: 3.997 ± 0.151	0.966AspHis: 0.966 ± 0.038	4.0AspIle: 4.0 ± 0.085	4.34AspLys: 4.34 ± 0.093	6.014AspLeu: 6.014 ± 0.104	1.432AspMet: 1.432 ± 0.054	2.242AspAsn: 2.242 ± 0.065	1.477AspPro: 1.477 ± 0.06	2.163AspGln: 2.163 ± 0.067	2.072AspArg: 2.072 ± 0.057	3.014AspSer: 3.014 ± 0.08	2.515AspThr: 2.515 ± 0.06	3.602AspVal: 3.602 ± 0.091	0.647AspTrp: 0.647 ± 0.038	2.777AspTyr: 2.777 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	5.515GluAla: 5.515 ± 0.114	0.314GluCys: 0.314 ± 0.027	3.767GluAsp: 3.767 ± 0.096	6.457GluGlu: 6.457 ± 0.123	2.683GluPhe: 2.683 ± 0.068	3.863GluGly: 3.863 ± 0.083	1.305GluHis: 1.305 ± 0.053	5.505GluIle: 5.505 ± 0.087	6.208GluLys: 6.208 ± 0.112	7.093GluLeu: 7.093 ± 0.117	1.942GluMet: 1.942 ± 0.068	4.041GluAsn: 4.041 ± 0.098	1.57GluPro: 1.57 ± 0.056	2.933GluGln: 2.933 ± 0.077	3.367GluArg: 3.367 ± 0.088	3.666GluSer: 3.666 ± 0.086	3.83GluThr: 3.83 ± 0.072	5.146GluVal: 5.146 ± 0.106	0.666GluTrp: 0.666 ± 0.034	2.151GluTyr: 2.151 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.384PheAla: 3.384 ± 0.08	0.252PheCys: 0.252 ± 0.023	2.916PheAsp: 2.916 ± 0.073	3.287PheGlu: 3.287 ± 0.079	2.191PhePhe: 2.191 ± 0.084	3.175PheGly: 3.175 ± 0.082	0.837PheHis: 0.837 ± 0.043	3.16PheIle: 3.16 ± 0.088	2.616PheLys: 2.616 ± 0.073	4.93PheLeu: 4.93 ± 0.107	1.214PheMet: 1.214 ± 0.05	1.93PheAsn: 1.93 ± 0.059	1.53PhePro: 1.53 ± 0.054	1.712PheGln: 1.712 ± 0.061	1.587PheArg: 1.587 ± 0.054	3.285PheSer: 3.285 ± 0.081	2.403PheThr: 2.403 ± 0.067	3.227PheVal: 3.227 ± 0.08	0.516PheTrp: 0.516 ± 0.03	1.983PheTyr: 1.983 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.796GlyAla: 4.796 ± 0.107	0.473GlyCys: 0.473 ± 0.031	3.414GlyAsp: 3.414 ± 0.081	3.928GlyGlu: 3.928 ± 0.086	3.247GlyPhe: 3.247 ± 0.072	4.259GlyGly: 4.259 ± 0.103	1.292GlyHis: 1.292 ± 0.052	5.376GlyIle: 5.376 ± 0.099	4.872GlyLys: 4.872 ± 0.112	6.776GlyLeu: 6.776 ± 0.123	1.777GlyMet: 1.777 ± 0.055	2.789GlyAsn: 2.789 ± 0.069	1.383GlyPro: 1.383 ± 0.048	3.029GlyGln: 3.029 ± 0.074	2.762GlyArg: 2.762 ± 0.079	3.803GlySer: 3.803 ± 0.092	3.635GlyThr: 3.635 ± 0.089	4.956GlyVal: 4.956 ± 0.096	0.714GlyTrp: 0.714 ± 0.042	2.623GlyTyr: 2.623 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	1.175HisAla: 1.175 ± 0.045	0.146HisCys: 0.146 ± 0.016	0.95HisAsp: 0.95 ± 0.041	1.094HisGlu: 1.094 ± 0.044	1.168HisPhe: 1.168 ± 0.047	1.307HisGly: 1.307 ± 0.045	0.558HisHis: 0.558 ± 0.034	1.324HisIle: 1.324 ± 0.042	1.01HisLys: 1.01 ± 0.044	2.137HisLeu: 2.137 ± 0.063	0.422HisMet: 0.422 ± 0.027	0.698HisAsn: 0.698 ± 0.035	0.918HisPro: 0.918 ± 0.038	0.978HisGln: 0.978 ± 0.042	0.878HisArg: 0.878 ± 0.035	1.084HisSer: 1.084 ± 0.044	0.931HisThr: 0.931 ± 0.038	1.153HisVal: 1.153 ± 0.055	0.156HisTrp: 0.156 ± 0.018	1.045HisTyr: 1.045 ± 0.049	0.0HisXaa: 0.0 ± 0.0
Ile	5.765IleAla: 5.765 ± 0.105	0.582IleCys: 0.582 ± 0.034	4.071IleAsp: 4.071 ± 0.088	4.981IleGlu: 4.981 ± 0.09	3.457IlePhe: 3.457 ± 0.091	4.915IleGly: 4.915 ± 0.108	1.41IleHis: 1.41 ± 0.051	4.805IleIle: 4.805 ± 0.108	4.311IleLys: 4.311 ± 0.088	7.786IleLeu: 7.786 ± 0.13	1.647IleMet: 1.647 ± 0.061	2.942IleAsn: 2.942 ± 0.069	2.817IlePro: 2.817 ± 0.068	2.765IleGln: 2.765 ± 0.063	2.986IleArg: 2.986 ± 0.071	4.966IleSer: 4.966 ± 0.102	3.662IleThr: 3.662 ± 0.083	4.908IleVal: 4.908 ± 0.101	0.626IleTrp: 0.626 ± 0.033	2.508IleTyr: 2.508 ± 0.07	0.003IleXaa: 0.003 ± 0.002
Lys	4.733LysAla: 4.733 ± 0.095	0.268LysCys: 0.268 ± 0.021	4.036LysAsp: 4.036 ± 0.103	6.39LysGlu: 6.39 ± 0.105	2.028LysPhe: 2.028 ± 0.061	4.053LysGly: 4.053 ± 0.096	1.185LysHis: 1.185 ± 0.042	4.877LysIle: 4.877 ± 0.093	5.052LysLys: 5.052 ± 0.116	6.121LysLeu: 6.121 ± 0.106	2.122LysMet: 2.122 ± 0.055	3.414LysAsn: 3.414 ± 0.083	2.113LysPro: 2.113 ± 0.067	2.757LysGln: 2.757 ± 0.063	3.146LysArg: 3.146 ± 0.097	3.947LysSer: 3.947 ± 0.094	3.841LysThr: 3.841 ± 0.09	4.734LysVal: 4.734 ± 0.087	0.655LysTrp: 0.655 ± 0.035	2.17LysTyr: 2.17 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	8.797LeuAla: 8.797 ± 0.128	0.559LeuCys: 0.559 ± 0.034	5.82LeuAsp: 5.82 ± 0.106	7.426LeuGlu: 7.426 ± 0.126	4.666LeuPhe: 4.666 ± 0.117	6.577LeuGly: 6.577 ± 0.1	1.705LeuHis: 1.705 ± 0.056	6.601LeuIle: 6.601 ± 0.132	6.548LeuLys: 6.548 ± 0.119	10.519LeuLeu: 10.519 ± 0.19	2.613LeuMet: 2.613 ± 0.076	4.036LeuAsn: 4.036 ± 0.09	4.216LeuPro: 4.216 ± 0.092	3.573LeuGln: 3.573 ± 0.09	3.839LeuArg: 3.839 ± 0.087	7.56LeuSer: 7.56 ± 0.11	6.223LeuThr: 6.223 ± 0.108	7.266LeuVal: 7.266 ± 0.127	0.794LeuTrp: 0.794 ± 0.034	3.287LeuTyr: 3.287 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	1.986MetAla: 1.986 ± 0.072	0.124MetCys: 0.124 ± 0.015	1.439MetAsp: 1.439 ± 0.047	1.757MetGlu: 1.757 ± 0.059	0.818MetPhe: 0.818 ± 0.038	1.774MetGly: 1.774 ± 0.059	0.362MetHis: 0.362 ± 0.023	2.024MetIle: 2.024 ± 0.064	2.209MetLys: 2.209 ± 0.063	2.35MetLeu: 2.35 ± 0.067	0.823MetMet: 0.823 ± 0.04	1.269MetAsn: 1.269 ± 0.045	0.906MetPro: 0.906 ± 0.04	0.943MetGln: 0.943 ± 0.044	1.115MetArg: 1.115 ± 0.041	1.662MetSer: 1.662 ± 0.049	1.947MetThr: 1.947 ± 0.057	1.777MetVal: 1.777 ± 0.053	0.184MetTrp: 0.184 ± 0.017	0.638MetTyr: 0.638 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.758AsnAla: 2.758 ± 0.073	0.307AsnCys: 0.307 ± 0.025	2.036AsnAsp: 2.036 ± 0.062	2.383AsnGlu: 2.383 ± 0.061	1.942AsnPhe: 1.942 ± 0.061	3.384AsnGly: 3.384 ± 0.078	1.086AsnHis: 1.086 ± 0.041	3.101AsnIle: 3.101 ± 0.075	2.637AsnLys: 2.637 ± 0.075	4.661AsnLeu: 4.661 ± 0.104	1.254AsnMet: 1.254 ± 0.042	1.81AsnAsn: 1.81 ± 0.065	2.323AsnPro: 2.323 ± 0.067	2.254AsnGln: 2.254 ± 0.075	2.038AsnArg: 2.038 ± 0.056	2.378AsnSer: 2.378 ± 0.064	2.122AsnThr: 2.122 ± 0.061	2.614AsnVal: 2.614 ± 0.074	0.606AsnTrp: 0.606 ± 0.035	1.863AsnTyr: 1.863 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.544ProAla: 2.544 ± 0.061	0.192ProCys: 0.192 ± 0.019	2.0ProAsp: 2.0 ± 0.056	2.98ProGlu: 2.98 ± 0.082	1.69ProPhe: 1.69 ± 0.057	1.657ProGly: 1.657 ± 0.06	0.669ProHis: 0.669 ± 0.038	2.465ProIle: 2.465 ± 0.059	1.932ProLys: 1.932 ± 0.064	2.985ProLeu: 2.985 ± 0.079	0.815ProMet: 0.815 ± 0.04	1.607ProAsn: 1.607 ± 0.052	0.59ProPro: 0.59 ± 0.036	1.316ProGln: 1.316 ± 0.047	1.13ProArg: 1.13 ± 0.043	2.216ProSer: 2.216 ± 0.063	2.0ProThr: 2.0 ± 0.068	2.724ProVal: 2.724 ± 0.071	0.348ProTrp: 0.348 ± 0.024	1.333ProTyr: 1.333 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.686GlnAla: 3.686 ± 0.089	0.173GlnCys: 0.173 ± 0.018	2.221GlnAsp: 2.221 ± 0.065	3.633GlnGlu: 3.633 ± 0.087	1.681GlnPhe: 1.681 ± 0.052	2.58GlnGly: 2.58 ± 0.066	0.734GlnHis: 0.734 ± 0.037	2.981GlnIle: 2.981 ± 0.075	2.916GlnLys: 2.916 ± 0.078	4.077GlnLeu: 4.077 ± 0.101	1.017GlnMet: 1.017 ± 0.046	1.758GlnAsn: 1.758 ± 0.054	1.209GlnPro: 1.209 ± 0.054	1.448GlnGln: 1.448 ± 0.058	1.515GlnArg: 1.515 ± 0.054	2.153GlnSer: 2.153 ± 0.056	2.436GlnThr: 2.436 ± 0.067	3.386GlnVal: 3.386 ± 0.086	0.321GlnTrp: 0.321 ± 0.022	1.268GlnTyr: 1.268 ± 0.046	0.002GlnXaa: 0.002 ± 0.002
Arg	2.578ArgAla: 2.578 ± 0.066	0.221ArgCys: 0.221 ± 0.02	2.273ArgAsp: 2.273 ± 0.066	3.11ArgGlu: 3.11 ± 0.093	2.144ArgPhe: 2.144 ± 0.058	2.34ArgGly: 2.34 ± 0.076	0.793ArgHis: 0.793 ± 0.039	3.072ArgIle: 3.072 ± 0.072	3.065ArgLys: 3.065 ± 0.074	4.234ArgLeu: 4.234 ± 0.085	1.237ArgMet: 1.237 ± 0.047	1.861ArgAsn: 1.861 ± 0.055	1.285ArgPro: 1.285 ± 0.049	1.904ArgGln: 1.904 ± 0.066	1.877ArgArg: 1.877 ± 0.058	2.062ArgSer: 2.062 ± 0.057	2.01ArgThr: 2.01 ± 0.058	2.853ArgVal: 2.853 ± 0.077	0.317ArgTrp: 0.317 ± 0.024	1.75ArgTyr: 1.75 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	3.808SerAla: 3.808 ± 0.134	0.479SerCys: 0.479 ± 0.03	3.283SerAsp: 3.283 ± 0.074	3.662SerGlu: 3.662 ± 0.07	3.074SerPhe: 3.074 ± 0.069	4.294SerGly: 4.294 ± 0.089	1.333SerHis: 1.333 ± 0.046	4.446SerIle: 4.446 ± 0.093	4.237SerLys: 4.237 ± 0.092	6.958SerLeu: 6.958 ± 0.125	1.647SerMet: 1.647 ± 0.054	2.604SerAsn: 2.604 ± 0.069	2.045SerPro: 2.045 ± 0.064	3.132SerGln: 3.132 ± 0.078	2.633SerArg: 2.633 ± 0.076	4.407SerSer: 4.407 ± 0.118	3.197SerThr: 3.197 ± 0.094	4.074SerVal: 4.074 ± 0.085	0.678SerTrp: 0.678 ± 0.039	2.573SerTyr: 2.573 ± 0.079	0.0SerXaa: 0.0 ± 0.0
Thr	3.988ThrAla: 3.988 ± 0.095	0.352ThrCys: 0.352 ± 0.028	3.122ThrAsp: 3.122 ± 0.07	3.46ThrGlu: 3.46 ± 0.074	2.623ThrPhe: 2.623 ± 0.069	4.088ThrGly: 4.088 ± 0.095	1.069ThrHis: 1.069 ± 0.046	4.374ThrIle: 4.374 ± 0.087	3.148ThrLys: 3.148 ± 0.077	5.18ThrLeu: 5.18 ± 0.1	1.166ThrMet: 1.166 ± 0.045	2.215ThrAsn: 2.215 ± 0.061	2.314ThrPro: 2.314 ± 0.056	1.707ThrGln: 1.707 ± 0.053	2.034ThrArg: 2.034 ± 0.057	3.827ThrSer: 3.827 ± 0.107	3.091ThrThr: 3.091 ± 0.089	4.415ThrVal: 4.415 ± 0.11	0.599ThrTrp: 0.599 ± 0.031	2.127ThrTyr: 2.127 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.798ValAla: 5.798 ± 0.094	0.496ValCys: 0.496 ± 0.028	4.004ValAsp: 4.004 ± 0.083	5.124ValGlu: 5.124 ± 0.105	3.216ValPhe: 3.216 ± 0.083	4.451ValGly: 4.451 ± 0.092	1.204ValHis: 1.204 ± 0.045	4.781ValIle: 4.781 ± 0.085	4.457ValLys: 4.457 ± 0.093	7.294ValLeu: 7.294 ± 0.124	1.71ValMet: 1.71 ± 0.054	3.038ValAsn: 3.038 ± 0.079	2.441ValPro: 2.441 ± 0.067	2.386ValGln: 2.386 ± 0.062	2.727ValArg: 2.727 ± 0.072	4.527ValSer: 4.527 ± 0.093	4.311ValThr: 4.311 ± 0.088	4.923ValVal: 4.923 ± 0.104	0.585ValTrp: 0.585 ± 0.034	2.436ValTyr: 2.436 ± 0.058	0.002ValXaa: 0.002 ± 0.002
Trp	0.542TrpAla: 0.542 ± 0.035	0.067TrpCys: 0.067 ± 0.012	0.511TrpAsp: 0.511 ± 0.028	0.621TrpGlu: 0.621 ± 0.037	0.515TrpPhe: 0.515 ± 0.036	0.66TrpGly: 0.66 ± 0.037	0.185TrpHis: 0.185 ± 0.016	0.707TrpIle: 0.707 ± 0.034	0.635TrpLys: 0.635 ± 0.031	1.034TrpLeu: 1.034 ± 0.044	0.278TrpMet: 0.278 ± 0.023	0.532TrpAsn: 0.532 ± 0.031	0.184TrpPro: 0.184 ± 0.016	0.491TrpGln: 0.491 ± 0.032	0.362TrpArg: 0.362 ± 0.024	0.618TrpSer: 0.618 ± 0.032	0.535TrpThr: 0.535 ± 0.032	0.509TrpVal: 0.509 ± 0.031	0.146TrpTrp: 0.146 ± 0.017	0.523TrpTyr: 0.523 ± 0.042	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.468TyrAla: 2.468 ± 0.061	0.237TyrCys: 0.237 ± 0.021	2.18TyrAsp: 2.18 ± 0.056	2.331TyrGlu: 2.331 ± 0.062	1.993TyrPhe: 1.993 ± 0.064	2.482TyrGly: 2.482 ± 0.075	0.921TyrHis: 0.921 ± 0.045	2.412TyrIle: 2.412 ± 0.073	2.132TyrLys: 2.132 ± 0.063	4.402TyrLeu: 4.402 ± 0.1	0.873TyrMet: 0.873 ± 0.036	1.582TyrAsn: 1.582 ± 0.063	1.407TyrPro: 1.407 ± 0.061	2.34TyrGln: 2.34 ± 0.07	1.75TyrArg: 1.75 ± 0.059	2.256TyrSer: 2.256 ± 0.063	1.786TyrThr: 1.786 ± 0.052	2.136TyrVal: 2.136 ± 0.059	0.352TyrTrp: 0.352 ± 0.028	1.75TyrTyr: 1.75 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2823 proteins (582959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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