Amino acid dipepetide frequency for Haloquadratum sp. J07HQX50

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.475AlaAla: 9.475 ± 0.18	0.757AlaCys: 0.757 ± 0.035	6.651AlaAsp: 6.651 ± 0.12	6.777AlaGlu: 6.777 ± 0.104	3.006AlaPhe: 3.006 ± 0.076	7.545AlaGly: 7.545 ± 0.122	1.944AlaHis: 1.944 ± 0.056	5.509AlaIle: 5.509 ± 0.086	2.223AlaLys: 2.223 ± 0.063	8.008AlaLeu: 8.008 ± 0.116	1.794AlaMet: 1.794 ± 0.053	2.787AlaAsn: 2.787 ± 0.074	3.165AlaPro: 3.165 ± 0.074	3.07AlaGln: 3.07 ± 0.069	4.897AlaArg: 4.897 ± 0.094	5.946AlaSer: 5.946 ± 0.11	6.229AlaThr: 6.229 ± 0.12	8.377AlaVal: 8.377 ± 0.138	0.895AlaTrp: 0.895 ± 0.038	2.336AlaTyr: 2.336 ± 0.06	0.017AlaXaa: 0.017 ± 0.004
Cys	0.708CysAla: 0.708 ± 0.037	0.132CysCys: 0.132 ± 0.014	0.647CysAsp: 0.647 ± 0.036	0.701CysGlu: 0.701 ± 0.035	0.275CysPhe: 0.275 ± 0.023	0.984CysGly: 0.984 ± 0.041	0.243CysHis: 0.243 ± 0.017	0.421CysIle: 0.421 ± 0.024	0.2CysLys: 0.2 ± 0.018	0.727CysLeu: 0.727 ± 0.036	0.181CysMet: 0.181 ± 0.015	0.285CysAsn: 0.285 ± 0.021	0.517CysPro: 0.517 ± 0.03	0.335CysGln: 0.335 ± 0.023	0.624CysArg: 0.624 ± 0.034	0.655CysSer: 0.655 ± 0.032	0.459CysThr: 0.459 ± 0.027	0.636CysVal: 0.636 ± 0.03	0.112CysTrp: 0.112 ± 0.014	0.208CysTyr: 0.208 ± 0.018	0.006CysXaa: 0.006 ± 0.003
Asp	6.523AspAla: 6.523 ± 0.118	0.606AspCys: 0.606 ± 0.032	4.718AspAsp: 4.718 ± 0.107	5.749AspGlu: 5.749 ± 0.107	1.804AspPhe: 1.804 ± 0.057	5.291AspGly: 5.291 ± 0.105	1.438AspHis: 1.438 ± 0.046	4.647AspIle: 4.647 ± 0.095	1.228AspLys: 1.228 ± 0.042	5.024AspLeu: 5.024 ± 0.102	1.337AspMet: 1.337 ± 0.046	1.9AspAsn: 1.9 ± 0.055	3.391AspPro: 3.391 ± 0.076	2.128AspGln: 2.128 ± 0.061	4.578AspArg: 4.578 ± 0.094	4.617AspSer: 4.617 ± 0.093	5.011AspThr: 5.011 ± 0.093	5.429AspVal: 5.429 ± 0.09	0.745AspTrp: 0.745 ± 0.037	1.45AspTyr: 1.45 ± 0.05	0.012AspXaa: 0.012 ± 0.004
Glu	6.795GluAla: 6.795 ± 0.122	0.679GluCys: 0.679 ± 0.036	4.069GluAsp: 4.069 ± 0.087	4.917GluGlu: 4.917 ± 0.101	2.88GluPhe: 2.88 ± 0.069	3.677GluGly: 3.677 ± 0.081	1.82GluHis: 1.82 ± 0.058	4.491GluIle: 4.491 ± 0.093	1.967GluLys: 1.967 ± 0.069	7.086GluLeu: 7.086 ± 0.111	1.877GluMet: 1.877 ± 0.057	2.613GluAsn: 2.613 ± 0.062	2.975GluPro: 2.975 ± 0.07	3.341GluGln: 3.341 ± 0.076	5.45GluArg: 5.45 ± 0.102	6.278GluSer: 6.278 ± 0.113	6.757GluThr: 6.757 ± 0.11	4.811GluVal: 4.811 ± 0.098	0.961GluTrp: 0.961 ± 0.041	2.581GluTyr: 2.581 ± 0.067	0.011GluXaa: 0.011 ± 0.004
Phe	3.174PheAla: 3.174 ± 0.07	0.277PheCys: 0.277 ± 0.024	2.949PheAsp: 2.949 ± 0.078	3.073PheGlu: 3.073 ± 0.066	1.135PhePhe: 1.135 ± 0.045	2.906PheGly: 2.906 ± 0.071	0.678PheHis: 0.678 ± 0.033	1.903PheIle: 1.903 ± 0.057	0.676PheLys: 0.676 ± 0.032	2.622PheLeu: 2.622 ± 0.067	0.571PheMet: 0.571 ± 0.034	1.042PheAsn: 1.042 ± 0.044	1.29PhePro: 1.29 ± 0.048	1.037PheGln: 1.037 ± 0.034	1.822PheArg: 1.822 ± 0.058	2.269PheSer: 2.269 ± 0.064	2.126PheThr: 2.126 ± 0.065	2.752PheVal: 2.752 ± 0.069	0.352PheTrp: 0.352 ± 0.026	0.925PheTyr: 0.925 ± 0.036	0.009PheXaa: 0.009 ± 0.004
Gly	6.088GlyAla: 6.088 ± 0.109	0.716GlyCys: 0.716 ± 0.034	4.504GlyAsp: 4.504 ± 0.095	5.444GlyGlu: 5.444 ± 0.097	3.124GlyPhe: 3.124 ± 0.069	6.35GlyGly: 6.35 ± 0.157	1.563GlyHis: 1.563 ± 0.052	4.849GlyIle: 4.849 ± 0.091	2.082GlyLys: 2.082 ± 0.056	6.636GlyLeu: 6.636 ± 0.149	1.554GlyMet: 1.554 ± 0.046	2.353GlyAsn: 2.353 ± 0.068	2.773GlyPro: 2.773 ± 0.065	2.405GlyGln: 2.405 ± 0.065	3.833GlyArg: 3.833 ± 0.077	5.333GlySer: 5.333 ± 0.114	5.045GlyThr: 5.045 ± 0.112	6.403GlyVal: 6.403 ± 0.103	1.002GlyTrp: 1.002 ± 0.037	2.516GlyTyr: 2.516 ± 0.066	0.023GlyXaa: 0.023 ± 0.006
His	1.886HisAla: 1.886 ± 0.057	0.266HisCys: 0.266 ± 0.019	1.606HisAsp: 1.606 ± 0.054	1.707HisGlu: 1.707 ± 0.053	0.592HisPhe: 0.592 ± 0.031	1.787HisGly: 1.787 ± 0.058	0.673HisHis: 0.673 ± 0.036	1.245HisIle: 1.245 ± 0.05	0.451HisLys: 0.451 ± 0.028	1.926HisLeu: 1.926 ± 0.063	0.381HisMet: 0.381 ± 0.023	0.667HisAsn: 0.667 ± 0.032	1.313HisPro: 1.313 ± 0.045	0.815HisGln: 0.815 ± 0.033	1.554HisArg: 1.554 ± 0.049	1.516HisSer: 1.516 ± 0.047	1.498HisThr: 1.498 ± 0.045	1.672HisVal: 1.672 ± 0.051	0.268HisTrp: 0.268 ± 0.02	0.534HisTyr: 0.534 ± 0.027	0.011HisXaa: 0.011 ± 0.004
Ile	5.64IleAla: 5.64 ± 0.096	0.526IleCys: 0.526 ± 0.033	4.626IleAsp: 4.626 ± 0.08	5.625IleGlu: 5.625 ± 0.109	1.7IlePhe: 1.7 ± 0.059	4.956IleGly: 4.956 ± 0.105	1.282IleHis: 1.282 ± 0.041	3.292IleIle: 3.292 ± 0.083	1.478IleLys: 1.478 ± 0.045	4.552IleLeu: 4.552 ± 0.095	0.886IleMet: 0.886 ± 0.036	1.81IleAsn: 1.81 ± 0.058	2.815IlePro: 2.815 ± 0.064	2.197IleGln: 2.197 ± 0.06	3.365IleArg: 3.365 ± 0.076	3.976IleSer: 3.976 ± 0.079	3.875IleThr: 3.875 ± 0.08	4.302IleVal: 4.302 ± 0.083	0.442IleTrp: 0.442 ± 0.028	1.233IleTyr: 1.233 ± 0.041	0.009IleXaa: 0.009 ± 0.004
Lys	1.964LysAla: 1.964 ± 0.06	0.181LysCys: 0.181 ± 0.016	1.213LysAsp: 1.213 ± 0.044	1.553LysGlu: 1.553 ± 0.054	0.679LysPhe: 0.679 ± 0.033	1.348LysGly: 1.348 ± 0.046	0.691LysHis: 0.691 ± 0.034	1.328LysIle: 1.328 ± 0.049	0.733LysLys: 0.733 ± 0.031	2.076LysLeu: 2.076 ± 0.065	0.526LysMet: 0.526 ± 0.028	0.942LysAsn: 0.942 ± 0.038	1.114LysPro: 1.114 ± 0.041	1.588LysGln: 1.588 ± 0.053	1.941LysArg: 1.941 ± 0.059	1.895LysSer: 1.895 ± 0.054	1.967LysThr: 1.967 ± 0.048	1.245LysVal: 1.245 ± 0.043	0.294LysTrp: 0.294 ± 0.022	0.825LysTyr: 0.825 ± 0.035	0.003LysXaa: 0.003 ± 0.002
Leu	8.137LeuAla: 8.137 ± 0.125	0.873LeuCys: 0.873 ± 0.037	5.681LeuAsp: 5.681 ± 0.099	5.681LeuGlu: 5.681 ± 0.107	3.197LeuPhe: 3.197 ± 0.075	6.122LeuGly: 6.122 ± 0.124	1.73LeuHis: 1.73 ± 0.059	4.857LeuIle: 4.857 ± 0.096	2.148LeuLys: 2.148 ± 0.063	7.786LeuLeu: 7.786 ± 0.157	1.452LeuMet: 1.452 ± 0.055	2.838LeuAsn: 2.838 ± 0.063	3.982LeuPro: 3.982 ± 0.084	2.998LeuGln: 2.998 ± 0.081	5.379LeuArg: 5.379 ± 0.086	7.569LeuSer: 7.569 ± 0.132	6.235LeuThr: 6.235 ± 0.104	6.137LeuVal: 6.137 ± 0.119	0.826LeuTrp: 0.826 ± 0.038	2.224LeuTyr: 2.224 ± 0.062	0.021LeuXaa: 0.021 ± 0.006
Met	1.525MetAla: 1.525 ± 0.045	0.208MetCys: 0.208 ± 0.018	1.111MetAsp: 1.111 ± 0.047	1.042MetGlu: 1.042 ± 0.044	0.528MetPhe: 0.528 ± 0.03	1.294MetGly: 1.294 ± 0.04	0.419MetHis: 0.419 ± 0.022	1.193MetIle: 1.193 ± 0.044	0.646MetLys: 0.646 ± 0.031	1.684MetLeu: 1.684 ± 0.055	0.431MetMet: 0.431 ± 0.028	0.927MetAsn: 0.927 ± 0.035	0.87MetPro: 0.87 ± 0.033	0.731MetGln: 0.731 ± 0.036	1.234MetArg: 1.234 ± 0.042	2.018MetSer: 2.018 ± 0.053	1.684MetThr: 1.684 ± 0.055	1.172MetVal: 1.172 ± 0.049	0.173MetTrp: 0.173 ± 0.016	0.486MetTyr: 0.486 ± 0.029	0.003MetXaa: 0.003 ± 0.002
Asn	2.88AsnAla: 2.88 ± 0.071	0.283AsnCys: 0.283 ± 0.018	1.949AsnAsp: 1.949 ± 0.057	2.266AsnGlu: 2.266 ± 0.063	0.89AsnPhe: 0.89 ± 0.036	2.31AsnGly: 2.31 ± 0.066	0.8AsnHis: 0.8 ± 0.038	1.953AsnIle: 1.953 ± 0.063	0.875AsnLys: 0.875 ± 0.041	2.602AsnLeu: 2.602 ± 0.066	0.649AsnMet: 0.649 ± 0.03	1.052AsnAsn: 1.052 ± 0.046	1.981AsnPro: 1.981 ± 0.051	1.299AsnGln: 1.299 ± 0.048	2.34AsnArg: 2.34 ± 0.06	2.061AsnSer: 2.061 ± 0.065	2.171AsnThr: 2.171 ± 0.064	2.418AsnVal: 2.418 ± 0.077	0.327AsnTrp: 0.327 ± 0.024	0.785AsnTyr: 0.785 ± 0.035	0.002AsnXaa: 0.002 ± 0.002
Pro	3.979ProAla: 3.979 ± 0.094	0.309ProCys: 0.309 ± 0.02	3.625ProAsp: 3.625 ± 0.079	3.789ProGlu: 3.789 ± 0.073	1.464ProPhe: 1.464 ± 0.046	3.033ProGly: 3.033 ± 0.069	1.065ProHis: 1.065 ± 0.04	2.33ProIle: 2.33 ± 0.063	0.889ProLys: 0.889 ± 0.033	3.699ProLeu: 3.699 ± 0.081	0.803ProMet: 0.803 ± 0.036	1.265ProAsn: 1.265 ± 0.042	2.125ProPro: 2.125 ± 0.068	1.499ProGln: 1.499 ± 0.053	2.272ProArg: 2.272 ± 0.066	3.255ProSer: 3.255 ± 0.07	3.554ProThr: 3.554 ± 0.075	3.861ProVal: 3.861 ± 0.079	0.464ProTrp: 0.464 ± 0.026	1.08ProTyr: 1.08 ± 0.043	0.008ProXaa: 0.008 ± 0.003
Gln	3.41GlnAla: 3.41 ± 0.067	0.304GlnCys: 0.304 ± 0.023	1.732GlnAsp: 1.732 ± 0.053	2.241GlnGlu: 2.241 ± 0.065	1.493GlnPhe: 1.493 ± 0.05	1.88GlnGly: 1.88 ± 0.054	0.887GlnHis: 0.887 ± 0.037	2.201GlnIle: 2.201 ± 0.057	1.048GlnLys: 1.048 ± 0.043	3.48GlnLeu: 3.48 ± 0.084	0.857GlnMet: 0.857 ± 0.036	1.259GlnAsn: 1.259 ± 0.05	1.501GlnPro: 1.501 ± 0.048	1.961GlnGln: 1.961 ± 0.067	2.677GlnArg: 2.677 ± 0.071	3.127GlnSer: 3.127 ± 0.071	3.159GlnThr: 3.159 ± 0.074	2.285GlnVal: 2.285 ± 0.057	0.516GlnTrp: 0.516 ± 0.029	1.27GlnTyr: 1.27 ± 0.037	0.006GlnXaa: 0.006 ± 0.003
Arg	5.108ArgAla: 5.108 ± 0.088	0.618ArgCys: 0.618 ± 0.035	4.051ArgAsp: 4.051 ± 0.089	5.123ArgGlu: 5.123 ± 0.105	2.221ArgPhe: 2.221 ± 0.054	4.155ArgGly: 4.155 ± 0.08	1.355ArgHis: 1.355 ± 0.053	3.46ArgIle: 3.46 ± 0.074	1.611ArgLys: 1.611 ± 0.057	5.538ArgLeu: 5.538 ± 0.102	1.28ArgMet: 1.28 ± 0.045	1.97ArgAsn: 1.97 ± 0.051	2.457ArgPro: 2.457 ± 0.067	2.622ArgGln: 2.622 ± 0.067	4.341ArgArg: 4.341 ± 0.09	4.077ArgSer: 4.077 ± 0.086	3.817ArgThr: 3.817 ± 0.073	4.842ArgVal: 4.842 ± 0.096	0.737ArgTrp: 0.737 ± 0.033	1.914ArgTyr: 1.914 ± 0.055	0.017ArgXaa: 0.017 ± 0.005
Ser	6.391SerAla: 6.391 ± 0.121	0.583SerCys: 0.583 ± 0.032	4.799SerAsp: 4.799 ± 0.101	5.411SerGlu: 5.411 ± 0.098	2.302SerPhe: 2.302 ± 0.054	5.879SerGly: 5.879 ± 0.106	1.615SerHis: 1.615 ± 0.055	4.072SerIle: 4.072 ± 0.07	1.845SerLys: 1.845 ± 0.056	6.301SerLeu: 6.301 ± 0.114	1.498SerMet: 1.498 ± 0.049	2.273SerAsn: 2.273 ± 0.06	3.313SerPro: 3.313 ± 0.085	2.59SerGln: 2.59 ± 0.074	4.237SerArg: 4.237 ± 0.092	4.917SerSer: 4.917 ± 0.121	4.93SerThr: 4.93 ± 0.093	6.171SerVal: 6.171 ± 0.108	0.766SerTrp: 0.766 ± 0.034	2.007SerTyr: 2.007 ± 0.052	0.02SerXaa: 0.02 ± 0.006
Thr	7.309ThrAla: 7.309 ± 0.101	0.512ThrCys: 0.512 ± 0.026	5.114ThrAsp: 5.114 ± 0.097	5.538ThrGlu: 5.538 ± 0.098	2.148ThrPhe: 2.148 ± 0.062	5.926ThrGly: 5.926 ± 0.114	1.747ThrHis: 1.747 ± 0.045	3.98ThrIle: 3.98 ± 0.073	1.449ThrLys: 1.449 ± 0.049	6.182ThrLeu: 6.182 ± 0.104	1.181ThrMet: 1.181 ± 0.044	2.004ThrAsn: 2.004 ± 0.066	3.653ThrPro: 3.653 ± 0.079	2.735ThrGln: 2.735 ± 0.071	3.785ThrArg: 3.785 ± 0.068	3.98ThrSer: 3.98 ± 0.085	5.336ThrThr: 5.336 ± 0.119	7.203ThrVal: 7.203 ± 0.12	0.595ThrTrp: 0.595 ± 0.033	1.851ThrTyr: 1.851 ± 0.055	0.017ThrXaa: 0.017 ± 0.005
Val	7.2ValAla: 7.2 ± 0.135	0.821ValCys: 0.821 ± 0.037	5.717ValAsp: 5.717 ± 0.099	6.402ValGlu: 6.402 ± 0.111	2.847ValPhe: 2.847 ± 0.074	6.495ValGly: 6.495 ± 0.151	1.519ValHis: 1.519 ± 0.051	4.762ValIle: 4.762 ± 0.102	1.674ValLys: 1.674 ± 0.053	6.29ValLeu: 6.29 ± 0.11	1.418ValMet: 1.418 ± 0.044	2.545ValAsn: 2.545 ± 0.067	3.361ValPro: 3.361 ± 0.077	2.275ValGln: 2.275 ± 0.063	4.282ValArg: 4.282 ± 0.088	6.269ValSer: 6.269 ± 0.114	5.882ValThr: 5.882 ± 0.112	6.324ValVal: 6.324 ± 0.123	0.636ValTrp: 0.636 ± 0.036	1.986ValTyr: 1.986 ± 0.06	0.012ValXaa: 0.012 ± 0.004
Trp	0.811TrpAla: 0.811 ± 0.039	0.127TrpCys: 0.127 ± 0.014	0.635TrpAsp: 0.635 ± 0.031	0.803TrpGlu: 0.803 ± 0.041	0.399TrpPhe: 0.399 ± 0.023	0.71TrpGly: 0.71 ± 0.035	0.219TrpHis: 0.219 ± 0.019	0.636TrpIle: 0.636 ± 0.037	0.346TrpLys: 0.346 ± 0.024	1.007TrpLeu: 1.007 ± 0.045	0.255TrpMet: 0.255 ± 0.02	0.474TrpAsn: 0.474 ± 0.029	0.422TrpPro: 0.422 ± 0.028	0.464TrpGln: 0.464 ± 0.027	0.76TrpArg: 0.76 ± 0.035	0.603TrpSer: 0.603 ± 0.03	0.662TrpThr: 0.662 ± 0.036	0.731TrpVal: 0.731 ± 0.035	0.2TrpTrp: 0.2 ± 0.017	0.378TrpTyr: 0.378 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.061	0.272TyrCys: 0.272 ± 0.02	2.214TyrAsp: 2.214 ± 0.054	2.184TyrGlu: 2.184 ± 0.063	0.896TyrPhe: 0.896 ± 0.035	1.941TyrGly: 1.941 ± 0.053	0.673TyrHis: 0.673 ± 0.034	1.438TyrIle: 1.438 ± 0.05	0.531TyrLys: 0.531 ± 0.029	2.631TyrLeu: 2.631 ± 0.065	0.441TyrMet: 0.441 ± 0.026	0.88TyrAsn: 0.88 ± 0.042	1.343TyrPro: 1.343 ± 0.041	1.202TyrGln: 1.202 ± 0.044	1.921TyrArg: 1.921 ± 0.054	1.55TyrSer: 1.55 ± 0.048	1.83TyrThr: 1.83 ± 0.054	1.929TyrVal: 1.929 ± 0.048	0.327TyrTrp: 0.327 ± 0.026	0.831TyrTyr: 0.831 ± 0.04	0.008TyrXaa: 0.008 ± 0.003
Xaa	0.02XaaAla: 0.02 ± 0.006	0.003XaaCys: 0.003 ± 0.002	0.017XaaAsp: 0.017 ± 0.006	0.012XaaGlu: 0.012 ± 0.004	0.008XaaPhe: 0.008 ± 0.004	0.008XaaGly: 0.008 ± 0.003	0.005XaaHis: 0.005 ± 0.003	0.017XaaIle: 0.017 ± 0.005	0.008XaaLys: 0.008 ± 0.004	0.018XaaLeu: 0.018 ± 0.005	0.008XaaMet: 0.008 ± 0.004	0.008XaaAsn: 0.008 ± 0.003	0.006XaaPro: 0.006 ± 0.004	0.002XaaGln: 0.002 ± 0.002	0.018XaaArg: 0.018 ± 0.006	0.012XaaSer: 0.012 ± 0.005	0.018XaaThr: 0.018 ± 0.005	0.017XaaVal: 0.017 ± 0.005	0.005XaaTrp: 0.005 ± 0.003	0.006XaaTyr: 0.006 ± 0.003	1.349XaaXaa: 1.349 ± 0.101

Statistics based on 2865 proteins (653713 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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