Amino acid dipepetide frequency for Flavobacteria bacterium (strain MS024-2A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.989AlaAla: 4.989 ± 0.151	0.581AlaCys: 0.581 ± 0.04	2.991AlaAsp: 2.991 ± 0.086	3.632AlaGlu: 3.632 ± 0.083	3.624AlaPhe: 3.624 ± 0.095	4.398AlaGly: 4.398 ± 0.113	1.298AlaHis: 1.298 ± 0.059	5.267AlaIle: 5.267 ± 0.112	4.338AlaLys: 4.338 ± 0.103	7.293AlaLeu: 7.293 ± 0.149	1.494AlaMet: 1.494 ± 0.054	2.915AlaAsn: 2.915 ± 0.071	2.231AlaPro: 2.231 ± 0.06	2.716AlaGln: 2.716 ± 0.071	2.176AlaArg: 2.176 ± 0.067	4.548AlaSer: 4.548 ± 0.103	3.821AlaThr: 3.821 ± 0.137	4.123AlaVal: 4.123 ± 0.101	0.633AlaTrp: 0.633 ± 0.033	2.311AlaTyr: 2.311 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.441CysAla: 0.441 ± 0.03	0.091CysCys: 0.091 ± 0.011	0.471CysAsp: 0.471 ± 0.038	0.473CysGlu: 0.473 ± 0.033	0.425CysPhe: 0.425 ± 0.022	0.576CysGly: 0.576 ± 0.042	0.184CysHis: 0.184 ± 0.023	0.596CysIle: 0.596 ± 0.034	0.403CysLys: 0.403 ± 0.025	0.662CysLeu: 0.662 ± 0.036	0.167CysMet: 0.167 ± 0.016	0.317CysAsn: 0.317 ± 0.025	0.322CysPro: 0.322 ± 0.027	0.294CysGln: 0.294 ± 0.024	0.192CysArg: 0.192 ± 0.016	0.611CysSer: 0.611 ± 0.038	0.415CysThr: 0.415 ± 0.029	0.469CysVal: 0.469 ± 0.033	0.068CysTrp: 0.068 ± 0.012	0.262CysTyr: 0.262 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.71AspAla: 3.71 ± 0.087	0.38AspCys: 0.38 ± 0.027	2.528AspAsp: 2.528 ± 0.157	3.192AspGlu: 3.192 ± 0.085	3.605AspPhe: 3.605 ± 0.084	3.89AspGly: 3.89 ± 0.252	1.062AspHis: 1.062 ± 0.049	3.799AspIle: 3.799 ± 0.088	3.3AspLys: 3.3 ± 0.098	5.278AspLeu: 5.278 ± 0.101	0.908AspMet: 0.908 ± 0.042	2.493AspAsn: 2.493 ± 0.12	2.307AspPro: 2.307 ± 0.088	2.192AspGln: 2.192 ± 0.071	2.105AspArg: 2.105 ± 0.064	3.62AspSer: 3.62 ± 0.109	2.881AspThr: 2.881 ± 0.108	3.058AspVal: 3.058 ± 0.074	0.77AspTrp: 0.77 ± 0.044	2.422AspTyr: 2.422 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.683GluAla: 4.683 ± 0.117	0.376GluCys: 0.376 ± 0.024	3.337GluAsp: 3.337 ± 0.086	4.846GluGlu: 4.846 ± 0.122	2.618GluPhe: 2.618 ± 0.062	4.272GluGly: 4.272 ± 0.106	1.131GluHis: 1.131 ± 0.049	5.374GluIle: 5.374 ± 0.107	5.49GluLys: 5.49 ± 0.137	5.745GluLeu: 5.745 ± 0.106	1.661GluMet: 1.661 ± 0.061	4.241GluAsn: 4.241 ± 0.094	1.478GluPro: 1.478 ± 0.051	2.316GluGln: 2.316 ± 0.062	2.515GluArg: 2.515 ± 0.077	3.829GluSer: 3.829 ± 0.077	3.689GluThr: 3.689 ± 0.072	4.469GluVal: 4.469 ± 0.096	0.739GluTrp: 0.739 ± 0.038	2.111GluTyr: 2.111 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.699PheAla: 2.699 ± 0.08	0.392PheCys: 0.392 ± 0.025	3.467PheAsp: 3.467 ± 0.086	3.662PheGlu: 3.662 ± 0.093	3.082PhePhe: 3.082 ± 0.098	3.757PheGly: 3.757 ± 0.101	0.802PheHis: 0.802 ± 0.038	4.143PheIle: 4.143 ± 0.102	3.473PheLys: 3.473 ± 0.084	5.154PheLeu: 5.154 ± 0.124	1.129PheMet: 1.129 ± 0.05	3.04PheAsn: 3.04 ± 0.096	1.948PhePro: 1.948 ± 0.067	1.84PheGln: 1.84 ± 0.058	1.688PheArg: 1.688 ± 0.056	4.331PheSer: 4.331 ± 0.099	2.736PheThr: 2.736 ± 0.081	2.813PheVal: 2.813 ± 0.074	0.651PheTrp: 0.651 ± 0.035	2.064PheTyr: 2.064 ± 0.071	0.0PheXaa: 0.0 ± 0.0
Gly	4.71GlyAla: 4.71 ± 0.111	0.643GlyCys: 0.643 ± 0.045	3.613GlyAsp: 3.613 ± 0.142	3.46GlyGlu: 3.46 ± 0.076	3.688GlyPhe: 3.688 ± 0.09	5.188GlyGly: 5.188 ± 0.144	1.244GlyHis: 1.244 ± 0.056	5.91GlyIle: 5.91 ± 0.109	4.758GlyLys: 4.758 ± 0.104	6.346GlyLeu: 6.346 ± 0.116	1.818GlyMet: 1.818 ± 0.061	3.455GlyAsn: 3.455 ± 0.09	1.649GlyPro: 1.649 ± 0.052	1.99GlyGln: 1.99 ± 0.06	2.28GlyArg: 2.28 ± 0.078	4.557GlySer: 4.557 ± 0.148	4.123GlyThr: 4.123 ± 0.137	4.824GlyVal: 4.824 ± 0.103	0.862GlyTrp: 0.862 ± 0.046	2.682GlyTyr: 2.682 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.139HisAla: 1.139 ± 0.046	0.17HisCys: 0.17 ± 0.018	0.802HisAsp: 0.802 ± 0.039	1.011HisGlu: 1.011 ± 0.047	1.305HisPhe: 1.305 ± 0.051	1.126HisGly: 1.126 ± 0.05	0.577HisHis: 0.577 ± 0.033	1.247HisIle: 1.247 ± 0.053	1.126HisLys: 1.126 ± 0.046	2.051HisLeu: 2.051 ± 0.07	0.332HisMet: 0.332 ± 0.023	0.878HisAsn: 0.878 ± 0.037	1.165HisPro: 1.165 ± 0.043	0.808HisGln: 0.808 ± 0.039	0.741HisArg: 0.741 ± 0.04	1.217HisSer: 1.217 ± 0.049	0.879HisThr: 0.879 ± 0.044	1.018HisVal: 1.018 ± 0.039	0.278HisTrp: 0.278 ± 0.023	0.871HisTyr: 0.871 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	5.585IleAla: 5.585 ± 0.138	0.609IleCys: 0.609 ± 0.03	4.9IleAsp: 4.9 ± 0.092	5.521IleGlu: 5.521 ± 0.118	3.446IlePhe: 3.446 ± 0.097	5.404IleGly: 5.404 ± 0.103	1.548IleHis: 1.548 ± 0.051	5.701IleIle: 5.701 ± 0.131	5.323IleLys: 5.323 ± 0.12	7.328IleLeu: 7.328 ± 0.146	1.316IleMet: 1.316 ± 0.05	4.385IleAsn: 4.385 ± 0.098	3.613IlePro: 3.613 ± 0.084	3.138IleGln: 3.138 ± 0.079	2.827IleArg: 2.827 ± 0.078	5.892IleSer: 5.892 ± 0.121	4.334IleThr: 4.334 ± 0.14	4.439IleVal: 4.439 ± 0.094	0.678IleTrp: 0.678 ± 0.038	2.43IleTyr: 2.43 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	4.896LysAla: 4.896 ± 0.115	0.294LysCys: 0.294 ± 0.02	3.551LysAsp: 3.551 ± 0.089	5.856LysGlu: 5.856 ± 0.154	2.479LysPhe: 2.479 ± 0.08	4.699LysGly: 4.699 ± 0.103	1.197LysHis: 1.197 ± 0.051	5.806LysIle: 5.806 ± 0.128	6.643LysLys: 6.643 ± 0.162	5.762LysLeu: 5.762 ± 0.131	1.791LysMet: 1.791 ± 0.064	4.802LysAsn: 4.802 ± 0.113	2.23LysPro: 2.23 ± 0.067	2.55LysGln: 2.55 ± 0.074	2.82LysArg: 2.82 ± 0.075	4.356LysSer: 4.356 ± 0.106	4.501LysThr: 4.501 ± 0.111	4.277LysVal: 4.277 ± 0.093	0.756LysTrp: 0.756 ± 0.04	2.221LysTyr: 2.221 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.936LeuAla: 5.936 ± 0.123	0.785LeuCys: 0.785 ± 0.039	5.343LeuAsp: 5.343 ± 0.132	6.611LeuGlu: 6.611 ± 0.139	5.568LeuPhe: 5.568 ± 0.151	6.493LeuGly: 6.493 ± 0.112	1.7LeuHis: 1.7 ± 0.067	7.539LeuIle: 7.539 ± 0.158	7.478LeuLys: 7.478 ± 0.157	9.468LeuLeu: 9.468 ± 0.209	2.339LeuMet: 2.339 ± 0.067	5.701LeuAsn: 5.701 ± 0.112	4.064LeuPro: 4.064 ± 0.089	3.149LeuGln: 3.149 ± 0.085	3.296LeuArg: 3.296 ± 0.086	7.404LeuSer: 7.404 ± 0.14	5.212LeuThr: 5.212 ± 0.1	5.453LeuVal: 5.453 ± 0.105	0.967LeuTrp: 0.967 ± 0.048	3.109LeuTyr: 3.109 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	1.588MetAla: 1.588 ± 0.052	0.149MetCys: 0.149 ± 0.016	1.154MetAsp: 1.154 ± 0.045	1.58MetGlu: 1.58 ± 0.06	0.797MetPhe: 0.797 ± 0.047	1.772MetGly: 1.772 ± 0.065	0.437MetHis: 0.437 ± 0.027	1.678MetIle: 1.678 ± 0.058	1.905MetLys: 1.905 ± 0.067	1.884MetLeu: 1.884 ± 0.064	0.555MetMet: 0.555 ± 0.034	1.246MetAsn: 1.246 ± 0.048	0.827MetPro: 0.827 ± 0.043	0.815MetGln: 0.815 ± 0.039	0.847MetArg: 0.847 ± 0.039	1.414MetSer: 1.414 ± 0.053	1.18MetThr: 1.18 ± 0.048	1.291MetVal: 1.291 ± 0.051	0.172MetTrp: 0.172 ± 0.017	0.604MetTyr: 0.604 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.64AsnAla: 3.64 ± 0.082	0.429AsnCys: 0.429 ± 0.03	2.93AsnAsp: 2.93 ± 0.112	3.435AsnGlu: 3.435 ± 0.087	2.793AsnPhe: 2.793 ± 0.093	3.416AsnGly: 3.416 ± 0.107	1.08AsnHis: 1.08 ± 0.042	4.255AsnIle: 4.255 ± 0.089	3.737AsnLys: 3.737 ± 0.097	5.094AsnLeu: 5.094 ± 0.103	1.127AsnMet: 1.127 ± 0.052	2.952AsnAsn: 2.952 ± 0.095	2.834AsnPro: 2.834 ± 0.074	2.508AsnGln: 2.508 ± 0.09	2.1AsnArg: 2.1 ± 0.073	3.833AsnSer: 3.833 ± 0.103	3.352AsnThr: 3.352 ± 0.112	3.072AsnVal: 3.072 ± 0.07	0.808AsnTrp: 0.808 ± 0.046	2.346AsnTyr: 2.346 ± 0.071	0.002AsnXaa: 0.002 ± 0.002
Pro	1.998ProAla: 1.998 ± 0.073	0.213ProCys: 0.213 ± 0.021	2.196ProAsp: 2.196 ± 0.067	3.109ProGlu: 3.109 ± 0.077	2.098ProPhe: 2.098 ± 0.063	2.179ProGly: 2.179 ± 0.073	0.781ProHis: 0.781 ± 0.044	3.075ProIle: 3.075 ± 0.073	2.78ProLys: 2.78 ± 0.075	3.774ProLeu: 3.774 ± 0.076	0.805ProMet: 0.805 ± 0.036	2.395ProAsn: 2.395 ± 0.081	1.087ProPro: 1.087 ± 0.051	1.315ProGln: 1.315 ± 0.047	1.045ProArg: 1.045 ± 0.048	2.633ProSer: 2.633 ± 0.072	1.992ProThr: 1.992 ± 0.076	2.206ProVal: 2.206 ± 0.064	0.408ProTrp: 0.408 ± 0.029	1.514ProTyr: 1.514 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.338GlnAla: 2.338 ± 0.066	0.226GlnCys: 0.226 ± 0.021	1.74GlnAsp: 1.74 ± 0.063	2.552GlnGlu: 2.552 ± 0.08	1.83GlnPhe: 1.83 ± 0.059	2.209GlnGly: 2.209 ± 0.072	0.65GlnHis: 0.65 ± 0.034	2.95GlnIle: 2.95 ± 0.073	3.146GlnLys: 3.146 ± 0.096	3.856GlnLeu: 3.856 ± 0.084	0.979GlnMet: 0.979 ± 0.048	2.268GlnAsn: 2.268 ± 0.071	1.119GlnPro: 1.119 ± 0.048	1.543GlnGln: 1.543 ± 0.071	1.536GlnArg: 1.536 ± 0.051	2.143GlnSer: 2.143 ± 0.054	2.024GlnThr: 2.024 ± 0.052	1.966GlnVal: 1.966 ± 0.056	0.565GlnTrp: 0.565 ± 0.033	1.327GlnTyr: 1.327 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.253ArgAla: 2.253 ± 0.072	0.211ArgCys: 0.211 ± 0.02	1.617ArgAsp: 1.617 ± 0.05	2.221ArgGlu: 2.221 ± 0.064	2.091ArgPhe: 2.091 ± 0.058	2.211ArgGly: 2.211 ± 0.064	0.616ArgHis: 0.616 ± 0.034	3.124ArgIle: 3.124 ± 0.078	2.611ArgLys: 2.611 ± 0.082	3.619ArgLeu: 3.619 ± 0.096	0.945ArgMet: 0.945 ± 0.046	2.047ArgAsn: 2.047 ± 0.063	1.215ArgPro: 1.215 ± 0.043	1.138ArgGln: 1.138 ± 0.045	1.303ArgArg: 1.303 ± 0.048	2.319ArgSer: 2.319 ± 0.073	1.727ArgThr: 1.727 ± 0.056	2.268ArgVal: 2.268 ± 0.07	0.466ArgTrp: 0.466 ± 0.03	1.588ArgTyr: 1.588 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	3.988SerAla: 3.988 ± 0.119	0.658SerCys: 0.658 ± 0.038	3.662SerAsp: 3.662 ± 0.142	4.29SerGlu: 4.29 ± 0.082	4.11SerPhe: 4.11 ± 0.082	5.001SerGly: 5.001 ± 0.132	1.168SerHis: 1.168 ± 0.046	5.72SerIle: 5.72 ± 0.097	4.827SerLys: 4.827 ± 0.11	7.256SerLeu: 7.256 ± 0.138	1.391SerMet: 1.391 ± 0.045	3.823SerAsn: 3.823 ± 0.104	2.557SerPro: 2.557 ± 0.082	2.552SerGln: 2.552 ± 0.067	2.354SerArg: 2.354 ± 0.07	5.056SerSer: 5.056 ± 0.172	3.607SerThr: 3.607 ± 0.161	4.044SerVal: 4.044 ± 0.102	0.915SerTrp: 0.915 ± 0.052	2.697SerTyr: 2.697 ± 0.08	0.0SerXaa: 0.0 ± 0.0
Thr	3.808ThrAla: 3.808 ± 0.124	0.273ThrCys: 0.273 ± 0.025	2.991ThrAsp: 2.991 ± 0.148	3.078ThrGlu: 3.078 ± 0.081	2.984ThrPhe: 2.984 ± 0.071	3.878ThrGly: 3.878 ± 0.127	1.119ThrHis: 1.119 ± 0.042	4.397ThrIle: 4.397 ± 0.152	3.242ThrLys: 3.242 ± 0.077	6.211ThrLeu: 6.211 ± 0.127	0.825ThrMet: 0.825 ± 0.047	2.731ThrAsn: 2.731 ± 0.091	2.908ThrPro: 2.908 ± 0.076	2.287ThrGln: 2.287 ± 0.075	1.706ThrArg: 1.706 ± 0.057	3.948ThrSer: 3.948 ± 0.186	3.421ThrThr: 3.421 ± 0.184	3.521ThrVal: 3.521 ± 0.143	0.56ThrTrp: 0.56 ± 0.036	2.118ThrTyr: 2.118 ± 0.081	0.0ThrXaa: 0.0 ± 0.0
Val	4.067ValAla: 4.067 ± 0.109	0.516ValCys: 0.516 ± 0.039	3.343ValAsp: 3.343 ± 0.083	3.451ValGlu: 3.451 ± 0.081	3.421ValPhe: 3.421 ± 0.082	3.978ValGly: 3.978 ± 0.099	1.031ValHis: 1.031 ± 0.042	4.653ValIle: 4.653 ± 0.096	3.732ValLys: 3.732 ± 0.091	6.206ValLeu: 6.206 ± 0.125	1.289ValMet: 1.289 ± 0.05	3.2ValAsn: 3.2 ± 0.09	2.214ValPro: 2.214 ± 0.076	1.894ValGln: 1.894 ± 0.064	2.037ValArg: 2.037 ± 0.06	4.677ValSer: 4.677 ± 0.132	3.372ValThr: 3.372 ± 0.134	4.069ValVal: 4.069 ± 0.102	0.665ValTrp: 0.665 ± 0.035	2.165ValTyr: 2.165 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.037	0.103TrpCys: 0.103 ± 0.012	0.754TrpAsp: 0.754 ± 0.05	0.884TrpGlu: 0.884 ± 0.042	0.532TrpPhe: 0.532 ± 0.029	0.812TrpGly: 0.812 ± 0.044	0.262TrpHis: 0.262 ± 0.02	0.905TrpIle: 0.905 ± 0.042	0.819TrpLys: 0.819 ± 0.042	0.987TrpLeu: 0.987 ± 0.052	0.331TrpMet: 0.331 ± 0.023	0.82TrpAsn: 0.82 ± 0.05	0.289TrpPro: 0.289 ± 0.025	0.429TrpGln: 0.429 ± 0.031	0.454TrpArg: 0.454 ± 0.028	0.722TrpSer: 0.722 ± 0.039	0.559TrpThr: 0.559 ± 0.031	0.727TrpVal: 0.727 ± 0.039	0.159TrpTrp: 0.159 ± 0.018	0.38TrpTyr: 0.38 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.07	0.339TyrCys: 0.339 ± 0.022	2.106TyrAsp: 2.106 ± 0.066	2.057TyrGlu: 2.057 ± 0.064	2.376TyrPhe: 2.376 ± 0.067	2.542TyrGly: 2.542 ± 0.073	0.856TyrHis: 0.856 ± 0.039	2.278TyrIle: 2.278 ± 0.058	2.356TyrLys: 2.356 ± 0.066	3.644TyrLeu: 3.644 ± 0.101	0.69TyrMet: 0.69 ± 0.035	2.034TyrAsn: 2.034 ± 0.063	1.546TyrPro: 1.546 ± 0.049	1.495TyrGln: 1.495 ± 0.049	1.568TyrArg: 1.568 ± 0.062	2.564TyrSer: 2.564 ± 0.079	2.182TyrThr: 2.182 ± 0.087	1.875TyrVal: 1.875 ± 0.054	0.471TyrTrp: 0.471 ± 0.027	1.563TyrTyr: 1.563 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1770 proteins (592508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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