Amino acid dipepetide frequency for Algibacter lectus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.127AlaAla: 4.127 ± 0.077	0.551AlaCys: 0.551 ± 0.023	3.487AlaAsp: 3.487 ± 0.056	4.078AlaGlu: 4.078 ± 0.072	3.458AlaPhe: 3.458 ± 0.053	4.021AlaGly: 4.021 ± 0.066	1.104AlaHis: 1.104 ± 0.027	5.365AlaIle: 5.365 ± 0.07	4.568AlaLys: 4.568 ± 0.073	6.289AlaLeu: 6.289 ± 0.084	1.45AlaMet: 1.45 ± 0.04	3.746AlaAsn: 3.746 ± 0.065	1.93AlaPro: 1.93 ± 0.043	2.306AlaGln: 2.306 ± 0.043	1.806AlaArg: 1.806 ± 0.039	4.353AlaSer: 4.353 ± 0.058	3.889AlaThr: 3.889 ± 0.078	4.155AlaVal: 4.155 ± 0.061	0.661AlaTrp: 0.661 ± 0.024	2.615AlaTyr: 2.615 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.022	0.1CysCys: 0.1 ± 0.01	0.48CysAsp: 0.48 ± 0.03	0.451CysGlu: 0.451 ± 0.02	0.426CysPhe: 0.426 ± 0.021	0.584CysGly: 0.584 ± 0.023	0.181CysHis: 0.181 ± 0.013	0.555CysIle: 0.555 ± 0.024	0.495CysLys: 0.495 ± 0.018	0.643CysLeu: 0.643 ± 0.022	0.154CysMet: 0.154 ± 0.011	0.424CysAsn: 0.424 ± 0.019	0.291CysPro: 0.291 ± 0.018	0.196CysGln: 0.196 ± 0.012	0.181CysArg: 0.181 ± 0.014	0.563CysSer: 0.563 ± 0.022	0.426CysThr: 0.426 ± 0.029	0.423CysVal: 0.423 ± 0.018	0.072CysTrp: 0.072 ± 0.007	0.309CysTyr: 0.309 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.152AspAla: 4.152 ± 0.061	0.437AspCys: 0.437 ± 0.025	3.342AspAsp: 3.342 ± 0.065	3.683AspGlu: 3.683 ± 0.053	3.768AspPhe: 3.768 ± 0.055	3.967AspGly: 3.967 ± 0.08	0.842AspHis: 0.842 ± 0.025	4.875AspIle: 4.875 ± 0.058	4.198AspLys: 4.198 ± 0.054	5.558AspLeu: 5.558 ± 0.069	1.172AspMet: 1.172 ± 0.029	3.592AspAsn: 3.592 ± 0.068	1.642AspPro: 1.642 ± 0.044	1.404AspGln: 1.404 ± 0.034	1.772AspArg: 1.772 ± 0.037	3.316AspSer: 3.316 ± 0.06	2.996AspThr: 2.996 ± 0.056	4.035AspVal: 4.035 ± 0.07	0.798AspTrp: 0.798 ± 0.028	2.941AspTyr: 2.941 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.675GluAla: 4.675 ± 0.075	0.312GluCys: 0.312 ± 0.015	3.892GluAsp: 3.892 ± 0.054	4.206GluGlu: 4.206 ± 0.069	3.026GluPhe: 3.026 ± 0.048	3.644GluGly: 3.644 ± 0.057	1.217GluHis: 1.217 ± 0.033	5.233GluIle: 5.233 ± 0.073	5.354GluLys: 5.354 ± 0.078	6.009GluLeu: 6.009 ± 0.084	1.375GluMet: 1.375 ± 0.033	4.94GluAsn: 4.94 ± 0.07	1.573GluPro: 1.573 ± 0.033	2.191GluGln: 2.191 ± 0.042	2.236GluArg: 2.236 ± 0.049	3.561GluSer: 3.561 ± 0.05	4.213GluThr: 4.213 ± 0.054	4.281GluVal: 4.281 ± 0.06	0.596GluTrp: 0.596 ± 0.023	2.33GluTyr: 2.33 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.859PheAla: 2.859 ± 0.044	0.439PheCys: 0.439 ± 0.018	3.434PheAsp: 3.434 ± 0.057	3.414PheGlu: 3.414 ± 0.052	2.6PhePhe: 2.6 ± 0.059	3.542PheGly: 3.542 ± 0.053	0.801PheHis: 0.801 ± 0.025	3.833PheIle: 3.833 ± 0.062	4.184PheLys: 4.184 ± 0.062	4.473PheLeu: 4.473 ± 0.068	1.163PheMet: 1.163 ± 0.028	3.755PheAsn: 3.755 ± 0.063	1.618PhePro: 1.618 ± 0.035	1.478PheGln: 1.478 ± 0.033	1.486PheArg: 1.486 ± 0.035	4.138PheSer: 4.138 ± 0.056	3.22PheThr: 3.22 ± 0.055	3.007PheVal: 3.007 ± 0.048	0.585PheTrp: 0.585 ± 0.022	2.144PheTyr: 2.144 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.158GlyAla: 4.158 ± 0.062	0.581GlyCys: 0.581 ± 0.035	3.697GlyAsp: 3.697 ± 0.061	3.75GlyGlu: 3.75 ± 0.057	3.715GlyPhe: 3.715 ± 0.059	4.335GlyGly: 4.335 ± 0.078	1.155GlyHis: 1.155 ± 0.029	4.998GlyIle: 4.998 ± 0.069	4.687GlyLys: 4.687 ± 0.069	5.802GlyLeu: 5.802 ± 0.073	1.436GlyMet: 1.436 ± 0.035	3.69GlyAsn: 3.69 ± 0.065	1.338GlyPro: 1.338 ± 0.034	1.772GlyGln: 1.772 ± 0.039	2.052GlyArg: 2.052 ± 0.041	3.974GlySer: 3.974 ± 0.061	3.988GlyThr: 3.988 ± 0.076	4.624GlyVal: 4.624 ± 0.063	0.788GlyTrp: 0.788 ± 0.028	2.856GlyTyr: 2.856 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.021HisAla: 1.021 ± 0.032	0.173HisCys: 0.173 ± 0.011	0.963HisAsp: 0.963 ± 0.028	0.929HisGlu: 0.929 ± 0.03	1.142HisPhe: 1.142 ± 0.033	1.081HisGly: 1.081 ± 0.033	0.455HisHis: 0.455 ± 0.021	1.377HisIle: 1.377 ± 0.036	1.197HisLys: 1.197 ± 0.033	1.764HisLeu: 1.764 ± 0.042	0.33HisMet: 0.33 ± 0.016	1.046HisAsn: 1.046 ± 0.029	0.84HisPro: 0.84 ± 0.027	0.608HisGln: 0.608 ± 0.021	0.598HisArg: 0.598 ± 0.021	1.024HisSer: 1.024 ± 0.024	0.906HisThr: 0.906 ± 0.028	1.015HisVal: 1.015 ± 0.028	0.218HisTrp: 0.218 ± 0.012	0.77HisTyr: 0.77 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.186IleAla: 5.186 ± 0.074	0.601IleCys: 0.601 ± 0.02	5.11IleAsp: 5.11 ± 0.063	5.685IleGlu: 5.685 ± 0.075	3.359IlePhe: 3.359 ± 0.054	5.005IleGly: 5.005 ± 0.078	1.268IleHis: 1.268 ± 0.033	5.942IleIle: 5.942 ± 0.071	6.041IleLys: 6.041 ± 0.08	6.71IleLeu: 6.71 ± 0.088	1.455IleMet: 1.455 ± 0.029	5.053IleAsn: 5.053 ± 0.075	3.027IlePro: 3.027 ± 0.048	2.284IleGln: 2.284 ± 0.04	2.306IleArg: 2.306 ± 0.045	5.745IleSer: 5.745 ± 0.068	5.115IleThr: 5.115 ± 0.082	4.555IleVal: 4.555 ± 0.072	0.706IleTrp: 0.706 ± 0.028	2.881IleTyr: 2.881 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.187LysAla: 5.187 ± 0.079	0.313LysCys: 0.313 ± 0.016	4.477LysAsp: 4.477 ± 0.062	5.593LysGlu: 5.593 ± 0.083	2.928LysPhe: 2.928 ± 0.049	4.429LysGly: 4.429 ± 0.064	1.528LysHis: 1.528 ± 0.032	5.932LysIle: 5.932 ± 0.075	6.414LysLys: 6.414 ± 0.094	6.595LysLeu: 6.595 ± 0.078	1.944LysMet: 1.944 ± 0.04	5.335LysAsn: 5.335 ± 0.073	2.556LysPro: 2.556 ± 0.041	2.919LysGln: 2.919 ± 0.056	2.793LysArg: 2.793 ± 0.049	4.72LysSer: 4.72 ± 0.067	5.367LysThr: 5.367 ± 0.072	4.423LysVal: 4.423 ± 0.062	0.83LysTrp: 0.83 ± 0.025	3.038LysTyr: 3.038 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	5.628LeuAla: 5.628 ± 0.068	0.683LeuCys: 0.683 ± 0.024	5.306LeuAsp: 5.306 ± 0.064	6.188LeuGlu: 6.188 ± 0.075	4.645LeuPhe: 4.645 ± 0.069	5.743LeuGly: 5.743 ± 0.075	1.432LeuHis: 1.432 ± 0.034	6.759LeuIle: 6.759 ± 0.094	8.138LeuLys: 8.138 ± 0.093	8.185LeuLeu: 8.185 ± 0.118	2.013LeuMet: 2.013 ± 0.037	6.065LeuAsn: 6.065 ± 0.081	3.473LeuPro: 3.473 ± 0.053	2.974LeuGln: 2.974 ± 0.052	2.892LeuArg: 2.892 ± 0.048	6.682LeuSer: 6.682 ± 0.071	5.129LeuThr: 5.129 ± 0.066	5.408LeuVal: 5.408 ± 0.069	0.813LeuTrp: 0.813 ± 0.029	3.125LeuTyr: 3.125 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.562MetAla: 1.562 ± 0.039	0.143MetCys: 0.143 ± 0.009	1.101MetAsp: 1.101 ± 0.031	1.275MetGlu: 1.275 ± 0.034	0.981MetPhe: 0.981 ± 0.032	1.317MetGly: 1.317 ± 0.035	0.409MetHis: 0.409 ± 0.017	1.399MetIle: 1.399 ± 0.037	1.94MetLys: 1.94 ± 0.036	2.032MetLeu: 2.032 ± 0.042	0.523MetMet: 0.523 ± 0.022	1.194MetAsn: 1.194 ± 0.032	0.866MetPro: 0.866 ± 0.027	0.838MetGln: 0.838 ± 0.026	0.796MetArg: 0.796 ± 0.024	1.395MetSer: 1.395 ± 0.034	1.064MetThr: 1.064 ± 0.029	1.399MetVal: 1.399 ± 0.035	0.175MetTrp: 0.175 ± 0.011	0.714MetTyr: 0.714 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.105AsnAla: 4.105 ± 0.064	0.476AsnCys: 0.476 ± 0.022	3.525AsnAsp: 3.525 ± 0.055	3.895AsnGlu: 3.895 ± 0.061	3.213AsnPhe: 3.213 ± 0.057	4.322AsnGly: 4.322 ± 0.068	1.12AsnHis: 1.12 ± 0.03	5.323AsnIle: 5.323 ± 0.073	4.734AsnLys: 4.734 ± 0.069	5.781AsnLeu: 5.781 ± 0.066	1.318AsnMet: 1.318 ± 0.037	4.557AsnAsn: 4.557 ± 0.08	2.7AsnPro: 2.7 ± 0.055	2.171AsnGln: 2.171 ± 0.046	2.13AsnArg: 2.13 ± 0.045	4.144AsnSer: 4.144 ± 0.065	4.336AsnThr: 4.336 ± 0.068	3.913AsnVal: 3.913 ± 0.063	0.835AsnTrp: 0.835 ± 0.028	3.01AsnTyr: 3.01 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.823ProAla: 1.823 ± 0.044	0.198ProCys: 0.198 ± 0.012	2.031ProAsp: 2.031 ± 0.042	2.909ProGlu: 2.909 ± 0.049	1.879ProPhe: 1.879 ± 0.039	1.784ProGly: 1.784 ± 0.046	0.627ProHis: 0.627 ± 0.022	2.608ProIle: 2.608 ± 0.046	2.598ProLys: 2.598 ± 0.041	2.854ProLeu: 2.854 ± 0.044	0.666ProMet: 0.666 ± 0.023	2.397ProAsn: 2.397 ± 0.047	0.689ProPro: 0.689 ± 0.026	0.975ProGln: 0.975 ± 0.029	0.863ProArg: 0.863 ± 0.025	2.132ProSer: 2.132 ± 0.043	2.025ProThr: 2.025 ± 0.053	2.25ProVal: 2.25 ± 0.044	0.352ProTrp: 0.352 ± 0.018	1.371ProTyr: 1.371 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.018GlnAla: 2.018 ± 0.041	0.17GlnCys: 0.17 ± 0.013	1.796GlnAsp: 1.796 ± 0.036	1.993GlnGlu: 1.993 ± 0.047	1.64GlnPhe: 1.64 ± 0.031	1.797GlnGly: 1.797 ± 0.041	0.6GlnHis: 0.6 ± 0.022	2.477GlnIle: 2.477 ± 0.038	2.514GlnLys: 2.514 ± 0.052	3.126GlnLeu: 3.126 ± 0.053	0.725GlnMet: 0.725 ± 0.022	2.141GlnAsn: 2.141 ± 0.04	1.06GlnPro: 1.06 ± 0.025	1.196GlnGln: 1.196 ± 0.036	1.1GlnArg: 1.1 ± 0.03	1.874GlnSer: 1.874 ± 0.038	1.969GlnThr: 1.969 ± 0.042	1.967GlnVal: 1.967 ± 0.04	0.362GlnTrp: 0.362 ± 0.017	1.291GlnTyr: 1.291 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.039ArgAla: 2.039 ± 0.041	0.184ArgCys: 0.184 ± 0.012	1.812ArgAsp: 1.812 ± 0.04	1.905ArgGlu: 1.905 ± 0.042	1.793ArgPhe: 1.793 ± 0.035	1.949ArgGly: 1.949 ± 0.039	0.574ArgHis: 0.574 ± 0.023	2.568ArgIle: 2.568 ± 0.05	2.402ArgLys: 2.402 ± 0.048	3.009ArgLeu: 3.009 ± 0.051	0.796ArgMet: 0.796 ± 0.023	1.932ArgAsn: 1.932 ± 0.043	1.029ArgPro: 1.029 ± 0.031	0.975ArgGln: 0.975 ± 0.026	1.169ArgArg: 1.169 ± 0.029	1.836ArgSer: 1.836 ± 0.037	1.756ArgThr: 1.756 ± 0.038	2.046ArgVal: 2.046 ± 0.048	0.402ArgTrp: 0.402 ± 0.018	1.513ArgTyr: 1.513 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.851SerAla: 3.851 ± 0.059	0.684SerCys: 0.684 ± 0.024	3.748SerAsp: 3.748 ± 0.055	4.259SerGlu: 4.259 ± 0.063	3.75SerPhe: 3.75 ± 0.058	4.669SerGly: 4.669 ± 0.072	1.116SerHis: 1.116 ± 0.027	5.381SerIle: 5.381 ± 0.062	5.231SerLys: 5.231 ± 0.082	5.878SerLeu: 5.878 ± 0.072	1.31SerMet: 1.31 ± 0.032	4.304SerAsn: 4.304 ± 0.066	2.057SerPro: 2.057 ± 0.044	2.011SerGln: 2.011 ± 0.042	2.098SerArg: 2.098 ± 0.041	4.504SerSer: 4.504 ± 0.083	3.839SerThr: 3.839 ± 0.062	4.264SerVal: 4.264 ± 0.064	0.723SerTrp: 0.723 ± 0.025	2.783SerTyr: 2.783 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.867ThrAla: 3.867 ± 0.075	0.397ThrCys: 0.397 ± 0.027	3.698ThrAsp: 3.698 ± 0.069	3.844ThrGlu: 3.844 ± 0.061	3.19ThrPhe: 3.19 ± 0.053	4.08ThrGly: 4.08 ± 0.074	1.043ThrHis: 1.043 ± 0.027	5.084ThrIle: 5.084 ± 0.083	4.032ThrLys: 4.032 ± 0.053	5.625ThrLeu: 5.625 ± 0.071	0.978ThrMet: 0.978 ± 0.025	3.726ThrAsn: 3.726 ± 0.07	2.555ThrPro: 2.555 ± 0.051	1.871ThrGln: 1.871 ± 0.039	1.63ThrArg: 1.63 ± 0.034	4.262ThrSer: 4.262 ± 0.066	3.773ThrThr: 3.773 ± 0.081	4.07ThrVal: 4.07 ± 0.094	0.675ThrTrp: 0.675 ± 0.026	2.571ThrTyr: 2.571 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.024ValAla: 4.024 ± 0.067	0.568ValCys: 0.568 ± 0.02	3.687ValAsp: 3.687 ± 0.06	3.967ValGlu: 3.967 ± 0.052	3.589ValPhe: 3.589 ± 0.059	3.812ValGly: 3.812 ± 0.059	0.95ValHis: 0.95 ± 0.028	4.819ValIle: 4.819 ± 0.069	4.551ValLys: 4.551 ± 0.067	6.223ValLeu: 6.223 ± 0.08	1.276ValMet: 1.276 ± 0.031	3.928ValAsn: 3.928 ± 0.068	2.064ValPro: 2.064 ± 0.05	1.629ValGln: 1.629 ± 0.037	1.857ValArg: 1.857 ± 0.046	4.779ValSer: 4.779 ± 0.056	3.867ValThr: 3.867 ± 0.101	4.286ValVal: 4.286 ± 0.066	0.64ValTrp: 0.64 ± 0.024	2.46ValTyr: 2.46 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.596TrpAla: 0.596 ± 0.024	0.109TrpCys: 0.109 ± 0.011	0.691TrpAsp: 0.691 ± 0.027	0.686TrpGlu: 0.686 ± 0.025	0.603TrpPhe: 0.603 ± 0.024	0.705TrpGly: 0.705 ± 0.027	0.285TrpHis: 0.285 ± 0.016	0.692TrpIle: 0.692 ± 0.025	0.812TrpLys: 0.812 ± 0.027	0.992TrpLeu: 0.992 ± 0.024	0.303TrpMet: 0.303 ± 0.015	0.753TrpAsn: 0.753 ± 0.027	0.271TrpPro: 0.271 ± 0.016	0.438TrpGln: 0.438 ± 0.018	0.425TrpArg: 0.425 ± 0.02	0.709TrpSer: 0.709 ± 0.026	0.566TrpThr: 0.566 ± 0.019	0.632TrpVal: 0.632 ± 0.024	0.154TrpTrp: 0.154 ± 0.012	0.464TrpTyr: 0.464 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.62TyrAla: 2.62 ± 0.039	0.299TyrCys: 0.299 ± 0.015	2.214TyrAsp: 2.214 ± 0.041	2.156TyrGlu: 2.156 ± 0.043	2.466TyrPhe: 2.466 ± 0.053	2.612TyrGly: 2.612 ± 0.049	0.745TyrHis: 0.745 ± 0.024	2.816TyrIle: 2.816 ± 0.046	3.235TyrLys: 3.235 ± 0.053	3.736TyrLeu: 3.736 ± 0.064	0.737TyrMet: 0.737 ± 0.021	3.029TyrAsn: 3.029 ± 0.055	1.452TyrPro: 1.452 ± 0.035	1.582TyrGln: 1.582 ± 0.037	1.498TyrArg: 1.498 ± 0.036	2.745TyrSer: 2.745 ± 0.053	2.523TyrThr: 2.523 ± 0.062	2.223TyrVal: 2.223 ± 0.039	0.501TyrTrp: 0.501 ± 0.022	1.86TyrTyr: 1.86 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4609 proteins (1356275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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