Amino acid dipepetide frequency for Salmonella phage UPF_BP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.975AlaAla: 10.975 ± 1.367
1.138AlaCys: 1.138 ± 0.33
6.585AlaAsp: 6.585 ± 0.709
7.886AlaGlu: 7.886 ± 1.068
3.252AlaPhe: 3.252 ± 0.519
5.934AlaGly: 5.934 ± 1.065
1.057AlaHis: 1.057 ± 0.312
5.691AlaIle: 5.691 ± 0.655
5.772AlaLys: 5.772 ± 0.672
6.341AlaLeu: 6.341 ± 0.979
3.252AlaMet: 3.252 ± 0.592
5.772AlaAsn: 5.772 ± 0.8
2.276AlaPro: 2.276 ± 0.373
3.821AlaGln: 3.821 ± 0.734
5.365AlaArg: 5.365 ± 0.709
5.122AlaSer: 5.122 ± 0.844
6.341AlaThr: 6.341 ± 0.778
5.04AlaVal: 5.04 ± 0.572
1.463AlaTrp: 1.463 ± 0.319
2.276AlaTyr: 2.276 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.813CysAla: 0.813 ± 0.266
0.244CysCys: 0.244 ± 0.152
0.732CysAsp: 0.732 ± 0.25
1.138CysGlu: 1.138 ± 0.384
0.488CysPhe: 0.488 ± 0.18
1.219CysGly: 1.219 ± 0.334
0.325CysHis: 0.325 ± 0.151
0.406CysIle: 0.406 ± 0.163
0.976CysLys: 0.976 ± 0.314
0.325CysLeu: 0.325 ± 0.17
0.325CysMet: 0.325 ± 0.148
0.65CysAsn: 0.65 ± 0.211
0.488CysPro: 0.488 ± 0.197
0.081CysGln: 0.081 ± 0.069
0.894CysArg: 0.894 ± 0.245
0.976CysSer: 0.976 ± 0.309
0.569CysThr: 0.569 ± 0.232
0.732CysVal: 0.732 ± 0.278
0.081CysTrp: 0.081 ± 0.078
0.406CysTyr: 0.406 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
6.991AspAla: 6.991 ± 0.822
0.488AspCys: 0.488 ± 0.229
4.227AspAsp: 4.227 ± 0.623
4.309AspGlu: 4.309 ± 0.637
1.626AspPhe: 1.626 ± 0.375
6.26AspGly: 6.26 ± 0.764
1.138AspHis: 1.138 ± 0.335
4.146AspIle: 4.146 ± 0.578
3.658AspLys: 3.658 ± 0.532
4.227AspLeu: 4.227 ± 0.735
1.219AspMet: 1.219 ± 0.348
2.195AspAsn: 2.195 ± 0.422
1.87AspPro: 1.87 ± 0.388
1.788AspGln: 1.788 ± 0.354
1.788AspArg: 1.788 ± 0.345
3.333AspSer: 3.333 ± 0.498
1.301AspThr: 1.301 ± 0.337
5.203AspVal: 5.203 ± 0.629
1.301AspTrp: 1.301 ± 0.325
2.764AspTyr: 2.764 ± 0.463
0.0AspXaa: 0.0 ± 0.0
Glu
6.585GluAla: 6.585 ± 0.791
1.301GluCys: 1.301 ± 0.342
3.089GluAsp: 3.089 ± 0.491
5.528GluGlu: 5.528 ± 0.892
1.788GluPhe: 1.788 ± 0.399
3.414GluGly: 3.414 ± 0.477
1.138GluHis: 1.138 ± 0.298
4.715GluIle: 4.715 ± 0.578
3.74GluLys: 3.74 ± 0.665
7.235GluLeu: 7.235 ± 0.875
2.195GluMet: 2.195 ± 0.479
3.333GluAsn: 3.333 ± 0.591
1.87GluPro: 1.87 ± 0.36
3.577GluGln: 3.577 ± 0.526
3.658GluArg: 3.658 ± 0.668
3.496GluSer: 3.496 ± 0.684
3.008GluThr: 3.008 ± 0.455
3.902GluVal: 3.902 ± 0.755
1.788GluTrp: 1.788 ± 0.36
1.626GluTyr: 1.626 ± 0.461
0.0GluXaa: 0.0 ± 0.0
Phe
2.276PheAla: 2.276 ± 0.37
0.569PheCys: 0.569 ± 0.197
2.439PheAsp: 2.439 ± 0.517
1.707PheGlu: 1.707 ± 0.331
1.219PhePhe: 1.219 ± 0.413
2.439PheGly: 2.439 ± 0.463
0.732PheHis: 0.732 ± 0.286
2.52PheIle: 2.52 ± 0.598
2.276PheLys: 2.276 ± 0.435
2.114PheLeu: 2.114 ± 0.344
0.976PheMet: 0.976 ± 0.227
1.707PheAsn: 1.707 ± 0.372
1.138PhePro: 1.138 ± 0.257
1.301PheGln: 1.301 ± 0.388
1.707PheArg: 1.707 ± 0.41
3.008PheSer: 3.008 ± 0.607
1.788PheThr: 1.788 ± 0.417
1.057PheVal: 1.057 ± 0.23
0.65PheTrp: 0.65 ± 0.205
1.626PheTyr: 1.626 ± 0.353
0.0PheXaa: 0.0 ± 0.0
Gly
5.609GlyAla: 5.609 ± 0.9
0.569GlyCys: 0.569 ± 0.199
3.902GlyAsp: 3.902 ± 0.728
3.577GlyGlu: 3.577 ± 0.464
2.927GlyPhe: 2.927 ± 0.48
4.796GlyGly: 4.796 ± 0.861
0.976GlyHis: 0.976 ± 0.277
4.39GlyIle: 4.39 ± 0.843
5.203GlyLys: 5.203 ± 0.779
4.471GlyLeu: 4.471 ± 0.817
3.17GlyMet: 3.17 ± 0.55
3.333GlyAsn: 3.333 ± 0.631
1.138GlyPro: 1.138 ± 0.308
3.496GlyGln: 3.496 ± 0.703
4.796GlyArg: 4.796 ± 0.624
4.959GlySer: 4.959 ± 0.879
3.17GlyThr: 3.17 ± 0.444
5.528GlyVal: 5.528 ± 0.793
1.788GlyTrp: 1.788 ± 0.362
2.276GlyTyr: 2.276 ± 0.54
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.247
0.244HisCys: 0.244 ± 0.144
0.65HisAsp: 0.65 ± 0.228
1.707HisGlu: 1.707 ± 0.436
0.813HisPhe: 0.813 ± 0.256
1.301HisGly: 1.301 ± 0.421
0.325HisHis: 0.325 ± 0.147
0.894HisIle: 0.894 ± 0.258
0.976HisLys: 0.976 ± 0.357
1.138HisLeu: 1.138 ± 0.322
0.488HisMet: 0.488 ± 0.177
0.406HisAsn: 0.406 ± 0.169
0.894HisPro: 0.894 ± 0.223
0.569HisGln: 0.569 ± 0.191
0.813HisArg: 0.813 ± 0.241
0.65HisSer: 0.65 ± 0.234
0.325HisThr: 0.325 ± 0.144
0.813HisVal: 0.813 ± 0.289
0.163HisTrp: 0.163 ± 0.105
0.976HisTyr: 0.976 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
6.422IleAla: 6.422 ± 0.644
0.406IleCys: 0.406 ± 0.177
3.496IleAsp: 3.496 ± 0.543
3.496IleGlu: 3.496 ± 0.54
1.788IlePhe: 1.788 ± 0.36
4.959IleGly: 4.959 ± 0.704
0.976IleHis: 0.976 ± 0.264
3.333IleIle: 3.333 ± 0.57
3.74IleLys: 3.74 ± 0.646
3.008IleLeu: 3.008 ± 0.575
1.138IleMet: 1.138 ± 0.304
3.17IleAsn: 3.17 ± 0.482
2.358IlePro: 2.358 ± 0.447
2.195IleGln: 2.195 ± 0.402
4.146IleArg: 4.146 ± 0.441
4.959IleSer: 4.959 ± 0.663
3.821IleThr: 3.821 ± 0.562
3.496IleVal: 3.496 ± 0.636
0.325IleTrp: 0.325 ± 0.141
1.951IleTyr: 1.951 ± 0.454
0.0IleXaa: 0.0 ± 0.0
Lys
5.772LysAla: 5.772 ± 0.766
0.732LysCys: 0.732 ± 0.252
3.983LysAsp: 3.983 ± 0.537
3.658LysGlu: 3.658 ± 0.691
2.114LysPhe: 2.114 ± 0.481
4.39LysGly: 4.39 ± 0.569
0.813LysHis: 0.813 ± 0.315
3.414LysIle: 3.414 ± 0.37
4.065LysLys: 4.065 ± 0.6
6.666LysLeu: 6.666 ± 0.881
1.87LysMet: 1.87 ± 0.367
2.032LysAsn: 2.032 ± 0.415
3.658LysPro: 3.658 ± 0.547
3.414LysGln: 3.414 ± 0.702
4.878LysArg: 4.878 ± 0.718
3.496LysSer: 3.496 ± 0.601
4.065LysThr: 4.065 ± 0.557
2.764LysVal: 2.764 ± 0.409
0.65LysTrp: 0.65 ± 0.236
2.358LysTyr: 2.358 ± 0.498
0.0LysXaa: 0.0 ± 0.0
Leu
7.316LeuAla: 7.316 ± 1.035
0.813LeuCys: 0.813 ± 0.243
3.577LeuAsp: 3.577 ± 0.569
4.796LeuGlu: 4.796 ± 0.764
2.439LeuPhe: 2.439 ± 0.478
4.552LeuGly: 4.552 ± 0.749
1.138LeuHis: 1.138 ± 0.331
4.39LeuIle: 4.39 ± 0.785
6.585LeuLys: 6.585 ± 0.817
5.609LeuLeu: 5.609 ± 0.739
2.358LeuMet: 2.358 ± 0.394
3.902LeuAsn: 3.902 ± 0.534
3.496LeuPro: 3.496 ± 0.678
2.439LeuGln: 2.439 ± 0.508
4.796LeuArg: 4.796 ± 0.596
5.609LeuSer: 5.609 ± 0.618
5.365LeuThr: 5.365 ± 0.632
3.74LeuVal: 3.74 ± 0.428
1.057LeuTrp: 1.057 ± 0.323
2.927LeuTyr: 2.927 ± 0.461
0.0LeuXaa: 0.0 ± 0.0
Met
3.414MetAla: 3.414 ± 0.586
0.0MetCys: 0.0 ± 0.0
1.219MetAsp: 1.219 ± 0.33
1.707MetGlu: 1.707 ± 0.433
0.406MetPhe: 0.406 ± 0.261
1.626MetGly: 1.626 ± 0.36
0.325MetHis: 0.325 ± 0.153
1.301MetIle: 1.301 ± 0.314
2.439MetLys: 2.439 ± 0.514
1.87MetLeu: 1.87 ± 0.333
0.65MetMet: 0.65 ± 0.209
1.463MetAsn: 1.463 ± 0.342
1.138MetPro: 1.138 ± 0.312
1.301MetGln: 1.301 ± 0.278
2.195MetArg: 2.195 ± 0.543
2.195MetSer: 2.195 ± 0.41
2.114MetThr: 2.114 ± 0.405
1.87MetVal: 1.87 ± 0.354
0.406MetTrp: 0.406 ± 0.181
1.057MetTyr: 1.057 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
5.284AsnAla: 5.284 ± 0.764
0.65AsnCys: 0.65 ± 0.245
2.358AsnAsp: 2.358 ± 0.432
3.496AsnGlu: 3.496 ± 0.515
0.732AsnPhe: 0.732 ± 0.237
3.821AsnGly: 3.821 ± 0.531
0.813AsnHis: 0.813 ± 0.278
2.927AsnIle: 2.927 ± 0.476
3.089AsnLys: 3.089 ± 0.474
3.008AsnLeu: 3.008 ± 0.604
1.545AsnMet: 1.545 ± 0.34
2.276AsnAsn: 2.276 ± 0.55
2.683AsnPro: 2.683 ± 0.437
3.008AsnGln: 3.008 ± 0.647
2.276AsnArg: 2.276 ± 0.397
2.845AsnSer: 2.845 ± 0.426
3.252AsnThr: 3.252 ± 0.677
2.927AsnVal: 2.927 ± 0.536
0.65AsnTrp: 0.65 ± 0.28
1.545AsnTyr: 1.545 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
3.089ProAla: 3.089 ± 0.473
0.406ProCys: 0.406 ± 0.181
2.601ProAsp: 2.601 ± 0.511
3.902ProGlu: 3.902 ± 0.668
1.626ProPhe: 1.626 ± 0.279
1.788ProGly: 1.788 ± 0.298
0.488ProHis: 0.488 ± 0.191
2.52ProIle: 2.52 ± 0.461
2.276ProLys: 2.276 ± 0.451
2.764ProLeu: 2.764 ± 0.408
0.732ProMet: 0.732 ± 0.256
1.463ProAsn: 1.463 ± 0.338
1.87ProPro: 1.87 ± 0.455
1.87ProGln: 1.87 ± 0.38
1.545ProArg: 1.545 ± 0.342
2.764ProSer: 2.764 ± 0.436
1.951ProThr: 1.951 ± 0.371
3.252ProVal: 3.252 ± 0.497
0.569ProTrp: 0.569 ± 0.236
1.057ProTyr: 1.057 ± 0.285
0.0ProXaa: 0.0 ± 0.0
Gln
3.821GlnAla: 3.821 ± 0.6
0.488GlnCys: 0.488 ± 0.171
2.601GlnAsp: 2.601 ± 0.459
2.114GlnGlu: 2.114 ± 0.487
1.788GlnPhe: 1.788 ± 0.376
2.601GlnGly: 2.601 ± 0.576
0.65GlnHis: 0.65 ± 0.199
2.764GlnIle: 2.764 ± 0.452
2.927GlnLys: 2.927 ± 0.616
3.821GlnLeu: 3.821 ± 0.472
1.301GlnMet: 1.301 ± 0.33
1.707GlnAsn: 1.707 ± 0.731
1.545GlnPro: 1.545 ± 0.337
3.414GlnGln: 3.414 ± 0.912
3.089GlnArg: 3.089 ± 0.536
3.414GlnSer: 3.414 ± 0.548
1.87GlnThr: 1.87 ± 0.428
2.114GlnVal: 2.114 ± 0.467
1.057GlnTrp: 1.057 ± 0.298
2.439GlnTyr: 2.439 ± 0.509
0.0GlnXaa: 0.0 ± 0.0
Arg
4.878ArgAla: 4.878 ± 0.663
0.488ArgCys: 0.488 ± 0.2
4.634ArgAsp: 4.634 ± 0.552
4.552ArgGlu: 4.552 ± 0.656
2.032ArgPhe: 2.032 ± 0.411
2.927ArgGly: 2.927 ± 0.427
0.813ArgHis: 0.813 ± 0.237
3.74ArgIle: 3.74 ± 0.625
3.821ArgLys: 3.821 ± 0.777
5.284ArgLeu: 5.284 ± 0.718
1.626ArgMet: 1.626 ± 0.38
2.845ArgAsn: 2.845 ± 0.536
1.87ArgPro: 1.87 ± 0.384
2.764ArgGln: 2.764 ± 0.552
3.333ArgArg: 3.333 ± 0.796
3.74ArgSer: 3.74 ± 0.511
2.195ArgThr: 2.195 ± 0.399
3.821ArgVal: 3.821 ± 0.567
0.732ArgTrp: 0.732 ± 0.254
2.032ArgTyr: 2.032 ± 0.485
0.0ArgXaa: 0.0 ± 0.0
Ser
6.097SerAla: 6.097 ± 0.892
0.894SerCys: 0.894 ± 0.262
3.008SerAsp: 3.008 ± 0.452
4.309SerGlu: 4.309 ± 0.676
2.927SerPhe: 2.927 ± 0.563
6.016SerGly: 6.016 ± 0.934
1.057SerHis: 1.057 ± 0.245
2.764SerIle: 2.764 ± 0.444
2.927SerLys: 2.927 ± 0.42
5.609SerLeu: 5.609 ± 0.724
2.032SerMet: 2.032 ± 0.377
3.008SerAsn: 3.008 ± 0.384
3.008SerPro: 3.008 ± 0.572
3.252SerGln: 3.252 ± 0.477
3.577SerArg: 3.577 ± 0.543
3.496SerSer: 3.496 ± 0.759
3.17SerThr: 3.17 ± 0.646
3.821SerVal: 3.821 ± 0.572
0.488SerTrp: 0.488 ± 0.224
2.114SerTyr: 2.114 ± 0.435
0.0SerXaa: 0.0 ± 0.0
Thr
4.552ThrAla: 4.552 ± 0.711
0.488ThrCys: 0.488 ± 0.195
3.496ThrAsp: 3.496 ± 0.628
2.845ThrGlu: 2.845 ± 0.483
1.382ThrPhe: 1.382 ± 0.421
4.959ThrGly: 4.959 ± 0.646
0.569ThrHis: 0.569 ± 0.178
3.414ThrIle: 3.414 ± 0.479
3.577ThrLys: 3.577 ± 0.615
4.227ThrLeu: 4.227 ± 0.677
0.813ThrMet: 0.813 ± 0.211
3.089ThrAsn: 3.089 ± 0.643
3.252ThrPro: 3.252 ± 0.441
3.089ThrGln: 3.089 ± 0.416
2.195ThrArg: 2.195 ± 0.429
2.683ThrSer: 2.683 ± 0.502
2.764ThrThr: 2.764 ± 0.51
3.496ThrVal: 3.496 ± 0.583
0.813ThrTrp: 0.813 ± 0.222
1.219ThrTyr: 1.219 ± 0.38
0.0ThrXaa: 0.0 ± 0.0
Val
5.934ValAla: 5.934 ± 0.628
0.732ValCys: 0.732 ± 0.262
3.658ValAsp: 3.658 ± 0.554
3.902ValGlu: 3.902 ± 0.546
1.951ValPhe: 1.951 ± 0.367
3.496ValGly: 3.496 ± 0.61
0.976ValHis: 0.976 ± 0.285
3.902ValIle: 3.902 ± 0.55
3.821ValLys: 3.821 ± 0.514
4.796ValLeu: 4.796 ± 0.607
1.707ValMet: 1.707 ± 0.386
4.552ValAsn: 4.552 ± 0.545
1.626ValPro: 1.626 ± 0.38
1.707ValGln: 1.707 ± 0.372
3.089ValArg: 3.089 ± 0.414
3.658ValSer: 3.658 ± 0.71
3.496ValThr: 3.496 ± 0.609
3.983ValVal: 3.983 ± 0.584
1.219ValTrp: 1.219 ± 0.342
1.951ValTyr: 1.951 ± 0.51
0.0ValXaa: 0.0 ± 0.0
Trp
1.301TrpAla: 1.301 ± 0.394
0.813TrpCys: 0.813 ± 0.249
0.894TrpAsp: 0.894 ± 0.221
0.569TrpGlu: 0.569 ± 0.199
0.569TrpPhe: 0.569 ± 0.24
1.463TrpGly: 1.463 ± 0.324
0.244TrpHis: 0.244 ± 0.136
0.65TrpIle: 0.65 ± 0.242
1.301TrpLys: 1.301 ± 0.359
1.788TrpLeu: 1.788 ± 0.397
0.569TrpMet: 0.569 ± 0.207
0.488TrpAsn: 0.488 ± 0.187
0.813TrpPro: 0.813 ± 0.263
0.488TrpGln: 0.488 ± 0.146
1.301TrpArg: 1.301 ± 0.32
0.976TrpSer: 0.976 ± 0.427
0.732TrpThr: 0.732 ± 0.219
0.732TrpVal: 0.732 ± 0.192
0.163TrpTrp: 0.163 ± 0.112
0.325TrpTyr: 0.325 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.252TyrAla: 3.252 ± 0.509
0.406TyrCys: 0.406 ± 0.19
2.683TyrAsp: 2.683 ± 0.524
1.788TyrGlu: 1.788 ± 0.508
1.382TyrPhe: 1.382 ± 0.324
2.114TyrGly: 2.114 ± 0.539
0.569TyrHis: 0.569 ± 0.194
1.382TyrIle: 1.382 ± 0.44
1.626TyrLys: 1.626 ± 0.344
2.601TyrLeu: 2.601 ± 0.397
0.65TyrMet: 0.65 ± 0.237
1.788TyrAsn: 1.788 ± 0.405
1.545TyrPro: 1.545 ± 0.4
1.951TyrGln: 1.951 ± 0.364
2.683TyrArg: 2.683 ± 0.411
2.195TyrSer: 2.195 ± 0.427
1.626TyrThr: 1.626 ± 0.292
1.87TyrVal: 1.87 ± 0.432
0.813TyrTrp: 0.813 ± 0.244
0.813TyrTyr: 0.813 ± 0.275
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (12302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski