Amino acid dipepetide frequency for Acidovorax sp. (strain JS42)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.949AlaAla: 18.949 ± 0.178	1.432AlaCys: 1.432 ± 0.032	6.391AlaAsp: 6.391 ± 0.078	6.742AlaGlu: 6.742 ± 0.086	3.88AlaPhe: 3.88 ± 0.05	10.853AlaGly: 10.853 ± 0.102	3.028AlaHis: 3.028 ± 0.056	4.871AlaIle: 4.871 ± 0.066	3.775AlaLys: 3.775 ± 0.082	15.891AlaLeu: 15.891 ± 0.159	3.488AlaMet: 3.488 ± 0.054	2.607AlaAsn: 2.607 ± 0.042	7.101AlaPro: 7.101 ± 0.094	7.244AlaGln: 7.244 ± 0.094	9.701AlaArg: 9.701 ± 0.111	6.481AlaSer: 6.481 ± 0.072	6.296AlaThr: 6.296 ± 0.074	9.305AlaVal: 9.305 ± 0.102	2.112AlaTrp: 2.112 ± 0.041	2.407AlaTyr: 2.407 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.307CysAla: 1.307 ± 0.032	0.14CysCys: 0.14 ± 0.01	0.515CysAsp: 0.515 ± 0.021	0.522CysGlu: 0.522 ± 0.022	0.305CysPhe: 0.305 ± 0.014	1.036CysGly: 1.036 ± 0.033	0.29CysHis: 0.29 ± 0.015	0.432CysIle: 0.432 ± 0.016	0.235CysLys: 0.235 ± 0.015	0.827CysLeu: 0.827 ± 0.028	0.25CysMet: 0.25 ± 0.014	0.232CysAsn: 0.232 ± 0.013	0.596CysPro: 0.596 ± 0.024	0.334CysGln: 0.334 ± 0.014	0.597CysArg: 0.597 ± 0.022	0.498CysSer: 0.498 ± 0.019	0.54CysThr: 0.54 ± 0.019	0.793CysVal: 0.793 ± 0.025	0.122CysTrp: 0.122 ± 0.009	0.203CysTyr: 0.203 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.364AspAla: 7.364 ± 0.096	0.486AspCys: 0.486 ± 0.02	2.55AspAsp: 2.55 ± 0.049	3.164AspGlu: 3.164 ± 0.056	1.869AspPhe: 1.869 ± 0.044	4.474AspGly: 4.474 ± 0.066	1.165AspHis: 1.165 ± 0.033	2.254AspIle: 2.254 ± 0.041	1.828AspLys: 1.828 ± 0.045	5.205AspLeu: 5.205 ± 0.074	1.285AspMet: 1.285 ± 0.034	1.168AspAsn: 1.168 ± 0.029	2.711AspPro: 2.711 ± 0.046	1.671AspGln: 1.671 ± 0.033	3.192AspArg: 3.192 ± 0.054	2.043AspSer: 2.043 ± 0.047	2.572AspThr: 2.572 ± 0.053	3.95AspVal: 3.95 ± 0.051	1.004AspTrp: 1.004 ± 0.029	1.331AspTyr: 1.331 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.79GluAla: 6.79 ± 0.085	0.432GluCys: 0.432 ± 0.018	2.318GluAsp: 2.318 ± 0.048	2.557GluGlu: 2.557 ± 0.05	1.679GluPhe: 1.679 ± 0.037	3.963GluGly: 3.963 ± 0.058	1.41GluHis: 1.41 ± 0.041	2.466GluIle: 2.466 ± 0.052	1.877GluLys: 1.877 ± 0.044	5.837GluLeu: 5.837 ± 0.073	1.26GluMet: 1.26 ± 0.027	1.228GluAsn: 1.228 ± 0.03	2.58GluPro: 2.58 ± 0.043	2.841GluGln: 2.841 ± 0.051	4.828GluArg: 4.828 ± 0.072	2.422GluSer: 2.422 ± 0.042	2.412GluThr: 2.412 ± 0.046	4.11GluVal: 4.11 ± 0.058	0.704GluTrp: 0.704 ± 0.027	1.013GluTyr: 1.013 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.16PheAla: 4.16 ± 0.059	0.4PheCys: 0.4 ± 0.019	2.298PheAsp: 2.298 ± 0.032	1.918PheGlu: 1.918 ± 0.036	1.274PhePhe: 1.274 ± 0.033	3.027PheGly: 3.027 ± 0.052	0.737PheHis: 0.737 ± 0.026	1.458PheIle: 1.458 ± 0.036	1.122PheLys: 1.122 ± 0.026	2.829PheLeu: 2.829 ± 0.045	0.787PheMet: 0.787 ± 0.028	0.991PheAsn: 0.991 ± 0.03	1.439PhePro: 1.439 ± 0.033	1.081PheGln: 1.081 ± 0.031	1.786PheArg: 1.786 ± 0.037	1.842PheSer: 1.842 ± 0.038	1.857PheThr: 1.857 ± 0.043	2.555PheVal: 2.555 ± 0.049	0.511PheTrp: 0.511 ± 0.023	0.817PheTyr: 0.817 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.373GlyAla: 9.373 ± 0.089	0.945GlyCys: 0.945 ± 0.028	4.007GlyAsp: 4.007 ± 0.063	4.354GlyGlu: 4.354 ± 0.062	3.044GlyPhe: 3.044 ± 0.055	6.92GlyGly: 6.92 ± 0.098	2.075GlyHis: 2.075 ± 0.048	3.677GlyIle: 3.677 ± 0.056	3.146GlyLys: 3.146 ± 0.064	8.715GlyLeu: 8.715 ± 0.092	2.434GlyMet: 2.434 ± 0.046	2.071GlyAsn: 2.071 ± 0.047	2.915GlyPro: 2.915 ± 0.046	3.651GlyGln: 3.651 ± 0.066	5.545GlyArg: 5.545 ± 0.076	4.278GlySer: 4.278 ± 0.057	4.381GlyThr: 4.381 ± 0.066	6.647GlyVal: 6.647 ± 0.083	1.518GlyTrp: 1.518 ± 0.037	2.282GlyTyr: 2.282 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	3.276HisAla: 3.276 ± 0.061	0.349HisCys: 0.349 ± 0.017	1.236HisAsp: 1.236 ± 0.035	1.233HisGlu: 1.233 ± 0.033	0.829HisPhe: 0.829 ± 0.027	2.311HisGly: 2.311 ± 0.049	0.708HisHis: 0.708 ± 0.025	0.996HisIle: 0.996 ± 0.025	0.622HisLys: 0.622 ± 0.025	2.431HisLeu: 2.431 ± 0.05	0.563HisMet: 0.563 ± 0.021	0.508HisAsn: 0.508 ± 0.02	1.624HisPro: 1.624 ± 0.042	0.874HisGln: 0.874 ± 0.028	1.652HisArg: 1.652 ± 0.04	1.082HisSer: 1.082 ± 0.027	1.199HisThr: 1.199 ± 0.035	1.681HisVal: 1.681 ± 0.036	0.457HisTrp: 0.457 ± 0.021	0.667HisTyr: 0.667 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.844IleAla: 5.844 ± 0.073	0.369IleCys: 0.369 ± 0.018	2.818IleAsp: 2.818 ± 0.05	2.882IleGlu: 2.882 ± 0.056	1.19IlePhe: 1.19 ± 0.035	3.638IleGly: 3.638 ± 0.058	0.914IleHis: 0.914 ± 0.029	1.452IleIle: 1.452 ± 0.038	1.434IleLys: 1.434 ± 0.037	3.068IleLeu: 3.068 ± 0.056	0.739IleMet: 0.739 ± 0.028	1.297IleAsn: 1.297 ± 0.032	1.948IlePro: 1.948 ± 0.039	1.324IleGln: 1.324 ± 0.036	2.451IleArg: 2.451 ± 0.041	2.021IleSer: 2.021 ± 0.041	2.501IleThr: 2.501 ± 0.042	3.214IleVal: 3.214 ± 0.048	0.448IleTrp: 0.448 ± 0.019	0.931IleTyr: 0.931 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.034LysAla: 4.034 ± 0.071	0.171LysCys: 0.171 ± 0.012	1.646LysAsp: 1.646 ± 0.04	1.614LysGlu: 1.614 ± 0.04	0.85LysPhe: 0.85 ± 0.025	2.433LysGly: 2.433 ± 0.052	0.676LysHis: 0.676 ± 0.023	1.381LysIle: 1.381 ± 0.036	1.457LysLys: 1.457 ± 0.049	3.278LysLeu: 3.278 ± 0.054	0.77LysMet: 0.77 ± 0.027	0.954LysAsn: 0.954 ± 0.033	1.937LysPro: 1.937 ± 0.049	1.213LysGln: 1.213 ± 0.035	2.215LysArg: 2.215 ± 0.045	1.635LysSer: 1.635 ± 0.032	1.928LysThr: 1.928 ± 0.043	2.382LysVal: 2.382 ± 0.051	0.337LysTrp: 0.337 ± 0.017	0.664LysTyr: 0.664 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.264LeuAla: 15.264 ± 0.145	1.072LeuCys: 1.072 ± 0.029	5.726LeuAsp: 5.726 ± 0.075	5.201LeuGlu: 5.201 ± 0.066	3.248LeuPhe: 3.248 ± 0.055	8.483LeuGly: 8.483 ± 0.089	2.63LeuHis: 2.63 ± 0.05	4.011LeuIle: 4.011 ± 0.061	3.366LeuLys: 3.366 ± 0.05	11.576LeuLeu: 11.576 ± 0.144	2.468LeuMet: 2.468 ± 0.047	2.587LeuAsn: 2.587 ± 0.046	6.479LeuPro: 6.479 ± 0.09	5.256LeuGln: 5.256 ± 0.078	8.14LeuArg: 8.14 ± 0.092	5.737LeuSer: 5.737 ± 0.069	5.193LeuThr: 5.193 ± 0.056	7.831LeuVal: 7.831 ± 0.087	1.472LeuTrp: 1.472 ± 0.041	2.105LeuTyr: 2.105 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.22MetAla: 3.22 ± 0.055	0.178MetCys: 0.178 ± 0.011	1.173MetAsp: 1.173 ± 0.025	1.109MetGlu: 1.109 ± 0.031	0.695MetPhe: 0.695 ± 0.028	1.941MetGly: 1.941 ± 0.04	0.616MetHis: 0.616 ± 0.025	0.824MetIle: 0.824 ± 0.027	0.92MetLys: 0.92 ± 0.034	2.638MetLeu: 2.638 ± 0.05	0.547MetMet: 0.547 ± 0.021	0.836MetAsn: 0.836 ± 0.027	1.549MetPro: 1.549 ± 0.035	1.251MetGln: 1.251 ± 0.03	1.836MetArg: 1.836 ± 0.034	1.488MetSer: 1.488 ± 0.032	1.487MetThr: 1.487 ± 0.034	1.793MetVal: 1.793 ± 0.039	0.2MetTrp: 0.2 ± 0.012	0.356MetTyr: 0.356 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.207AsnAla: 3.207 ± 0.051	0.24AsnCys: 0.24 ± 0.015	1.265AsnAsp: 1.265 ± 0.037	1.136AsnGlu: 1.136 ± 0.031	0.85AsnPhe: 0.85 ± 0.024	2.052AsnGly: 2.052 ± 0.051	0.515AsnHis: 0.515 ± 0.019	1.096AsnIle: 1.096 ± 0.035	0.787AsnLys: 0.787 ± 0.026	2.445AsnLeu: 2.445 ± 0.049	0.552AsnMet: 0.552 ± 0.02	0.677AsnAsn: 0.677 ± 0.027	1.75AsnPro: 1.75 ± 0.033	0.931AsnGln: 0.931 ± 0.032	1.585AsnArg: 1.585 ± 0.035	1.029AsnSer: 1.029 ± 0.028	1.319AsnThr: 1.319 ± 0.031	1.88AsnVal: 1.88 ± 0.041	0.372AsnTrp: 0.372 ± 0.017	0.624AsnTyr: 0.624 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.776ProAla: 7.776 ± 0.09	0.41ProCys: 0.41 ± 0.015	3.142ProAsp: 3.142 ± 0.055	3.34ProGlu: 3.34 ± 0.051	1.717ProPhe: 1.717 ± 0.039	4.595ProGly: 4.595 ± 0.061	1.338ProHis: 1.338 ± 0.031	1.748ProIle: 1.748 ± 0.034	1.442ProLys: 1.442 ± 0.036	5.683ProLeu: 5.683 ± 0.068	1.293ProMet: 1.293 ± 0.03	1.143ProAsn: 1.143 ± 0.032	3.078ProPro: 3.078 ± 0.069	2.613ProGln: 2.613 ± 0.045	3.291ProArg: 3.291 ± 0.053	2.803ProSer: 2.803 ± 0.053	2.7ProThr: 2.7 ± 0.052	4.343ProVal: 4.343 ± 0.057	0.856ProTrp: 0.856 ± 0.028	1.198ProTyr: 1.198 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	6.858GlnAla: 6.858 ± 0.086	0.367GlnCys: 0.367 ± 0.019	2.025GlnAsp: 2.025 ± 0.043	2.077GlnGlu: 2.077 ± 0.049	1.349GlnPhe: 1.349 ± 0.032	3.638GlnGly: 3.638 ± 0.051	1.116GlnHis: 1.116 ± 0.032	1.811GlnIle: 1.811 ± 0.036	1.162GlnLys: 1.162 ± 0.033	4.688GlnLeu: 4.688 ± 0.065	1.045GlnMet: 1.045 ± 0.026	0.899GlnAsn: 0.899 ± 0.029	2.708GlnPro: 2.708 ± 0.05	2.417GlnGln: 2.417 ± 0.052	4.094GlnArg: 4.094 ± 0.072	2.152GlnSer: 2.152 ± 0.039	1.969GlnThr: 1.969 ± 0.04	3.328GlnVal: 3.328 ± 0.052	0.843GlnTrp: 0.843 ± 0.024	0.854GlnTyr: 0.854 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.597ArgAla: 8.597 ± 0.089	0.643ArgCys: 0.643 ± 0.024	3.578ArgAsp: 3.578 ± 0.057	4.261ArgGlu: 4.261 ± 0.065	2.688ArgPhe: 2.688 ± 0.04	4.834ArgGly: 4.834 ± 0.07	1.996ArgHis: 1.996 ± 0.042	3.341ArgIle: 3.341 ± 0.049	2.129ArgLys: 2.129 ± 0.043	8.219ArgLeu: 8.219 ± 0.085	2.031ArgMet: 2.031 ± 0.045	1.773ArgAsn: 1.773 ± 0.038	3.5ArgPro: 3.5 ± 0.063	3.316ArgGln: 3.316 ± 0.051	5.477ArgArg: 5.477 ± 0.078	3.461ArgSer: 3.461 ± 0.058	3.413ArgThr: 3.413 ± 0.051	5.156ArgVal: 5.156 ± 0.078	1.315ArgTrp: 1.315 ± 0.031	1.866ArgTyr: 1.866 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.279SerAla: 6.279 ± 0.08	0.487SerCys: 0.487 ± 0.02	2.466SerAsp: 2.466 ± 0.044	2.318SerGlu: 2.318 ± 0.04	1.797SerPhe: 1.797 ± 0.041	4.68SerGly: 4.68 ± 0.069	1.223SerHis: 1.223 ± 0.032	2.176SerIle: 2.176 ± 0.044	1.502SerLys: 1.502 ± 0.04	5.168SerLeu: 5.168 ± 0.071	1.345SerMet: 1.345 ± 0.035	1.273SerAsn: 1.273 ± 0.031	2.792SerPro: 2.792 ± 0.051	1.935SerGln: 1.935 ± 0.037	3.337SerArg: 3.337 ± 0.049	2.813SerSer: 2.813 ± 0.054	2.813SerThr: 2.813 ± 0.053	3.67SerVal: 3.67 ± 0.056	0.689SerTrp: 0.689 ± 0.024	1.149SerTyr: 1.149 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.372ThrAla: 6.372 ± 0.079	0.438ThrCys: 0.438 ± 0.021	2.432ThrAsp: 2.432 ± 0.048	2.369ThrGlu: 2.369 ± 0.045	1.629ThrPhe: 1.629 ± 0.035	4.493ThrGly: 4.493 ± 0.068	1.238ThrHis: 1.238 ± 0.032	1.974ThrIle: 1.974 ± 0.045	1.299ThrLys: 1.299 ± 0.036	6.312ThrLeu: 6.312 ± 0.08	1.077ThrMet: 1.077 ± 0.028	1.133ThrAsn: 1.133 ± 0.031	3.682ThrPro: 3.682 ± 0.052	2.192ThrGln: 2.192 ± 0.041	3.373ThrArg: 3.373 ± 0.056	2.527ThrSer: 2.527 ± 0.042	2.807ThrThr: 2.807 ± 0.059	4.187ThrVal: 4.187 ± 0.055	0.639ThrTrp: 0.639 ± 0.021	1.043ThrTyr: 1.043 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.73ValAla: 9.73 ± 0.095	0.76ValCys: 0.76 ± 0.027	3.893ValAsp: 3.893 ± 0.057	4.108ValGlu: 4.108 ± 0.055	2.594ValPhe: 2.594 ± 0.047	5.621ValGly: 5.621 ± 0.067	1.764ValHis: 1.764 ± 0.04	3.131ValIle: 3.131 ± 0.05	2.276ValLys: 2.276 ± 0.052	8.437ValLeu: 8.437 ± 0.096	1.805ValMet: 1.805 ± 0.043	1.963ValAsn: 1.963 ± 0.042	4.218ValPro: 4.218 ± 0.054	3.532ValGln: 3.532 ± 0.059	5.473ValArg: 5.473 ± 0.062	3.699ValSer: 3.699 ± 0.049	3.912ValThr: 3.912 ± 0.058	6.343ValVal: 6.343 ± 0.076	1.018ValTrp: 1.018 ± 0.029	1.536ValTyr: 1.536 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.565TrpAla: 1.565 ± 0.038	0.184TrpCys: 0.184 ± 0.012	0.615TrpAsp: 0.615 ± 0.024	0.593TrpGlu: 0.593 ± 0.026	0.55TrpPhe: 0.55 ± 0.023	1.036TrpGly: 1.036 ± 0.033	0.398TrpHis: 0.398 ± 0.017	0.64TrpIle: 0.64 ± 0.021	0.475TrpLys: 0.475 ± 0.021	2.214TrpLeu: 2.214 ± 0.045	0.487TrpMet: 0.487 ± 0.017	0.395TrpAsn: 0.395 ± 0.019	0.778TrpPro: 0.778 ± 0.025	0.838TrpGln: 0.838 ± 0.025	1.371TrpArg: 1.371 ± 0.035	0.799TrpSer: 0.799 ± 0.026	0.708TrpThr: 0.708 ± 0.022	1.064TrpVal: 1.064 ± 0.027	0.316TrpTrp: 0.316 ± 0.017	0.267TrpTyr: 0.267 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.046	0.273TyrCys: 0.273 ± 0.013	1.19TyrAsp: 1.19 ± 0.031	1.228TyrGlu: 1.228 ± 0.03	0.854TyrPhe: 0.854 ± 0.028	1.953TyrGly: 1.953 ± 0.045	0.464TyrHis: 0.464 ± 0.018	0.742TyrIle: 0.742 ± 0.026	0.72TyrLys: 0.72 ± 0.027	2.383TyrLeu: 2.383 ± 0.045	0.429TyrMet: 0.429 ± 0.019	0.575TyrAsn: 0.575 ± 0.023	1.127TyrPro: 1.127 ± 0.03	0.887TyrGln: 0.887 ± 0.025	1.65TyrArg: 1.65 ± 0.035	1.102TyrSer: 1.102 ± 0.03	1.208TyrThr: 1.208 ± 0.034	1.582TyrVal: 1.582 ± 0.031	0.359TyrTrp: 0.359 ± 0.017	0.571TyrTyr: 0.571 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4045 proteins (1298069 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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