Amino acid dipepetide frequency for Prevotella sp. P3-122

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.279AlaAla: 6.279 ± 0.124	1.092AlaCys: 1.092 ± 0.037	5.393AlaAsp: 5.393 ± 0.077	4.996AlaGlu: 4.996 ± 0.08	3.115AlaPhe: 3.115 ± 0.066	4.992AlaGly: 4.992 ± 0.086	1.333AlaHis: 1.333 ± 0.041	4.939AlaIle: 4.939 ± 0.083	4.504AlaLys: 4.504 ± 0.077	6.614AlaLeu: 6.614 ± 0.103	2.38AlaMet: 2.38 ± 0.051	3.621AlaAsn: 3.621 ± 0.068	2.264AlaPro: 2.264 ± 0.059	2.927AlaGln: 2.927 ± 0.057	3.328AlaArg: 3.328 ± 0.061	4.498AlaSer: 4.498 ± 0.067	4.49AlaThr: 4.49 ± 0.081	5.09AlaVal: 5.09 ± 0.078	0.93AlaTrp: 0.93 ± 0.029	3.074AlaTyr: 3.074 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.895CysAla: 0.895 ± 0.03	0.259CysCys: 0.259 ± 0.016	0.896CysAsp: 0.896 ± 0.033	0.761CysGlu: 0.761 ± 0.027	0.597CysPhe: 0.597 ± 0.025	1.178CysGly: 1.178 ± 0.038	0.386CysHis: 0.386 ± 0.021	0.902CysIle: 0.902 ± 0.031	0.73CysLys: 0.73 ± 0.028	1.228CysLeu: 1.228 ± 0.033	0.391CysMet: 0.391 ± 0.019	0.664CysAsn: 0.664 ± 0.024	0.584CysPro: 0.584 ± 0.024	0.451CysGln: 0.451 ± 0.022	0.814CysArg: 0.814 ± 0.026	0.917CysSer: 0.917 ± 0.034	0.736CysThr: 0.736 ± 0.026	0.91CysVal: 0.91 ± 0.028	0.2CysTrp: 0.2 ± 0.013	0.627CysTyr: 0.627 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.672AspAla: 4.672 ± 0.079	0.817AspCys: 0.817 ± 0.027	3.617AspAsp: 3.617 ± 0.062	4.18AspGlu: 4.18 ± 0.066	3.025AspPhe: 3.025 ± 0.054	5.09AspGly: 5.09 ± 0.091	0.974AspHis: 0.974 ± 0.028	4.744AspIle: 4.744 ± 0.075	4.114AspLys: 4.114 ± 0.069	4.268AspLeu: 4.268 ± 0.073	1.883AspMet: 1.883 ± 0.042	3.648AspAsn: 3.648 ± 0.066	1.737AspPro: 1.737 ± 0.048	1.279AspGln: 1.279 ± 0.032	2.665AspArg: 2.665 ± 0.05	3.679AspSer: 3.679 ± 0.065	3.094AspThr: 3.094 ± 0.056	3.984AspVal: 3.984 ± 0.061	0.846AspTrp: 0.846 ± 0.029	3.013AspTyr: 3.013 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.823GluAla: 4.823 ± 0.074	0.736GluCys: 0.736 ± 0.027	3.33GluAsp: 3.33 ± 0.061	4.396GluGlu: 4.396 ± 0.084	2.22GluPhe: 2.22 ± 0.049	4.072GluGly: 4.072 ± 0.075	1.257GluHis: 1.257 ± 0.033	3.955GluIle: 3.955 ± 0.069	4.319GluLys: 4.319 ± 0.08	5.436GluLeu: 5.436 ± 0.082	2.03GluMet: 2.03 ± 0.038	3.177GluAsn: 3.177 ± 0.055	1.755GluPro: 1.755 ± 0.038	2.571GluGln: 2.571 ± 0.053	3.196GluArg: 3.196 ± 0.06	2.957GluSer: 2.957 ± 0.056	3.403GluThr: 3.403 ± 0.052	3.804GluVal: 3.804 ± 0.058	0.895GluTrp: 0.895 ± 0.032	2.722GluTyr: 2.722 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.117PheAla: 3.117 ± 0.057	0.764PheCys: 0.764 ± 0.031	2.902PheAsp: 2.902 ± 0.053	2.176PheGlu: 2.176 ± 0.045	1.881PhePhe: 1.881 ± 0.047	3.228PheGly: 3.228 ± 0.063	0.855PheHis: 0.855 ± 0.029	2.555PheIle: 2.555 ± 0.057	2.159PheLys: 2.159 ± 0.049	3.419PheLeu: 3.419 ± 0.073	1.122PheMet: 1.122 ± 0.032	2.186PheAsn: 2.186 ± 0.044	1.442PhePro: 1.442 ± 0.031	1.089PheGln: 1.089 ± 0.033	2.07PheArg: 2.07 ± 0.045	3.131PheSer: 3.131 ± 0.065	2.594PheThr: 2.594 ± 0.05	3.015PheVal: 3.015 ± 0.057	0.529PheTrp: 0.529 ± 0.025	1.786PheTyr: 1.786 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.506GlyAla: 4.506 ± 0.07	1.133GlyCys: 1.133 ± 0.034	3.932GlyAsp: 3.932 ± 0.071	4.0GlyGlu: 4.0 ± 0.07	2.907GlyPhe: 2.907 ± 0.059	4.713GlyGly: 4.713 ± 0.083	1.469GlyHis: 1.469 ± 0.037	5.012GlyIle: 5.012 ± 0.069	5.154GlyLys: 5.154 ± 0.083	5.547GlyLeu: 5.547 ± 0.078	2.245GlyMet: 2.245 ± 0.047	3.825GlyAsn: 3.825 ± 0.067	1.317GlyPro: 1.317 ± 0.04	2.33GlyGln: 2.33 ± 0.05	3.229GlyArg: 3.229 ± 0.064	4.034GlySer: 4.034 ± 0.072	4.436GlyThr: 4.436 ± 0.097	4.746GlyVal: 4.746 ± 0.079	1.061GlyTrp: 1.061 ± 0.036	3.176GlyTyr: 3.176 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.246HisAla: 1.246 ± 0.034	0.336HisCys: 0.336 ± 0.017	1.199HisAsp: 1.199 ± 0.035	1.085HisGlu: 1.085 ± 0.035	0.965HisPhe: 0.965 ± 0.032	1.426HisGly: 1.426 ± 0.034	0.555HisHis: 0.555 ± 0.03	1.45HisIle: 1.45 ± 0.035	1.03HisLys: 1.03 ± 0.029	1.739HisLeu: 1.739 ± 0.047	0.375HisMet: 0.375 ± 0.019	0.983HisAsn: 0.983 ± 0.032	1.008HisPro: 1.008 ± 0.036	0.598HisGln: 0.598 ± 0.025	0.95HisArg: 0.95 ± 0.029	1.161HisSer: 1.161 ± 0.037	1.079HisThr: 1.079 ± 0.029	1.239HisVal: 1.239 ± 0.032	0.294HisTrp: 0.294 ± 0.014	1.003HisTyr: 1.003 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.169IleAla: 5.169 ± 0.072	1.01IleCys: 1.01 ± 0.032	4.71IleAsp: 4.71 ± 0.069	4.222IleGlu: 4.222 ± 0.068	2.42IlePhe: 2.42 ± 0.059	4.416IleGly: 4.416 ± 0.073	1.197IleHis: 1.197 ± 0.032	4.322IleIle: 4.322 ± 0.079	3.734IleLys: 3.734 ± 0.062	5.073IleLeu: 5.073 ± 0.078	1.631IleMet: 1.631 ± 0.046	3.313IleAsn: 3.313 ± 0.056	2.754IlePro: 2.754 ± 0.056	1.865IleGln: 1.865 ± 0.045	3.194IleArg: 3.194 ± 0.054	4.39IleSer: 4.39 ± 0.068	3.995IleThr: 3.995 ± 0.061	4.739IleVal: 4.739 ± 0.066	0.666IleTrp: 0.666 ± 0.023	2.56IleTyr: 2.56 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.202LysAla: 5.202 ± 0.074	0.692LysCys: 0.692 ± 0.025	3.725LysAsp: 3.725 ± 0.069	4.488LysGlu: 4.488 ± 0.079	2.048LysPhe: 2.048 ± 0.041	4.215LysGly: 4.215 ± 0.066	1.159LysHis: 1.159 ± 0.033	3.553LysIle: 3.553 ± 0.064	4.253LysLys: 4.253 ± 0.086	4.997LysLeu: 4.997 ± 0.066	2.076LysMet: 2.076 ± 0.045	2.977LysAsn: 2.977 ± 0.06	2.243LysPro: 2.243 ± 0.046	2.264LysGln: 2.264 ± 0.047	2.983LysArg: 2.983 ± 0.063	3.375LysSer: 3.375 ± 0.053	3.689LysThr: 3.689 ± 0.059	4.152LysVal: 4.152 ± 0.068	0.838LysTrp: 0.838 ± 0.028	2.822LysTyr: 2.822 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.799LeuAla: 6.799 ± 0.096	1.412LeuCys: 1.412 ± 0.039	4.873LeuAsp: 4.873 ± 0.069	4.336LeuGlu: 4.336 ± 0.075	3.852LeuPhe: 3.852 ± 0.073	5.432LeuGly: 5.432 ± 0.093	1.737LeuHis: 1.737 ± 0.051	4.533LeuIle: 4.533 ± 0.072	5.211LeuLys: 5.211 ± 0.082	8.015LeuLeu: 8.015 ± 0.114	2.536LeuMet: 2.536 ± 0.054	4.133LeuAsn: 4.133 ± 0.059	3.732LeuPro: 3.732 ± 0.058	3.118LeuGln: 3.118 ± 0.052	4.649LeuArg: 4.649 ± 0.075	6.43LeuSer: 6.43 ± 0.091	5.313LeuThr: 5.313 ± 0.08	5.222LeuVal: 5.222 ± 0.081	1.058LeuTrp: 1.058 ± 0.034	3.566LeuTyr: 3.566 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.627MetAla: 2.627 ± 0.055	0.325MetCys: 0.325 ± 0.017	1.617MetAsp: 1.617 ± 0.037	1.899MetGlu: 1.899 ± 0.044	1.096MetPhe: 1.096 ± 0.041	1.887MetGly: 1.887 ± 0.051	0.523MetHis: 0.523 ± 0.022	1.48MetIle: 1.48 ± 0.042	2.121MetLys: 2.121 ± 0.045	2.911MetLeu: 2.911 ± 0.055	1.014MetMet: 1.014 ± 0.034	1.468MetAsn: 1.468 ± 0.037	1.421MetPro: 1.421 ± 0.039	1.154MetGln: 1.154 ± 0.038	1.715MetArg: 1.715 ± 0.043	1.861MetSer: 1.861 ± 0.041	1.841MetThr: 1.841 ± 0.039	1.843MetVal: 1.843 ± 0.046	0.285MetTrp: 0.285 ± 0.017	0.88MetTyr: 0.88 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.889AsnAla: 3.889 ± 0.066	0.598AsnCys: 0.598 ± 0.022	2.961AsnAsp: 2.961 ± 0.059	2.79AsnGlu: 2.79 ± 0.051	1.938AsnPhe: 1.938 ± 0.044	4.381AsnGly: 4.381 ± 0.08	0.973AsnHis: 0.973 ± 0.031	4.006AsnIle: 4.006 ± 0.063	2.946AsnLys: 2.946 ± 0.049	3.896AsnLeu: 3.896 ± 0.07	1.367AsnMet: 1.367 ± 0.034	2.872AsnAsn: 2.872 ± 0.069	2.273AsnPro: 2.273 ± 0.051	1.418AsnGln: 1.418 ± 0.037	2.401AsnArg: 2.401 ± 0.045	3.06AsnSer: 3.06 ± 0.054	2.925AsnThr: 2.925 ± 0.065	3.436AsnVal: 3.436 ± 0.064	0.674AsnTrp: 0.674 ± 0.027	2.233AsnTyr: 2.233 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.62ProAla: 2.62 ± 0.057	0.45ProCys: 0.45 ± 0.02	2.646ProAsp: 2.646 ± 0.05	2.755ProGlu: 2.755 ± 0.061	1.619ProPhe: 1.619 ± 0.038	2.161ProGly: 2.161 ± 0.046	0.728ProHis: 0.728 ± 0.024	2.068ProIle: 2.068 ± 0.046	1.972ProLys: 1.972 ± 0.042	3.071ProLeu: 3.071 ± 0.052	0.992ProMet: 0.992 ± 0.03	1.573ProAsn: 1.573 ± 0.038	0.669ProPro: 0.669 ± 0.028	1.443ProGln: 1.443 ± 0.034	1.356ProArg: 1.356 ± 0.039	2.267ProSer: 2.267 ± 0.056	2.105ProThr: 2.105 ± 0.046	2.749ProVal: 2.749 ± 0.049	0.484ProTrp: 0.484 ± 0.02	1.597ProTyr: 1.597 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.515GlnAla: 2.515 ± 0.048	0.376GlnCys: 0.376 ± 0.019	1.665GlnAsp: 1.665 ± 0.041	2.048GlnGlu: 2.048 ± 0.048	1.26GlnPhe: 1.26 ± 0.031	2.094GlnGly: 2.094 ± 0.049	0.729GlnHis: 0.729 ± 0.026	2.183GlnIle: 2.183 ± 0.041	2.293GlnLys: 2.293 ± 0.043	3.275GlnLeu: 3.275 ± 0.06	1.246GlnMet: 1.246 ± 0.036	1.637GlnAsn: 1.637 ± 0.044	1.244GlnPro: 1.244 ± 0.035	1.758GlnGln: 1.758 ± 0.058	1.778GlnArg: 1.778 ± 0.05	1.923GlnSer: 1.923 ± 0.038	2.197GlnThr: 2.197 ± 0.049	1.93GlnVal: 1.93 ± 0.043	0.523GlnTrp: 0.523 ± 0.022	1.547GlnTyr: 1.547 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.839ArgAla: 2.839 ± 0.059	0.616ArgCys: 0.616 ± 0.025	2.468ArgAsp: 2.468 ± 0.046	2.975ArgGlu: 2.975 ± 0.068	2.099ArgPhe: 2.099 ± 0.044	2.69ArgGly: 2.69 ± 0.055	1.243ArgHis: 1.243 ± 0.037	3.491ArgIle: 3.491 ± 0.062	3.581ArgLys: 3.581 ± 0.06	4.715ArgLeu: 4.715 ± 0.076	1.822ArgMet: 1.822 ± 0.04	2.736ArgAsn: 2.736 ± 0.056	1.6ArgPro: 1.6 ± 0.038	2.266ArgGln: 2.266 ± 0.054	2.694ArgArg: 2.694 ± 0.054	2.439ArgSer: 2.439 ± 0.046	2.608ArgThr: 2.608 ± 0.051	2.712ArgVal: 2.712 ± 0.048	0.747ArgTrp: 0.747 ± 0.026	2.335ArgTyr: 2.335 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.601SerAla: 4.601 ± 0.07	0.888SerCys: 0.888 ± 0.031	3.714SerAsp: 3.714 ± 0.063	3.377SerGlu: 3.377 ± 0.056	3.026SerPhe: 3.026 ± 0.056	4.346SerGly: 4.346 ± 0.074	1.276SerHis: 1.276 ± 0.035	4.071SerIle: 4.071 ± 0.059	3.493SerLys: 3.493 ± 0.064	6.026SerLeu: 6.026 ± 0.087	1.735SerMet: 1.735 ± 0.046	2.839SerAsn: 2.839 ± 0.063	2.294SerPro: 2.294 ± 0.05	2.096SerGln: 2.096 ± 0.044	2.841SerArg: 2.841 ± 0.055	4.032SerSer: 4.032 ± 0.072	3.512SerThr: 3.512 ± 0.063	4.355SerVal: 4.355 ± 0.072	0.849SerTrp: 0.849 ± 0.029	2.694SerTyr: 2.694 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.75ThrAla: 4.75 ± 0.087	0.665ThrCys: 0.665 ± 0.027	3.873ThrAsp: 3.873 ± 0.06	3.339ThrGlu: 3.339 ± 0.058	2.741ThrPhe: 2.741 ± 0.05	4.327ThrGly: 4.327 ± 0.084	1.054ThrHis: 1.054 ± 0.032	4.468ThrIle: 4.468 ± 0.073	2.91ThrLys: 2.91 ± 0.054	5.537ThrLeu: 5.537 ± 0.082	1.53ThrMet: 1.53 ± 0.037	2.614ThrAsn: 2.614 ± 0.057	2.59ThrPro: 2.59 ± 0.046	1.699ThrGln: 1.699 ± 0.037	2.411ThrArg: 2.411 ± 0.046	3.649ThrSer: 3.649 ± 0.07	3.683ThrThr: 3.683 ± 0.08	4.286ThrVal: 4.286 ± 0.077	0.74ThrTrp: 0.74 ± 0.029	2.492ThrTyr: 2.492 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.325ValAla: 5.325 ± 0.084	1.11ValCys: 1.11 ± 0.032	4.102ValAsp: 4.102 ± 0.061	4.119ValGlu: 4.119 ± 0.065	2.802ValPhe: 2.802 ± 0.062	4.21ValGly: 4.21 ± 0.075	1.014ValHis: 1.014 ± 0.03	4.085ValIle: 4.085 ± 0.065	4.006ValLys: 4.006 ± 0.064	5.424ValLeu: 5.424 ± 0.081	1.971ValMet: 1.971 ± 0.044	3.386ValAsn: 3.386 ± 0.057	2.462ValPro: 2.462 ± 0.047	1.847ValGln: 1.847 ± 0.044	3.371ValArg: 3.371 ± 0.05	4.648ValSer: 4.648 ± 0.077	4.193ValThr: 4.193 ± 0.079	4.978ValVal: 4.978 ± 0.09	0.823ValTrp: 0.823 ± 0.028	2.7ValTyr: 2.7 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.831TrpAla: 0.831 ± 0.031	0.204TrpCys: 0.204 ± 0.013	0.767TrpAsp: 0.767 ± 0.029	0.685TrpGlu: 0.685 ± 0.025	0.57TrpPhe: 0.57 ± 0.023	0.91TrpGly: 0.91 ± 0.029	0.331TrpHis: 0.331 ± 0.016	0.773TrpIle: 0.773 ± 0.026	0.837TrpLys: 0.837 ± 0.029	1.274TrpLeu: 1.274 ± 0.038	0.476TrpMet: 0.476 ± 0.02	0.852TrpAsn: 0.852 ± 0.03	0.331TrpPro: 0.331 ± 0.018	0.63TrpGln: 0.63 ± 0.024	0.682TrpArg: 0.682 ± 0.021	0.764TrpSer: 0.764 ± 0.026	0.829TrpThr: 0.829 ± 0.033	0.687TrpVal: 0.687 ± 0.03	0.228TrpTrp: 0.228 ± 0.015	0.578TrpTyr: 0.578 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.152TyrAla: 3.152 ± 0.06	0.644TyrCys: 0.644 ± 0.024	2.94TyrAsp: 2.94 ± 0.062	2.429TyrGlu: 2.429 ± 0.052	1.84TyrPhe: 1.84 ± 0.04	3.005TyrGly: 3.005 ± 0.054	0.929TyrHis: 0.929 ± 0.032	2.79TyrIle: 2.79 ± 0.054	2.383TyrLys: 2.383 ± 0.052	3.49TyrLeu: 3.49 ± 0.063	1.144TyrMet: 1.144 ± 0.037	2.529TyrAsn: 2.529 ± 0.061	1.604TyrPro: 1.604 ± 0.042	1.418TyrGln: 1.418 ± 0.034	2.349TyrArg: 2.349 ± 0.049	2.85TyrSer: 2.85 ± 0.062	2.636TyrThr: 2.636 ± 0.06	2.703TyrVal: 2.703 ± 0.053	0.57TyrTrp: 0.57 ± 0.02	2.153TyrTyr: 2.153 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3001 proteins (1114468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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