Amino acid dipepetide frequency for Sinorhizobium phage phi2LM21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.29AlaAla: 15.29 ± 1.231
1.166AlaCys: 1.166 ± 0.283
6.925AlaAsp: 6.925 ± 0.719
7.199AlaGlu: 7.199 ± 0.786
4.525AlaPhe: 4.525 ± 0.525
9.667AlaGly: 9.667 ± 0.909
1.714AlaHis: 1.714 ± 0.329
5.622AlaIle: 5.622 ± 0.593
5.005AlaLys: 5.005 ± 0.591
9.736AlaLeu: 9.736 ± 0.83
2.948AlaMet: 2.948 ± 0.452
3.222AlaAsn: 3.222 ± 0.425
4.799AlaPro: 4.799 ± 0.641
2.88AlaGln: 2.88 ± 0.458
9.119AlaArg: 9.119 ± 0.676
6.376AlaSer: 6.376 ± 0.719
5.896AlaThr: 5.896 ± 0.562
7.268AlaVal: 7.268 ± 0.757
1.166AlaTrp: 1.166 ± 0.285
2.743AlaTyr: 2.743 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
1.44CysAla: 1.44 ± 0.308
0.069CysCys: 0.069 ± 0.07
0.754CysAsp: 0.754 ± 0.206
0.891CysGlu: 0.891 ± 0.257
0.411CysPhe: 0.411 ± 0.152
1.166CysGly: 1.166 ± 0.324
0.206CysHis: 0.206 ± 0.106
0.48CysIle: 0.48 ± 0.156
0.411CysLys: 0.411 ± 0.136
0.96CysLeu: 0.96 ± 0.252
0.206CysMet: 0.206 ± 0.112
0.274CysAsn: 0.274 ± 0.115
0.411CysPro: 0.411 ± 0.162
0.343CysGln: 0.343 ± 0.154
0.823CysArg: 0.823 ± 0.249
0.754CysSer: 0.754 ± 0.244
0.137CysThr: 0.137 ± 0.093
0.891CysVal: 0.891 ± 0.244
0.274CysTrp: 0.274 ± 0.127
0.274CysTyr: 0.274 ± 0.113
0.0CysXaa: 0.0 ± 0.0
Asp
6.376AspAla: 6.376 ± 0.615
0.891AspCys: 0.891 ± 0.293
3.908AspAsp: 3.908 ± 0.401
4.594AspGlu: 4.594 ± 0.644
2.057AspPhe: 2.057 ± 0.29
6.171AspGly: 6.171 ± 0.684
1.303AspHis: 1.303 ± 0.341
3.085AspIle: 3.085 ± 0.518
2.743AspLys: 2.743 ± 0.496
3.771AspLeu: 3.771 ± 0.547
1.234AspMet: 1.234 ± 0.347
1.851AspAsn: 1.851 ± 0.4
3.977AspPro: 3.977 ± 0.447
2.057AspGln: 2.057 ± 0.382
4.731AspArg: 4.731 ± 0.702
3.017AspSer: 3.017 ± 0.56
2.263AspThr: 2.263 ± 0.425
5.417AspVal: 5.417 ± 0.67
1.166AspTrp: 1.166 ± 0.332
1.783AspTyr: 1.783 ± 0.289
0.0AspXaa: 0.0 ± 0.0
Glu
7.542GluAla: 7.542 ± 0.775
0.549GluCys: 0.549 ± 0.218
3.291GluAsp: 3.291 ± 0.57
4.045GluGlu: 4.045 ± 0.606
2.674GluPhe: 2.674 ± 0.404
4.045GluGly: 4.045 ± 0.45
1.44GluHis: 1.44 ± 0.35
4.045GluIle: 4.045 ± 0.519
2.948GluLys: 2.948 ± 0.481
6.719GluLeu: 6.719 ± 0.702
1.371GluMet: 1.371 ± 0.245
1.92GluAsn: 1.92 ± 0.371
2.537GluPro: 2.537 ± 0.453
3.222GluGln: 3.222 ± 0.428
6.034GluArg: 6.034 ± 0.682
2.605GluSer: 2.605 ± 0.307
2.537GluThr: 2.537 ± 0.432
5.211GluVal: 5.211 ± 0.751
1.303GluTrp: 1.303 ± 0.34
1.028GluTyr: 1.028 ± 0.258
0.0GluXaa: 0.0 ± 0.0
Phe
3.908PheAla: 3.908 ± 0.56
0.137PheCys: 0.137 ± 0.093
4.182PheAsp: 4.182 ± 0.65
2.674PheGlu: 2.674 ± 0.471
1.028PhePhe: 1.028 ± 0.337
3.565PheGly: 3.565 ± 0.446
0.617PheHis: 0.617 ± 0.27
0.686PheIle: 0.686 ± 0.163
1.92PheLys: 1.92 ± 0.376
2.743PheLeu: 2.743 ± 0.392
0.823PheMet: 0.823 ± 0.227
1.714PheAsn: 1.714 ± 0.407
1.234PhePro: 1.234 ± 0.281
1.166PheGln: 1.166 ± 0.283
1.851PheArg: 1.851 ± 0.364
2.948PheSer: 2.948 ± 0.422
2.263PheThr: 2.263 ± 0.364
2.468PheVal: 2.468 ± 0.405
0.411PheTrp: 0.411 ± 0.176
1.028PheTyr: 1.028 ± 0.32
0.0PheXaa: 0.0 ± 0.0
Gly
9.188GlyAla: 9.188 ± 0.762
1.028GlyCys: 1.028 ± 0.238
3.977GlyAsp: 3.977 ± 0.538
5.348GlyGlu: 5.348 ± 0.657
3.36GlyPhe: 3.36 ± 0.396
8.502GlyGly: 8.502 ± 1.106
1.577GlyHis: 1.577 ± 0.34
2.331GlyIle: 2.331 ± 0.375
4.594GlyLys: 4.594 ± 0.725
6.102GlyLeu: 6.102 ± 0.818
2.468GlyMet: 2.468 ± 0.43
3.085GlyAsn: 3.085 ± 0.487
2.948GlyPro: 2.948 ± 0.381
3.291GlyGln: 3.291 ± 0.453
6.856GlyArg: 6.856 ± 0.571
4.251GlySer: 4.251 ± 0.669
3.908GlyThr: 3.908 ± 0.481
5.348GlyVal: 5.348 ± 0.572
1.714GlyTrp: 1.714 ± 0.344
2.605GlyTyr: 2.605 ± 0.357
0.0GlyXaa: 0.0 ± 0.0
His
1.783HisAla: 1.783 ± 0.337
0.274HisCys: 0.274 ± 0.137
1.028HisAsp: 1.028 ± 0.261
0.96HisGlu: 0.96 ± 0.208
1.097HisPhe: 1.097 ± 0.23
1.714HisGly: 1.714 ± 0.307
0.206HisHis: 0.206 ± 0.111
0.96HisIle: 0.96 ± 0.294
0.48HisLys: 0.48 ± 0.194
2.057HisLeu: 2.057 ± 0.355
0.206HisMet: 0.206 ± 0.15
0.274HisAsn: 0.274 ± 0.137
1.646HisPro: 1.646 ± 0.377
0.411HisGln: 0.411 ± 0.152
1.234HisArg: 1.234 ± 0.265
0.686HisSer: 0.686 ± 0.205
1.028HisThr: 1.028 ± 0.202
1.097HisVal: 1.097 ± 0.309
0.686HisTrp: 0.686 ± 0.202
0.343HisTyr: 0.343 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
5.759IleAla: 5.759 ± 0.666
0.686IleCys: 0.686 ± 0.236
3.977IleAsp: 3.977 ± 0.502
4.594IleGlu: 4.594 ± 0.535
1.234IlePhe: 1.234 ± 0.173
4.251IleGly: 4.251 ± 0.374
0.96IleHis: 0.96 ± 0.228
2.674IleIle: 2.674 ± 0.418
2.331IleLys: 2.331 ± 0.361
3.497IleLeu: 3.497 ± 0.456
1.234IleMet: 1.234 ± 0.337
1.714IleAsn: 1.714 ± 0.324
1.92IlePro: 1.92 ± 0.303
1.166IleGln: 1.166 ± 0.286
3.291IleArg: 3.291 ± 0.459
2.88IleSer: 2.88 ± 0.437
2.948IleThr: 2.948 ± 0.426
3.497IleVal: 3.497 ± 0.422
0.823IleTrp: 0.823 ± 0.161
1.097IleTyr: 1.097 ± 0.291
0.0IleXaa: 0.0 ± 0.0
Lys
6.308LysAla: 6.308 ± 0.755
0.411LysCys: 0.411 ± 0.172
1.851LysAsp: 1.851 ± 0.403
2.674LysGlu: 2.674 ± 0.511
1.851LysPhe: 1.851 ± 0.347
4.182LysGly: 4.182 ± 0.512
0.754LysHis: 0.754 ± 0.185
2.331LysIle: 2.331 ± 0.468
1.851LysLys: 1.851 ± 0.351
4.182LysLeu: 4.182 ± 0.606
1.028LysMet: 1.028 ± 0.284
1.166LysAsn: 1.166 ± 0.279
2.468LysPro: 2.468 ± 0.422
2.057LysGln: 2.057 ± 0.306
2.743LysArg: 2.743 ± 0.49
2.468LysSer: 2.468 ± 0.379
2.743LysThr: 2.743 ± 0.442
2.605LysVal: 2.605 ± 0.35
1.166LysTrp: 1.166 ± 0.246
1.234LysTyr: 1.234 ± 0.259
0.0LysXaa: 0.0 ± 0.0
Leu
9.53LeuAla: 9.53 ± 0.958
1.028LeuCys: 1.028 ± 0.274
5.005LeuAsp: 5.005 ± 0.533
4.457LeuGlu: 4.457 ± 0.656
2.605LeuPhe: 2.605 ± 0.335
6.788LeuGly: 6.788 ± 0.742
0.823LeuHis: 0.823 ± 0.206
4.32LeuIle: 4.32 ± 0.59
3.565LeuLys: 3.565 ± 0.498
6.034LeuLeu: 6.034 ± 0.91
1.234LeuMet: 1.234 ± 0.254
3.497LeuAsn: 3.497 ± 0.695
4.251LeuPro: 4.251 ± 0.607
3.702LeuGln: 3.702 ± 0.544
6.445LeuArg: 6.445 ± 0.537
5.005LeuSer: 5.005 ± 0.675
5.211LeuThr: 5.211 ± 0.548
5.142LeuVal: 5.142 ± 0.481
0.891LeuTrp: 0.891 ± 0.276
1.851LeuTyr: 1.851 ± 0.337
0.0LeuXaa: 0.0 ± 0.0
Met
3.017MetAla: 3.017 ± 0.356
0.206MetCys: 0.206 ± 0.112
1.166MetAsp: 1.166 ± 0.292
1.714MetGlu: 1.714 ± 0.339
0.617MetPhe: 0.617 ± 0.21
1.166MetGly: 1.166 ± 0.263
0.411MetHis: 0.411 ± 0.214
1.234MetIle: 1.234 ± 0.256
0.823MetLys: 0.823 ± 0.232
1.851MetLeu: 1.851 ± 0.282
0.48MetMet: 0.48 ± 0.172
0.823MetAsn: 0.823 ± 0.226
1.44MetPro: 1.44 ± 0.292
0.823MetGln: 0.823 ± 0.246
1.851MetArg: 1.851 ± 0.392
2.4MetSer: 2.4 ± 0.43
1.851MetThr: 1.851 ± 0.334
1.166MetVal: 1.166 ± 0.371
0.343MetTrp: 0.343 ± 0.157
0.343MetTyr: 0.343 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
2.537AsnAla: 2.537 ± 0.396
0.137AsnCys: 0.137 ± 0.083
2.194AsnAsp: 2.194 ± 0.38
2.057AsnGlu: 2.057 ± 0.398
0.823AsnPhe: 0.823 ± 0.248
3.634AsnGly: 3.634 ± 0.529
0.96AsnHis: 0.96 ± 0.262
2.057AsnIle: 2.057 ± 0.37
1.44AsnLys: 1.44 ± 0.304
2.811AsnLeu: 2.811 ± 0.486
0.823AsnMet: 0.823 ± 0.21
1.028AsnAsn: 1.028 ± 0.297
2.605AsnPro: 2.605 ± 0.36
1.234AsnGln: 1.234 ± 0.273
2.331AsnArg: 2.331 ± 0.38
1.234AsnSer: 1.234 ± 0.346
1.097AsnThr: 1.097 ± 0.325
1.714AsnVal: 1.714 ± 0.33
0.549AsnTrp: 0.549 ± 0.205
1.097AsnTyr: 1.097 ± 0.261
0.0AsnXaa: 0.0 ± 0.0
Pro
5.485ProAla: 5.485 ± 0.79
0.823ProCys: 0.823 ± 0.241
3.36ProAsp: 3.36 ± 0.613
4.114ProGlu: 4.114 ± 0.693
1.851ProPhe: 1.851 ± 0.411
4.251ProGly: 4.251 ± 0.585
0.686ProHis: 0.686 ± 0.222
2.811ProIle: 2.811 ± 0.411
2.537ProLys: 2.537 ± 0.447
3.017ProLeu: 3.017 ± 0.46
1.234ProMet: 1.234 ± 0.277
1.508ProAsn: 1.508 ± 0.313
2.811ProPro: 2.811 ± 0.526
1.714ProGln: 1.714 ± 0.298
2.468ProArg: 2.468 ± 0.469
3.085ProSer: 3.085 ± 0.374
2.811ProThr: 2.811 ± 0.428
3.154ProVal: 3.154 ± 0.414
0.617ProTrp: 0.617 ± 0.196
1.508ProTyr: 1.508 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
3.565GlnAla: 3.565 ± 0.465
0.274GlnCys: 0.274 ± 0.174
1.44GlnAsp: 1.44 ± 0.263
1.851GlnGlu: 1.851 ± 0.359
1.234GlnPhe: 1.234 ± 0.33
2.948GlnGly: 2.948 ± 0.409
0.549GlnHis: 0.549 ± 0.177
2.674GlnIle: 2.674 ± 0.428
1.714GlnLys: 1.714 ± 0.315
3.702GlnLeu: 3.702 ± 0.452
1.028GlnMet: 1.028 ± 0.202
1.714GlnAsn: 1.714 ± 0.315
1.371GlnPro: 1.371 ± 0.28
2.4GlnGln: 2.4 ± 0.399
2.88GlnArg: 2.88 ± 0.303
1.988GlnSer: 1.988 ± 0.314
2.263GlnThr: 2.263 ± 0.435
2.4GlnVal: 2.4 ± 0.427
0.411GlnTrp: 0.411 ± 0.14
0.686GlnTyr: 0.686 ± 0.183
0.0GlnXaa: 0.0 ± 0.0
Arg
7.679ArgAla: 7.679 ± 0.799
0.96ArgCys: 0.96 ± 0.184
5.279ArgAsp: 5.279 ± 0.543
5.074ArgGlu: 5.074 ± 0.52
2.743ArgPhe: 2.743 ± 0.539
4.937ArgGly: 4.937 ± 0.515
1.234ArgHis: 1.234 ± 0.243
3.565ArgIle: 3.565 ± 0.676
3.565ArgLys: 3.565 ± 0.633
6.582ArgLeu: 6.582 ± 0.696
2.057ArgMet: 2.057 ± 0.367
2.057ArgAsn: 2.057 ± 0.351
3.908ArgPro: 3.908 ± 0.558
2.743ArgGln: 2.743 ± 0.377
6.514ArgArg: 6.514 ± 0.644
3.634ArgSer: 3.634 ± 0.451
2.948ArgThr: 2.948 ± 0.386
5.074ArgVal: 5.074 ± 0.52
1.646ArgTrp: 1.646 ± 0.336
1.783ArgTyr: 1.783 ± 0.306
0.0ArgXaa: 0.0 ± 0.0
Ser
6.788SerAla: 6.788 ± 0.723
0.343SerCys: 0.343 ± 0.131
3.702SerAsp: 3.702 ± 0.493
3.497SerGlu: 3.497 ± 0.538
2.674SerPhe: 2.674 ± 0.474
4.662SerGly: 4.662 ± 0.716
1.097SerHis: 1.097 ± 0.214
2.537SerIle: 2.537 ± 0.454
3.222SerLys: 3.222 ± 0.502
4.937SerLeu: 4.937 ± 0.58
1.783SerMet: 1.783 ± 0.398
1.577SerAsn: 1.577 ± 0.364
2.263SerPro: 2.263 ± 0.37
2.331SerGln: 2.331 ± 0.344
3.977SerArg: 3.977 ± 0.416
2.811SerSer: 2.811 ± 0.447
2.948SerThr: 2.948 ± 0.411
2.948SerVal: 2.948 ± 0.447
0.549SerTrp: 0.549 ± 0.181
1.646SerTyr: 1.646 ± 0.333
0.0SerXaa: 0.0 ± 0.0
Thr
5.759ThrAla: 5.759 ± 0.758
0.48ThrCys: 0.48 ± 0.182
2.88ThrAsp: 2.88 ± 0.32
3.222ThrGlu: 3.222 ± 0.44
1.92ThrPhe: 1.92 ± 0.395
4.32ThrGly: 4.32 ± 0.595
0.823ThrHis: 0.823 ± 0.229
3.702ThrIle: 3.702 ± 0.515
2.194ThrLys: 2.194 ± 0.404
4.182ThrLeu: 4.182 ± 0.509
1.097ThrMet: 1.097 ± 0.228
1.508ThrAsn: 1.508 ± 0.305
3.085ThrPro: 3.085 ± 0.436
1.44ThrGln: 1.44 ± 0.311
2.605ThrArg: 2.605 ± 0.445
3.085ThrSer: 3.085 ± 0.446
1.988ThrThr: 1.988 ± 0.336
3.908ThrVal: 3.908 ± 0.487
0.891ThrTrp: 0.891 ± 0.22
1.646ThrTyr: 1.646 ± 0.294
0.0ThrXaa: 0.0 ± 0.0
Val
7.748ValAla: 7.748 ± 0.763
0.754ValCys: 0.754 ± 0.192
5.279ValAsp: 5.279 ± 0.597
3.977ValGlu: 3.977 ± 0.51
2.605ValPhe: 2.605 ± 0.329
3.908ValGly: 3.908 ± 0.471
1.646ValHis: 1.646 ± 0.288
3.771ValIle: 3.771 ± 0.482
2.88ValLys: 2.88 ± 0.4
4.868ValLeu: 4.868 ± 0.686
1.646ValMet: 1.646 ± 0.317
1.988ValAsn: 1.988 ± 0.466
3.222ValPro: 3.222 ± 0.452
2.194ValGln: 2.194 ± 0.435
4.457ValArg: 4.457 ± 0.482
4.594ValSer: 4.594 ± 0.601
3.291ValThr: 3.291 ± 0.515
4.457ValVal: 4.457 ± 0.548
1.646ValTrp: 1.646 ± 0.351
1.371ValTyr: 1.371 ± 0.304
0.0ValXaa: 0.0 ± 0.0
Trp
0.96TrpAla: 0.96 ± 0.221
0.686TrpCys: 0.686 ± 0.213
0.754TrpAsp: 0.754 ± 0.217
0.754TrpGlu: 0.754 ± 0.265
0.823TrpPhe: 0.823 ± 0.238
0.754TrpGly: 0.754 ± 0.169
0.549TrpHis: 0.549 ± 0.21
0.891TrpIle: 0.891 ± 0.258
0.823TrpLys: 0.823 ± 0.186
1.577TrpLeu: 1.577 ± 0.353
0.411TrpMet: 0.411 ± 0.178
0.617TrpAsn: 0.617 ± 0.204
1.303TrpPro: 1.303 ± 0.402
0.96TrpGln: 0.96 ± 0.248
1.371TrpArg: 1.371 ± 0.379
0.96TrpSer: 0.96 ± 0.198
1.371TrpThr: 1.371 ± 0.306
0.754TrpVal: 0.754 ± 0.261
0.069TrpTrp: 0.069 ± 0.067
0.274TrpTyr: 0.274 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.674TyrAla: 2.674 ± 0.403
0.274TyrCys: 0.274 ± 0.127
1.44TyrAsp: 1.44 ± 0.37
1.371TyrGlu: 1.371 ± 0.295
1.234TyrPhe: 1.234 ± 0.318
1.851TyrGly: 1.851 ± 0.282
0.617TyrHis: 0.617 ± 0.179
0.754TyrIle: 0.754 ± 0.201
1.028TyrLys: 1.028 ± 0.238
2.057TyrLeu: 2.057 ± 0.345
0.343TyrMet: 0.343 ± 0.117
0.823TyrAsn: 0.823 ± 0.322
1.646TyrPro: 1.646 ± 0.321
0.96TyrGln: 0.96 ± 0.22
2.4TyrArg: 2.4 ± 0.409
1.508TyrSer: 1.508 ± 0.258
1.234TyrThr: 1.234 ± 0.212
1.783TyrVal: 1.783 ± 0.367
0.343TyrTrp: 0.343 ± 0.135
0.754TyrTyr: 0.754 ± 0.314
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (14586 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski