Amino acid dipepetide frequency for Psychrobacillus insolitus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.438AlaAla: 5.438 ± 0.103	0.573AlaCys: 0.573 ± 0.027	3.349AlaAsp: 3.349 ± 0.072	4.626AlaGlu: 4.626 ± 0.076	3.356AlaPhe: 3.356 ± 0.064	5.151AlaGly: 5.151 ± 0.076	1.329AlaHis: 1.329 ± 0.036	6.551AlaIle: 6.551 ± 0.106	4.672AlaLys: 4.672 ± 0.077	7.092AlaLeu: 7.092 ± 0.093	2.009AlaMet: 2.009 ± 0.043	2.869AlaAsn: 2.869 ± 0.06	2.054AlaPro: 2.054 ± 0.061	2.254AlaGln: 2.254 ± 0.055	2.565AlaArg: 2.565 ± 0.07	4.181AlaSer: 4.181 ± 0.074	3.886AlaThr: 3.886 ± 0.073	5.218AlaVal: 5.218 ± 0.091	0.557AlaTrp: 0.557 ± 0.023	2.348AlaTyr: 2.348 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.417CysAla: 0.417 ± 0.022	0.079CysCys: 0.079 ± 0.01	0.33CysAsp: 0.33 ± 0.02	0.426CysGlu: 0.426 ± 0.024	0.264CysPhe: 0.264 ± 0.019	0.628CysGly: 0.628 ± 0.029	0.164CysHis: 0.164 ± 0.013	0.52CysIle: 0.52 ± 0.023	0.314CysLys: 0.314 ± 0.021	0.573CysLeu: 0.573 ± 0.028	0.162CysMet: 0.162 ± 0.013	0.277CysAsn: 0.277 ± 0.018	0.326CysPro: 0.326 ± 0.023	0.201CysGln: 0.201 ± 0.014	0.246CysArg: 0.246 ± 0.016	0.465CysSer: 0.465 ± 0.022	0.379CysThr: 0.379 ± 0.021	0.417CysVal: 0.417 ± 0.022	0.047CysTrp: 0.047 ± 0.006	0.215CysTyr: 0.215 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.6AspAla: 3.6 ± 0.065	0.324AspCys: 0.324 ± 0.022	2.346AspAsp: 2.346 ± 0.067	4.478AspGlu: 4.478 ± 0.075	2.559AspPhe: 2.559 ± 0.058	3.388AspGly: 3.388 ± 0.072	1.033AspHis: 1.033 ± 0.033	4.18AspIle: 4.18 ± 0.079	2.942AspLys: 2.942 ± 0.058	4.899AspLeu: 4.899 ± 0.087	1.318AspMet: 1.318 ± 0.035	1.797AspAsn: 1.797 ± 0.047	1.734AspPro: 1.734 ± 0.044	1.877AspGln: 1.877 ± 0.048	1.967AspArg: 1.967 ± 0.051	2.686AspSer: 2.686 ± 0.055	2.487AspThr: 2.487 ± 0.06	3.888AspVal: 3.888 ± 0.07	0.561AspTrp: 0.561 ± 0.03	1.991AspTyr: 1.991 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.295GluAla: 5.295 ± 0.084	0.372GluCys: 0.372 ± 0.021	3.866GluAsp: 3.866 ± 0.078	7.254GluGlu: 7.254 ± 0.126	2.692GluPhe: 2.692 ± 0.057	4.189GluGly: 4.189 ± 0.083	1.451GluHis: 1.451 ± 0.045	6.168GluIle: 6.168 ± 0.1	6.481GluLys: 6.481 ± 0.093	7.403GluLeu: 7.403 ± 0.106	2.408GluMet: 2.408 ± 0.054	3.792GluAsn: 3.792 ± 0.065	1.903GluPro: 1.903 ± 0.045	3.599GluGln: 3.599 ± 0.069	3.231GluArg: 3.231 ± 0.064	3.826GluSer: 3.826 ± 0.064	4.062GluThr: 4.062 ± 0.066	5.674GluVal: 5.674 ± 0.089	0.834GluTrp: 0.834 ± 0.037	2.159GluTyr: 2.159 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.079PheAla: 3.079 ± 0.069	0.312PheCys: 0.312 ± 0.019	2.372PheAsp: 2.372 ± 0.055	3.185PheGlu: 3.185 ± 0.063	2.337PhePhe: 2.337 ± 0.067	3.441PheGly: 3.441 ± 0.069	0.944PheHis: 0.944 ± 0.032	3.985PheIle: 3.985 ± 0.081	2.376PheLys: 2.376 ± 0.052	4.516PheLeu: 4.516 ± 0.095	1.211PheMet: 1.211 ± 0.038	1.922PheAsn: 1.922 ± 0.047	1.659PhePro: 1.659 ± 0.043	1.609PheGln: 1.609 ± 0.045	1.378PheArg: 1.378 ± 0.045	3.219PheSer: 3.219 ± 0.061	2.786PheThr: 2.786 ± 0.058	3.428PheVal: 3.428 ± 0.066	0.48PheTrp: 0.48 ± 0.026	1.673PheTyr: 1.673 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.938GlyAla: 4.938 ± 0.104	0.521GlyCys: 0.521 ± 0.026	3.143GlyAsp: 3.143 ± 0.07	4.478GlyGlu: 4.478 ± 0.072	3.417GlyPhe: 3.417 ± 0.066	4.503GlyGly: 4.503 ± 0.093	1.349GlyHis: 1.349 ± 0.045	6.163GlyIle: 6.163 ± 0.089	4.936GlyLys: 4.936 ± 0.09	6.347GlyLeu: 6.347 ± 0.098	1.994GlyMet: 1.994 ± 0.048	2.767GlyAsn: 2.767 ± 0.051	1.674GlyPro: 1.674 ± 0.042	2.216GlyGln: 2.216 ± 0.064	2.466GlyArg: 2.466 ± 0.058	3.89GlySer: 3.89 ± 0.072	3.964GlyThr: 3.964 ± 0.067	4.939GlyVal: 4.939 ± 0.085	0.706GlyTrp: 0.706 ± 0.034	2.714GlyTyr: 2.714 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.322HisAla: 1.322 ± 0.04	0.164HisCys: 0.164 ± 0.014	0.927HisAsp: 0.927 ± 0.034	1.423HisGlu: 1.423 ± 0.042	0.961HisPhe: 0.961 ± 0.033	1.353HisGly: 1.353 ± 0.038	0.554HisHis: 0.554 ± 0.03	1.614HisIle: 1.614 ± 0.042	1.025HisLys: 1.025 ± 0.032	2.072HisLeu: 2.072 ± 0.048	0.512HisMet: 0.512 ± 0.022	0.721HisAsn: 0.721 ± 0.031	1.045HisPro: 1.045 ± 0.035	0.775HisGln: 0.775 ± 0.027	0.784HisArg: 0.784 ± 0.028	1.159HisSer: 1.159 ± 0.03	1.08HisThr: 1.08 ± 0.039	1.416HisVal: 1.416 ± 0.045	0.161HisTrp: 0.161 ± 0.013	0.793HisTyr: 0.793 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.514IleAla: 6.514 ± 0.086	0.623IleCys: 0.623 ± 0.027	4.593IleAsp: 4.593 ± 0.074	6.39IleGlu: 6.39 ± 0.087	3.431IlePhe: 3.431 ± 0.074	6.234IleGly: 6.234 ± 0.1	1.782IleHis: 1.782 ± 0.046	6.781IleIle: 6.781 ± 0.12	4.492IleLys: 4.492 ± 0.068	7.635IleLeu: 7.635 ± 0.13	1.903IleMet: 1.903 ± 0.05	3.255IleAsn: 3.255 ± 0.065	3.525IlePro: 3.525 ± 0.067	3.243IleGln: 3.243 ± 0.063	3.116IleArg: 3.116 ± 0.063	5.507IleSer: 5.507 ± 0.087	4.654IleThr: 4.654 ± 0.08	6.264IleVal: 6.264 ± 0.093	0.66IleTrp: 0.66 ± 0.031	2.374IleTyr: 2.374 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.08	0.29LysCys: 0.29 ± 0.017	3.621LysAsp: 3.621 ± 0.068	6.758LysGlu: 6.758 ± 0.112	2.167LysPhe: 2.167 ± 0.048	4.14LysGly: 4.14 ± 0.069	1.178LysHis: 1.178 ± 0.038	4.842LysIle: 4.842 ± 0.079	5.796LysLys: 5.796 ± 0.083	5.991LysLeu: 5.991 ± 0.084	2.382LysMet: 2.382 ± 0.055	3.379LysAsn: 3.379 ± 0.059	2.077LysPro: 2.077 ± 0.05	2.905LysGln: 2.905 ± 0.062	3.01LysArg: 3.01 ± 0.062	3.654LysSer: 3.654 ± 0.067	3.658LysThr: 3.658 ± 0.075	4.905LysVal: 4.905 ± 0.079	0.86LysTrp: 0.86 ± 0.031	2.15LysTyr: 2.15 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.288LeuAla: 7.288 ± 0.098	0.624LeuCys: 0.624 ± 0.034	4.695LeuAsp: 4.695 ± 0.071	6.993LeuGlu: 6.993 ± 0.108	4.976LeuPhe: 4.976 ± 0.097	6.271LeuGly: 6.271 ± 0.091	1.887LeuHis: 1.887 ± 0.052	7.491LeuIle: 7.491 ± 0.115	6.416LeuLys: 6.416 ± 0.092	10.253LeuLeu: 10.253 ± 0.152	2.521LeuMet: 2.521 ± 0.056	4.283LeuAsn: 4.283 ± 0.066	3.713LeuPro: 3.713 ± 0.069	3.754LeuGln: 3.754 ± 0.067	3.419LeuArg: 3.419 ± 0.062	6.653LeuSer: 6.653 ± 0.082	5.785LeuThr: 5.785 ± 0.088	6.724LeuVal: 6.724 ± 0.085	0.746LeuTrp: 0.746 ± 0.031	3.025LeuTyr: 3.025 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.848MetAla: 1.848 ± 0.046	0.143MetCys: 0.143 ± 0.014	1.571MetAsp: 1.571 ± 0.041	2.103MetGlu: 2.103 ± 0.045	1.02MetPhe: 1.02 ± 0.037	1.759MetGly: 1.759 ± 0.049	0.523MetHis: 0.523 ± 0.026	2.154MetIle: 2.154 ± 0.053	2.529MetLys: 2.529 ± 0.05	2.541MetLeu: 2.541 ± 0.059	0.824MetMet: 0.824 ± 0.03	1.619MetAsn: 1.619 ± 0.046	0.99MetPro: 0.99 ± 0.033	1.068MetGln: 1.068 ± 0.036	1.02MetArg: 1.02 ± 0.035	1.755MetSer: 1.755 ± 0.044	1.877MetThr: 1.877 ± 0.049	1.633MetVal: 1.633 ± 0.044	0.19MetTrp: 0.19 ± 0.015	0.841MetTyr: 0.841 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.93AsnAla: 2.93 ± 0.055	0.289AsnCys: 0.289 ± 0.015	2.262AsnAsp: 2.262 ± 0.052	3.646AsnGlu: 3.646 ± 0.077	1.779AsnPhe: 1.779 ± 0.047	3.18AsnGly: 3.18 ± 0.055	0.962AsnHis: 0.962 ± 0.03	3.539AsnIle: 3.539 ± 0.066	2.984AsnLys: 2.984 ± 0.067	3.89AsnLeu: 3.89 ± 0.071	1.236AsnMet: 1.236 ± 0.04	2.113AsnAsn: 2.113 ± 0.059	2.061AsnPro: 2.061 ± 0.047	1.64AsnGln: 1.64 ± 0.047	1.956AsnArg: 1.956 ± 0.047	2.578AsnSer: 2.578 ± 0.06	2.397AsnThr: 2.397 ± 0.05	3.084AsnVal: 3.084 ± 0.05	0.492AsnTrp: 0.492 ± 0.024	1.561AsnTyr: 1.561 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.065ProAla: 2.065 ± 0.052	0.206ProCys: 0.206 ± 0.014	1.719ProAsp: 1.719 ± 0.045	2.714ProGlu: 2.714 ± 0.065	1.927ProPhe: 1.927 ± 0.054	2.127ProGly: 2.127 ± 0.056	0.692ProHis: 0.692 ± 0.027	2.979ProIle: 2.979 ± 0.055	2.167ProLys: 2.167 ± 0.054	3.32ProLeu: 3.32 ± 0.062	0.906ProMet: 0.906 ± 0.031	1.716ProAsn: 1.716 ± 0.046	0.864ProPro: 0.864 ± 0.035	1.078ProGln: 1.078 ± 0.04	1.04ProArg: 1.04 ± 0.03	2.225ProSer: 2.225 ± 0.052	2.183ProThr: 2.183 ± 0.047	2.795ProVal: 2.795 ± 0.069	0.32ProTrp: 0.32 ± 0.021	1.286ProTyr: 1.286 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.788GlnAla: 2.788 ± 0.058	0.164GlnCys: 0.164 ± 0.014	1.632GlnAsp: 1.632 ± 0.044	2.769GlnGlu: 2.769 ± 0.058	1.66GlnPhe: 1.66 ± 0.046	2.081GlnGly: 2.081 ± 0.056	0.74GlnHis: 0.74 ± 0.027	2.747GlnIle: 2.747 ± 0.062	2.756GlnLys: 2.756 ± 0.058	4.158GlnLeu: 4.158 ± 0.08	1.134GlnMet: 1.134 ± 0.038	1.626GlnAsn: 1.626 ± 0.043	1.077GlnPro: 1.077 ± 0.041	1.763GlnGln: 1.763 ± 0.051	1.32GlnArg: 1.32 ± 0.036	2.276GlnSer: 2.276 ± 0.061	2.096GlnThr: 2.096 ± 0.05	2.652GlnVal: 2.652 ± 0.051	0.322GlnTrp: 0.322 ± 0.021	1.226GlnTyr: 1.226 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.44ArgAla: 2.44 ± 0.055	0.189ArgCys: 0.189 ± 0.014	1.934ArgAsp: 1.934 ± 0.045	2.884ArgGlu: 2.884 ± 0.059	1.771ArgPhe: 1.771 ± 0.042	2.274ArgGly: 2.274 ± 0.051	0.725ArgHis: 0.725 ± 0.029	3.062ArgIle: 3.062 ± 0.053	2.986ArgLys: 2.986 ± 0.05	3.776ArgLeu: 3.776 ± 0.075	1.188ArgMet: 1.188 ± 0.036	1.818ArgAsn: 1.818 ± 0.045	1.212ArgPro: 1.212 ± 0.042	1.411ArgGln: 1.411 ± 0.04	1.525ArgArg: 1.525 ± 0.045	2.033ArgSer: 2.033 ± 0.043	1.983ArgThr: 1.983 ± 0.042	2.67ArgVal: 2.67 ± 0.05	0.313ArgTrp: 0.313 ± 0.02	1.327ArgTyr: 1.327 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.823SerAla: 3.823 ± 0.077	0.34SerCys: 0.34 ± 0.019	2.815SerAsp: 2.815 ± 0.049	4.114SerGlu: 4.114 ± 0.06	3.335SerPhe: 3.335 ± 0.057	4.391SerGly: 4.391 ± 0.078	1.105SerHis: 1.105 ± 0.033	5.711SerIle: 5.711 ± 0.085	4.124SerLys: 4.124 ± 0.076	6.176SerLeu: 6.176 ± 0.092	1.757SerMet: 1.757 ± 0.04	2.745SerAsn: 2.745 ± 0.057	2.05SerPro: 2.05 ± 0.048	1.914SerGln: 1.914 ± 0.049	2.204SerArg: 2.204 ± 0.047	4.042SerSer: 4.042 ± 0.077	3.539SerThr: 3.539 ± 0.067	4.284SerVal: 4.284 ± 0.075	0.555SerTrp: 0.555 ± 0.026	2.282SerTyr: 2.282 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.051ThrAla: 4.051 ± 0.067	0.323ThrCys: 0.323 ± 0.02	2.797ThrAsp: 2.797 ± 0.058	3.875ThrGlu: 3.875 ± 0.069	2.769ThrPhe: 2.769 ± 0.058	4.292ThrGly: 4.292 ± 0.07	1.148ThrHis: 1.148 ± 0.035	4.942ThrIle: 4.942 ± 0.07	3.603ThrLys: 3.603 ± 0.062	5.473ThrLeu: 5.473 ± 0.087	1.374ThrMet: 1.374 ± 0.046	2.687ThrAsn: 2.687 ± 0.054	2.262ThrPro: 2.262 ± 0.054	1.586ThrGln: 1.586 ± 0.046	1.824ThrArg: 1.824 ± 0.042	3.678ThrSer: 3.678 ± 0.066	3.41ThrThr: 3.41 ± 0.074	4.231ThrVal: 4.231 ± 0.073	0.557ThrTrp: 0.557 ± 0.026	2.081ThrTyr: 2.081 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.131ValAla: 5.131 ± 0.084	0.56ValCys: 0.56 ± 0.027	3.722ValAsp: 3.722 ± 0.06	5.449ValGlu: 5.449 ± 0.086	3.22ValPhe: 3.22 ± 0.063	4.788ValGly: 4.788 ± 0.085	1.385ValHis: 1.385 ± 0.039	6.194ValIle: 6.194 ± 0.096	4.695ValLys: 4.695 ± 0.078	7.093ValLeu: 7.093 ± 0.094	1.905ValMet: 1.905 ± 0.048	3.21ValAsn: 3.21 ± 0.058	2.587ValPro: 2.587 ± 0.06	2.541ValGln: 2.541 ± 0.049	2.728ValArg: 2.728 ± 0.069	4.746ValSer: 4.746 ± 0.072	4.319ValThr: 4.319 ± 0.075	5.283ValVal: 5.283 ± 0.084	0.55ValTrp: 0.55 ± 0.028	2.252ValTyr: 2.252 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.504TrpAla: 0.504 ± 0.028	0.079TrpCys: 0.079 ± 0.009	0.466TrpAsp: 0.466 ± 0.023	0.585TrpGlu: 0.585 ± 0.028	0.5TrpPhe: 0.5 ± 0.023	0.594TrpGly: 0.594 ± 0.028	0.197TrpHis: 0.197 ± 0.015	0.824TrpIle: 0.824 ± 0.029	0.703TrpLys: 0.703 ± 0.031	1.016TrpLeu: 1.016 ± 0.037	0.334TrpMet: 0.334 ± 0.018	0.545TrpAsn: 0.545 ± 0.029	0.227TrpPro: 0.227 ± 0.015	0.349TrpGln: 0.349 ± 0.017	0.339TrpArg: 0.339 ± 0.017	0.597TrpSer: 0.597 ± 0.029	0.544TrpThr: 0.544 ± 0.025	0.606TrpVal: 0.606 ± 0.027	0.119TrpTrp: 0.119 ± 0.013	0.26TrpTyr: 0.26 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.282TyrAla: 2.282 ± 0.055	0.272TyrCys: 0.272 ± 0.018	1.894TyrAsp: 1.894 ± 0.049	2.512TyrGlu: 2.512 ± 0.056	1.77TyrPhe: 1.77 ± 0.042	2.341TyrGly: 2.341 ± 0.053	0.714TyrHis: 0.714 ± 0.03	2.528TyrIle: 2.528 ± 0.049	2.096TyrLys: 2.096 ± 0.049	3.296TyrLeu: 3.296 ± 0.061	0.929TyrMet: 0.929 ± 0.029	1.437TyrAsn: 1.437 ± 0.045	1.287TyrPro: 1.287 ± 0.037	1.203TyrGln: 1.203 ± 0.038	1.382TyrArg: 1.382 ± 0.038	2.137TyrSer: 2.137 ± 0.046	1.873TyrThr: 1.873 ± 0.045	2.249TyrVal: 2.249 ± 0.051	0.357TyrTrp: 0.357 ± 0.02	1.287TyrTyr: 1.287 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3267 proteins (919246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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