Amino acid dipepetide frequency for bacterium A52C2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.8AlaAla: 16.8 ± 0.178	1.038AlaCys: 1.038 ± 0.033	7.146AlaAsp: 7.146 ± 0.094	7.979AlaGlu: 7.979 ± 0.088	4.461AlaPhe: 4.461 ± 0.066	11.193AlaGly: 11.193 ± 0.111	2.143AlaHis: 2.143 ± 0.046	6.257AlaIle: 6.257 ± 0.087	3.557AlaLys: 3.557 ± 0.063	12.874AlaLeu: 12.874 ± 0.132	3.422AlaMet: 3.422 ± 0.052	2.721AlaAsn: 2.721 ± 0.05	5.807AlaPro: 5.807 ± 0.104	3.592AlaGln: 3.592 ± 0.063	8.717AlaArg: 8.717 ± 0.102	7.056AlaSer: 7.056 ± 0.077	6.032AlaThr: 6.032 ± 0.079	8.871AlaVal: 8.871 ± 0.098	1.41AlaTrp: 1.41 ± 0.036	2.351AlaTyr: 2.351 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.871CysAla: 0.871 ± 0.029	0.105CysCys: 0.105 ± 0.009	0.476CysAsp: 0.476 ± 0.021	0.425CysGlu: 0.425 ± 0.018	0.333CysPhe: 0.333 ± 0.018	0.859CysGly: 0.859 ± 0.026	0.211CysHis: 0.211 ± 0.016	0.351CysIle: 0.351 ± 0.016	0.178CysLys: 0.178 ± 0.013	0.778CysLeu: 0.778 ± 0.024	0.152CysMet: 0.152 ± 0.009	0.208CysAsn: 0.208 ± 0.013	0.423CysPro: 0.423 ± 0.022	0.192CysGln: 0.192 ± 0.014	0.655CysArg: 0.655 ± 0.025	0.458CysSer: 0.458 ± 0.02	0.389CysThr: 0.389 ± 0.017	0.567CysVal: 0.567 ± 0.024	0.102CysTrp: 0.102 ± 0.009	0.166CysTyr: 0.166 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.889AspAla: 6.889 ± 0.086	0.44AspCys: 0.44 ± 0.018	3.008AspAsp: 3.008 ± 0.067	3.742AspGlu: 3.742 ± 0.061	2.132AspPhe: 2.132 ± 0.04	5.009AspGly: 5.009 ± 0.072	1.234AspHis: 1.234 ± 0.031	2.802AspIle: 2.802 ± 0.041	1.556AspLys: 1.556 ± 0.04	6.429AspLeu: 6.429 ± 0.075	1.317AspMet: 1.317 ± 0.033	1.205AspAsn: 1.205 ± 0.035	3.521AspPro: 3.521 ± 0.057	1.743AspGln: 1.743 ± 0.038	4.707AspArg: 4.707 ± 0.073	2.128AspSer: 2.128 ± 0.045	2.466AspThr: 2.466 ± 0.06	4.337AspVal: 4.337 ± 0.06	1.017AspTrp: 1.017 ± 0.028	1.428AspTyr: 1.428 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.08GluAla: 8.08 ± 0.097	0.322GluCys: 0.322 ± 0.017	2.878GluAsp: 2.878 ± 0.057	3.465GluGlu: 3.465 ± 0.055	1.867GluPhe: 1.867 ± 0.043	4.598GluGly: 4.598 ± 0.064	1.315GluHis: 1.315 ± 0.031	3.722GluIle: 3.722 ± 0.059	2.176GluLys: 2.176 ± 0.047	5.406GluLeu: 5.406 ± 0.068	1.508GluMet: 1.508 ± 0.035	1.592GluAsn: 1.592 ± 0.038	2.966GluPro: 2.966 ± 0.055	2.038GluGln: 2.038 ± 0.042	5.271GluArg: 5.271 ± 0.092	2.38GluSer: 2.38 ± 0.047	3.644GluThr: 3.644 ± 0.058	3.862GluVal: 3.862 ± 0.06	0.707GluTrp: 0.707 ± 0.023	0.927GluTyr: 0.927 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.491PheAla: 4.491 ± 0.073	0.385PheCys: 0.385 ± 0.02	2.518PheAsp: 2.518 ± 0.045	1.997PheGlu: 1.997 ± 0.039	1.471PhePhe: 1.471 ± 0.046	3.841PheGly: 3.841 ± 0.061	0.764PheHis: 0.764 ± 0.024	1.657PheIle: 1.657 ± 0.04	0.896PheLys: 0.896 ± 0.027	3.493PheLeu: 3.493 ± 0.055	0.788PheMet: 0.788 ± 0.023	1.0PheAsn: 1.0 ± 0.031	1.716PhePro: 1.716 ± 0.038	1.054PheGln: 1.054 ± 0.026	2.606PheArg: 2.606 ± 0.047	2.239PheSer: 2.239 ± 0.042	1.94PheThr: 1.94 ± 0.04	2.902PheVal: 2.902 ± 0.052	0.569PheTrp: 0.569 ± 0.021	0.904PheTyr: 0.904 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.339GlyAla: 9.339 ± 0.105	0.841GlyCys: 0.841 ± 0.027	4.524GlyAsp: 4.524 ± 0.083	5.321GlyGlu: 5.321 ± 0.068	3.658GlyPhe: 3.658 ± 0.057	7.742GlyGly: 7.742 ± 0.128	1.917GlyHis: 1.917 ± 0.041	4.739GlyIle: 4.739 ± 0.073	3.147GlyLys: 3.147 ± 0.059	8.973GlyLeu: 8.973 ± 0.096	2.305GlyMet: 2.305 ± 0.043	2.272GlyAsn: 2.272 ± 0.067	3.775GlyPro: 3.775 ± 0.053	3.06GlyGln: 3.06 ± 0.067	6.736GlyArg: 6.736 ± 0.074	5.323GlySer: 5.323 ± 0.074	4.879GlyThr: 4.879 ± 0.063	6.055GlyVal: 6.055 ± 0.068	1.371GlyTrp: 1.371 ± 0.035	2.235GlyTyr: 2.235 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.227HisAla: 2.227 ± 0.041	0.189HisCys: 0.189 ± 0.013	1.231HisAsp: 1.231 ± 0.034	1.189HisGlu: 1.189 ± 0.036	0.856HisPhe: 0.856 ± 0.024	1.957HisGly: 1.957 ± 0.044	0.563HisHis: 0.563 ± 0.025	0.858HisIle: 0.858 ± 0.024	0.414HisLys: 0.414 ± 0.017	2.099HisLeu: 2.099 ± 0.042	0.513HisMet: 0.513 ± 0.021	0.458HisAsn: 0.458 ± 0.018	1.416HisPro: 1.416 ± 0.035	0.555HisGln: 0.555 ± 0.022	1.468HisArg: 1.468 ± 0.038	1.039HisSer: 1.039 ± 0.03	0.814HisThr: 0.814 ± 0.025	1.586HisVal: 1.586 ± 0.032	0.316HisTrp: 0.316 ± 0.017	0.513HisTyr: 0.513 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.878IleAla: 6.878 ± 0.082	0.506IleCys: 0.506 ± 0.022	3.244IleAsp: 3.244 ± 0.051	3.135IleGlu: 3.135 ± 0.054	1.77IlePhe: 1.77 ± 0.043	4.975IleGly: 4.975 ± 0.067	0.958IleHis: 0.958 ± 0.032	1.964IleIle: 1.964 ± 0.05	1.218IleLys: 1.218 ± 0.033	4.674IleLeu: 4.674 ± 0.073	0.942IleMet: 0.942 ± 0.028	1.263IleAsn: 1.263 ± 0.035	2.452IlePro: 2.452 ± 0.043	1.222IleGln: 1.222 ± 0.036	3.587IleArg: 3.587 ± 0.052	2.881IleSer: 2.881 ± 0.054	2.521IleThr: 2.521 ± 0.042	4.401IleVal: 4.401 ± 0.077	0.59IleTrp: 0.59 ± 0.021	1.143IleTyr: 1.143 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.955LysAla: 3.955 ± 0.066	0.144LysCys: 0.144 ± 0.011	1.588LysAsp: 1.588 ± 0.039	1.385LysGlu: 1.385 ± 0.037	0.778LysPhe: 0.778 ± 0.026	2.534LysGly: 2.534 ± 0.055	0.556LysHis: 0.556 ± 0.024	1.562LysIle: 1.562 ± 0.035	1.089LysLys: 1.089 ± 0.037	3.134LysLeu: 3.134 ± 0.055	0.65LysMet: 0.65 ± 0.023	0.772LysAsn: 0.772 ± 0.029	2.02LysPro: 2.02 ± 0.041	1.001LysGln: 1.001 ± 0.034	2.344LysArg: 2.344 ± 0.044	1.766LysSer: 1.766 ± 0.038	1.779LysThr: 1.779 ± 0.047	2.3LysVal: 2.3 ± 0.046	0.33LysTrp: 0.33 ± 0.015	0.54LysTyr: 0.54 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.404LeuAla: 13.404 ± 0.134	0.825LeuCys: 0.825 ± 0.023	6.035LeuAsp: 6.035 ± 0.072	5.103LeuGlu: 5.103 ± 0.073	3.608LeuPhe: 3.608 ± 0.061	8.634LeuGly: 8.634 ± 0.116	1.917LeuHis: 1.917 ± 0.044	4.958LeuIle: 4.958 ± 0.073	3.476LeuLys: 3.476 ± 0.061	9.546LeuLeu: 9.546 ± 0.119	2.24LeuMet: 2.24 ± 0.039	2.463LeuAsn: 2.463 ± 0.045	5.635LeuPro: 5.635 ± 0.076	3.04LeuGln: 3.04 ± 0.056	7.039LeuArg: 7.039 ± 0.084	6.585LeuSer: 6.585 ± 0.075	5.366LeuThr: 5.366 ± 0.087	7.885LeuVal: 7.885 ± 0.077	1.141LeuTrp: 1.141 ± 0.03	1.943LeuTyr: 1.943 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.852MetAla: 2.852 ± 0.05	0.123MetCys: 0.123 ± 0.009	1.103MetAsp: 1.103 ± 0.027	1.156MetGlu: 1.156 ± 0.028	0.619MetPhe: 0.619 ± 0.019	1.743MetGly: 1.743 ± 0.04	0.425MetHis: 0.425 ± 0.019	1.304MetIle: 1.304 ± 0.034	0.995MetLys: 0.995 ± 0.033	2.34MetLeu: 2.34 ± 0.042	0.582MetMet: 0.582 ± 0.023	0.796MetAsn: 0.796 ± 0.026	1.439MetPro: 1.439 ± 0.031	0.85MetGln: 0.85 ± 0.025	1.865MetArg: 1.865 ± 0.04	1.614MetSer: 1.614 ± 0.039	1.728MetThr: 1.728 ± 0.042	1.595MetVal: 1.595 ± 0.035	0.184MetTrp: 0.184 ± 0.011	0.295MetTyr: 0.295 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.102AsnAla: 3.102 ± 0.059	0.197AsnCys: 0.197 ± 0.014	1.337AsnAsp: 1.337 ± 0.042	1.269AsnGlu: 1.269 ± 0.035	0.89AsnPhe: 0.89 ± 0.029	2.425AsnGly: 2.425 ± 0.048	0.444AsnHis: 0.444 ± 0.018	1.184AsnIle: 1.184 ± 0.029	0.679AsnLys: 0.679 ± 0.026	2.474AsnLeu: 2.474 ± 0.048	0.546AsnMet: 0.546 ± 0.022	0.661AsnAsn: 0.661 ± 0.023	1.775AsnPro: 1.775 ± 0.039	0.75AsnGln: 0.75 ± 0.024	1.865AsnArg: 1.865 ± 0.042	1.287AsnSer: 1.287 ± 0.035	1.16AsnThr: 1.16 ± 0.032	1.987AsnVal: 1.987 ± 0.041	0.426AsnTrp: 0.426 ± 0.019	0.62AsnTyr: 0.62 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.9ProAla: 6.9 ± 0.109	0.318ProCys: 0.318 ± 0.016	3.917ProAsp: 3.917 ± 0.059	4.184ProGlu: 4.184 ± 0.075	2.041ProPhe: 2.041 ± 0.045	4.773ProGly: 4.773 ± 0.071	1.097ProHis: 1.097 ± 0.033	2.263ProIle: 2.263 ± 0.042	1.59ProLys: 1.59 ± 0.042	4.716ProLeu: 4.716 ± 0.066	1.115ProMet: 1.115 ± 0.031	1.362ProAsn: 1.362 ± 0.029	2.639ProPro: 2.639 ± 0.063	1.576ProGln: 1.576 ± 0.045	3.058ProArg: 3.058 ± 0.047	2.919ProSer: 2.919 ± 0.05	2.565ProThr: 2.565 ± 0.054	4.524ProVal: 4.524 ± 0.069	0.676ProTrp: 0.676 ± 0.023	1.144ProTyr: 1.144 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.168GlnAla: 4.168 ± 0.07	0.172GlnCys: 0.172 ± 0.012	1.488GlnAsp: 1.488 ± 0.038	1.522GlnGlu: 1.522 ± 0.036	1.018GlnPhe: 1.018 ± 0.029	2.517GlnGly: 2.517 ± 0.048	0.637GlnHis: 0.637 ± 0.024	1.767GlnIle: 1.767 ± 0.039	1.068GlnLys: 1.068 ± 0.031	2.66GlnLeu: 2.66 ± 0.041	0.778GlnMet: 0.778 ± 0.026	0.944GlnAsn: 0.944 ± 0.032	1.882GlnPro: 1.882 ± 0.043	1.266GlnGln: 1.266 ± 0.045	2.342GlnArg: 2.342 ± 0.04	1.884GlnSer: 1.884 ± 0.039	1.724GlnThr: 1.724 ± 0.035	2.259GlnVal: 2.259 ± 0.037	0.326GlnTrp: 0.326 ± 0.016	0.547GlnTyr: 0.547 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.85ArgAla: 7.85 ± 0.094	0.514ArgCys: 0.514 ± 0.022	4.198ArgAsp: 4.198 ± 0.063	4.662ArgGlu: 4.662 ± 0.07	3.162ArgPhe: 3.162 ± 0.056	5.203ArgGly: 5.203 ± 0.07	1.751ArgHis: 1.751 ± 0.043	4.063ArgIle: 4.063 ± 0.059	2.28ArgLys: 2.28 ± 0.042	8.164ArgLeu: 8.164 ± 0.087	1.812ArgMet: 1.812 ± 0.041	1.922ArgAsn: 1.922 ± 0.039	3.945ArgPro: 3.945 ± 0.071	2.746ArgGln: 2.746 ± 0.046	6.288ArgArg: 6.288 ± 0.08	4.112ArgSer: 4.112 ± 0.062	3.724ArgThr: 3.724 ± 0.058	5.044ArgVal: 5.044 ± 0.061	0.992ArgTrp: 0.992 ± 0.029	1.674ArgTyr: 1.674 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.569SerAla: 6.569 ± 0.089	0.428SerCys: 0.428 ± 0.022	3.151SerAsp: 3.151 ± 0.056	3.121SerGlu: 3.121 ± 0.055	2.407SerPhe: 2.407 ± 0.045	5.937SerGly: 5.937 ± 0.078	1.132SerHis: 1.132 ± 0.033	2.688SerIle: 2.688 ± 0.044	1.438SerLys: 1.438 ± 0.034	5.736SerLeu: 5.736 ± 0.082	1.294SerMet: 1.294 ± 0.035	1.275SerAsn: 1.275 ± 0.034	3.069SerPro: 3.069 ± 0.05	1.505SerGln: 1.505 ± 0.038	4.143SerArg: 4.143 ± 0.067	3.315SerSer: 3.315 ± 0.049	2.802SerThr: 2.802 ± 0.051	4.355SerVal: 4.355 ± 0.061	0.762SerTrp: 0.762 ± 0.028	1.345SerTyr: 1.345 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.28ThrAla: 6.28 ± 0.077	0.412ThrCys: 0.412 ± 0.019	2.923ThrAsp: 2.923 ± 0.05	2.746ThrGlu: 2.746 ± 0.056	2.04ThrPhe: 2.04 ± 0.045	5.226ThrGly: 5.226 ± 0.072	0.972ThrHis: 0.972 ± 0.028	2.776ThrIle: 2.776 ± 0.048	1.312ThrLys: 1.312 ± 0.031	5.724ThrLeu: 5.724 ± 0.072	1.148ThrMet: 1.148 ± 0.032	1.176ThrAsn: 1.176 ± 0.032	3.126ThrPro: 3.126 ± 0.057	1.367ThrGln: 1.367 ± 0.04	3.449ThrArg: 3.449 ± 0.052	2.883ThrSer: 2.883 ± 0.055	2.706ThrThr: 2.706 ± 0.062	4.48ThrVal: 4.48 ± 0.065	0.642ThrTrp: 0.642 ± 0.024	1.187ThrTyr: 1.187 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.353ValAla: 9.353 ± 0.087	0.6ValCys: 0.6 ± 0.019	4.3ValAsp: 4.3 ± 0.057	4.619ValGlu: 4.619 ± 0.07	2.765ValPhe: 2.765 ± 0.046	5.942ValGly: 5.942 ± 0.083	1.452ValHis: 1.452 ± 0.033	3.896ValIle: 3.896 ± 0.064	2.153ValLys: 2.153 ± 0.044	7.931ValLeu: 7.931 ± 0.089	1.747ValMet: 1.747 ± 0.042	1.961ValAsn: 1.961 ± 0.045	3.975ValPro: 3.975 ± 0.055	2.249ValGln: 2.249 ± 0.047	5.055ValArg: 5.055 ± 0.067	4.537ValSer: 4.537 ± 0.06	4.542ValThr: 4.542 ± 0.056	6.026ValVal: 6.026 ± 0.079	0.877ValTrp: 0.877 ± 0.025	1.433ValTyr: 1.433 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.035	0.114TrpCys: 0.114 ± 0.008	0.637TrpAsp: 0.637 ± 0.021	0.548TrpGlu: 0.548 ± 0.023	0.52TrpPhe: 0.52 ± 0.02	0.886TrpGly: 0.886 ± 0.032	0.336TrpHis: 0.336 ± 0.018	0.684TrpIle: 0.684 ± 0.023	0.454TrpLys: 0.454 ± 0.021	1.562TrpLeu: 1.562 ± 0.041	0.335TrpMet: 0.335 ± 0.016	0.468TrpAsn: 0.468 ± 0.019	0.705TrpPro: 0.705 ± 0.025	0.531TrpGln: 0.531 ± 0.022	1.121TrpArg: 1.121 ± 0.031	0.883TrpSer: 0.883 ± 0.032	0.76TrpThr: 0.76 ± 0.025	0.774TrpVal: 0.774 ± 0.028	0.226TrpTrp: 0.226 ± 0.015	0.263TrpTyr: 0.263 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.256TyrAla: 2.256 ± 0.044	0.227TyrCys: 0.227 ± 0.012	1.404TyrAsp: 1.404 ± 0.036	1.155TyrGlu: 1.155 ± 0.034	0.835TyrPhe: 0.835 ± 0.029	2.217TyrGly: 2.217 ± 0.074	0.436TyrHis: 0.436 ± 0.018	0.829TyrIle: 0.829 ± 0.025	0.551TyrLys: 0.551 ± 0.02	2.13TyrLeu: 2.13 ± 0.042	0.412TyrMet: 0.412 ± 0.017	0.561TyrAsn: 0.561 ± 0.021	1.089TyrPro: 1.089 ± 0.03	0.633TyrGln: 0.633 ± 0.024	1.79TyrArg: 1.79 ± 0.038	1.183TyrSer: 1.183 ± 0.034	1.033TyrThr: 1.033 ± 0.033	1.605TyrVal: 1.605 ± 0.033	0.313TyrTrp: 0.313 ± 0.015	0.511TyrTyr: 0.511 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4028 proteins (1253240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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