Amino acid dipepetide frequency for Pararcticibacter amylolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.447AlaAla: 6.447 ± 0.085	0.61AlaCys: 0.61 ± 0.019	4.297AlaAsp: 4.297 ± 0.061	4.69AlaGlu: 4.69 ± 0.056	3.454AlaPhe: 3.454 ± 0.046	6.71AlaGly: 6.71 ± 0.071	1.013AlaHis: 1.013 ± 0.027	4.559AlaIle: 4.559 ± 0.06	3.87AlaLys: 3.87 ± 0.05	6.572AlaLeu: 6.572 ± 0.076	1.527AlaMet: 1.527 ± 0.03	3.373AlaAsn: 3.373 ± 0.055	2.454AlaPro: 2.454 ± 0.038	2.446AlaGln: 2.446 ± 0.041	3.104AlaArg: 3.104 ± 0.049	5.397AlaSer: 5.397 ± 0.076	3.683AlaThr: 3.683 ± 0.07	5.151AlaVal: 5.151 ± 0.06	0.872AlaTrp: 0.872 ± 0.023	2.843AlaTyr: 2.843 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.468CysAla: 0.468 ± 0.015	0.121CysCys: 0.121 ± 0.009	0.377CysAsp: 0.377 ± 0.016	0.348CysGlu: 0.348 ± 0.014	0.413CysPhe: 0.413 ± 0.016	0.598CysGly: 0.598 ± 0.019	0.163CysHis: 0.163 ± 0.01	0.55CysIle: 0.55 ± 0.02	0.444CysLys: 0.444 ± 0.014	0.752CysLeu: 0.752 ± 0.018	0.172CysMet: 0.172 ± 0.01	0.339CysAsn: 0.339 ± 0.013	0.286CysPro: 0.286 ± 0.011	0.209CysGln: 0.209 ± 0.011	0.418CysArg: 0.418 ± 0.016	0.6CysSer: 0.6 ± 0.02	0.389CysThr: 0.389 ± 0.015	0.423CysVal: 0.423 ± 0.015	0.093CysTrp: 0.093 ± 0.014	0.335CysTyr: 0.335 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.865AspAla: 3.865 ± 0.049	0.358AspCys: 0.358 ± 0.015	2.517AspAsp: 2.517 ± 0.04	3.269AspGlu: 3.269 ± 0.045	3.007AspPhe: 3.007 ± 0.043	4.159AspGly: 4.159 ± 0.085	0.972AspHis: 0.972 ± 0.025	3.923AspIle: 3.923 ± 0.051	3.553AspLys: 3.553 ± 0.047	5.04AspLeu: 5.04 ± 0.053	1.136AspMet: 1.136 ± 0.028	2.672AspAsn: 2.672 ± 0.049	2.49AspPro: 2.49 ± 0.034	1.915AspGln: 1.915 ± 0.035	2.442AspArg: 2.442 ± 0.041	2.996AspSer: 2.996 ± 0.048	2.404AspThr: 2.404 ± 0.036	3.373AspVal: 3.373 ± 0.049	0.819AspTrp: 0.819 ± 0.02	2.668AspTyr: 2.668 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.408GluAla: 4.408 ± 0.053	0.356GluCys: 0.356 ± 0.015	2.928GluAsp: 2.928 ± 0.05	4.034GluGlu: 4.034 ± 0.066	2.407GluPhe: 2.407 ± 0.044	3.858GluGly: 3.858 ± 0.047	1.039GluHis: 1.039 ± 0.028	4.252GluIle: 4.252 ± 0.062	4.746GluLys: 4.746 ± 0.06	5.56GluLeu: 5.56 ± 0.066	1.44GluMet: 1.44 ± 0.03	3.332GluAsn: 3.332 ± 0.048	1.746GluPro: 1.746 ± 0.033	2.328GluGln: 2.328 ± 0.039	2.934GluArg: 2.934 ± 0.043	3.205GluSer: 3.205 ± 0.044	2.915GluThr: 2.915 ± 0.046	3.734GluVal: 3.734 ± 0.049	0.701GluTrp: 0.701 ± 0.025	2.31GluTyr: 2.31 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.109PheAla: 3.109 ± 0.046	0.446PheCys: 0.446 ± 0.017	2.755PheAsp: 2.755 ± 0.041	2.597PheGlu: 2.597 ± 0.045	2.526PhePhe: 2.526 ± 0.039	3.292PheGly: 3.292 ± 0.057	0.831PheHis: 0.831 ± 0.022	3.265PheIle: 3.265 ± 0.047	2.811PheLys: 2.811 ± 0.035	4.368PheLeu: 4.368 ± 0.066	1.039PheMet: 1.039 ± 0.027	2.978PheAsn: 2.978 ± 0.047	1.793PhePro: 1.793 ± 0.033	1.354PheGln: 1.354 ± 0.032	2.47PheArg: 2.47 ± 0.042	4.219PheSer: 4.219 ± 0.055	3.102PheThr: 3.102 ± 0.042	2.741PheVal: 2.741 ± 0.043	0.601PheTrp: 0.601 ± 0.02	2.147PheTyr: 2.147 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.838GlyAla: 4.838 ± 0.071	0.613GlyCys: 0.613 ± 0.021	3.629GlyAsp: 3.629 ± 0.053	3.729GlyGlu: 3.729 ± 0.05	3.718GlyPhe: 3.718 ± 0.051	5.222GlyGly: 5.222 ± 0.066	1.18GlyHis: 1.18 ± 0.03	5.359GlyIle: 5.359 ± 0.061	5.451GlyLys: 5.451 ± 0.065	6.448GlyLeu: 6.448 ± 0.072	1.754GlyMet: 1.754 ± 0.03	4.207GlyAsn: 4.207 ± 0.062	1.667GlyPro: 1.667 ± 0.034	2.438GlyGln: 2.438 ± 0.039	3.282GlyArg: 3.282 ± 0.044	5.188GlySer: 5.188 ± 0.069	4.8GlyThr: 4.8 ± 0.093	4.569GlyVal: 4.569 ± 0.055	1.127GlyTrp: 1.127 ± 0.029	3.439GlyTyr: 3.439 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.074HisAla: 1.074 ± 0.026	0.161HisCys: 0.161 ± 0.01	0.83HisAsp: 0.83 ± 0.024	0.92HisGlu: 0.92 ± 0.024	1.044HisPhe: 1.044 ± 0.026	1.079HisGly: 1.079 ± 0.028	0.456HisHis: 0.456 ± 0.019	1.248HisIle: 1.248 ± 0.029	0.837HisLys: 0.837 ± 0.023	1.748HisLeu: 1.748 ± 0.036	0.319HisMet: 0.319 ± 0.014	0.816HisAsn: 0.816 ± 0.024	0.945HisPro: 0.945 ± 0.023	0.668HisGln: 0.668 ± 0.019	0.78HisArg: 0.78 ± 0.024	1.145HisSer: 1.145 ± 0.027	0.95HisThr: 0.95 ± 0.019	0.93HisVal: 0.93 ± 0.023	0.252HisTrp: 0.252 ± 0.012	0.846HisTyr: 0.846 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.184IleAla: 5.184 ± 0.064	0.644IleCys: 0.644 ± 0.019	3.734IleAsp: 3.734 ± 0.049	3.915IleGlu: 3.915 ± 0.055	2.865IlePhe: 2.865 ± 0.043	4.371IleGly: 4.371 ± 0.058	1.213IleHis: 1.213 ± 0.027	4.405IleIle: 4.405 ± 0.068	4.171IleLys: 4.171 ± 0.053	5.91IleLeu: 5.91 ± 0.071	1.213IleMet: 1.213 ± 0.029	3.57IleAsn: 3.57 ± 0.042	3.029IlePro: 3.029 ± 0.045	2.059IleGln: 2.059 ± 0.04	3.683IleArg: 3.683 ± 0.048	5.444IleSer: 5.444 ± 0.061	4.258IleThr: 4.258 ± 0.066	3.954IleVal: 3.954 ± 0.056	0.726IleTrp: 0.726 ± 0.024	2.558IleTyr: 2.558 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.876LysAla: 4.876 ± 0.063	0.308LysCys: 0.308 ± 0.014	3.961LysAsp: 3.961 ± 0.05	4.528LysGlu: 4.528 ± 0.055	2.314LysPhe: 2.314 ± 0.036	4.642LysGly: 4.642 ± 0.051	1.074LysHis: 1.074 ± 0.027	4.386LysIle: 4.386 ± 0.056	4.767LysLys: 4.767 ± 0.059	5.658LysLeu: 5.658 ± 0.063	1.599LysMet: 1.599 ± 0.03	3.64LysAsn: 3.64 ± 0.049	2.553LysPro: 2.553 ± 0.036	2.357LysGln: 2.357 ± 0.045	2.963LysArg: 2.963 ± 0.038	3.725LysSer: 3.725 ± 0.054	3.742LysThr: 3.742 ± 0.047	4.188LysVal: 4.188 ± 0.053	0.846LysTrp: 0.846 ± 0.023	2.755LysTyr: 2.755 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	6.531LeuAla: 6.531 ± 0.074	0.755LeuCys: 0.755 ± 0.02	4.567LeuAsp: 4.567 ± 0.057	4.891LeuGlu: 4.891 ± 0.064	4.506LeuPhe: 4.506 ± 0.058	5.557LeuGly: 5.557 ± 0.07	1.623LeuHis: 1.623 ± 0.035	6.081LeuIle: 6.081 ± 0.078	6.955LeuLys: 6.955 ± 0.076	9.074LeuLeu: 9.074 ± 0.096	2.007LeuMet: 2.007 ± 0.032	5.38LeuAsn: 5.38 ± 0.061	4.207LeuPro: 4.207 ± 0.043	3.32LeuGln: 3.32 ± 0.043	4.391LeuArg: 4.391 ± 0.058	7.58LeuSer: 7.58 ± 0.07	5.412LeuThr: 5.412 ± 0.068	5.283LeuVal: 5.283 ± 0.063	1.029LeuTrp: 1.029 ± 0.026	3.567LeuTyr: 3.567 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.584MetAla: 1.584 ± 0.032	0.125MetCys: 0.125 ± 0.008	1.097MetAsp: 1.097 ± 0.029	1.219MetGlu: 1.219 ± 0.028	0.818MetPhe: 0.818 ± 0.021	1.404MetGly: 1.404 ± 0.03	0.358MetHis: 0.358 ± 0.014	1.472MetIle: 1.472 ± 0.03	1.973MetLys: 1.973 ± 0.036	2.06MetLeu: 2.06 ± 0.033	0.556MetMet: 0.556 ± 0.018	1.303MetAsn: 1.303 ± 0.029	1.008MetPro: 1.008 ± 0.021	0.832MetGln: 0.832 ± 0.021	1.016MetArg: 1.016 ± 0.023	1.358MetSer: 1.358 ± 0.03	1.1MetThr: 1.1 ± 0.026	1.295MetVal: 1.295 ± 0.027	0.205MetTrp: 0.205 ± 0.012	0.69MetTyr: 0.69 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.87AsnAla: 3.87 ± 0.054	0.364AsnCys: 0.364 ± 0.016	2.676AsnAsp: 2.676 ± 0.041	2.985AsnGlu: 2.985 ± 0.039	2.506AsnPhe: 2.506 ± 0.048	4.328AsnGly: 4.328 ± 0.07	0.896AsnHis: 0.896 ± 0.024	3.855AsnIle: 3.855 ± 0.053	3.278AsnLys: 3.278 ± 0.048	4.714AsnLeu: 4.714 ± 0.061	1.085AsnMet: 1.085 ± 0.024	3.098AsnAsn: 3.098 ± 0.053	2.824AsnPro: 2.824 ± 0.05	1.859AsnGln: 1.859 ± 0.029	2.569AsnArg: 2.569 ± 0.045	3.566AsnSer: 3.566 ± 0.051	3.274AsnThr: 3.274 ± 0.054	3.171AsnVal: 3.171 ± 0.053	0.767AsnTrp: 0.767 ± 0.023	2.633AsnTyr: 2.633 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	3.585ProAla: 3.585 ± 0.062	0.232ProCys: 0.232 ± 0.011	2.828ProAsp: 2.828 ± 0.042	3.164ProGlu: 3.164 ± 0.047	1.941ProPhe: 1.941 ± 0.034	3.611ProGly: 3.611 ± 0.047	0.635ProHis: 0.635 ± 0.02	1.668ProIle: 1.668 ± 0.034	1.722ProLys: 1.722 ± 0.03	3.632ProLeu: 3.632 ± 0.052	0.729ProMet: 0.729 ± 0.023	1.611ProAsn: 1.611 ± 0.031	1.115ProPro: 1.115 ± 0.029	1.39ProGln: 1.39 ± 0.029	1.368ProArg: 1.368 ± 0.029	2.766ProSer: 2.766 ± 0.043	1.544ProThr: 1.544 ± 0.038	3.98ProVal: 3.98 ± 0.056	0.465ProTrp: 0.465 ± 0.018	1.649ProTyr: 1.649 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.579GlnAla: 2.579 ± 0.038	0.185GlnCys: 0.185 ± 0.011	1.618GlnAsp: 1.618 ± 0.029	2.058GlnGlu: 2.058 ± 0.035	1.544GlnPhe: 1.544 ± 0.031	2.174GlnGly: 2.174 ± 0.035	0.657GlnHis: 0.657 ± 0.019	2.166GlnIle: 2.166 ± 0.036	2.475GlnLys: 2.475 ± 0.041	3.442GlnLeu: 3.442 ± 0.047	0.81GlnMet: 0.81 ± 0.022	2.003GlnAsn: 2.003 ± 0.037	1.39GlnPro: 1.39 ± 0.033	1.662GlnGln: 1.662 ± 0.035	1.64GlnArg: 1.64 ± 0.035	2.189GlnSer: 2.189 ± 0.036	2.056GlnThr: 2.056 ± 0.036	2.281GlnVal: 2.281 ± 0.04	0.446GlnTrp: 0.446 ± 0.017	1.598GlnTyr: 1.598 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.901ArgAla: 2.901 ± 0.051	0.27ArgCys: 0.27 ± 0.013	2.431ArgAsp: 2.431 ± 0.04	2.924ArgGlu: 2.924 ± 0.046	2.48ArgPhe: 2.48 ± 0.038	2.711ArgGly: 2.711 ± 0.045	0.801ArgHis: 0.801 ± 0.023	3.551ArgIle: 3.551 ± 0.048	3.407ArgLys: 3.407 ± 0.053	4.52ArgLeu: 4.52 ± 0.06	1.159ArgMet: 1.159 ± 0.024	2.756ArgAsn: 2.756 ± 0.039	1.662ArgPro: 1.662 ± 0.033	1.821ArgGln: 1.821 ± 0.043	2.168ArgArg: 2.168 ± 0.04	2.887ArgSer: 2.887 ± 0.046	2.496ArgThr: 2.496 ± 0.042	2.864ArgVal: 2.864 ± 0.039	0.713ArgTrp: 0.713 ± 0.019	2.258ArgTyr: 2.258 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.314SerAla: 5.314 ± 0.069	0.581SerCys: 0.581 ± 0.017	3.684SerAsp: 3.684 ± 0.045	3.736SerGlu: 3.736 ± 0.051	4.072SerPhe: 4.072 ± 0.055	6.232SerGly: 6.232 ± 0.079	1.148SerHis: 1.148 ± 0.024	4.451SerIle: 4.451 ± 0.057	3.727SerLys: 3.727 ± 0.052	6.894SerLeu: 6.894 ± 0.076	1.341SerMet: 1.341 ± 0.029	3.345SerAsn: 3.345 ± 0.055	2.845SerPro: 2.845 ± 0.04	2.258SerGln: 2.258 ± 0.04	3.255SerArg: 3.255 ± 0.041	5.258SerSer: 5.258 ± 0.077	3.529SerThr: 3.529 ± 0.056	5.091SerVal: 5.091 ± 0.068	0.889SerTrp: 0.889 ± 0.024	3.216SerTyr: 3.216 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.528ThrAla: 4.528 ± 0.074	0.337ThrCys: 0.337 ± 0.014	3.373ThrAsp: 3.373 ± 0.049	3.137ThrGlu: 3.137 ± 0.047	2.704ThrPhe: 2.704 ± 0.05	5.43ThrGly: 5.43 ± 0.068	0.845ThrHis: 0.845 ± 0.02	3.828ThrIle: 3.828 ± 0.056	2.696ThrLys: 2.696 ± 0.036	5.038ThrLeu: 5.038 ± 0.058	0.931ThrMet: 0.931 ± 0.026	2.609ThrAsn: 2.609 ± 0.041	2.538ThrPro: 2.538 ± 0.043	1.628ThrGln: 1.628 ± 0.033	2.379ThrArg: 2.379 ± 0.037	3.906ThrSer: 3.906 ± 0.062	3.224ThrThr: 3.224 ± 0.062	4.101ThrVal: 4.101 ± 0.069	0.674ThrTrp: 0.674 ± 0.022	2.483ThrTyr: 2.483 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.371ValAla: 4.371 ± 0.065	0.55ValCys: 0.55 ± 0.016	3.078ValAsp: 3.078 ± 0.046	3.235ValGlu: 3.235 ± 0.044	3.252ValPhe: 3.252 ± 0.036	3.345ValGly: 3.345 ± 0.057	1.022ValHis: 1.022 ± 0.024	4.553ValIle: 4.553 ± 0.05	4.514ValLys: 4.514 ± 0.058	6.18ValLeu: 6.18 ± 0.069	1.448ValMet: 1.448 ± 0.032	3.8ValAsn: 3.8 ± 0.06	2.79ValPro: 2.79 ± 0.036	2.084ValGln: 2.084 ± 0.033	3.045ValArg: 3.045 ± 0.045	5.313ValSer: 5.313 ± 0.073	4.142ValThr: 4.142 ± 0.09	4.329ValVal: 4.329 ± 0.061	0.755ValTrp: 0.755 ± 0.019	2.68ValTyr: 2.68 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.023	0.124TrpCys: 0.124 ± 0.008	0.69TrpAsp: 0.69 ± 0.02	0.755TrpGlu: 0.755 ± 0.023	0.613TrpPhe: 0.613 ± 0.02	0.945TrpGly: 0.945 ± 0.033	0.24TrpHis: 0.24 ± 0.012	0.765TrpIle: 0.765 ± 0.022	0.913TrpLys: 0.913 ± 0.023	1.217TrpLeu: 1.217 ± 0.028	0.379TrpMet: 0.379 ± 0.014	0.773TrpAsn: 0.773 ± 0.021	0.398TrpPro: 0.398 ± 0.017	0.574TrpGln: 0.574 ± 0.018	0.586TrpArg: 0.586 ± 0.017	0.78TrpSer: 0.78 ± 0.026	0.735TrpThr: 0.735 ± 0.021	0.728TrpVal: 0.728 ± 0.021	0.215TrpTrp: 0.215 ± 0.011	0.543TrpTyr: 0.543 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.75TyrAla: 2.75 ± 0.042	0.355TyrCys: 0.355 ± 0.014	2.506TyrAsp: 2.506 ± 0.053	2.103TyrGlu: 2.103 ± 0.037	2.259TyrPhe: 2.259 ± 0.035	2.991TyrGly: 2.991 ± 0.056	0.879TyrHis: 0.879 ± 0.026	2.567TyrIle: 2.567 ± 0.043	2.573TyrLys: 2.573 ± 0.044	3.893TyrLeu: 3.893 ± 0.05	0.827TyrMet: 0.827 ± 0.022	2.71TyrAsn: 2.71 ± 0.051	1.893TyrPro: 1.893 ± 0.036	1.768TyrGln: 1.768 ± 0.03	2.287TyrArg: 2.287 ± 0.035	3.348TyrSer: 3.348 ± 0.049	2.637TyrThr: 2.637 ± 0.047	2.301TyrVal: 2.301 ± 0.036	0.572TyrTrp: 0.572 ± 0.017	2.053TyrTyr: 2.053 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4966 proteins (1864360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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