Amino acid dipepetide frequency for Streptococcus satellite phage Javan733

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.95AlaAla: 0.95 ± 0.588
0.633AlaCys: 0.633 ± 0.511
4.115AlaAsp: 4.115 ± 1.47
4.115AlaGlu: 4.115 ± 1.294
3.166AlaPhe: 3.166 ± 0.838
3.482AlaGly: 3.482 ± 0.787
0.0AlaHis: 0.0 ± 0.0
4.115AlaIle: 4.115 ± 1.012
5.698AlaLys: 5.698 ± 0.977
3.799AlaLeu: 3.799 ± 1.015
2.216AlaMet: 2.216 ± 1.011
3.482AlaAsn: 3.482 ± 0.786
0.95AlaPro: 0.95 ± 0.357
1.266AlaGln: 1.266 ± 0.63
6.015AlaArg: 6.015 ± 1.035
3.799AlaSer: 3.799 ± 0.917
4.748AlaThr: 4.748 ± 1.008
4.748AlaVal: 4.748 ± 0.966
0.317AlaTrp: 0.317 ± 0.253
2.849AlaTyr: 2.849 ± 0.984
0.0AlaXaa: 0.0 ± 0.0
Cys
0.317CysAla: 0.317 ± 0.316
0.0CysCys: 0.0 ± 0.0
0.317CysAsp: 0.317 ± 0.256
0.317CysGlu: 0.317 ± 0.253
0.317CysPhe: 0.317 ± 0.316
0.317CysGly: 0.317 ± 0.328
0.317CysHis: 0.317 ± 0.258
0.317CysIle: 0.317 ± 0.338
0.317CysLys: 0.317 ± 0.361
1.266CysLeu: 1.266 ± 0.601
0.0CysMet: 0.0 ± 0.0
0.317CysAsn: 0.317 ± 0.34
0.317CysPro: 0.317 ± 0.258
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.317CysVal: 0.317 ± 0.253
0.0CysTrp: 0.0 ± 0.0
0.633CysTyr: 0.633 ± 0.307
0.0CysXaa: 0.0 ± 0.0
Asp
1.899AspAla: 1.899 ± 0.714
0.633AspCys: 0.633 ± 0.447
5.381AspAsp: 5.381 ± 1.406
7.914AspGlu: 7.914 ± 1.602
3.799AspPhe: 3.799 ± 1.12
2.216AspGly: 2.216 ± 0.803
0.317AspHis: 0.317 ± 0.253
6.648AspIle: 6.648 ± 1.294
5.381AspLys: 5.381 ± 1.16
9.497AspLeu: 9.497 ± 2.118
3.166AspMet: 3.166 ± 0.962
3.166AspAsn: 3.166 ± 0.742
1.583AspPro: 1.583 ± 0.497
0.95AspGln: 0.95 ± 0.488
2.532AspArg: 2.532 ± 0.896
1.266AspSer: 1.266 ± 0.584
2.849AspThr: 2.849 ± 1.021
2.216AspVal: 2.216 ± 0.983
0.317AspTrp: 0.317 ± 0.253
2.532AspTyr: 2.532 ± 1.275
0.0AspXaa: 0.0 ± 0.0
Glu
4.748GluAla: 4.748 ± 1.781
0.633GluCys: 0.633 ± 0.38
3.482GluAsp: 3.482 ± 1.152
6.964GluGlu: 6.964 ± 2.148
2.216GluPhe: 2.216 ± 0.84
2.532GluGly: 2.532 ± 0.684
1.899GluHis: 1.899 ± 0.746
8.547GluIle: 8.547 ± 1.446
8.547GluLys: 8.547 ± 1.534
11.713GluLeu: 11.713 ± 2.408
3.799GluMet: 3.799 ± 0.974
6.331GluAsn: 6.331 ± 1.944
0.633GluPro: 0.633 ± 0.401
4.115GluGln: 4.115 ± 1.074
4.115GluArg: 4.115 ± 1.011
6.015GluSer: 6.015 ± 1.552
4.115GluThr: 4.115 ± 1.121
7.914GluVal: 7.914 ± 1.692
0.633GluTrp: 0.633 ± 0.319
4.115GluTyr: 4.115 ± 0.767
0.0GluXaa: 0.0 ± 0.0
Phe
1.583PheAla: 1.583 ± 0.598
0.0PheCys: 0.0 ± 0.0
4.432PheAsp: 4.432 ± 1.144
4.115PheGlu: 4.115 ± 1.153
2.532PhePhe: 2.532 ± 1.203
1.899PheGly: 1.899 ± 0.461
0.95PheHis: 0.95 ± 0.448
2.849PheIle: 2.849 ± 0.855
3.482PheLys: 3.482 ± 1.091
4.432PheLeu: 4.432 ± 1.416
1.266PheMet: 1.266 ± 0.653
1.266PheAsn: 1.266 ± 0.579
0.317PhePro: 0.317 ± 0.253
2.216PheGln: 2.216 ± 0.769
1.899PheArg: 1.899 ± 0.726
3.166PheSer: 3.166 ± 0.774
2.849PheThr: 2.849 ± 1.179
1.899PheVal: 1.899 ± 0.814
0.95PheTrp: 0.95 ± 0.45
1.899PheTyr: 1.899 ± 0.668
0.0PheXaa: 0.0 ± 0.0
Gly
3.482GlyAla: 3.482 ± 1.452
0.317GlyCys: 0.317 ± 0.258
1.583GlyAsp: 1.583 ± 0.568
4.432GlyGlu: 4.432 ± 0.842
2.216GlyPhe: 2.216 ± 0.727
1.583GlyGly: 1.583 ± 0.618
0.633GlyHis: 0.633 ± 0.397
3.799GlyIle: 3.799 ± 1.198
3.166GlyLys: 3.166 ± 0.878
5.698GlyLeu: 5.698 ± 1.519
0.317GlyMet: 0.317 ± 0.378
2.532GlyAsn: 2.532 ± 1.029
0.317GlyPro: 0.317 ± 0.258
0.95GlyGln: 0.95 ± 0.523
2.532GlyArg: 2.532 ± 0.802
1.266GlySer: 1.266 ± 0.561
2.216GlyThr: 2.216 ± 0.793
5.065GlyVal: 5.065 ± 1.099
0.633GlyTrp: 0.633 ± 0.68
3.799GlyTyr: 3.799 ± 1.082
0.0GlyXaa: 0.0 ± 0.0
His
0.95HisAla: 0.95 ± 0.774
0.0HisCys: 0.0 ± 0.0
0.633HisAsp: 0.633 ± 0.428
0.633HisGlu: 0.633 ± 0.557
1.266HisPhe: 1.266 ± 0.694
0.95HisGly: 0.95 ± 0.489
0.317HisHis: 0.317 ± 0.256
0.95HisIle: 0.95 ± 0.517
0.95HisLys: 0.95 ± 0.578
0.633HisLeu: 0.633 ± 0.516
0.317HisMet: 0.317 ± 0.253
1.899HisAsn: 1.899 ± 0.769
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.633HisArg: 0.633 ± 0.482
0.633HisSer: 0.633 ± 0.365
0.95HisThr: 0.95 ± 0.563
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.95HisTyr: 0.95 ± 0.687
0.0HisXaa: 0.0 ± 0.0
Ile
4.115IleAla: 4.115 ± 1.062
0.317IleCys: 0.317 ± 0.34
7.281IleAsp: 7.281 ± 2.448
6.331IleGlu: 6.331 ± 1.579
4.432IlePhe: 4.432 ± 1.351
2.849IleGly: 2.849 ± 0.961
0.317IleHis: 0.317 ± 0.256
4.748IleIle: 4.748 ± 1.197
9.18IleLys: 9.18 ± 1.635
4.748IleLeu: 4.748 ± 1.305
0.95IleMet: 0.95 ± 0.571
1.899IleAsn: 1.899 ± 0.86
3.166IlePro: 3.166 ± 0.99
2.849IleGln: 2.849 ± 0.997
3.166IleArg: 3.166 ± 0.879
4.115IleSer: 4.115 ± 1.144
4.115IleThr: 4.115 ± 1.205
3.482IleVal: 3.482 ± 0.894
0.0IleTrp: 0.0 ± 0.0
3.166IleTyr: 3.166 ± 0.842
0.0IleXaa: 0.0 ± 0.0
Lys
8.864LysAla: 8.864 ± 1.799
0.317LysCys: 0.317 ± 0.316
5.381LysAsp: 5.381 ± 1.453
9.497LysGlu: 9.497 ± 1.722
3.166LysPhe: 3.166 ± 1.059
4.115LysGly: 4.115 ± 0.793
1.899LysHis: 1.899 ± 0.664
6.331LysIle: 6.331 ± 1.161
7.597LysLys: 7.597 ± 1.604
8.547LysLeu: 8.547 ± 1.333
2.216LysMet: 2.216 ± 0.931
6.331LysAsn: 6.331 ± 1.404
0.95LysPro: 0.95 ± 0.462
2.532LysGln: 2.532 ± 0.847
6.331LysArg: 6.331 ± 1.412
6.331LysSer: 6.331 ± 0.921
6.648LysThr: 6.648 ± 1.736
2.532LysVal: 2.532 ± 0.666
0.633LysTrp: 0.633 ± 0.428
3.482LysTyr: 3.482 ± 1.238
0.0LysXaa: 0.0 ± 0.0
Leu
6.648LeuAla: 6.648 ± 1.485
0.0LeuCys: 0.0 ± 0.0
8.547LeuAsp: 8.547 ± 1.628
12.662LeuGlu: 12.662 ± 2.033
5.065LeuPhe: 5.065 ± 1.586
4.115LeuGly: 4.115 ± 0.825
0.633LeuHis: 0.633 ± 0.373
5.065LeuIle: 5.065 ± 1.374
8.547LeuLys: 8.547 ± 1.373
7.597LeuLeu: 7.597 ± 1.666
2.216LeuMet: 2.216 ± 0.832
8.23LeuAsn: 8.23 ± 1.394
3.482LeuPro: 3.482 ± 0.832
4.115LeuGln: 4.115 ± 1.064
4.115LeuArg: 4.115 ± 0.919
4.432LeuSer: 4.432 ± 1.197
8.864LeuThr: 8.864 ± 1.179
3.482LeuVal: 3.482 ± 1.003
0.633LeuTrp: 0.633 ± 0.502
3.482LeuTyr: 3.482 ± 1.128
0.0LeuXaa: 0.0 ± 0.0
Met
2.849MetAla: 2.849 ± 0.925
0.0MetCys: 0.0 ± 0.0
2.849MetAsp: 2.849 ± 1.008
3.166MetGlu: 3.166 ± 1.16
0.317MetPhe: 0.317 ± 0.353
2.216MetGly: 2.216 ± 0.578
0.0MetHis: 0.0 ± 0.0
0.633MetIle: 0.633 ± 0.419
2.532MetLys: 2.532 ± 0.744
0.95MetLeu: 0.95 ± 0.604
0.633MetMet: 0.633 ± 0.449
2.216MetAsn: 2.216 ± 0.777
0.95MetPro: 0.95 ± 0.617
0.95MetGln: 0.95 ± 0.429
1.266MetArg: 1.266 ± 0.902
0.95MetSer: 0.95 ± 0.591
2.216MetThr: 2.216 ± 0.943
1.899MetVal: 1.899 ± 0.839
0.0MetTrp: 0.0 ± 0.0
0.317MetTyr: 0.317 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
2.532AsnAla: 2.532 ± 0.904
0.0AsnCys: 0.0 ± 0.0
2.532AsnAsp: 2.532 ± 0.805
2.216AsnGlu: 2.216 ± 0.7
1.583AsnPhe: 1.583 ± 0.819
4.432AsnGly: 4.432 ± 1.181
0.95AsnHis: 0.95 ± 0.521
3.799AsnIle: 3.799 ± 1.176
5.381AsnLys: 5.381 ± 0.981
5.381AsnLeu: 5.381 ± 1.345
0.95AsnMet: 0.95 ± 0.523
1.266AsnAsn: 1.266 ± 0.767
2.532AsnPro: 2.532 ± 0.673
3.166AsnGln: 3.166 ± 0.99
2.216AsnArg: 2.216 ± 0.843
3.166AsnSer: 3.166 ± 1.027
4.115AsnThr: 4.115 ± 1.105
2.849AsnVal: 2.849 ± 0.947
0.633AsnTrp: 0.633 ± 0.365
2.849AsnTyr: 2.849 ± 1.116
0.0AsnXaa: 0.0 ± 0.0
Pro
1.583ProAla: 1.583 ± 0.59
0.0ProCys: 0.0 ± 0.0
2.532ProAsp: 2.532 ± 0.828
2.532ProGlu: 2.532 ± 0.81
0.95ProPhe: 0.95 ± 0.444
0.317ProGly: 0.317 ± 0.355
0.0ProHis: 0.0 ± 0.0
1.899ProIle: 1.899 ± 0.744
2.532ProLys: 2.532 ± 0.952
1.266ProLeu: 1.266 ± 0.495
0.317ProMet: 0.317 ± 0.253
1.266ProAsn: 1.266 ± 0.434
2.532ProPro: 2.532 ± 1.006
0.95ProGln: 0.95 ± 0.703
3.166ProArg: 3.166 ± 0.914
1.266ProSer: 1.266 ± 0.645
1.899ProThr: 1.899 ± 0.624
0.317ProVal: 0.317 ± 0.316
0.0ProTrp: 0.0 ± 0.0
1.583ProTyr: 1.583 ± 0.625
0.0ProXaa: 0.0 ± 0.0
Gln
4.115GlnAla: 4.115 ± 0.915
0.0GlnCys: 0.0 ± 0.0
2.216GlnAsp: 2.216 ± 0.826
4.115GlnGlu: 4.115 ± 0.907
0.633GlnPhe: 0.633 ± 0.505
2.216GlnGly: 2.216 ± 0.72
0.317GlnHis: 0.317 ± 0.29
2.216GlnIle: 2.216 ± 0.825
4.115GlnLys: 4.115 ± 1.087
5.381GlnLeu: 5.381 ± 1.317
1.583GlnMet: 1.583 ± 0.754
0.633GlnAsn: 0.633 ± 0.417
0.317GlnPro: 0.317 ± 0.353
2.532GlnGln: 2.532 ± 0.839
1.583GlnArg: 1.583 ± 0.693
1.266GlnSer: 1.266 ± 0.727
2.216GlnThr: 2.216 ± 0.807
2.532GlnVal: 2.532 ± 0.891
0.317GlnTrp: 0.317 ± 0.258
0.633GlnTyr: 0.633 ± 0.307
0.0GlnXaa: 0.0 ± 0.0
Arg
3.166ArgAla: 3.166 ± 1.188
0.317ArgCys: 0.317 ± 0.328
2.849ArgAsp: 2.849 ± 0.924
6.331ArgGlu: 6.331 ± 1.132
2.849ArgPhe: 2.849 ± 0.634
1.899ArgGly: 1.899 ± 0.801
1.266ArgHis: 1.266 ± 0.548
4.432ArgIle: 4.432 ± 1.293
3.799ArgLys: 3.799 ± 0.923
5.698ArgLeu: 5.698 ± 1.318
1.583ArgMet: 1.583 ± 0.642
1.899ArgAsn: 1.899 ± 0.899
0.95ArgPro: 0.95 ± 0.581
4.115ArgGln: 4.115 ± 1.057
3.482ArgArg: 3.482 ± 1.056
2.216ArgSer: 2.216 ± 0.689
2.532ArgThr: 2.532 ± 0.72
1.583ArgVal: 1.583 ± 0.538
0.0ArgTrp: 0.0 ± 0.0
2.849ArgTyr: 2.849 ± 0.89
0.0ArgXaa: 0.0 ± 0.0
Ser
2.532SerAla: 2.532 ± 1.01
0.95SerCys: 0.95 ± 0.578
1.899SerAsp: 1.899 ± 0.561
5.381SerGlu: 5.381 ± 1.404
2.532SerPhe: 2.532 ± 0.903
2.532SerGly: 2.532 ± 0.94
0.95SerHis: 0.95 ± 0.501
4.115SerIle: 4.115 ± 0.839
4.748SerLys: 4.748 ± 0.925
5.065SerLeu: 5.065 ± 1.067
1.266SerMet: 1.266 ± 0.611
1.899SerAsn: 1.899 ± 0.759
2.216SerPro: 2.216 ± 0.935
2.849SerGln: 2.849 ± 0.963
1.266SerArg: 1.266 ± 0.891
2.216SerSer: 2.216 ± 0.796
2.216SerThr: 2.216 ± 0.992
1.899SerVal: 1.899 ± 0.794
0.0SerTrp: 0.0 ± 0.0
1.583SerTyr: 1.583 ± 0.632
0.0SerXaa: 0.0 ± 0.0
Thr
3.482ThrAla: 3.482 ± 0.909
0.317ThrCys: 0.317 ± 0.361
2.532ThrAsp: 2.532 ± 1.021
3.166ThrGlu: 3.166 ± 0.743
1.899ThrPhe: 1.899 ± 0.585
4.432ThrGly: 4.432 ± 0.941
1.266ThrHis: 1.266 ± 0.432
5.065ThrIle: 5.065 ± 1.353
6.331ThrLys: 6.331 ± 1.569
8.23ThrLeu: 8.23 ± 1.621
2.216ThrMet: 2.216 ± 1.143
0.317ThrAsn: 0.317 ± 0.253
2.849ThrPro: 2.849 ± 1.029
3.166ThrGln: 3.166 ± 0.734
2.849ThrArg: 2.849 ± 0.859
1.583ThrSer: 1.583 ± 0.689
3.482ThrThr: 3.482 ± 0.754
3.799ThrVal: 3.799 ± 1.48
0.317ThrTrp: 0.317 ± 0.391
2.849ThrTyr: 2.849 ± 1.275
0.0ThrXaa: 0.0 ± 0.0
Val
3.799ValAla: 3.799 ± 1.303
0.317ValCys: 0.317 ± 0.361
3.799ValAsp: 3.799 ± 1.272
6.015ValGlu: 6.015 ± 1.777
1.899ValPhe: 1.899 ± 0.844
2.532ValGly: 2.532 ± 1.226
0.317ValHis: 0.317 ± 0.253
2.216ValIle: 2.216 ± 0.786
4.748ValLys: 4.748 ± 1.225
4.748ValLeu: 4.748 ± 0.885
1.266ValMet: 1.266 ± 0.61
4.432ValAsn: 4.432 ± 1.304
0.95ValPro: 0.95 ± 0.654
0.95ValGln: 0.95 ± 0.567
3.799ValArg: 3.799 ± 1.04
2.849ValSer: 2.849 ± 0.91
1.899ValThr: 1.899 ± 0.64
3.166ValVal: 3.166 ± 1.127
0.633ValTrp: 0.633 ± 0.502
1.266ValTyr: 1.266 ± 0.819
0.0ValXaa: 0.0 ± 0.0
Trp
0.317TrpAla: 0.317 ± 0.258
0.317TrpCys: 0.317 ± 0.253
0.633TrpAsp: 0.633 ± 0.542
0.95TrpGlu: 0.95 ± 0.479
0.0TrpPhe: 0.0 ± 0.0
0.633TrpGly: 0.633 ± 0.435
0.0TrpHis: 0.0 ± 0.0
0.633TrpIle: 0.633 ± 0.481
0.317TrpLys: 0.317 ± 0.34
0.633TrpLeu: 0.633 ± 0.417
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.633TrpArg: 0.633 ± 0.307
0.317TrpSer: 0.317 ± 0.258
0.317TrpThr: 0.317 ± 0.253
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.317TrpTyr: 0.317 ± 0.256
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.909
0.317TyrCys: 0.317 ± 0.258
1.266TyrAsp: 1.266 ± 0.471
2.216TyrGlu: 2.216 ± 0.708
3.166TyrPhe: 3.166 ± 0.885
1.266TyrGly: 1.266 ± 0.646
0.317TyrHis: 0.317 ± 0.253
2.849TyrIle: 2.849 ± 0.905
6.648TyrLys: 6.648 ± 1.593
6.648TyrLeu: 6.648 ± 1.397
0.317TyrMet: 0.317 ± 0.29
3.166TyrAsn: 3.166 ± 0.714
1.899TyrPro: 1.899 ± 0.736
1.266TyrGln: 1.266 ± 0.627
2.216TyrArg: 2.216 ± 0.827
1.266TyrSer: 1.266 ± 0.716
1.899TyrThr: 1.899 ± 0.652
1.899TyrVal: 1.899 ± 1.054
0.0TyrTrp: 0.0 ± 0.0
0.633TyrTyr: 0.633 ± 0.505
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (3160 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski