Amino acid dipepetide frequency for Gallibacterium salpingitidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.852AlaAla: 7.852 ± 0.145
0.899AlaCys: 0.899 ± 0.035
4.46AlaAsp: 4.46 ± 0.095
6.062AlaGlu: 6.062 ± 0.121
3.313AlaPhe: 3.313 ± 0.073
5.903AlaGly: 5.903 ± 0.133
1.46AlaHis: 1.46 ± 0.046
6.689AlaIle: 6.689 ± 0.106
5.883AlaLys: 5.883 ± 0.115
9.73AlaLeu: 9.73 ± 0.138
2.291AlaMet: 2.291 ± 0.057
3.919AlaAsn: 3.919 ± 0.116
2.563AlaPro: 2.563 ± 0.07
3.964AlaGln: 3.964 ± 0.092
3.253AlaArg: 3.253 ± 0.074
4.116AlaSer: 4.116 ± 0.077
4.665AlaThr: 4.665 ± 0.098
5.955AlaVal: 5.955 ± 0.104
0.922AlaTrp: 0.922 ± 0.041
2.395AlaTyr: 2.395 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.036
0.16CysCys: 0.16 ± 0.014
0.554CysAsp: 0.554 ± 0.033
0.581CysGlu: 0.581 ± 0.031
0.515CysPhe: 0.515 ± 0.023
0.958CysGly: 0.958 ± 0.041
0.33CysHis: 0.33 ± 0.027
0.619CysIle: 0.619 ± 0.03
0.422CysLys: 0.422 ± 0.027
1.005CysLeu: 1.005 ± 0.042
0.192CysMet: 0.192 ± 0.018
0.332CysAsn: 0.332 ± 0.022
0.443CysPro: 0.443 ± 0.027
0.51CysGln: 0.51 ± 0.026
0.475CysArg: 0.475 ± 0.026
0.646CysSer: 0.646 ± 0.029
0.476CysThr: 0.476 ± 0.024
0.667CysVal: 0.667 ± 0.033
0.128CysTrp: 0.128 ± 0.014
0.378CysTyr: 0.378 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.659AspAla: 3.659 ± 0.094
0.526AspCys: 0.526 ± 0.032
2.42AspAsp: 2.42 ± 0.069
3.26AspGlu: 3.26 ± 0.074
2.361AspPhe: 2.361 ± 0.058
3.348AspGly: 3.348 ± 0.126
1.012AspHis: 1.012 ± 0.043
3.783AspIle: 3.783 ± 0.09
3.237AspLys: 3.237 ± 0.08
5.179AspLeu: 5.179 ± 0.095
1.096AspMet: 1.096 ± 0.035
2.51AspAsn: 2.51 ± 0.076
2.087AspPro: 2.087 ± 0.063
2.104AspGln: 2.104 ± 0.056
2.109AspArg: 2.109 ± 0.055
2.483AspSer: 2.483 ± 0.069
2.391AspThr: 2.391 ± 0.073
3.382AspVal: 3.382 ± 0.076
0.761AspTrp: 0.761 ± 0.038
2.151AspTyr: 2.151 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.538GluAla: 4.538 ± 0.097
0.429GluCys: 0.429 ± 0.027
2.491GluAsp: 2.491 ± 0.061
3.608GluGlu: 3.608 ± 0.105
2.2GluPhe: 2.2 ± 0.063
3.113GluGly: 3.113 ± 0.077
1.314GluHis: 1.314 ± 0.05
4.441GluIle: 4.441 ± 0.086
4.608GluLys: 4.608 ± 0.105
6.22GluLeu: 6.22 ± 0.111
1.665GluMet: 1.665 ± 0.051
3.176GluAsn: 3.176 ± 0.065
1.672GluPro: 1.672 ± 0.05
4.227GluGln: 4.227 ± 0.09
2.744GluArg: 2.744 ± 0.074
2.629GluSer: 2.629 ± 0.064
2.929GluThr: 2.929 ± 0.066
3.893GluVal: 3.893 ± 0.085
0.732GluTrp: 0.732 ± 0.035
1.747GluTyr: 1.747 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.139PheAla: 4.139 ± 0.072
0.545PheCys: 0.545 ± 0.03
2.522PheAsp: 2.522 ± 0.062
1.988PheGlu: 1.988 ± 0.056
1.996PhePhe: 1.996 ± 0.079
3.173PheGly: 3.173 ± 0.072
0.826PheHis: 0.826 ± 0.034
3.406PheIle: 3.406 ± 0.088
2.03PheLys: 2.03 ± 0.056
4.098PheLeu: 4.098 ± 0.117
1.036PheMet: 1.036 ± 0.04
2.253PheAsn: 2.253 ± 0.059
1.493PhePro: 1.493 ± 0.054
1.45PheGln: 1.45 ± 0.056
1.48PheArg: 1.48 ± 0.041
3.334PheSer: 3.334 ± 0.083
2.463PheThr: 2.463 ± 0.061
2.847PheVal: 2.847 ± 0.076
0.529PheTrp: 0.529 ± 0.029
1.567PheTyr: 1.567 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.156GlyAla: 5.156 ± 0.121
0.826GlyCys: 0.826 ± 0.039
3.301GlyAsp: 3.301 ± 0.096
4.151GlyGlu: 4.151 ± 0.081
3.156GlyPhe: 3.156 ± 0.079
4.835GlyGly: 4.835 ± 0.161
1.341GlyHis: 1.341 ± 0.05
5.584GlyIle: 5.584 ± 0.102
4.692GlyLys: 4.692 ± 0.104
6.885GlyLeu: 6.885 ± 0.106
1.762GlyMet: 1.762 ± 0.054
2.991GlyAsn: 2.991 ± 0.127
1.306GlyPro: 1.306 ± 0.048
2.521GlyGln: 2.521 ± 0.065
2.763GlyArg: 2.763 ± 0.07
3.841GlySer: 3.841 ± 0.1
3.619GlyThr: 3.619 ± 0.12
5.097GlyVal: 5.097 ± 0.106
0.837GlyTrp: 0.837 ± 0.039
2.603GlyTyr: 2.603 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.235HisAla: 1.235 ± 0.039
0.332HisCys: 0.332 ± 0.023
0.857HisAsp: 0.857 ± 0.043
0.821HisGlu: 0.821 ± 0.037
1.13HisPhe: 1.13 ± 0.046
1.313HisGly: 1.313 ± 0.046
0.685HisHis: 0.685 ± 0.034
1.604HisIle: 1.604 ± 0.044
0.986HisLys: 0.986 ± 0.037
2.423HisLeu: 2.423 ± 0.07
0.397HisMet: 0.397 ± 0.022
1.009HisAsn: 1.009 ± 0.039
1.083HisPro: 1.083 ± 0.047
1.353HisGln: 1.353 ± 0.05
0.985HisArg: 0.985 ± 0.038
1.269HisSer: 1.269 ± 0.042
1.111HisThr: 1.111 ± 0.04
0.881HisVal: 0.881 ± 0.038
0.334HisTrp: 0.334 ± 0.021
0.973HisTyr: 0.973 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
7.369IleAla: 7.369 ± 0.118
0.822IleCys: 0.822 ± 0.033
4.199IleAsp: 4.199 ± 0.078
4.495IleGlu: 4.495 ± 0.085
3.023IlePhe: 3.023 ± 0.09
5.474IleGly: 5.474 ± 0.119
1.349IleHis: 1.349 ± 0.047
5.154IleIle: 5.154 ± 0.116
3.977IleLys: 3.977 ± 0.075
6.845IleLeu: 6.845 ± 0.137
1.408IleMet: 1.408 ± 0.054
3.56IleAsn: 3.56 ± 0.096
3.027IlePro: 3.027 ± 0.077
2.752IleGln: 2.752 ± 0.073
2.883IleArg: 2.883 ± 0.065
4.703IleSer: 4.703 ± 0.082
4.31IleThr: 4.31 ± 0.092
4.805IleVal: 4.805 ± 0.089
0.717IleTrp: 0.717 ± 0.033
2.175IleTyr: 2.175 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.116LysAla: 5.116 ± 0.119
0.312LysCys: 0.312 ± 0.022
2.907LysAsp: 2.907 ± 0.098
3.799LysGlu: 3.799 ± 0.09
1.898LysPhe: 1.898 ± 0.054
3.601LysGly: 3.601 ± 0.076
1.17LysHis: 1.17 ± 0.046
4.133LysIle: 4.133 ± 0.072
3.443LysLys: 3.443 ± 0.083
5.857LysLeu: 5.857 ± 0.1
1.756LysMet: 1.756 ± 0.052
2.868LysAsn: 2.868 ± 0.082
2.271LysPro: 2.271 ± 0.06
3.558LysGln: 3.558 ± 0.078
2.617LysArg: 2.617 ± 0.055
2.809LysSer: 2.809 ± 0.068
3.204LysThr: 3.204 ± 0.069
4.098LysVal: 4.098 ± 0.084
0.553LysTrp: 0.553 ± 0.026
1.741LysTyr: 1.741 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
10.387LeuAla: 10.387 ± 0.136
1.104LeuCys: 1.104 ± 0.04
5.404LeuAsp: 5.404 ± 0.099
5.447LeuGlu: 5.447 ± 0.115
4.834LeuPhe: 4.834 ± 0.127
7.149LeuGly: 7.149 ± 0.11
2.105LeuHis: 2.105 ± 0.056
7.217LeuIle: 7.217 ± 0.134
5.462LeuLys: 5.462 ± 0.089
11.799LeuLeu: 11.799 ± 0.242
2.408LeuMet: 2.408 ± 0.075
4.909LeuAsn: 4.909 ± 0.097
4.916LeuPro: 4.916 ± 0.104
5.198LeuGln: 5.198 ± 0.109
4.547LeuArg: 4.547 ± 0.09
7.376LeuSer: 7.376 ± 0.116
6.34LeuThr: 6.34 ± 0.097
6.818LeuVal: 6.818 ± 0.121
1.113LeuTrp: 1.113 ± 0.043
2.923LeuTyr: 2.923 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.268MetAla: 2.268 ± 0.06
0.191MetCys: 0.191 ± 0.017
0.939MetAsp: 0.939 ± 0.038
1.092MetGlu: 1.092 ± 0.043
0.915MetPhe: 0.915 ± 0.043
1.509MetGly: 1.509 ± 0.046
0.402MetHis: 0.402 ± 0.024
1.555MetIle: 1.555 ± 0.058
1.578MetLys: 1.578 ± 0.045
2.645MetLeu: 2.645 ± 0.072
0.681MetMet: 0.681 ± 0.032
1.104MetAsn: 1.104 ± 0.04
1.056MetPro: 1.056 ± 0.036
1.351MetGln: 1.351 ± 0.048
1.048MetArg: 1.048 ± 0.04
1.469MetSer: 1.469 ± 0.044
1.431MetThr: 1.431 ± 0.043
1.536MetVal: 1.536 ± 0.049
0.188MetTrp: 0.188 ± 0.015
0.525MetTyr: 0.525 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.744AsnAla: 3.744 ± 0.092
0.412AsnCys: 0.412 ± 0.026
2.213AsnAsp: 2.213 ± 0.063
2.528AsnGlu: 2.528 ± 0.057
1.844AsnPhe: 1.844 ± 0.051
3.325AsnGly: 3.325 ± 0.129
0.956AsnHis: 0.956 ± 0.035
3.507AsnIle: 3.507 ± 0.094
2.681AsnLys: 2.681 ± 0.071
4.644AsnLeu: 4.644 ± 0.084
0.985AsnMet: 0.985 ± 0.036
2.427AsnAsn: 2.427 ± 0.103
2.308AsnPro: 2.308 ± 0.054
2.509AsnGln: 2.509 ± 0.061
1.882AsnArg: 1.882 ± 0.059
2.676AsnSer: 2.676 ± 0.101
2.459AsnThr: 2.459 ± 0.093
3.051AsnVal: 3.051 ± 0.091
0.566AsnTrp: 0.566 ± 0.033
1.731AsnTyr: 1.731 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.98ProAla: 2.98 ± 0.072
0.319ProCys: 0.319 ± 0.022
2.026ProAsp: 2.026 ± 0.056
2.865ProGlu: 2.865 ± 0.077
1.844ProPhe: 1.844 ± 0.057
1.774ProGly: 1.774 ± 0.057
0.857ProHis: 0.857 ± 0.037
2.876ProIle: 2.876 ± 0.066
2.077ProLys: 2.077 ± 0.062
4.08ProLeu: 4.08 ± 0.087
0.943ProMet: 0.943 ± 0.039
1.984ProAsn: 1.984 ± 0.056
1.126ProPro: 1.126 ± 0.049
1.924ProGln: 1.924 ± 0.051
1.263ProArg: 1.263 ± 0.041
2.034ProSer: 2.034 ± 0.049
2.432ProThr: 2.432 ± 0.056
2.623ProVal: 2.623 ± 0.066
0.366ProTrp: 0.366 ± 0.021
1.429ProTyr: 1.429 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
4.566GlnAla: 4.566 ± 0.097
0.452GlnCys: 0.452 ± 0.027
2.194GlnAsp: 2.194 ± 0.06
2.596GlnGlu: 2.596 ± 0.074
2.166GlnPhe: 2.166 ± 0.066
3.113GlnGly: 3.113 ± 0.068
1.378GlnHis: 1.378 ± 0.048
3.426GlnIle: 3.426 ± 0.08
2.766GlnLys: 2.766 ± 0.066
6.107GlnLeu: 6.107 ± 0.13
1.009GlnMet: 1.009 ± 0.033
2.13GlnAsn: 2.13 ± 0.056
1.924GlnPro: 1.924 ± 0.055
5.66GlnGln: 5.66 ± 0.166
2.627GlnArg: 2.627 ± 0.076
2.475GlnSer: 2.475 ± 0.058
2.489GlnThr: 2.489 ± 0.065
3.124GlnVal: 3.124 ± 0.069
0.694GlnTrp: 0.694 ± 0.031
1.742GlnTyr: 1.742 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.949ArgAla: 2.949 ± 0.062
0.471ArgCys: 0.471 ± 0.026
2.018ArgAsp: 2.018 ± 0.057
2.685ArgGlu: 2.685 ± 0.07
2.163ArgPhe: 2.163 ± 0.057
2.42ArgGly: 2.42 ± 0.066
1.037ArgHis: 1.037 ± 0.037
3.108ArgIle: 3.108 ± 0.064
2.397ArgLys: 2.397 ± 0.059
4.589ArgLeu: 4.589 ± 0.102
0.952ArgMet: 0.952 ± 0.041
1.835ArgAsn: 1.835 ± 0.053
1.496ArgPro: 1.496 ± 0.051
2.428ArgGln: 2.428 ± 0.062
2.088ArgArg: 2.088 ± 0.059
2.222ArgSer: 2.222 ± 0.055
2.072ArgThr: 2.072 ± 0.051
2.778ArgVal: 2.778 ± 0.063
0.545ArgTrp: 0.545 ± 0.026
1.891ArgTyr: 1.891 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.886SerAla: 4.886 ± 0.086
0.588SerCys: 0.588 ± 0.032
2.888SerAsp: 2.888 ± 0.073
3.155SerGlu: 3.155 ± 0.073
2.617SerPhe: 2.617 ± 0.063
4.449SerGly: 4.449 ± 0.087
1.177SerHis: 1.177 ± 0.039
4.034SerIle: 4.034 ± 0.096
2.894SerLys: 2.894 ± 0.066
6.414SerLeu: 6.414 ± 0.103
1.343SerMet: 1.343 ± 0.044
2.326SerAsn: 2.326 ± 0.072
2.054SerPro: 2.054 ± 0.057
2.708SerGln: 2.708 ± 0.066
2.426SerArg: 2.426 ± 0.06
3.41SerSer: 3.41 ± 0.092
2.966SerThr: 2.966 ± 0.083
3.873SerVal: 3.873 ± 0.093
0.745SerTrp: 0.745 ± 0.031
2.05SerTyr: 2.05 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
5.053ThrAla: 5.053 ± 0.112
0.437ThrCys: 0.437 ± 0.025
2.781ThrAsp: 2.781 ± 0.086
3.231ThrGlu: 3.231 ± 0.068
2.36ThrPhe: 2.36 ± 0.058
4.111ThrGly: 4.111 ± 0.107
1.091ThrHis: 1.091 ± 0.039
3.991ThrIle: 3.991 ± 0.081
2.705ThrLys: 2.705 ± 0.074
6.512ThrLeu: 6.512 ± 0.116
1.076ThrMet: 1.076 ± 0.035
2.221ThrAsn: 2.221 ± 0.078
2.606ThrPro: 2.606 ± 0.063
2.292ThrGln: 2.292 ± 0.061
1.956ThrArg: 1.956 ± 0.055
2.804ThrSer: 2.804 ± 0.063
3.468ThrThr: 3.468 ± 0.1
3.787ThrVal: 3.787 ± 0.091
0.603ThrTrp: 0.603 ± 0.032
1.559ThrTyr: 1.559 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.212ValAla: 6.212 ± 0.116
0.721ValCys: 0.721 ± 0.035
3.517ValAsp: 3.517 ± 0.077
4.146ValGlu: 4.146 ± 0.095
2.629ValPhe: 2.629 ± 0.073
4.716ValGly: 4.716 ± 0.092
1.076ValHis: 1.076 ± 0.037
5.186ValIle: 5.186 ± 0.1
3.94ValLys: 3.94 ± 0.082
6.907ValLeu: 6.907 ± 0.119
1.71ValMet: 1.71 ± 0.051
3.125ValAsn: 3.125 ± 0.098
2.551ValPro: 2.551 ± 0.055
2.29ValGln: 2.29 ± 0.055
2.607ValArg: 2.607 ± 0.065
4.108ValSer: 4.108 ± 0.082
3.784ValThr: 3.784 ± 0.091
4.972ValVal: 4.972 ± 0.105
0.724ValTrp: 0.724 ± 0.035
1.986ValTyr: 1.986 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.74TrpAla: 0.74 ± 0.034
0.156TrpCys: 0.156 ± 0.015
0.535TrpAsp: 0.535 ± 0.027
0.514TrpGlu: 0.514 ± 0.028
0.587TrpPhe: 0.587 ± 0.031
0.713TrpGly: 0.713 ± 0.036
0.311TrpHis: 0.311 ± 0.022
0.78TrpIle: 0.78 ± 0.038
0.557TrpLys: 0.557 ± 0.027
1.698TrpLeu: 1.698 ± 0.053
0.206TrpMet: 0.206 ± 0.016
0.492TrpAsn: 0.492 ± 0.027
0.229TrpPro: 0.229 ± 0.02
1.204TrpGln: 1.204 ± 0.047
0.622TrpArg: 0.622 ± 0.031
0.595TrpSer: 0.595 ± 0.031
0.469TrpThr: 0.469 ± 0.027
0.768TrpVal: 0.768 ± 0.033
0.176TrpTrp: 0.176 ± 0.016
0.354TrpTyr: 0.354 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.668TyrAla: 2.668 ± 0.058
0.465TyrCys: 0.465 ± 0.027
1.633TyrAsp: 1.633 ± 0.05
1.352TyrGlu: 1.352 ± 0.039
1.626TyrPhe: 1.626 ± 0.054
2.269TyrGly: 2.269 ± 0.056
0.901TyrHis: 0.901 ± 0.036
1.955TyrIle: 1.955 ± 0.053
1.376TyrLys: 1.376 ± 0.039
3.818TyrLeu: 3.818 ± 0.074
0.566TyrMet: 0.566 ± 0.027
1.278TyrAsn: 1.278 ± 0.045
1.614TyrPro: 1.614 ± 0.046
2.634TyrGln: 2.634 ± 0.061
1.77TyrArg: 1.77 ± 0.055
2.004TyrSer: 2.004 ± 0.055
1.565TyrThr: 1.565 ± 0.049
1.951TyrVal: 1.951 ± 0.054
0.474TyrTrp: 0.474 ± 0.026
1.15TyrTyr: 1.15 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2228 proteins (743351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski