Amino acid dipepetide frequency for Bacillus urumqiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.308AlaAla: 11.308 ± 0.16	0.811AlaCys: 0.811 ± 0.03	5.074AlaAsp: 5.074 ± 0.079	7.714AlaGlu: 7.714 ± 0.106	3.876AlaPhe: 3.876 ± 0.068	8.352AlaGly: 8.352 ± 0.118	1.534AlaHis: 1.534 ± 0.045	3.632AlaIle: 3.632 ± 0.082	2.98AlaLys: 2.98 ± 0.064	8.488AlaLeu: 8.488 ± 0.117	2.353AlaMet: 2.353 ± 0.053	1.821AlaAsn: 1.821 ± 0.048	2.969AlaPro: 2.969 ± 0.055	2.572AlaGln: 2.572 ± 0.056	3.763AlaArg: 3.763 ± 0.069	5.575AlaSer: 5.575 ± 0.081	2.641AlaThr: 2.641 ± 0.056	8.724AlaVal: 8.724 ± 0.12	0.893AlaTrp: 0.893 ± 0.033	2.504AlaTyr: 2.504 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.563CysAla: 0.563 ± 0.026	0.089CysCys: 0.089 ± 0.011	0.331CysAsp: 0.331 ± 0.019	0.331CysGlu: 0.331 ± 0.016	0.261CysPhe: 0.261 ± 0.016	0.782CysGly: 0.782 ± 0.033	0.185CysHis: 0.185 ± 0.012	0.358CysIle: 0.358 ± 0.022	0.115CysLys: 0.115 ± 0.012	0.526CysLeu: 0.526 ± 0.023	0.174CysMet: 0.174 ± 0.012	0.152CysAsn: 0.152 ± 0.013	0.348CysPro: 0.348 ± 0.021	0.163CysGln: 0.163 ± 0.015	0.62CysArg: 0.62 ± 0.028	0.504CysSer: 0.504 ± 0.028	0.4CysThr: 0.4 ± 0.025	0.373CysVal: 0.373 ± 0.02	0.085CysTrp: 0.085 ± 0.009	0.2CysTyr: 0.2 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.69AspAla: 4.69 ± 0.087	0.313AspCys: 0.313 ± 0.017	3.059AspAsp: 3.059 ± 0.099	4.711AspGlu: 4.711 ± 0.09	2.141AspPhe: 2.141 ± 0.052	4.328AspGly: 4.328 ± 0.091	1.317AspHis: 1.317 ± 0.038	3.72AspIle: 3.72 ± 0.059	2.175AspLys: 2.175 ± 0.061	4.623AspLeu: 4.623 ± 0.066	1.693AspMet: 1.693 ± 0.048	1.616AspAsn: 1.616 ± 0.052	2.533AspPro: 2.533 ± 0.06	2.066AspGln: 2.066 ± 0.046	2.954AspArg: 2.954 ± 0.06	2.778AspSer: 2.778 ± 0.066	3.163AspThr: 3.163 ± 0.067	4.587AspVal: 4.587 ± 0.086	0.736AspTrp: 0.736 ± 0.031	1.952AspTyr: 1.952 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	8.861GluAla: 8.861 ± 0.116	0.341GluCys: 0.341 ± 0.021	4.807GluAsp: 4.807 ± 0.093	10.27GluGlu: 10.27 ± 0.177	2.11GluPhe: 2.11 ± 0.048	5.408GluGly: 5.408 ± 0.091	1.586GluHis: 1.586 ± 0.042	4.39GluIle: 4.39 ± 0.076	5.907GluLys: 5.907 ± 0.098	7.302GluLeu: 7.302 ± 0.099	2.671GluMet: 2.671 ± 0.059	3.543GluAsn: 3.543 ± 0.082	2.771GluPro: 2.771 ± 0.061	3.705GluGln: 3.705 ± 0.076	4.621GluArg: 4.621 ± 0.073	3.996GluSer: 3.996 ± 0.068	5.23GluThr: 5.23 ± 0.075	5.245GluVal: 5.245 ± 0.08	1.005GluTrp: 1.005 ± 0.034	1.926GluTyr: 1.926 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.259PheAla: 3.259 ± 0.066	0.323PheCys: 0.323 ± 0.017	2.369PheAsp: 2.369 ± 0.053	2.473PheGlu: 2.473 ± 0.055	2.194PhePhe: 2.194 ± 0.054	3.137PheGly: 3.137 ± 0.065	1.104PheHis: 1.104 ± 0.037	2.706PheIle: 2.706 ± 0.066	1.306PheLys: 1.306 ± 0.043	4.267PheLeu: 4.267 ± 0.093	1.078PheMet: 1.078 ± 0.038	1.2PheAsn: 1.2 ± 0.037	1.813PhePro: 1.813 ± 0.048	1.837PheGln: 1.837 ± 0.041	2.031PheArg: 2.031 ± 0.046	3.072PheSer: 3.072 ± 0.061	2.749PheThr: 2.749 ± 0.06	2.77PheVal: 2.77 ± 0.057	0.494PheTrp: 0.494 ± 0.025	1.553PheTyr: 1.553 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.612GlyAla: 6.612 ± 0.114	0.582GlyCys: 0.582 ± 0.029	3.621GlyAsp: 3.621 ± 0.079	5.468GlyGlu: 5.468 ± 0.091	3.294GlyPhe: 3.294 ± 0.063	5.977GlyGly: 5.977 ± 0.107	1.41GlyHis: 1.41 ± 0.043	5.171GlyIle: 5.171 ± 0.083	3.533GlyLys: 3.533 ± 0.077	6.623GlyLeu: 6.623 ± 0.102	2.663GlyMet: 2.663 ± 0.061	2.18GlyAsn: 2.18 ± 0.055	2.156GlyPro: 2.156 ± 0.05	2.026GlyGln: 2.026 ± 0.054	4.58GlyArg: 4.58 ± 0.071	4.848GlySer: 4.848 ± 0.092	4.897GlyThr: 4.897 ± 0.069	5.417GlyVal: 5.417 ± 0.083	1.009GlyTrp: 1.009 ± 0.033	2.525GlyTyr: 2.525 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.855HisAla: 1.855 ± 0.044	0.176HisCys: 0.176 ± 0.014	1.19HisAsp: 1.19 ± 0.035	1.569HisGlu: 1.569 ± 0.042	0.978HisPhe: 0.978 ± 0.029	1.595HisGly: 1.595 ± 0.051	0.743HisHis: 0.743 ± 0.034	1.326HisIle: 1.326 ± 0.036	0.72HisLys: 0.72 ± 0.029	2.23HisLeu: 2.23 ± 0.053	0.529HisMet: 0.529 ± 0.024	0.592HisAsn: 0.592 ± 0.026	1.395HisPro: 1.395 ± 0.04	0.923HisGln: 0.923 ± 0.032	1.28HisArg: 1.28 ± 0.037	1.167HisSer: 1.167 ± 0.033	1.263HisThr: 1.263 ± 0.037	1.693HisVal: 1.693 ± 0.043	0.26HisTrp: 0.26 ± 0.017	0.833HisTyr: 0.833 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.86IleAla: 4.86 ± 0.082	0.411IleCys: 0.411 ± 0.021	3.692IleAsp: 3.692 ± 0.056	4.192IleGlu: 4.192 ± 0.071	2.229IlePhe: 2.229 ± 0.061	4.968IleGly: 4.968 ± 0.086	1.645IleHis: 1.645 ± 0.039	3.494IleIle: 3.494 ± 0.069	2.089IleLys: 2.089 ± 0.059	5.355IleLeu: 5.355 ± 0.095	1.427IleMet: 1.427 ± 0.041	1.868IleAsn: 1.868 ± 0.045	2.854IlePro: 2.854 ± 0.057	2.518IleGln: 2.518 ± 0.05	3.41IleArg: 3.41 ± 0.055	3.718IleSer: 3.718 ± 0.078	3.529IleThr: 3.529 ± 0.058	4.188IleVal: 4.188 ± 0.078	0.536IleTrp: 0.536 ± 0.025	1.731IleTyr: 1.731 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.073	0.171LysCys: 0.171 ± 0.014	2.423LysAsp: 2.423 ± 0.061	5.258LysGlu: 5.258 ± 0.087	1.001LysPhe: 1.001 ± 0.032	2.979LysGly: 2.979 ± 0.059	1.015LysHis: 1.015 ± 0.03	2.242LysIle: 2.242 ± 0.06	3.84LysLys: 3.84 ± 0.09	4.057LysLeu: 4.057 ± 0.087	1.527LysMet: 1.527 ± 0.045	1.795LysAsn: 1.795 ± 0.052	1.842LysPro: 1.842 ± 0.047	2.565LysGln: 2.565 ± 0.058	3.052LysArg: 3.052 ± 0.062	2.182LysSer: 2.182 ± 0.057	2.929LysThr: 2.929 ± 0.064	2.728LysVal: 2.728 ± 0.058	0.529LysTrp: 0.529 ± 0.026	1.168LysTyr: 1.168 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	7.67LeuAla: 7.67 ± 0.107	0.565LeuCys: 0.565 ± 0.027	5.208LeuAsp: 5.208 ± 0.07	7.607LeuGlu: 7.607 ± 0.104	4.559LeuPhe: 4.559 ± 0.091	6.191LeuGly: 6.191 ± 0.093	2.425LeuHis: 2.425 ± 0.049	5.421LeuIle: 5.421 ± 0.097	4.485LeuLys: 4.485 ± 0.079	10.628LeuLeu: 10.628 ± 0.174	2.413LeuMet: 2.413 ± 0.053	2.96LeuAsn: 2.96 ± 0.055	4.605LeuPro: 4.605 ± 0.085	4.081LeuGln: 4.081 ± 0.075	4.765LeuArg: 4.765 ± 0.079	6.27LeuSer: 6.27 ± 0.078	5.676LeuThr: 5.676 ± 0.082	5.921LeuVal: 5.921 ± 0.085	0.886LeuTrp: 0.886 ± 0.033	3.004LeuTyr: 3.004 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.309MetAla: 2.309 ± 0.043	0.138MetCys: 0.138 ± 0.012	1.672MetAsp: 1.672 ± 0.044	2.655MetGlu: 2.655 ± 0.055	0.989MetPhe: 0.989 ± 0.032	1.658MetGly: 1.658 ± 0.05	0.629MetHis: 0.629 ± 0.027	1.969MetIle: 1.969 ± 0.049	2.223MetLys: 2.223 ± 0.049	2.8MetLeu: 2.8 ± 0.062	1.036MetMet: 1.036 ± 0.033	1.494MetAsn: 1.494 ± 0.042	1.141MetPro: 1.141 ± 0.039	1.294MetGln: 1.294 ± 0.039	1.368MetArg: 1.368 ± 0.04	1.616MetSer: 1.616 ± 0.047	2.146MetThr: 2.146 ± 0.048	1.614MetVal: 1.614 ± 0.04	0.205MetTrp: 0.205 ± 0.015	0.781MetTyr: 0.781 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.502AsnAla: 2.502 ± 0.052	0.177AsnCys: 0.177 ± 0.014	1.938AsnAsp: 1.938 ± 0.057	2.854AsnGlu: 2.854 ± 0.065	1.013AsnPhe: 1.013 ± 0.036	2.8AsnGly: 2.8 ± 0.064	0.694AsnHis: 0.694 ± 0.032	1.981AsnIle: 1.981 ± 0.049	1.356AsnLys: 1.356 ± 0.047	2.513AsnLeu: 2.513 ± 0.054	0.946AsnMet: 0.946 ± 0.03	1.243AsnAsn: 1.243 ± 0.044	1.632AsnPro: 1.632 ± 0.045	1.29AsnGln: 1.29 ± 0.04	1.794AsnArg: 1.794 ± 0.041	1.476AsnSer: 1.476 ± 0.043	1.705AsnThr: 1.705 ± 0.046	2.442AsnVal: 2.442 ± 0.052	0.423AsnTrp: 0.423 ± 0.022	1.002AsnTyr: 1.002 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.709ProAla: 3.709 ± 0.07	0.228ProCys: 0.228 ± 0.016	2.908ProAsp: 2.908 ± 0.065	4.644ProGlu: 4.644 ± 0.083	2.035ProPhe: 2.035 ± 0.048	3.281ProGly: 3.281 ± 0.07	0.897ProHis: 0.897 ± 0.035	1.876ProIle: 1.876 ± 0.05	1.66ProLys: 1.66 ± 0.044	3.954ProLeu: 3.954 ± 0.067	0.937ProMet: 0.937 ± 0.03	1.059ProAsn: 1.059 ± 0.033	1.499ProPro: 1.499 ± 0.043	1.286ProGln: 1.286 ± 0.041	1.359ProArg: 1.359 ± 0.039	2.425ProSer: 2.425 ± 0.052	1.464ProThr: 1.464 ± 0.041	3.863ProVal: 3.863 ± 0.055	0.45ProTrp: 0.45 ± 0.025	1.352ProTyr: 1.352 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.065	0.174GlnCys: 0.174 ± 0.015	1.78GlnAsp: 1.78 ± 0.045	3.819GlnGlu: 3.819 ± 0.071	1.472GlnPhe: 1.472 ± 0.04	2.264GlnGly: 2.264 ± 0.047	0.791GlnHis: 0.791 ± 0.031	1.964GlnIle: 1.964 ± 0.046	2.278GlnLys: 2.278 ± 0.053	3.982GlnLeu: 3.982 ± 0.084	1.305GlnMet: 1.305 ± 0.037	1.228GlnAsn: 1.228 ± 0.035	1.409GlnPro: 1.409 ± 0.036	2.093GlnGln: 2.093 ± 0.054	2.019GlnArg: 2.019 ± 0.048	2.165GlnSer: 2.165 ± 0.046	2.22GlnThr: 2.22 ± 0.049	2.418GlnVal: 2.418 ± 0.053	0.422GlnTrp: 0.422 ± 0.021	1.102GlnTyr: 1.102 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.874ArgAla: 3.874 ± 0.063	0.332ArgCys: 0.332 ± 0.019	2.487ArgAsp: 2.487 ± 0.048	4.582ArgGlu: 4.582 ± 0.07	2.464ArgPhe: 2.464 ± 0.048	3.48ArgGly: 3.48 ± 0.06	1.225ArgHis: 1.225 ± 0.035	3.33ArgIle: 3.33 ± 0.067	2.808ArgLys: 2.808 ± 0.063	5.275ArgLeu: 5.275 ± 0.082	1.976ArgMet: 1.976 ± 0.045	1.653ArgAsn: 1.653 ± 0.043	2.097ArgPro: 2.097 ± 0.041	2.089ArgGln: 2.089 ± 0.046	3.965ArgArg: 3.965 ± 0.076	3.347ArgSer: 3.347 ± 0.064	3.078ArgThr: 3.078 ± 0.056	3.39ArgVal: 3.39 ± 0.071	0.681ArgTrp: 0.681 ± 0.028	1.669ArgTyr: 1.669 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.733SerAla: 4.733 ± 0.075	0.443SerCys: 0.443 ± 0.023	2.896SerAsp: 2.896 ± 0.055	4.072SerGlu: 4.072 ± 0.073	3.115SerPhe: 3.115 ± 0.059	5.601SerGly: 5.601 ± 0.087	1.168SerHis: 1.168 ± 0.036	3.879SerIle: 3.879 ± 0.069	2.093SerLys: 2.093 ± 0.051	5.752SerLeu: 5.752 ± 0.077	2.015SerMet: 2.015 ± 0.049	1.544SerAsn: 1.544 ± 0.041	2.246SerPro: 2.246 ± 0.05	1.803SerGln: 1.803 ± 0.042	3.748SerArg: 3.748 ± 0.068	4.144SerSer: 4.144 ± 0.084	3.038SerThr: 3.038 ± 0.056	4.427SerVal: 4.427 ± 0.069	0.834SerTrp: 0.834 ± 0.034	1.988SerTyr: 1.988 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	6.073ThrAla: 6.073 ± 0.092	0.351ThrCys: 0.351 ± 0.021	3.023ThrAsp: 3.023 ± 0.06	4.152ThrGlu: 4.152 ± 0.068	2.614ThrPhe: 2.614 ± 0.058	4.955ThrGly: 4.955 ± 0.07	1.082ThrHis: 1.082 ± 0.04	3.71ThrIle: 3.71 ± 0.071	2.447ThrLys: 2.447 ± 0.051	5.214ThrLeu: 5.214 ± 0.071	1.61ThrMet: 1.61 ± 0.043	1.793ThrAsn: 1.793 ± 0.044	2.569ThrPro: 2.569 ± 0.058	1.442ThrGln: 1.442 ± 0.04	2.259ThrArg: 2.259 ± 0.047	3.229ThrSer: 3.229 ± 0.063	2.812ThrThr: 2.812 ± 0.051	4.424ThrVal: 4.424 ± 0.08	0.612ThrTrp: 0.612 ± 0.026	1.957ThrTyr: 1.957 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.128ValAla: 4.128 ± 0.071	0.6ValCys: 0.6 ± 0.027	4.24ValAsp: 4.24 ± 0.081	5.789ValGlu: 5.789 ± 0.091	3.346ValPhe: 3.346 ± 0.065	3.873ValGly: 3.873 ± 0.064	1.758ValHis: 1.758 ± 0.041	4.924ValIle: 4.924 ± 0.079	3.346ValLys: 3.346 ± 0.064	7.689ValLeu: 7.689 ± 0.093	2.077ValMet: 2.077 ± 0.049	2.561ValAsn: 2.561 ± 0.046	3.254ValPro: 3.254 ± 0.059	2.827ValGln: 2.827 ± 0.054	3.88ValArg: 3.88 ± 0.07	4.621ValSer: 4.621 ± 0.065	4.897ValThr: 4.897 ± 0.09	4.967ValVal: 4.967 ± 0.09	0.708ValTrp: 0.708 ± 0.027	2.477ValTyr: 2.477 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.725TrpAla: 0.725 ± 0.029	0.081TrpCys: 0.081 ± 0.009	0.561TrpAsp: 0.561 ± 0.025	0.935TrpGlu: 0.935 ± 0.034	0.518TrpPhe: 0.518 ± 0.025	0.619TrpGly: 0.619 ± 0.029	0.238TrpHis: 0.238 ± 0.018	0.773TrpIle: 0.773 ± 0.031	0.838TrpLys: 0.838 ± 0.03	1.157TrpLeu: 1.157 ± 0.036	0.497TrpMet: 0.497 ± 0.024	0.503TrpAsn: 0.503 ± 0.024	0.314TrpPro: 0.314 ± 0.018	0.504TrpGln: 0.504 ± 0.021	0.501TrpArg: 0.501 ± 0.021	0.649TrpSer: 0.649 ± 0.025	0.657TrpThr: 0.657 ± 0.03	0.646TrpVal: 0.646 ± 0.025	0.174TrpTrp: 0.174 ± 0.014	0.386TrpTyr: 0.386 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.378TyrAla: 2.378 ± 0.049	0.255TyrCys: 0.255 ± 0.016	1.876TyrAsp: 1.876 ± 0.049	2.604TyrGlu: 2.604 ± 0.06	1.527TyrPhe: 1.527 ± 0.04	2.341TyrGly: 2.341 ± 0.046	0.871TyrHis: 0.871 ± 0.031	1.848TyrIle: 1.848 ± 0.044	1.155TyrLys: 1.155 ± 0.036	2.905TyrLeu: 2.905 ± 0.056	0.811TyrMet: 0.811 ± 0.027	0.975TyrAsn: 0.975 ± 0.035	1.439TyrPro: 1.439 ± 0.038	1.248TyrGln: 1.248 ± 0.037	1.832TyrArg: 1.832 ± 0.043	1.755TyrSer: 1.755 ± 0.045	1.833TyrThr: 1.833 ± 0.04	2.123TyrVal: 2.123 ± 0.05	0.333TyrTrp: 0.333 ± 0.02	1.211TyrTyr: 1.211 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3136 proteins (944850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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