Amino acid dipepetide frequency for Hungatella hathewayi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.076AlaAla: 9.076 ± 0.091
1.288AlaCys: 1.288 ± 0.024
4.579AlaAsp: 4.579 ± 0.046
5.787AlaGlu: 5.787 ± 0.071
3.303AlaPhe: 3.303 ± 0.042
7.191AlaGly: 7.191 ± 0.069
1.052AlaHis: 1.052 ± 0.024
4.499AlaIle: 4.499 ± 0.056
3.865AlaLys: 3.865 ± 0.044
7.154AlaLeu: 7.154 ± 0.061
2.586AlaMet: 2.586 ± 0.04
2.274AlaAsn: 2.274 ± 0.034
2.275AlaPro: 2.275 ± 0.04
1.973AlaGln: 1.973 ± 0.035
3.245AlaArg: 3.245 ± 0.042
4.243AlaSer: 4.243 ± 0.045
2.916AlaThr: 2.916 ± 0.068
7.401AlaVal: 7.401 ± 0.07
0.805AlaTrp: 0.805 ± 0.021
2.845AlaTyr: 2.845 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.068CysAla: 1.068 ± 0.024
0.332CysCys: 0.332 ± 0.014
0.814CysAsp: 0.814 ± 0.022
0.885CysGlu: 0.885 ± 0.022
0.719CysPhe: 0.719 ± 0.019
1.616CysGly: 1.616 ± 0.034
0.308CysHis: 0.308 ± 0.013
1.048CysIle: 1.048 ± 0.023
0.586CysLys: 0.586 ± 0.021
1.342CysLeu: 1.342 ± 0.028
0.522CysMet: 0.522 ± 0.014
0.519CysAsn: 0.519 ± 0.017
0.626CysPro: 0.626 ± 0.018
0.407CysGln: 0.407 ± 0.014
0.982CysArg: 0.982 ± 0.025
1.008CysSer: 1.008 ± 0.025
0.725CysThr: 0.725 ± 0.023
0.988CysVal: 0.988 ± 0.021
0.147CysTrp: 0.147 ± 0.008
0.607CysTyr: 0.607 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.706AspAla: 3.706 ± 0.042
0.905AspCys: 0.905 ± 0.023
2.761AspAsp: 2.761 ± 0.047
4.217AspGlu: 4.217 ± 0.054
2.564AspPhe: 2.564 ± 0.036
4.987AspGly: 4.987 ± 0.057
1.005AspHis: 1.005 ± 0.022
3.978AspIle: 3.978 ± 0.045
2.764AspLys: 2.764 ± 0.041
4.531AspLeu: 4.531 ± 0.057
1.797AspMet: 1.797 ± 0.029
2.023AspAsn: 2.023 ± 0.034
1.906AspPro: 1.906 ± 0.031
1.558AspGln: 1.558 ± 0.026
2.935AspArg: 2.935 ± 0.044
3.162AspSer: 3.162 ± 0.042
2.96AspThr: 2.96 ± 0.042
3.296AspVal: 3.296 ± 0.044
0.721AspTrp: 0.721 ± 0.02
2.746AspTyr: 2.746 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.363GluAla: 6.363 ± 0.066
0.841GluCys: 0.841 ± 0.025
4.028GluAsp: 4.028 ± 0.049
7.302GluGlu: 7.302 ± 0.081
2.615GluPhe: 2.615 ± 0.037
4.789GluGly: 4.789 ± 0.054
1.324GluHis: 1.324 ± 0.027
5.081GluIle: 5.081 ± 0.053
5.618GluLys: 5.618 ± 0.061
6.559GluLeu: 6.559 ± 0.061
2.407GluMet: 2.407 ± 0.035
3.624GluAsn: 3.624 ± 0.045
2.093GluPro: 2.093 ± 0.038
2.727GluGln: 2.727 ± 0.041
3.786GluArg: 3.786 ± 0.049
3.496GluSer: 3.496 ± 0.047
4.145GluThr: 4.145 ± 0.062
4.299GluVal: 4.299 ± 0.052
0.784GluTrp: 0.784 ± 0.018
3.098GluTyr: 3.098 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.042PheAla: 3.042 ± 0.042
0.766PheCys: 0.766 ± 0.021
2.476PheAsp: 2.476 ± 0.038
2.588PheGlu: 2.588 ± 0.036
2.011PhePhe: 2.011 ± 0.038
3.147PheGly: 3.147 ± 0.044
0.933PheHis: 0.933 ± 0.022
2.848PheIle: 2.848 ± 0.044
2.055PheLys: 2.055 ± 0.034
4.457PheLeu: 4.457 ± 0.055
1.225PheMet: 1.225 ± 0.023
1.537PheAsn: 1.537 ± 0.032
1.53PhePro: 1.53 ± 0.028
1.396PheGln: 1.396 ± 0.025
1.862PheArg: 1.862 ± 0.03
3.033PheSer: 3.033 ± 0.044
2.625PheThr: 2.625 ± 0.039
2.705PheVal: 2.705 ± 0.036
0.489PheTrp: 0.489 ± 0.015
1.911PheTyr: 1.911 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.614GlyAla: 5.614 ± 0.094
1.406GlyCys: 1.406 ± 0.03
3.793GlyAsp: 3.793 ± 0.049
5.07GlyGlu: 5.07 ± 0.057
3.309GlyPhe: 3.309 ± 0.043
5.604GlyGly: 5.604 ± 0.079
1.27GlyHis: 1.27 ± 0.022
6.266GlyIle: 6.266 ± 0.066
4.939GlyLys: 4.939 ± 0.055
6.475GlyLeu: 6.475 ± 0.057
2.653GlyMet: 2.653 ± 0.045
3.074GlyAsn: 3.074 ± 0.047
1.73GlyPro: 1.73 ± 0.046
2.195GlyGln: 2.195 ± 0.038
3.707GlyArg: 3.707 ± 0.05
4.534GlySer: 4.534 ± 0.06
4.532GlyThr: 4.532 ± 0.057
5.084GlyVal: 5.084 ± 0.055
0.963GlyTrp: 0.963 ± 0.029
3.453GlyTyr: 3.453 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.137HisAla: 1.137 ± 0.021
0.298HisCys: 0.298 ± 0.011
0.939HisAsp: 0.939 ± 0.024
1.13HisGlu: 1.13 ± 0.022
0.905HisPhe: 0.905 ± 0.021
1.412HisGly: 1.412 ± 0.028
0.445HisHis: 0.445 ± 0.02
1.238HisIle: 1.238 ± 0.022
0.764HisLys: 0.764 ± 0.018
1.595HisLeu: 1.595 ± 0.03
0.611HisMet: 0.611 ± 0.016
0.648HisAsn: 0.648 ± 0.018
0.807HisPro: 0.807 ± 0.022
0.554HisGln: 0.554 ± 0.018
0.797HisArg: 0.797 ± 0.023
0.937HisSer: 0.937 ± 0.022
1.011HisThr: 1.011 ± 0.023
1.167HisVal: 1.167 ± 0.026
0.212HisTrp: 0.212 ± 0.011
0.857HisTyr: 0.857 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.204IleAla: 5.204 ± 0.054
1.236IleCys: 1.236 ± 0.026
3.583IleAsp: 3.583 ± 0.049
4.09IleGlu: 4.09 ± 0.049
2.818IlePhe: 2.818 ± 0.046
4.961IleGly: 4.961 ± 0.062
1.312IleHis: 1.312 ± 0.028
4.56IleIle: 4.56 ± 0.06
3.179IleLys: 3.179 ± 0.04
6.904IleLeu: 6.904 ± 0.071
1.983IleMet: 1.983 ± 0.031
2.691IleAsn: 2.691 ± 0.046
3.356IlePro: 3.356 ± 0.041
2.056IleGln: 2.056 ± 0.034
3.943IleArg: 3.943 ± 0.046
4.616IleSer: 4.616 ± 0.054
4.264IleThr: 4.264 ± 0.053
4.505IleVal: 4.505 ± 0.054
0.724IleTrp: 0.724 ± 0.02
2.664IleTyr: 2.664 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.579LysAla: 4.579 ± 0.057
0.552LysCys: 0.552 ± 0.017
3.276LysAsp: 3.276 ± 0.038
5.681LysGlu: 5.681 ± 0.062
1.586LysPhe: 1.586 ± 0.031
3.784LysGly: 3.784 ± 0.051
0.873LysHis: 0.873 ± 0.021
3.787LysIle: 3.787 ± 0.05
4.867LysLys: 4.867 ± 0.065
4.659LysLeu: 4.659 ± 0.05
1.803LysMet: 1.803 ± 0.032
3.031LysAsn: 3.031 ± 0.043
1.944LysPro: 1.944 ± 0.028
2.023LysGln: 2.023 ± 0.032
3.119LysArg: 3.119 ± 0.041
3.027LysSer: 3.027 ± 0.039
3.415LysThr: 3.415 ± 0.044
3.291LysVal: 3.291 ± 0.051
0.672LysTrp: 0.672 ± 0.019
2.438LysTyr: 2.438 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
7.152LeuAla: 7.152 ± 0.068
1.492LeuCys: 1.492 ± 0.03
4.874LeuAsp: 4.874 ± 0.05
6.533LeuGlu: 6.533 ± 0.061
4.329LeuPhe: 4.329 ± 0.061
5.933LeuGly: 5.933 ± 0.064
1.592LeuHis: 1.592 ± 0.028
6.026LeuIle: 6.026 ± 0.069
6.115LeuLys: 6.115 ± 0.055
8.989LeuLeu: 8.989 ± 0.096
2.816LeuMet: 2.816 ± 0.038
3.83LeuAsn: 3.83 ± 0.046
3.817LeuPro: 3.817 ± 0.046
2.558LeuGln: 2.558 ± 0.038
3.781LeuArg: 3.781 ± 0.046
6.42LeuSer: 6.42 ± 0.068
5.376LeuThr: 5.376 ± 0.053
5.603LeuVal: 5.603 ± 0.061
0.934LeuTrp: 0.934 ± 0.024
3.612LeuTyr: 3.612 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.911MetAla: 2.911 ± 0.038
0.339MetCys: 0.339 ± 0.012
1.875MetAsp: 1.875 ± 0.032
2.893MetGlu: 2.893 ± 0.041
1.039MetPhe: 1.039 ± 0.022
2.288MetGly: 2.288 ± 0.039
0.389MetHis: 0.389 ± 0.014
2.229MetIle: 2.229 ± 0.041
2.569MetLys: 2.569 ± 0.036
2.591MetLeu: 2.591 ± 0.04
1.109MetMet: 1.109 ± 0.027
1.514MetAsn: 1.514 ± 0.024
1.204MetPro: 1.204 ± 0.03
0.92MetGln: 0.92 ± 0.023
1.379MetArg: 1.379 ± 0.028
1.704MetSer: 1.704 ± 0.033
1.919MetThr: 1.919 ± 0.036
2.237MetVal: 2.237 ± 0.034
0.27MetTrp: 0.27 ± 0.013
0.869MetTyr: 0.869 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.779AsnAla: 2.779 ± 0.041
0.576AsnCys: 0.576 ± 0.018
1.886AsnAsp: 1.886 ± 0.03
2.433AsnGlu: 2.433 ± 0.037
1.571AsnPhe: 1.571 ± 0.028
3.602AsnGly: 3.602 ± 0.047
0.866AsnHis: 0.866 ± 0.024
2.744AsnIle: 2.744 ± 0.032
1.89AsnLys: 1.89 ± 0.031
3.466AsnLeu: 3.466 ± 0.041
1.279AsnMet: 1.279 ± 0.023
1.483AsnAsn: 1.483 ± 0.031
2.133AsnPro: 2.133 ± 0.04
1.48AsnGln: 1.48 ± 0.03
2.288AsnArg: 2.288 ± 0.036
2.331AsnSer: 2.331 ± 0.041
2.295AsnThr: 2.295 ± 0.034
2.467AsnVal: 2.467 ± 0.037
0.491AsnTrp: 0.491 ± 0.016
1.86AsnTyr: 1.86 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.96ProAla: 2.96 ± 0.04
0.508ProCys: 0.508 ± 0.017
2.601ProAsp: 2.601 ± 0.042
3.698ProGlu: 3.698 ± 0.054
1.739ProPhe: 1.739 ± 0.027
2.754ProGly: 2.754 ± 0.04
0.669ProHis: 0.669 ± 0.018
1.906ProIle: 1.906 ± 0.032
1.588ProLys: 1.588 ± 0.03
3.165ProLeu: 3.165 ± 0.044
1.068ProMet: 1.068 ± 0.028
1.198ProAsn: 1.198 ± 0.029
0.907ProPro: 0.907 ± 0.022
1.058ProGln: 1.058 ± 0.022
1.124ProArg: 1.124 ± 0.023
1.937ProSer: 1.937 ± 0.036
1.523ProThr: 1.523 ± 0.043
3.512ProVal: 3.512 ± 0.045
0.462ProTrp: 0.462 ± 0.017
1.609ProTyr: 1.609 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.486GlnAla: 2.486 ± 0.033
0.368GlnCys: 0.368 ± 0.014
1.466GlnAsp: 1.466 ± 0.028
2.459GlnGlu: 2.459 ± 0.041
1.222GlnPhe: 1.222 ± 0.024
2.002GlnGly: 2.002 ± 0.05
0.382GlnHis: 0.382 ± 0.013
2.337GlnIle: 2.337 ± 0.04
2.257GlnLys: 2.257 ± 0.038
2.645GlnLeu: 2.645 ± 0.036
1.195GlnMet: 1.195 ± 0.022
1.479GlnAsn: 1.479 ± 0.026
1.038GlnPro: 1.038 ± 0.024
0.99GlnGln: 0.99 ± 0.024
1.295GlnArg: 1.295 ± 0.024
1.666GlnSer: 1.666 ± 0.03
1.681GlnThr: 1.681 ± 0.026
1.738GlnVal: 1.738 ± 0.027
0.362GlnTrp: 0.362 ± 0.016
1.505GlnTyr: 1.505 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
2.984ArgAla: 2.984 ± 0.042
0.649ArgCys: 0.649 ± 0.019
2.512ArgAsp: 2.512 ± 0.038
4.31ArgGlu: 4.31 ± 0.054
2.118ArgPhe: 2.118 ± 0.034
2.739ArgGly: 2.739 ± 0.042
0.849ArgHis: 0.849 ± 0.022
3.722ArgIle: 3.722 ± 0.043
3.298ArgLys: 3.298 ± 0.046
4.714ArgLeu: 4.714 ± 0.055
1.755ArgMet: 1.755 ± 0.028
2.024ArgAsn: 2.024 ± 0.034
1.532ArgPro: 1.532 ± 0.028
1.779ArgGln: 1.779 ± 0.028
2.679ArgArg: 2.679 ± 0.048
2.41ArgSer: 2.41 ± 0.036
2.473ArgThr: 2.473 ± 0.038
2.991ArgVal: 2.991 ± 0.037
0.509ArgTrp: 0.509 ± 0.018
2.175ArgTyr: 2.175 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.388SerAla: 4.388 ± 0.047
0.905SerCys: 0.905 ± 0.02
3.236SerAsp: 3.236 ± 0.045
3.773SerGlu: 3.773 ± 0.046
2.908SerPhe: 2.908 ± 0.035
5.462SerGly: 5.462 ± 0.068
1.085SerHis: 1.085 ± 0.023
3.982SerIle: 3.982 ± 0.052
2.615SerLys: 2.615 ± 0.039
5.588SerLeu: 5.588 ± 0.06
2.023SerMet: 2.023 ± 0.038
1.989SerAsn: 1.989 ± 0.029
2.02SerPro: 2.02 ± 0.029
1.773SerGln: 1.773 ± 0.026
3.061SerArg: 3.061 ± 0.043
3.704SerSer: 3.704 ± 0.048
2.676SerThr: 2.676 ± 0.037
4.584SerVal: 4.584 ± 0.044
0.722SerTrp: 0.722 ± 0.019
2.437SerTyr: 2.437 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.139ThrAla: 5.139 ± 0.059
0.65ThrCys: 0.65 ± 0.02
3.152ThrAsp: 3.152 ± 0.042
3.893ThrGlu: 3.893 ± 0.051
2.222ThrPhe: 2.222 ± 0.036
5.218ThrGly: 5.218 ± 0.107
0.834ThrHis: 0.834 ± 0.022
3.84ThrIle: 3.84 ± 0.05
2.549ThrLys: 2.549 ± 0.042
4.881ThrLeu: 4.881 ± 0.05
1.626ThrMet: 1.626 ± 0.027
1.825ThrAsn: 1.825 ± 0.028
2.291ThrPro: 2.291 ± 0.039
1.299ThrGln: 1.299 ± 0.026
2.043ThrArg: 2.043 ± 0.032
2.831ThrSer: 2.831 ± 0.038
2.716ThrThr: 2.716 ± 0.047
4.773ThrVal: 4.773 ± 0.056
0.62ThrTrp: 0.62 ± 0.019
2.106ThrTyr: 2.106 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
4.396ValAla: 4.396 ± 0.058
1.291ValCys: 1.291 ± 0.023
3.5ValAsp: 3.5 ± 0.041
4.4ValGlu: 4.4 ± 0.05
3.181ValPhe: 3.181 ± 0.043
4.1ValGly: 4.1 ± 0.056
1.109ValHis: 1.109 ± 0.025
5.176ValIle: 5.176 ± 0.053
4.122ValLys: 4.122 ± 0.051
6.858ValLeu: 6.858 ± 0.068
2.269ValMet: 2.269 ± 0.036
2.789ValAsn: 2.789 ± 0.042
2.804ValPro: 2.804 ± 0.041
1.753ValGln: 1.753 ± 0.03
3.233ValArg: 3.233 ± 0.037
4.773ValSer: 4.773 ± 0.054
4.486ValThr: 4.486 ± 0.057
4.638ValVal: 4.638 ± 0.062
0.802ValTrp: 0.802 ± 0.023
2.737ValTyr: 2.737 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.658TrpAla: 0.658 ± 0.019
0.193TrpCys: 0.193 ± 0.009
0.651TrpAsp: 0.651 ± 0.019
0.786TrpGlu: 0.786 ± 0.019
0.528TrpPhe: 0.528 ± 0.015
0.775TrpGly: 0.775 ± 0.02
0.22TrpHis: 0.22 ± 0.011
0.754TrpIle: 0.754 ± 0.019
0.843TrpLys: 0.843 ± 0.02
1.101TrpLeu: 1.101 ± 0.025
0.356TrpMet: 0.356 ± 0.012
0.73TrpAsn: 0.73 ± 0.02
0.303TrpPro: 0.303 ± 0.012
0.449TrpGln: 0.449 ± 0.013
0.5TrpArg: 0.5 ± 0.014
0.618TrpSer: 0.618 ± 0.02
0.526TrpThr: 0.526 ± 0.016
0.619TrpVal: 0.619 ± 0.017
0.17TrpTrp: 0.17 ± 0.011
0.552TrpTyr: 0.552 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.718TyrAla: 2.718 ± 0.035
0.654TyrCys: 0.654 ± 0.021
2.519TyrAsp: 2.519 ± 0.034
3.049TyrGlu: 3.049 ± 0.046
1.951TyrPhe: 1.951 ± 0.033
3.306TyrGly: 3.306 ± 0.047
0.946TyrHis: 0.946 ± 0.022
2.626TyrIle: 2.626 ± 0.04
1.925TyrLys: 1.925 ± 0.041
4.108TyrLeu: 4.108 ± 0.046
1.164TyrMet: 1.164 ± 0.025
1.64TyrAsn: 1.64 ± 0.03
1.67TyrPro: 1.67 ± 0.028
1.628TyrGln: 1.628 ± 0.031
2.462TyrArg: 2.462 ± 0.036
2.483TyrSer: 2.483 ± 0.04
2.244TyrThr: 2.244 ± 0.044
2.517TyrVal: 2.517 ± 0.04
0.471TyrTrp: 0.471 ± 0.015
2.062TyrTyr: 2.062 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6044 proteins (2069600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski