Amino acid dipepetide frequency for bacterium 2013Arg42i

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.976AlaAla: 3.976 ± 0.134
0.829AlaCys: 0.829 ± 0.037
2.951AlaAsp: 2.951 ± 0.076
3.017AlaGlu: 3.017 ± 0.084
2.1AlaPhe: 2.1 ± 0.063
2.981AlaGly: 2.981 ± 0.098
1.028AlaHis: 1.028 ± 0.048
4.535AlaIle: 4.535 ± 0.096
3.273AlaLys: 3.273 ± 0.094
5.231AlaLeu: 5.231 ± 0.111
1.296AlaMet: 1.296 ± 0.059
2.262AlaAsn: 2.262 ± 0.064
1.675AlaPro: 1.675 ± 0.074
1.668AlaGln: 1.668 ± 0.059
2.557AlaArg: 2.557 ± 0.084
4.504AlaSer: 4.504 ± 0.11
2.818AlaThr: 2.818 ± 0.092
4.093AlaVal: 4.093 ± 0.097
0.447AlaTrp: 0.447 ± 0.027
1.631AlaTyr: 1.631 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
1.025CysAla: 1.025 ± 0.047
0.536CysCys: 0.536 ± 0.029
1.209CysAsp: 1.209 ± 0.043
0.914CysGlu: 0.914 ± 0.042
0.96CysPhe: 0.96 ± 0.04
1.177CysGly: 1.177 ± 0.048
0.452CysHis: 0.452 ± 0.029
1.416CysIle: 1.416 ± 0.052
0.941CysLys: 0.941 ± 0.04
1.685CysLeu: 1.685 ± 0.052
0.385CysMet: 0.385 ± 0.03
0.952CysAsn: 0.952 ± 0.044
0.686CysPro: 0.686 ± 0.039
0.476CysGln: 0.476 ± 0.027
1.013CysArg: 1.013 ± 0.043
2.059CysSer: 2.059 ± 0.065
0.82CysThr: 0.82 ± 0.041
1.216CysVal: 1.216 ± 0.044
0.119CysTrp: 0.119 ± 0.015
0.655CysTyr: 0.655 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
2.78AspAla: 2.78 ± 0.078
1.052AspCys: 1.052 ± 0.048
4.066AspAsp: 4.066 ± 0.117
3.856AspGlu: 3.856 ± 0.088
2.565AspPhe: 2.565 ± 0.067
3.542AspGly: 3.542 ± 0.129
1.276AspHis: 1.276 ± 0.042
5.079AspIle: 5.079 ± 0.126
4.221AspLys: 4.221 ± 0.133
5.471AspLeu: 5.471 ± 0.097
1.436AspMet: 1.436 ± 0.047
3.384AspAsn: 3.384 ± 0.092
2.031AspPro: 2.031 ± 0.068
1.584AspGln: 1.584 ± 0.051
3.068AspArg: 3.068 ± 0.085
4.767AspSer: 4.767 ± 0.105
2.413AspThr: 2.413 ± 0.072
4.182AspVal: 4.182 ± 0.119
0.551AspTrp: 0.551 ± 0.043
2.248AspTyr: 2.248 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
2.741GluAla: 2.741 ± 0.078
0.933GluCys: 0.933 ± 0.038
3.172GluAsp: 3.172 ± 0.081
5.234GluGlu: 5.234 ± 0.173
2.415GluPhe: 2.415 ± 0.074
2.77GluGly: 2.77 ± 0.075
1.146GluHis: 1.146 ± 0.045
5.096GluIle: 5.096 ± 0.118
5.412GluLys: 5.412 ± 0.137
5.763GluLeu: 5.763 ± 0.123
1.503GluMet: 1.503 ± 0.05
3.096GluAsn: 3.096 ± 0.086
1.482GluPro: 1.482 ± 0.061
1.762GluGln: 1.762 ± 0.064
2.976GluArg: 2.976 ± 0.076
5.156GluSer: 5.156 ± 0.11
2.587GluThr: 2.587 ± 0.075
3.822GluVal: 3.822 ± 0.109
0.416GluTrp: 0.416 ± 0.028
1.91GluTyr: 1.91 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.108PheAla: 2.108 ± 0.067
1.247PheCys: 1.247 ± 0.044
3.205PheAsp: 3.205 ± 0.091
2.023PheGlu: 2.023 ± 0.064
3.169PhePhe: 3.169 ± 0.083
2.449PheGly: 2.449 ± 0.07
1.035PheHis: 1.035 ± 0.047
3.546PheIle: 3.546 ± 0.09
2.004PheLys: 2.004 ± 0.062
5.153PheLeu: 5.153 ± 0.113
1.112PheMet: 1.112 ± 0.045
2.082PheAsn: 2.082 ± 0.082
1.794PhePro: 1.794 ± 0.057
0.943PheGln: 0.943 ± 0.043
1.99PheArg: 1.99 ± 0.068
5.535PheSer: 5.535 ± 0.12
1.796PheThr: 1.796 ± 0.061
3.159PheVal: 3.159 ± 0.084
0.447PheTrp: 0.447 ± 0.031
1.644PheTyr: 1.644 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.015GlyAla: 3.015 ± 0.1
1.213GlyCys: 1.213 ± 0.046
3.017GlyAsp: 3.017 ± 0.081
2.824GlyGlu: 2.824 ± 0.081
2.884GlyPhe: 2.884 ± 0.119
3.409GlyGly: 3.409 ± 0.107
1.17GlyHis: 1.17 ± 0.048
4.569GlyIle: 4.569 ± 0.116
3.218GlyLys: 3.218 ± 0.075
4.598GlyLeu: 4.598 ± 0.106
1.564GlyMet: 1.564 ± 0.061
2.57GlyAsn: 2.57 ± 0.081
1.218GlyPro: 1.218 ± 0.052
1.412GlyGln: 1.412 ± 0.052
2.691GlyArg: 2.691 ± 0.088
4.716GlySer: 4.716 ± 0.096
2.632GlyThr: 2.632 ± 0.068
4.342GlyVal: 4.342 ± 0.105
0.501GlyTrp: 0.501 ± 0.038
2.659GlyTyr: 2.659 ± 0.146
0.0GlyXaa: 0.0 ± 0.0
His
1.069HisAla: 1.069 ± 0.046
0.377HisCys: 0.377 ± 0.03
1.16HisAsp: 1.16 ± 0.044
1.288HisGlu: 1.288 ± 0.049
0.793HisPhe: 0.793 ± 0.038
1.451HisGly: 1.451 ± 0.052
0.626HisHis: 0.626 ± 0.035
1.648HisIle: 1.648 ± 0.055
1.453HisLys: 1.453 ± 0.058
2.101HisLeu: 2.101 ± 0.067
0.409HisMet: 0.409 ± 0.029
1.097HisAsn: 1.097 ± 0.046
1.151HisPro: 1.151 ± 0.046
0.682HisGln: 0.682 ± 0.036
1.161HisArg: 1.161 ± 0.048
1.586HisSer: 1.586 ± 0.058
0.988HisThr: 0.988 ± 0.046
1.206HisVal: 1.206 ± 0.043
0.194HisTrp: 0.194 ± 0.016
0.747HisTyr: 0.747 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
4.545IleAla: 4.545 ± 0.107
1.463IleCys: 1.463 ± 0.052
5.582IleAsp: 5.582 ± 0.118
4.573IleGlu: 4.573 ± 0.105
3.774IlePhe: 3.774 ± 0.092
4.085IleGly: 4.085 ± 0.093
1.632IleHis: 1.632 ± 0.049
6.515IleIle: 6.515 ± 0.146
5.558IleLys: 5.558 ± 0.148
6.8IleLeu: 6.8 ± 0.106
1.716IleMet: 1.716 ± 0.052
4.985IleAsn: 4.985 ± 0.132
3.036IlePro: 3.036 ± 0.075
1.492IleGln: 1.492 ± 0.05
4.269IleArg: 4.269 ± 0.091
8.649IleSer: 8.649 ± 0.144
4.049IleThr: 4.049 ± 0.104
5.393IleVal: 5.393 ± 0.089
0.522IleTrp: 0.522 ± 0.033
2.65IleTyr: 2.65 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
2.538LysAla: 2.538 ± 0.078
0.977LysCys: 0.977 ± 0.047
3.406LysAsp: 3.406 ± 0.075
4.455LysGlu: 4.455 ± 0.124
3.264LysPhe: 3.264 ± 0.101
2.447LysGly: 2.447 ± 0.07
1.296LysHis: 1.296 ± 0.058
6.814LysIle: 6.814 ± 0.184
6.056LysLys: 6.056 ± 0.164
6.374LysLeu: 6.374 ± 0.189
1.443LysMet: 1.443 ± 0.053
4.632LysAsn: 4.632 ± 0.128
1.537LysPro: 1.537 ± 0.059
1.559LysGln: 1.559 ± 0.056
3.111LysArg: 3.111 ± 0.075
6.021LysSer: 6.021 ± 0.124
2.881LysThr: 2.881 ± 0.084
3.621LysVal: 3.621 ± 0.08
0.495LysTrp: 0.495 ± 0.03
2.657LysTyr: 2.657 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
5.135LeuAla: 5.135 ± 0.126
1.888LeuCys: 1.888 ± 0.07
4.883LeuAsp: 4.883 ± 0.098
5.567LeuGlu: 5.567 ± 0.102
4.581LeuPhe: 4.581 ± 0.102
5.357LeuGly: 5.357 ± 0.132
2.031LeuHis: 2.031 ± 0.056
6.889LeuIle: 6.889 ± 0.132
5.466LeuLys: 5.466 ± 0.119
10.143LeuLeu: 10.143 ± 0.169
2.291LeuMet: 2.291 ± 0.073
4.136LeuAsn: 4.136 ± 0.082
4.499LeuPro: 4.499 ± 0.096
2.507LeuGln: 2.507 ± 0.077
5.108LeuArg: 5.108 ± 0.103
11.296LeuSer: 11.296 ± 0.158
4.3LeuThr: 4.3 ± 0.102
6.304LeuVal: 6.304 ± 0.12
0.749LeuTrp: 0.749 ± 0.037
2.656LeuTyr: 2.656 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.419MetAla: 1.419 ± 0.051
0.394MetCys: 0.394 ± 0.029
1.202MetAsp: 1.202 ± 0.045
1.378MetGlu: 1.378 ± 0.047
0.877MetPhe: 0.877 ± 0.039
1.395MetGly: 1.395 ± 0.053
0.438MetHis: 0.438 ± 0.027
1.97MetIle: 1.97 ± 0.052
1.479MetLys: 1.479 ± 0.05
2.101MetLeu: 2.101 ± 0.064
0.592MetMet: 0.592 ± 0.032
1.063MetAsn: 1.063 ± 0.04
0.834MetPro: 0.834 ± 0.043
0.59MetGln: 0.59 ± 0.057
1.104MetArg: 1.104 ± 0.04
2.34MetSer: 2.34 ± 0.062
1.185MetThr: 1.185 ± 0.04
1.723MetVal: 1.723 ± 0.049
0.169MetTrp: 0.169 ± 0.017
0.808MetTyr: 0.808 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.343AsnAla: 2.343 ± 0.061
1.131AsnCys: 1.131 ± 0.044
2.872AsnAsp: 2.872 ± 0.078
2.94AsnGlu: 2.94 ± 0.077
2.71AsnPhe: 2.71 ± 0.072
2.468AsnGly: 2.468 ± 0.087
1.208AsnHis: 1.208 ± 0.043
5.239AsnIle: 5.239 ± 0.165
3.984AsnLys: 3.984 ± 0.13
5.303AsnLeu: 5.303 ± 0.144
1.075AsnMet: 1.075 ± 0.046
3.433AsnAsn: 3.433 ± 0.122
1.83AsnPro: 1.83 ± 0.058
1.339AsnGln: 1.339 ± 0.052
2.512AsnArg: 2.512 ± 0.069
4.54AsnSer: 4.54 ± 0.107
2.507AsnThr: 2.507 ± 0.087
3.114AsnVal: 3.114 ± 0.071
0.396AsnTrp: 0.396 ± 0.026
2.265AsnTyr: 2.265 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.695ProAla: 1.695 ± 0.062
0.495ProCys: 0.495 ± 0.03
2.204ProAsp: 2.204 ± 0.054
2.386ProGlu: 2.386 ± 0.066
1.501ProPhe: 1.501 ± 0.047
2.047ProGly: 2.047 ± 0.068
0.814ProHis: 0.814 ± 0.039
2.71ProIle: 2.71 ± 0.07
1.895ProLys: 1.895 ± 0.075
3.305ProLeu: 3.305 ± 0.079
0.723ProMet: 0.723 ± 0.041
1.842ProAsn: 1.842 ± 0.06
1.421ProPro: 1.421 ± 0.077
1.199ProGln: 1.199 ± 0.053
1.397ProArg: 1.397 ± 0.056
3.251ProSer: 3.251 ± 0.077
1.941ProThr: 1.941 ± 0.083
2.637ProVal: 2.637 ± 0.082
0.312ProTrp: 0.312 ± 0.023
1.254ProTyr: 1.254 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.472GlnAla: 1.472 ± 0.063
0.425GlnCys: 0.425 ± 0.028
1.376GlnAsp: 1.376 ± 0.048
1.714GlnGlu: 1.714 ± 0.072
0.938GlnPhe: 0.938 ± 0.041
1.385GlnGly: 1.385 ± 0.07
0.619GlnHis: 0.619 ± 0.036
1.898GlnIle: 1.898 ± 0.059
2.06GlnLys: 2.06 ± 0.067
2.591GlnLeu: 2.591 ± 0.076
0.626GlnMet: 0.626 ± 0.041
1.341GlnAsn: 1.341 ± 0.062
0.88GlnPro: 0.88 ± 0.04
1.109GlnGln: 1.109 ± 0.056
1.31GlnArg: 1.31 ± 0.058
2.265GlnSer: 2.265 ± 0.063
1.213GlnThr: 1.213 ± 0.05
1.595GlnVal: 1.595 ± 0.06
0.237GlnTrp: 0.237 ± 0.021
0.996GlnTyr: 0.996 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.722ArgAla: 2.722 ± 0.076
0.941ArgCys: 0.941 ± 0.049
3.007ArgAsp: 3.007 ± 0.084
3.312ArgGlu: 3.312 ± 0.082
2.323ArgPhe: 2.323 ± 0.069
2.659ArgGly: 2.659 ± 0.1
1.032ArgHis: 1.032 ± 0.044
3.762ArgIle: 3.762 ± 0.083
3.618ArgLys: 3.618 ± 0.096
4.741ArgLeu: 4.741 ± 0.102
1.104ArgMet: 1.104 ± 0.047
2.802ArgAsn: 2.802 ± 0.076
1.322ArgPro: 1.322 ± 0.047
1.434ArgGln: 1.434 ± 0.06
3.212ArgArg: 3.212 ± 0.092
4.66ArgSer: 4.66 ± 0.103
1.922ArgThr: 1.922 ± 0.061
3.534ArgVal: 3.534 ± 0.101
0.478ArgTrp: 0.478 ± 0.032
2.054ArgTyr: 2.054 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
5.062SerAla: 5.062 ± 0.108
1.938SerCys: 1.938 ± 0.068
5.777SerAsp: 5.777 ± 0.097
5.028SerGlu: 5.028 ± 0.096
4.612SerPhe: 4.612 ± 0.119
5.316SerGly: 5.316 ± 0.118
1.951SerHis: 1.951 ± 0.067
7.554SerIle: 7.554 ± 0.146
5.903SerLys: 5.903 ± 0.143
9.659SerLeu: 9.659 ± 0.145
2.277SerMet: 2.277 ± 0.062
5.562SerAsn: 5.562 ± 0.167
3.444SerPro: 3.444 ± 0.095
2.321SerGln: 2.321 ± 0.071
4.801SerArg: 4.801 ± 0.109
11.061SerSer: 11.061 ± 0.247
4.641SerThr: 4.641 ± 0.114
6.51SerVal: 6.51 ± 0.115
0.957SerTrp: 0.957 ± 0.044
3.396SerTyr: 3.396 ± 0.084
0.0SerXaa: 0.0 ± 0.0
Thr
2.983ThrAla: 2.983 ± 0.099
0.626ThrCys: 0.626 ± 0.033
2.753ThrAsp: 2.753 ± 0.068
2.836ThrGlu: 2.836 ± 0.085
1.68ThrPhe: 1.68 ± 0.068
2.582ThrGly: 2.582 ± 0.074
0.943ThrHis: 0.943 ± 0.04
3.737ThrIle: 3.737 ± 0.097
3.067ThrLys: 3.067 ± 0.088
4.059ThrLeu: 4.059 ± 0.093
0.986ThrMet: 0.986 ± 0.045
2.523ThrAsn: 2.523 ± 0.085
2.035ThrPro: 2.035 ± 0.066
1.245ThrGln: 1.245 ± 0.047
2.016ThrArg: 2.016 ± 0.057
4.446ThrSer: 4.446 ± 0.111
3.312ThrThr: 3.312 ± 0.149
3.268ThrVal: 3.268 ± 0.086
0.305ThrTrp: 0.305 ± 0.023
1.636ThrTyr: 1.636 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
4.051ValAla: 4.051 ± 0.107
1.371ValCys: 1.371 ± 0.056
4.745ValAsp: 4.745 ± 0.107
3.646ValGlu: 3.646 ± 0.087
3.275ValPhe: 3.275 ± 0.091
3.89ValGly: 3.89 ± 0.11
1.371ValHis: 1.371 ± 0.051
5.088ValIle: 5.088 ± 0.102
3.418ValLys: 3.418 ± 0.083
6.58ValLeu: 6.58 ± 0.128
1.637ValMet: 1.637 ± 0.058
3.123ValAsn: 3.123 ± 0.071
2.497ValPro: 2.497 ± 0.077
1.354ValGln: 1.354 ± 0.047
3.751ValArg: 3.751 ± 0.089
6.957ValSer: 6.957 ± 0.11
3.339ValThr: 3.339 ± 0.084
5.836ValVal: 5.836 ± 0.15
0.588ValTrp: 0.588 ± 0.037
1.909ValTyr: 1.909 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.37TrpAla: 0.37 ± 0.025
0.142TrpCys: 0.142 ± 0.014
0.425TrpAsp: 0.425 ± 0.026
0.394TrpGlu: 0.394 ± 0.027
0.416TrpPhe: 0.416 ± 0.028
0.672TrpGly: 0.672 ± 0.039
0.218TrpHis: 0.218 ± 0.017
0.617TrpIle: 0.617 ± 0.035
0.525TrpLys: 0.525 ± 0.032
0.844TrpLeu: 0.844 ± 0.041
0.227TrpMet: 0.227 ± 0.021
0.461TrpAsn: 0.461 ± 0.032
0.261TrpPro: 0.261 ± 0.02
0.256TrpGln: 0.256 ± 0.026
0.498TrpArg: 0.498 ± 0.03
0.706TrpSer: 0.706 ± 0.041
0.302TrpThr: 0.302 ± 0.024
0.604TrpVal: 0.604 ± 0.036
0.097TrpTrp: 0.097 ± 0.012
0.273TrpTyr: 0.273 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.82TyrAla: 1.82 ± 0.061
0.72TyrCys: 0.72 ± 0.039
2.563TyrAsp: 2.563 ± 0.127
2.006TyrGlu: 2.006 ± 0.067
1.603TyrPhe: 1.603 ± 0.052
2.14TyrGly: 2.14 ± 0.076
0.901TyrHis: 0.901 ± 0.038
2.61TyrIle: 2.61 ± 0.089
2.031TyrLys: 2.031 ± 0.064
3.283TyrLeu: 3.283 ± 0.078
0.658TyrMet: 0.658 ± 0.033
1.866TyrAsn: 1.866 ± 0.075
1.395TyrPro: 1.395 ± 0.05
1.115TyrGln: 1.115 ± 0.051
2.093TyrArg: 2.093 ± 0.062
3.254TyrSer: 3.254 ± 0.086
1.392TyrThr: 1.392 ± 0.054
2.268TyrVal: 2.268 ± 0.067
0.327TyrTrp: 0.327 ± 0.023
1.376TyrTyr: 1.376 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1563 proteins (586317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski