Amino acid dipepetide frequency for Bergeriella denitrificans (Neisseria denitrificans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.442AlaAla: 18.442 ± 0.337
1.22AlaCys: 1.22 ± 0.046
7.236AlaAsp: 7.236 ± 0.114
8.186AlaGlu: 8.186 ± 0.153
4.197AlaPhe: 4.197 ± 0.095
8.706AlaGly: 8.706 ± 0.136
2.274AlaHis: 2.274 ± 0.057
4.275AlaIle: 4.275 ± 0.091
5.479AlaLys: 5.479 ± 0.105
12.413AlaLeu: 12.413 ± 0.198
2.898AlaMet: 2.898 ± 0.076
3.184AlaAsn: 3.184 ± 0.087
4.369AlaPro: 4.369 ± 0.102
5.498AlaGln: 5.498 ± 0.102
5.787AlaArg: 5.787 ± 0.103
4.345AlaSer: 4.345 ± 0.105
4.23AlaThr: 4.23 ± 0.114
9.47AlaVal: 9.47 ± 0.152
1.419AlaTrp: 1.419 ± 0.053
3.08AlaTyr: 3.08 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
1.018CysAla: 1.018 ± 0.043
0.161CysCys: 0.161 ± 0.016
0.482CysAsp: 0.482 ± 0.027
0.502CysGlu: 0.502 ± 0.025
0.371CysPhe: 0.371 ± 0.026
1.098CysGly: 1.098 ± 0.053
0.29CysHis: 0.29 ± 0.022
0.529CysIle: 0.529 ± 0.027
0.287CysLys: 0.287 ± 0.021
0.882CysLeu: 0.882 ± 0.042
0.205CysMet: 0.205 ± 0.019
0.316CysAsn: 0.316 ± 0.021
0.492CysPro: 0.492 ± 0.029
0.316CysGln: 0.316 ± 0.022
0.685CysArg: 0.685 ± 0.032
0.546CysSer: 0.546 ± 0.03
0.467CysThr: 0.467 ± 0.028
0.558CysVal: 0.558 ± 0.027
0.09CysTrp: 0.09 ± 0.01
0.254CysTyr: 0.254 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.288AspAla: 5.288 ± 0.107
0.474AspCys: 0.474 ± 0.026
2.766AspAsp: 2.766 ± 0.072
3.438AspGlu: 3.438 ± 0.091
2.449AspPhe: 2.449 ± 0.065
4.658AspGly: 4.658 ± 0.116
0.866AspHis: 0.866 ± 0.034
3.702AspIle: 3.702 ± 0.077
2.938AspLys: 2.938 ± 0.071
5.377AspLeu: 5.377 ± 0.091
1.464AspMet: 1.464 ± 0.051
2.011AspAsn: 2.011 ± 0.059
1.814AspPro: 1.814 ± 0.05
1.252AspGln: 1.252 ± 0.043
2.173AspArg: 2.173 ± 0.057
2.505AspSer: 2.505 ± 0.068
3.291AspThr: 3.291 ± 0.08
3.619AspVal: 3.619 ± 0.082
0.954AspTrp: 0.954 ± 0.036
1.942AspTyr: 1.942 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
7.8GluAla: 7.8 ± 0.15
0.476GluCys: 0.476 ± 0.032
2.569GluAsp: 2.569 ± 0.075
3.379GluGlu: 3.379 ± 0.081
2.047GluPhe: 2.047 ± 0.057
3.426GluGly: 3.426 ± 0.091
1.491GluHis: 1.491 ± 0.05
3.77GluIle: 3.77 ± 0.095
3.481GluLys: 3.481 ± 0.087
5.612GluLeu: 5.612 ± 0.092
1.72GluMet: 1.72 ± 0.047
2.606GluAsn: 2.606 ± 0.07
2.09GluPro: 2.09 ± 0.078
3.206GluGln: 3.206 ± 0.096
3.694GluArg: 3.694 ± 0.095
2.763GluSer: 2.763 ± 0.065
3.459GluThr: 3.459 ± 0.084
3.592GluVal: 3.592 ± 0.073
0.887GluTrp: 0.887 ± 0.039
1.696GluTyr: 1.696 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.494PheAla: 4.494 ± 0.107
0.476PheCys: 0.476 ± 0.027
2.614PheAsp: 2.614 ± 0.065
2.322PheGlu: 2.322 ± 0.066
1.631PhePhe: 1.631 ± 0.062
3.623PheGly: 3.623 ± 0.088
0.806PheHis: 0.806 ± 0.034
2.092PheIle: 2.092 ± 0.056
1.66PheLys: 1.66 ± 0.054
3.269PheLeu: 3.269 ± 0.093
0.902PheMet: 0.902 ± 0.041
1.564PheAsn: 1.564 ± 0.052
1.462PhePro: 1.462 ± 0.055
1.391PheGln: 1.391 ± 0.048
1.85PheArg: 1.85 ± 0.062
2.518PheSer: 2.518 ± 0.057
2.093PheThr: 2.093 ± 0.05
2.605PheVal: 2.605 ± 0.078
0.568PheTrp: 0.568 ± 0.029
1.235PheTyr: 1.235 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.01GlyAla: 7.01 ± 0.133
0.794GlyCys: 0.794 ± 0.035
3.536GlyAsp: 3.536 ± 0.085
4.517GlyGlu: 4.517 ± 0.088
3.481GlyPhe: 3.481 ± 0.08
6.602GlyGly: 6.602 ± 0.135
1.582GlyHis: 1.582 ± 0.05
4.754GlyIle: 4.754 ± 0.093
4.808GlyLys: 4.808 ± 0.1
8.084GlyLeu: 8.084 ± 0.128
2.373GlyMet: 2.373 ± 0.06
2.856GlyAsn: 2.856 ± 0.087
1.323GlyPro: 1.323 ± 0.046
2.861GlyGln: 2.861 ± 0.066
4.831GlyArg: 4.831 ± 0.102
4.71GlySer: 4.71 ± 0.1
3.501GlyThr: 3.501 ± 0.09
5.434GlyVal: 5.434 ± 0.099
1.243GlyTrp: 1.243 ± 0.057
2.363GlyTyr: 2.363 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
2.093HisAla: 2.093 ± 0.062
0.256HisCys: 0.256 ± 0.019
1.054HisAsp: 1.054 ± 0.042
1.19HisGlu: 1.19 ± 0.042
0.923HisPhe: 0.923 ± 0.036
1.72HisGly: 1.72 ± 0.052
0.65HisHis: 0.65 ± 0.042
1.597HisIle: 1.597 ± 0.055
0.939HisLys: 0.939 ± 0.041
2.085HisLeu: 2.085 ± 0.058
0.441HisMet: 0.441 ± 0.026
0.851HisAsn: 0.851 ± 0.036
1.337HisPro: 1.337 ± 0.051
0.852HisGln: 0.852 ± 0.039
1.129HisArg: 1.129 ± 0.042
1.13HisSer: 1.13 ± 0.043
1.442HisThr: 1.442 ± 0.051
1.162HisVal: 1.162 ± 0.042
0.317HisTrp: 0.317 ± 0.024
0.746HisTyr: 0.746 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.122IleAla: 6.122 ± 0.094
0.559IleCys: 0.559 ± 0.03
3.365IleAsp: 3.365 ± 0.079
3.643IleGlu: 3.643 ± 0.084
1.809IlePhe: 1.809 ± 0.061
4.79IleGly: 4.79 ± 0.109
1.132IleHis: 1.132 ± 0.044
2.889IleIle: 2.889 ± 0.073
2.352IleLys: 2.352 ± 0.065
4.633IleLeu: 4.633 ± 0.096
1.211IleMet: 1.211 ± 0.046
2.076IleAsn: 2.076 ± 0.074
2.472IlePro: 2.472 ± 0.064
1.781IleGln: 1.781 ± 0.054
3.187IleArg: 3.187 ± 0.074
3.034IleSer: 3.034 ± 0.077
3.133IleThr: 3.133 ± 0.084
3.583IleVal: 3.583 ± 0.075
0.558IleTrp: 0.558 ± 0.029
1.325IleTyr: 1.325 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.573LysAla: 5.573 ± 0.123
0.244LysCys: 0.244 ± 0.021
2.334LysAsp: 2.334 ± 0.07
2.576LysGlu: 2.576 ± 0.078
1.446LysPhe: 1.446 ± 0.054
3.236LysGly: 3.236 ± 0.082
1.077LysHis: 1.077 ± 0.041
3.03LysIle: 3.03 ± 0.068
2.566LysLys: 2.566 ± 0.075
4.866LysLeu: 4.866 ± 0.094
1.371LysMet: 1.371 ± 0.043
2.128LysAsn: 2.128 ± 0.071
2.515LysPro: 2.515 ± 0.077
2.496LysGln: 2.496 ± 0.067
2.699LysArg: 2.699 ± 0.068
2.566LysSer: 2.566 ± 0.066
2.935LysThr: 2.935 ± 0.07
3.022LysVal: 3.022 ± 0.083
0.52LysTrp: 0.52 ± 0.035
1.213LysTyr: 1.213 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
12.16LeuAla: 12.16 ± 0.194
0.996LeuCys: 0.996 ± 0.047
5.353LeuAsp: 5.353 ± 0.085
5.168LeuGlu: 5.168 ± 0.103
3.822LeuPhe: 3.822 ± 0.093
7.338LeuGly: 7.338 ± 0.139
2.189LeuHis: 2.189 ± 0.066
5.18LeuIle: 5.18 ± 0.105
5.391LeuLys: 5.391 ± 0.087
10.87LeuLeu: 10.87 ± 0.21
2.651LeuMet: 2.651 ± 0.081
4.1LeuAsn: 4.1 ± 0.092
5.986LeuPro: 5.986 ± 0.106
4.262LeuGln: 4.262 ± 0.092
5.264LeuArg: 5.264 ± 0.094
6.517LeuSer: 6.517 ± 0.125
5.343LeuThr: 5.343 ± 0.087
6.088LeuVal: 6.088 ± 0.108
1.28LeuTrp: 1.28 ± 0.047
2.533LeuTyr: 2.533 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.698MetAla: 2.698 ± 0.077
0.211MetCys: 0.211 ± 0.018
1.122MetAsp: 1.122 ± 0.04
1.157MetGlu: 1.157 ± 0.048
0.905MetPhe: 0.905 ± 0.041
1.787MetGly: 1.787 ± 0.061
0.474MetHis: 0.474 ± 0.026
1.181MetIle: 1.181 ± 0.042
1.51MetLys: 1.51 ± 0.048
2.85MetLeu: 2.85 ± 0.087
0.816MetMet: 0.816 ± 0.045
1.147MetAsn: 1.147 ± 0.043
1.433MetPro: 1.433 ± 0.044
1.207MetGln: 1.207 ± 0.046
1.382MetArg: 1.382 ± 0.042
1.655MetSer: 1.655 ± 0.051
1.599MetThr: 1.599 ± 0.053
1.605MetVal: 1.605 ± 0.053
0.248MetTrp: 0.248 ± 0.018
0.549MetTyr: 0.549 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.839AsnAla: 3.839 ± 0.097
0.262AsnCys: 0.262 ± 0.018
1.738AsnAsp: 1.738 ± 0.059
2.044AsnGlu: 2.044 ± 0.058
1.241AsnPhe: 1.241 ± 0.048
3.35AsnGly: 3.35 ± 0.095
0.806AsnHis: 0.806 ± 0.038
2.449AsnIle: 2.449 ± 0.065
1.575AsnLys: 1.575 ± 0.058
3.505AsnLeu: 3.505 ± 0.084
0.884AsnMet: 0.884 ± 0.038
1.317AsnAsn: 1.317 ± 0.059
2.46AsnPro: 2.46 ± 0.059
1.415AsnGln: 1.415 ± 0.048
2.285AsnArg: 2.285 ± 0.071
1.724AsnSer: 1.724 ± 0.061
2.125AsnThr: 2.125 ± 0.065
2.39AsnVal: 2.39 ± 0.078
0.464AsnTrp: 0.464 ± 0.028
0.896AsnTyr: 0.896 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.038ProAla: 5.038 ± 0.103
0.365ProCys: 0.365 ± 0.026
2.926ProAsp: 2.926 ± 0.076
3.746ProGlu: 3.746 ± 0.091
1.759ProPhe: 1.759 ± 0.051
2.333ProGly: 2.333 ± 0.065
1.099ProHis: 1.099 ± 0.041
1.715ProIle: 1.715 ± 0.052
2.088ProLys: 2.088 ± 0.061
4.354ProLeu: 4.354 ± 0.103
1.071ProMet: 1.071 ± 0.043
1.597ProAsn: 1.597 ± 0.059
1.766ProPro: 1.766 ± 0.065
2.27ProGln: 2.27 ± 0.072
1.829ProArg: 1.829 ± 0.064
2.227ProSer: 2.227 ± 0.069
1.978ProThr: 1.978 ± 0.066
3.569ProVal: 3.569 ± 0.079
0.428ProTrp: 0.428 ± 0.024
1.409ProTyr: 1.409 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
5.522GlnAla: 5.522 ± 0.116
0.293GlnCys: 0.293 ± 0.02
1.947GlnAsp: 1.947 ± 0.053
2.253GlnGlu: 2.253 ± 0.065
1.374GlnPhe: 1.374 ± 0.046
2.98GlnGly: 2.98 ± 0.066
1.033GlnHis: 1.033 ± 0.043
2.47GlnIle: 2.47 ± 0.07
2.023GlnLys: 2.023 ± 0.063
3.415GlnLeu: 3.415 ± 0.074
1.12GlnMet: 1.12 ± 0.041
1.788GlnAsn: 1.788 ± 0.056
1.904GlnPro: 1.904 ± 0.061
2.336GlnGln: 2.336 ± 0.089
2.14GlnArg: 2.14 ± 0.058
2.593GlnSer: 2.593 ± 0.079
2.977GlnThr: 2.977 ± 0.068
2.541GlnVal: 2.541 ± 0.066
0.589GlnTrp: 0.589 ± 0.029
1.376GlnTyr: 1.376 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
5.471ArgAla: 5.471 ± 0.115
0.498ArgCys: 0.498 ± 0.028
2.754ArgAsp: 2.754 ± 0.077
3.453ArgGlu: 3.453 ± 0.088
2.733ArgPhe: 2.733 ± 0.063
3.347ArgGly: 3.347 ± 0.07
1.612ArgHis: 1.612 ± 0.057
3.205ArgIle: 3.205 ± 0.071
2.464ArgLys: 2.464 ± 0.06
6.385ArgLeu: 6.385 ± 0.106
1.443ArgMet: 1.443 ± 0.05
2.08ArgAsn: 2.08 ± 0.061
2.37ArgPro: 2.37 ± 0.065
2.669ArgGln: 2.669 ± 0.072
3.717ArgArg: 3.717 ± 0.095
2.747ArgSer: 2.747 ± 0.074
2.424ArgThr: 2.424 ± 0.066
3.478ArgVal: 3.478 ± 0.074
0.64ArgTrp: 0.64 ± 0.034
2.104ArgTyr: 2.104 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.85SerAla: 5.85 ± 0.101
0.51SerCys: 0.51 ± 0.028
3.052SerAsp: 3.052 ± 0.069
3.35SerGlu: 3.35 ± 0.076
2.146SerPhe: 2.146 ± 0.056
5.418SerGly: 5.418 ± 0.115
1.154SerHis: 1.154 ± 0.037
2.455SerIle: 2.455 ± 0.073
2.234SerLys: 2.234 ± 0.061
5.313SerLeu: 5.313 ± 0.111
1.172SerMet: 1.172 ± 0.042
1.756SerAsn: 1.756 ± 0.061
2.15SerPro: 2.15 ± 0.059
1.859SerGln: 1.859 ± 0.059
3.294SerArg: 3.294 ± 0.079
2.71SerSer: 2.71 ± 0.08
2.331SerThr: 2.331 ± 0.078
3.874SerVal: 3.874 ± 0.081
0.677SerTrp: 0.677 ± 0.036
1.446SerTyr: 1.446 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.747ThrAla: 6.747 ± 0.111
0.384ThrCys: 0.384 ± 0.025
2.876ThrAsp: 2.876 ± 0.069
2.905ThrGlu: 2.905 ± 0.076
1.851ThrPhe: 1.851 ± 0.052
4.176ThrGly: 4.176 ± 0.091
1.032ThrHis: 1.032 ± 0.038
2.539ThrIle: 2.539 ± 0.075
1.63ThrLys: 1.63 ± 0.065
6.079ThrLeu: 6.079 ± 0.105
0.905ThrMet: 0.905 ± 0.039
1.471ThrAsn: 1.471 ± 0.055
3.019ThrPro: 3.019 ± 0.08
2.055ThrGln: 2.055 ± 0.055
2.801ThrArg: 2.801 ± 0.065
2.082ThrSer: 2.082 ± 0.069
2.479ThrThr: 2.479 ± 0.112
4.499ThrVal: 4.499 ± 0.129
0.517ThrTrp: 0.517 ± 0.029
1.367ThrTyr: 1.367 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
7.291ValAla: 7.291 ± 0.118
0.888ValCys: 0.888 ± 0.036
3.187ValAsp: 3.187 ± 0.08
3.894ValGlu: 3.894 ± 0.084
3.016ValPhe: 3.016 ± 0.073
4.903ValGly: 4.903 ± 0.092
1.325ValHis: 1.325 ± 0.046
3.744ValIle: 3.744 ± 0.077
3.402ValLys: 3.402 ± 0.093
7.421ValLeu: 7.421 ± 0.117
2.023ValMet: 2.023 ± 0.056
2.557ValAsn: 2.557 ± 0.079
2.781ValPro: 2.781 ± 0.077
2.434ValGln: 2.434 ± 0.06
3.852ValArg: 3.852 ± 0.084
4.381ValSer: 4.381 ± 0.073
3.418ValThr: 3.418 ± 0.116
4.936ValVal: 4.936 ± 0.102
1.017ValTrp: 1.017 ± 0.039
2.029ValTyr: 2.029 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.276TrpAla: 1.276 ± 0.049
0.135TrpCys: 0.135 ± 0.013
0.535TrpAsp: 0.535 ± 0.028
0.519TrpGlu: 0.519 ± 0.027
0.637TrpPhe: 0.637 ± 0.032
0.796TrpGly: 0.796 ± 0.043
0.366TrpHis: 0.366 ± 0.025
0.628TrpIle: 0.628 ± 0.032
0.479TrpLys: 0.479 ± 0.028
2.002TrpLeu: 2.002 ± 0.069
0.33TrpMet: 0.33 ± 0.027
0.423TrpAsn: 0.423 ± 0.029
0.434TrpPro: 0.434 ± 0.028
1.123TrpGln: 1.123 ± 0.043
0.854TrpArg: 0.854 ± 0.042
0.546TrpSer: 0.546 ± 0.03
0.528TrpThr: 0.528 ± 0.025
0.87TrpVal: 0.87 ± 0.037
0.179TrpTrp: 0.179 ± 0.017
0.392TrpTyr: 0.392 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.979TyrAla: 2.979 ± 0.073
0.347TyrCys: 0.347 ± 0.023
1.536TyrAsp: 1.536 ± 0.053
1.519TyrGlu: 1.519 ± 0.05
1.335TyrPhe: 1.335 ± 0.053
2.379TyrGly: 2.379 ± 0.062
0.655TyrHis: 0.655 ± 0.032
1.446TyrIle: 1.446 ± 0.05
1.108TyrLys: 1.108 ± 0.046
3.074TyrLeu: 3.074 ± 0.088
0.532TyrMet: 0.532 ± 0.028
0.938TyrAsn: 0.938 ± 0.046
1.389TyrPro: 1.389 ± 0.045
1.395TyrGln: 1.395 ± 0.045
2.144TyrArg: 2.144 ± 0.061
1.452TyrSer: 1.452 ± 0.052
1.661TyrThr: 1.661 ± 0.053
1.607TyrVal: 1.607 ± 0.048
0.456TyrTrp: 0.456 ± 0.026
0.881TyrTyr: 0.881 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2212 proteins (668743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski