Amino acid dipepetide frequency for Buchnera aphidicola subsp. Schlechtendalia chinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.352AlaAla: 2.352 ± 0.139
0.649AlaCys: 0.649 ± 0.078
1.291AlaAsp: 1.291 ± 0.093
1.628AlaGlu: 1.628 ± 0.094
1.722AlaPhe: 1.722 ± 0.107
2.115AlaGly: 2.115 ± 0.129
0.848AlaHis: 0.848 ± 0.079
5.19AlaIle: 5.19 ± 0.195
3.512AlaLys: 3.512 ± 0.176
5.052AlaLeu: 5.052 ± 0.191
1.035AlaMet: 1.035 ± 0.082
2.289AlaAsn: 2.289 ± 0.137
0.961AlaPro: 0.961 ± 0.086
1.291AlaGln: 1.291 ± 0.087
1.815AlaArg: 1.815 ± 0.122
2.932AlaSer: 2.932 ± 0.154
1.984AlaThr: 1.984 ± 0.121
2.183AlaVal: 2.183 ± 0.121
0.393AlaTrp: 0.393 ± 0.047
1.285AlaTyr: 1.285 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.618CysAla: 0.618 ± 0.059
0.187CysCys: 0.187 ± 0.039
0.661CysAsp: 0.661 ± 0.071
0.705CysGlu: 0.705 ± 0.078
0.767CysPhe: 0.767 ± 0.067
0.942CysGly: 0.942 ± 0.089
0.337CysHis: 0.337 ± 0.048
1.796CysIle: 1.796 ± 0.122
1.098CysLys: 1.098 ± 0.088
1.316CysLeu: 1.316 ± 0.092
0.318CysMet: 0.318 ± 0.042
1.042CysAsn: 1.042 ± 0.082
0.518CysPro: 0.518 ± 0.053
0.424CysGln: 0.424 ± 0.047
0.393CysArg: 0.393 ± 0.046
1.266CysSer: 1.266 ± 0.093
0.611CysThr: 0.611 ± 0.057
0.736CysVal: 0.736 ± 0.058
0.125CysTrp: 0.125 ± 0.031
0.63CysTyr: 0.63 ± 0.067
0.0CysXaa: 0.0 ± 0.0
Asp
1.778AspAla: 1.778 ± 0.104
0.518AspCys: 0.518 ± 0.061
1.422AspAsp: 1.422 ± 0.114
1.99AspGlu: 1.99 ± 0.124
2.483AspPhe: 2.483 ± 0.128
2.065AspGly: 2.065 ± 0.134
0.855AspHis: 0.855 ± 0.077
5.57AspIle: 5.57 ± 0.222
3.125AspLys: 3.125 ± 0.143
4.354AspLeu: 4.354 ± 0.173
1.029AspMet: 1.029 ± 0.083
2.501AspAsn: 2.501 ± 0.127
1.26AspPro: 1.26 ± 0.085
0.948AspGln: 0.948 ± 0.086
1.64AspArg: 1.64 ± 0.129
2.844AspSer: 2.844 ± 0.143
1.884AspThr: 1.884 ± 0.118
2.707AspVal: 2.707 ± 0.122
0.412AspTrp: 0.412 ± 0.047
1.472AspTyr: 1.472 ± 0.1
0.0AspXaa: 0.0 ± 0.0
Glu
2.002GluAla: 2.002 ± 0.138
0.543GluCys: 0.543 ± 0.06
1.846GluAsp: 1.846 ± 0.108
2.489GluGlu: 2.489 ± 0.176
2.096GluPhe: 2.096 ± 0.109
2.083GluGly: 2.083 ± 0.121
1.098GluHis: 1.098 ± 0.061
6.175GluIle: 6.175 ± 0.229
6.175GluLys: 6.175 ± 0.24
5.296GluLeu: 5.296 ± 0.194
1.279GluMet: 1.279 ± 0.082
4.404GluAsn: 4.404 ± 0.155
1.054GluPro: 1.054 ± 0.082
1.485GluGln: 1.485 ± 0.1
2.04GluArg: 2.04 ± 0.13
3.281GluSer: 3.281 ± 0.132
2.283GluThr: 2.283 ± 0.136
2.713GluVal: 2.713 ± 0.143
0.356GluTrp: 0.356 ± 0.044
1.765GluTyr: 1.765 ± 0.108
0.0GluXaa: 0.0 ± 0.0
Phe
1.272PheAla: 1.272 ± 0.091
1.092PheCys: 1.092 ± 0.086
2.096PheAsp: 2.096 ± 0.125
2.426PheGlu: 2.426 ± 0.137
3.637PhePhe: 3.637 ± 0.244
3.269PheGly: 3.269 ± 0.163
1.123PheHis: 1.123 ± 0.084
4.591PheIle: 4.591 ± 0.206
4.56PheLys: 4.56 ± 0.203
6.107PheLeu: 6.107 ± 0.257
0.973PheMet: 0.973 ± 0.084
3.443PheAsn: 3.443 ± 0.156
2.09PhePro: 2.09 ± 0.124
1.715PheGln: 1.715 ± 0.093
1.747PheArg: 1.747 ± 0.129
5.314PheSer: 5.314 ± 0.242
1.871PheThr: 1.871 ± 0.115
2.352PheVal: 2.352 ± 0.126
0.555PheTrp: 0.555 ± 0.066
2.033PheTyr: 2.033 ± 0.129
0.0PheXaa: 0.0 ± 0.0
Gly
2.576GlyAla: 2.576 ± 0.152
0.967GlyCys: 0.967 ± 0.078
2.221GlyAsp: 2.221 ± 0.131
2.614GlyGlu: 2.614 ± 0.146
2.732GlyPhe: 2.732 ± 0.152
3.462GlyGly: 3.462 ± 0.174
1.291GlyHis: 1.291 ± 0.098
6.693GlyIle: 6.693 ± 0.205
4.815GlyLys: 4.815 ± 0.179
5.028GlyLeu: 5.028 ± 0.174
1.428GlyMet: 1.428 ± 0.097
2.863GlyAsn: 2.863 ± 0.157
1.266GlyPro: 1.266 ± 0.095
1.416GlyGln: 1.416 ± 0.107
2.364GlyArg: 2.364 ± 0.143
3.699GlySer: 3.699 ± 0.17
3.125GlyThr: 3.125 ± 0.124
3.069GlyVal: 3.069 ± 0.174
0.518GlyTrp: 0.518 ± 0.061
1.878GlyTyr: 1.878 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
1.092HisAla: 1.092 ± 0.089
0.343HisCys: 0.343 ± 0.038
0.773HisAsp: 0.773 ± 0.07
0.674HisGlu: 0.674 ± 0.072
1.035HisPhe: 1.035 ± 0.081
1.385HisGly: 1.385 ± 0.076
0.511HisHis: 0.511 ± 0.054
2.377HisIle: 2.377 ± 0.116
1.541HisLys: 1.541 ± 0.099
1.959HisLeu: 1.959 ± 0.122
0.449HisMet: 0.449 ± 0.055
1.403HisAsn: 1.403 ± 0.107
0.961HisPro: 0.961 ± 0.095
0.661HisGln: 0.661 ± 0.063
0.842HisArg: 0.842 ± 0.078
1.522HisSer: 1.522 ± 0.108
1.054HisThr: 1.054 ± 0.071
1.223HisVal: 1.223 ± 0.072
0.175HisTrp: 0.175 ± 0.035
0.873HisTyr: 0.873 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
5.427IleAla: 5.427 ± 0.204
1.597IleCys: 1.597 ± 0.094
5.57IleAsp: 5.57 ± 0.191
5.888IleGlu: 5.888 ± 0.191
6.001IlePhe: 6.001 ± 0.303
6.475IleGly: 6.475 ± 0.223
2.208IleHis: 2.208 ± 0.13
11.889IleIle: 11.889 ± 0.3
9.98IleLys: 9.98 ± 0.353
11.901IleLeu: 11.901 ± 0.298
2.32IleMet: 2.32 ± 0.121
8.246IleAsn: 8.246 ± 0.294
3.88IlePro: 3.88 ± 0.145
3.624IleGln: 3.624 ± 0.181
3.998IleArg: 3.998 ± 0.169
10.211IleSer: 10.211 ± 0.274
5.289IleThr: 5.289 ± 0.176
6.163IleVal: 6.163 ± 0.196
0.83IleTrp: 0.83 ± 0.078
3.368IleTyr: 3.368 ± 0.174
0.0IleXaa: 0.0 ± 0.0
Lys
2.483LysAla: 2.483 ± 0.132
1.029LysCys: 1.029 ± 0.095
3.643LysAsp: 3.643 ± 0.175
5.121LysGlu: 5.121 ± 0.188
4.472LysPhe: 4.472 ± 0.188
3.568LysGly: 3.568 ± 0.16
1.959LysHis: 1.959 ± 0.116
12.662LysIle: 12.662 ± 0.372
13.891LysLys: 13.891 ± 0.432
8.764LysLeu: 8.764 ± 0.236
2.277LysMet: 2.277 ± 0.131
11.696LysAsn: 11.696 ± 0.36
1.984LysPro: 1.984 ± 0.117
2.208LysGln: 2.208 ± 0.135
3.406LysArg: 3.406 ± 0.135
6.425LysSer: 6.425 ± 0.256
4.254LysThr: 4.254 ± 0.186
4.385LysVal: 4.385 ± 0.187
0.78LysTrp: 0.78 ± 0.081
3.874LysTyr: 3.874 ± 0.193
0.0LysXaa: 0.0 ± 0.0
Leu
4.242LeuAla: 4.242 ± 0.173
1.553LeuCys: 1.553 ± 0.112
4.267LeuAsp: 4.267 ± 0.146
5.801LeuGlu: 5.801 ± 0.205
4.909LeuPhe: 4.909 ± 0.193
5.882LeuGly: 5.882 ± 0.192
2.052LeuHis: 2.052 ± 0.101
9.849LeuIle: 9.849 ± 0.285
11.203LeuLys: 11.203 ± 0.284
9.899LeuLeu: 9.899 ± 0.3
2.052LeuMet: 2.052 ± 0.104
7.298LeuAsn: 7.298 ± 0.236
3.063LeuPro: 3.063 ± 0.138
2.745LeuGln: 2.745 ± 0.127
3.849LeuArg: 3.849 ± 0.153
8.627LeuSer: 8.627 ± 0.238
4.323LeuThr: 4.323 ± 0.185
4.847LeuVal: 4.847 ± 0.212
0.742LeuTrp: 0.742 ± 0.073
3.194LeuTyr: 3.194 ± 0.163
0.0LeuXaa: 0.0 ± 0.0
Met
1.023MetAla: 1.023 ± 0.083
0.243MetCys: 0.243 ± 0.039
0.767MetAsp: 0.767 ± 0.068
0.892MetGlu: 0.892 ± 0.07
1.042MetPhe: 1.042 ± 0.078
1.154MetGly: 1.154 ± 0.097
0.499MetHis: 0.499 ± 0.06
2.295MetIle: 2.295 ± 0.119
2.164MetLys: 2.164 ± 0.117
2.639MetLeu: 2.639 ± 0.128
0.524MetMet: 0.524 ± 0.069
1.616MetAsn: 1.616 ± 0.093
0.624MetPro: 0.624 ± 0.068
0.649MetGln: 0.649 ± 0.068
1.048MetArg: 1.048 ± 0.086
1.765MetSer: 1.765 ± 0.097
1.16MetThr: 1.16 ± 0.077
1.092MetVal: 1.092 ± 0.084
0.125MetTrp: 0.125 ± 0.026
0.711MetTyr: 0.711 ± 0.063
0.0MetXaa: 0.0 ± 0.0
Asn
2.489AsnAla: 2.489 ± 0.114
1.004AsnCys: 1.004 ± 0.073
3.0AsnAsp: 3.0 ± 0.118
3.418AsnGlu: 3.418 ± 0.155
5.121AsnPhe: 5.121 ± 0.248
3.0AsnGly: 3.0 ± 0.148
1.41AsnHis: 1.41 ± 0.102
9.444AsnIle: 9.444 ± 0.266
6.836AsnLys: 6.836 ± 0.221
6.805AsnLeu: 6.805 ± 0.213
1.516AsnMet: 1.516 ± 0.094
5.826AsnAsn: 5.826 ± 0.222
2.202AsnPro: 2.202 ± 0.13
2.108AsnGln: 2.108 ± 0.104
2.626AsnArg: 2.626 ± 0.137
5.751AsnSer: 5.751 ± 0.199
3.368AsnThr: 3.368 ± 0.136
4.79AsnVal: 4.79 ± 0.179
0.742AsnTrp: 0.742 ± 0.075
3.181AsnTyr: 3.181 ± 0.17
0.0AsnXaa: 0.0 ± 0.0
Pro
0.992ProAla: 0.992 ± 0.093
0.399ProCys: 0.399 ± 0.051
1.117ProAsp: 1.117 ± 0.099
1.634ProGlu: 1.634 ± 0.097
1.466ProPhe: 1.466 ± 0.102
1.853ProGly: 1.853 ± 0.11
0.692ProHis: 0.692 ± 0.071
3.955ProIle: 3.955 ± 0.181
2.732ProLys: 2.732 ± 0.142
2.676ProLeu: 2.676 ± 0.125
0.724ProMet: 0.724 ± 0.063
2.152ProAsn: 2.152 ± 0.113
0.674ProPro: 0.674 ± 0.069
0.686ProGln: 0.686 ± 0.06
0.954ProArg: 0.954 ± 0.083
2.071ProSer: 2.071 ± 0.101
1.322ProThr: 1.322 ± 0.092
1.591ProVal: 1.591 ± 0.095
0.306ProTrp: 0.306 ± 0.049
1.117ProTyr: 1.117 ± 0.089
0.0ProXaa: 0.0 ± 0.0
Gln
1.204GlnAla: 1.204 ± 0.084
0.418GlnCys: 0.418 ± 0.057
1.104GlnAsp: 1.104 ± 0.076
1.871GlnGlu: 1.871 ± 0.113
1.547GlnPhe: 1.547 ± 0.104
1.366GlnGly: 1.366 ± 0.099
0.524GlnHis: 0.524 ± 0.055
3.144GlnIle: 3.144 ± 0.181
3.35GlnLys: 3.35 ± 0.165
2.957GlnLeu: 2.957 ± 0.163
0.605GlnMet: 0.605 ± 0.058
2.002GlnAsn: 2.002 ± 0.112
0.792GlnPro: 0.792 ± 0.068
0.674GlnGln: 0.674 ± 0.07
0.886GlnArg: 0.886 ± 0.077
1.765GlnSer: 1.765 ± 0.117
1.379GlnThr: 1.379 ± 0.096
1.485GlnVal: 1.485 ± 0.107
0.25GlnTrp: 0.25 ± 0.042
1.254GlnTyr: 1.254 ± 0.086
0.0GlnXaa: 0.0 ± 0.0
Arg
1.759ArgAla: 1.759 ± 0.084
0.53ArgCys: 0.53 ± 0.067
1.441ArgAsp: 1.441 ± 0.104
2.158ArgGlu: 2.158 ± 0.124
1.759ArgPhe: 1.759 ± 0.109
1.971ArgGly: 1.971 ± 0.113
0.755ArgHis: 0.755 ± 0.071
4.385ArgIle: 4.385 ± 0.194
3.63ArgLys: 3.63 ± 0.154
3.169ArgLeu: 3.169 ± 0.143
1.01ArgMet: 1.01 ± 0.078
2.813ArgAsn: 2.813 ± 0.14
1.148ArgPro: 1.148 ± 0.088
1.16ArgGln: 1.16 ± 0.088
1.703ArgArg: 1.703 ± 0.126
2.757ArgSer: 2.757 ± 0.139
1.84ArgThr: 1.84 ± 0.114
1.915ArgVal: 1.915 ± 0.12
0.337ArgTrp: 0.337 ± 0.045
1.397ArgTyr: 1.397 ± 0.105
0.0ArgXaa: 0.0 ± 0.0
Ser
3.019SerAla: 3.019 ± 0.153
1.241SerCys: 1.241 ± 0.084
3.612SerAsp: 3.612 ± 0.149
4.104SerGlu: 4.104 ± 0.16
3.836SerPhe: 3.836 ± 0.175
5.221SerGly: 5.221 ± 0.196
1.372SerHis: 1.372 ± 0.087
8.857SerIle: 8.857 ± 0.208
7.279SerLys: 7.279 ± 0.231
7.373SerLeu: 7.373 ± 0.24
1.572SerMet: 1.572 ± 0.111
5.458SerAsn: 5.458 ± 0.21
1.765SerPro: 1.765 ± 0.1
2.121SerGln: 2.121 ± 0.116
3.069SerArg: 3.069 ± 0.178
5.664SerSer: 5.664 ± 0.232
3.474SerThr: 3.474 ± 0.173
4.111SerVal: 4.111 ± 0.187
0.836SerTrp: 0.836 ± 0.07
2.844SerTyr: 2.844 ± 0.132
0.0SerXaa: 0.0 ± 0.0
Thr
2.052ThrAla: 2.052 ± 0.119
0.661ThrCys: 0.661 ± 0.063
1.778ThrAsp: 1.778 ± 0.108
2.046ThrGlu: 2.046 ± 0.131
2.508ThrPhe: 2.508 ± 0.126
2.857ThrGly: 2.857 ± 0.152
1.017ThrHis: 1.017 ± 0.082
5.726ThrIle: 5.726 ± 0.19
3.817ThrLys: 3.817 ± 0.166
5.233ThrLeu: 5.233 ± 0.19
0.786ThrMet: 0.786 ± 0.076
2.813ThrAsn: 2.813 ± 0.148
1.628ThrPro: 1.628 ± 0.116
1.372ThrGln: 1.372 ± 0.111
1.578ThrArg: 1.578 ± 0.096
3.481ThrSer: 3.481 ± 0.152
2.252ThrThr: 2.252 ± 0.133
2.377ThrVal: 2.377 ± 0.134
0.487ThrTrp: 0.487 ± 0.06
1.528ThrTyr: 1.528 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
2.358ValAla: 2.358 ± 0.149
0.724ValCys: 0.724 ± 0.078
2.283ValAsp: 2.283 ± 0.147
2.726ValGlu: 2.726 ± 0.149
2.501ValPhe: 2.501 ± 0.15
3.113ValGly: 3.113 ± 0.186
1.297ValHis: 1.297 ± 0.091
5.857ValIle: 5.857 ± 0.222
4.965ValLys: 4.965 ± 0.198
5.396ValLeu: 5.396 ± 0.191
1.117ValMet: 1.117 ± 0.095
3.362ValAsn: 3.362 ± 0.164
1.871ValPro: 1.871 ± 0.103
1.771ValGln: 1.771 ± 0.093
2.102ValArg: 2.102 ± 0.11
4.167ValSer: 4.167 ± 0.175
2.582ValThr: 2.582 ± 0.125
3.05ValVal: 3.05 ± 0.153
0.38ValTrp: 0.38 ± 0.051
1.509ValTyr: 1.509 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.25TrpAla: 0.25 ± 0.041
0.15TrpCys: 0.15 ± 0.033
0.312TrpAsp: 0.312 ± 0.043
0.518TrpGlu: 0.518 ± 0.063
0.48TrpPhe: 0.48 ± 0.058
0.349TrpGly: 0.349 ± 0.048
0.187TrpHis: 0.187 ± 0.038
1.223TrpIle: 1.223 ± 0.092
0.986TrpLys: 0.986 ± 0.09
0.954TrpLeu: 0.954 ± 0.106
0.237TrpMet: 0.237 ± 0.036
0.83TrpAsn: 0.83 ± 0.074
0.293TrpPro: 0.293 ± 0.042
0.225TrpGln: 0.225 ± 0.041
0.331TrpArg: 0.331 ± 0.047
0.462TrpSer: 0.462 ± 0.057
0.356TrpThr: 0.356 ± 0.043
0.343TrpVal: 0.343 ± 0.051
0.05TrpTrp: 0.05 ± 0.017
0.268TrpTyr: 0.268 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.541TyrAla: 1.541 ± 0.108
0.642TyrCys: 0.642 ± 0.067
1.653TyrAsp: 1.653 ± 0.094
1.759TyrGlu: 1.759 ± 0.116
2.152TyrPhe: 2.152 ± 0.113
1.896TyrGly: 1.896 ± 0.106
0.817TyrHis: 0.817 ± 0.08
3.187TyrIle: 3.187 ± 0.154
3.225TyrLys: 3.225 ± 0.171
3.518TyrLeu: 3.518 ± 0.147
0.773TyrMet: 0.773 ± 0.068
2.582TyrAsn: 2.582 ± 0.118
1.079TyrPro: 1.079 ± 0.083
1.291TyrGln: 1.291 ± 0.09
1.248TyrArg: 1.248 ± 0.081
2.826TyrSer: 2.826 ± 0.121
1.584TyrThr: 1.584 ± 0.116
2.002TyrVal: 2.002 ± 0.114
0.405TyrTrp: 0.405 ± 0.054
1.453TyrTyr: 1.453 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 499 proteins (160319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski