Amino acid dipepetide frequency for Rickettsiales endosymbiont of Stachyamoeba lipophora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.509AlaAla: 5.509 ± 0.155
0.781AlaCys: 0.781 ± 0.048
3.267AlaAsp: 3.267 ± 0.085
4.384AlaGlu: 4.384 ± 0.139
2.583AlaPhe: 2.583 ± 0.082
4.187AlaGly: 4.187 ± 0.116
1.356AlaHis: 1.356 ± 0.055
6.477AlaIle: 6.477 ± 0.129
5.623AlaLys: 5.623 ± 0.14
7.527AlaLeu: 7.527 ± 0.175
1.548AlaMet: 1.548 ± 0.054
4.02AlaAsn: 4.02 ± 0.132
1.964AlaPro: 1.964 ± 0.076
3.024AlaGln: 3.024 ± 0.093
2.818AlaArg: 2.818 ± 0.101
4.613AlaSer: 4.613 ± 0.101
3.888AlaThr: 3.888 ± 0.134
3.998AlaVal: 3.998 ± 0.108
0.546AlaTrp: 0.546 ± 0.029
2.129AlaTyr: 2.129 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.538CysAla: 0.538 ± 0.034
0.123CysCys: 0.123 ± 0.017
0.48CysAsp: 0.48 ± 0.035
0.482CysGlu: 0.482 ± 0.03
0.536CysPhe: 0.536 ± 0.033
0.699CysGly: 0.699 ± 0.038
0.207CysHis: 0.207 ± 0.022
0.821CysIle: 0.821 ± 0.041
0.747CysLys: 0.747 ± 0.047
0.996CysLeu: 0.996 ± 0.054
0.181CysMet: 0.181 ± 0.021
0.655CysAsn: 0.655 ± 0.041
0.341CysPro: 0.341 ± 0.031
0.325CysGln: 0.325 ± 0.03
0.259CysArg: 0.259 ± 0.025
0.667CysSer: 0.667 ± 0.038
0.41CysThr: 0.41 ± 0.032
0.37CysVal: 0.37 ± 0.034
0.1CysTrp: 0.1 ± 0.014
0.454CysTyr: 0.454 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.88AspAla: 2.88 ± 0.08
0.386AspCys: 0.386 ± 0.028
2.197AspAsp: 2.197 ± 0.095
3.117AspGlu: 3.117 ± 0.086
2.462AspPhe: 2.462 ± 0.07
2.376AspGly: 2.376 ± 0.092
1.149AspHis: 1.149 ± 0.057
4.788AspIle: 4.788 ± 0.105
3.665AspLys: 3.665 ± 0.115
5.567AspLeu: 5.567 ± 0.125
0.89AspMet: 0.89 ± 0.048
3.504AspAsn: 3.504 ± 0.109
1.757AspPro: 1.757 ± 0.069
2.249AspGln: 2.249 ± 0.066
1.767AspArg: 1.767 ± 0.074
2.633AspSer: 2.633 ± 0.078
1.994AspThr: 1.994 ± 0.077
2.434AspVal: 2.434 ± 0.094
0.436AspTrp: 0.436 ± 0.028
2.209AspTyr: 2.209 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.462GluAla: 4.462 ± 0.12
0.492GluCys: 0.492 ± 0.032
2.898GluAsp: 2.898 ± 0.095
4.683GluGlu: 4.683 ± 0.15
2.852GluPhe: 2.852 ± 0.076
2.789GluGly: 2.789 ± 0.089
1.554GluHis: 1.554 ± 0.06
6.067GluIle: 6.067 ± 0.123
4.551GluLys: 4.551 ± 0.131
6.971GluLeu: 6.971 ± 0.147
1.41GluMet: 1.41 ± 0.059
3.705GluAsn: 3.705 ± 0.089
1.55GluPro: 1.55 ± 0.063
3.543GluGln: 3.543 ± 0.098
2.36GluArg: 2.36 ± 0.095
3.089GluSer: 3.089 ± 0.083
2.587GluThr: 2.587 ± 0.078
3.788GluVal: 3.788 ± 0.102
0.5GluTrp: 0.5 ± 0.03
2.426GluTyr: 2.426 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.338PheAla: 3.338 ± 0.09
0.524PheCys: 0.524 ± 0.034
2.556PheAsp: 2.556 ± 0.077
2.771PheGlu: 2.771 ± 0.074
2.159PhePhe: 2.159 ± 0.08
2.657PheGly: 2.657 ± 0.079
0.813PheHis: 0.813 ± 0.043
4.452PheIle: 4.452 ± 0.108
3.671PheLys: 3.671 ± 0.099
4.211PheLeu: 4.211 ± 0.113
0.888PheMet: 0.888 ± 0.049
3.376PheAsn: 3.376 ± 0.1
1.231PhePro: 1.231 ± 0.055
1.293PheGln: 1.293 ± 0.059
1.346PheArg: 1.346 ± 0.05
3.117PheSer: 3.117 ± 0.091
2.731PheThr: 2.731 ± 0.084
2.303PheVal: 2.303 ± 0.072
0.408PheTrp: 0.408 ± 0.03
1.916PheTyr: 1.916 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.01GlyAla: 4.01 ± 0.152
0.705GlyCys: 0.705 ± 0.042
2.504GlyAsp: 2.504 ± 0.09
3.189GlyGlu: 3.189 ± 0.1
2.755GlyPhe: 2.755 ± 0.086
3.627GlyGly: 3.627 ± 0.112
1.203GlyHis: 1.203 ± 0.069
5.207GlyIle: 5.207 ± 0.123
4.239GlyLys: 4.239 ± 0.1
5.145GlyLeu: 5.145 ± 0.127
1.38GlyMet: 1.38 ± 0.061
3.147GlyAsn: 3.147 ± 0.139
1.157GlyPro: 1.157 ± 0.047
1.771GlyGln: 1.771 ± 0.054
2.054GlyArg: 2.054 ± 0.071
3.448GlySer: 3.448 ± 0.106
2.795GlyThr: 2.795 ± 0.136
3.37GlyVal: 3.37 ± 0.095
0.532GlyTrp: 0.532 ± 0.039
2.171GlyTyr: 2.171 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.38HisAla: 1.38 ± 0.059
0.177HisCys: 0.177 ± 0.017
0.928HisAsp: 0.928 ± 0.05
1.175HisGlu: 1.175 ± 0.05
1.072HisPhe: 1.072 ± 0.056
1.155HisGly: 1.155 ± 0.051
0.621HisHis: 0.621 ± 0.037
1.813HisIle: 1.813 ± 0.078
1.667HisLys: 1.667 ± 0.064
2.324HisLeu: 2.324 ± 0.075
0.343HisMet: 0.343 ± 0.027
1.653HisAsn: 1.653 ± 0.052
0.946HisPro: 0.946 ± 0.041
1.002HisGln: 1.002 ± 0.034
0.709HisArg: 0.709 ± 0.044
1.325HisSer: 1.325 ± 0.061
1.127HisThr: 1.127 ± 0.061
0.92HisVal: 0.92 ± 0.046
0.165HisTrp: 0.165 ± 0.019
0.986HisTyr: 0.986 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
7.527IleAla: 7.527 ± 0.139
1.038IleCys: 1.038 ± 0.048
5.197IleAsp: 5.197 ± 0.112
6.157IleGlu: 6.157 ± 0.122
3.974IlePhe: 3.974 ± 0.109
5.388IleGly: 5.388 ± 0.137
1.558IleHis: 1.558 ± 0.057
9.724IleIle: 9.724 ± 0.191
7.939IleLys: 7.939 ± 0.157
8.734IleLeu: 8.734 ± 0.181
1.817IleMet: 1.817 ± 0.068
6.922IleAsn: 6.922 ± 0.13
3.075IlePro: 3.075 ± 0.097
2.777IleGln: 2.777 ± 0.08
2.767IleArg: 2.767 ± 0.08
6.392IleSer: 6.392 ± 0.121
5.794IleThr: 5.794 ± 0.124
4.824IleVal: 4.824 ± 0.12
0.617IleTrp: 0.617 ± 0.041
3.083IleTyr: 3.083 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
5.292LysAla: 5.292 ± 0.118
0.502LysCys: 0.502 ± 0.032
3.854LysAsp: 3.854 ± 0.107
5.45LysGlu: 5.45 ± 0.133
3.625LysPhe: 3.625 ± 0.094
3.549LysGly: 3.549 ± 0.096
1.749LysHis: 1.749 ± 0.06
7.74LysIle: 7.74 ± 0.138
5.276LysLys: 5.276 ± 0.145
8.605LysLeu: 8.605 ± 0.157
1.671LysMet: 1.671 ± 0.06
4.988LysAsn: 4.988 ± 0.127
2.448LysPro: 2.448 ± 0.08
3.571LysGln: 3.571 ± 0.097
2.512LysArg: 2.512 ± 0.072
4.332LysSer: 4.332 ± 0.094
3.802LysThr: 3.802 ± 0.097
4.322LysVal: 4.322 ± 0.104
0.538LysTrp: 0.538 ± 0.034
2.872LysTyr: 2.872 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
7.906LeuAla: 7.906 ± 0.152
1.058LeuCys: 1.058 ± 0.048
5.159LeuAsp: 5.159 ± 0.126
6.607LeuGlu: 6.607 ± 0.118
4.239LeuPhe: 4.239 ± 0.122
5.651LeuGly: 5.651 ± 0.138
2.079LeuHis: 2.079 ± 0.081
9.284LeuIle: 9.284 ± 0.168
8.491LeuLys: 8.491 ± 0.14
10.206LeuLeu: 10.206 ± 0.202
2.255LeuMet: 2.255 ± 0.075
6.944LeuAsn: 6.944 ± 0.155
4.249LeuPro: 4.249 ± 0.107
3.713LeuGln: 3.713 ± 0.106
3.466LeuArg: 3.466 ± 0.085
7.844LeuSer: 7.844 ± 0.133
5.968LeuThr: 5.968 ± 0.139
5.762LeuVal: 5.762 ± 0.12
0.733LeuTrp: 0.733 ± 0.04
3.255LeuTyr: 3.255 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.502MetAla: 1.502 ± 0.052
0.151MetCys: 0.151 ± 0.018
0.962MetAsp: 0.962 ± 0.047
0.974MetGlu: 0.974 ± 0.047
0.856MetPhe: 0.856 ± 0.047
1.253MetGly: 1.253 ± 0.054
0.536MetHis: 0.536 ± 0.033
1.884MetIle: 1.884 ± 0.073
1.333MetLys: 1.333 ± 0.056
2.426MetLeu: 2.426 ± 0.071
0.518MetMet: 0.518 ± 0.034
1.157MetAsn: 1.157 ± 0.042
0.829MetPro: 0.829 ± 0.04
0.986MetGln: 0.986 ± 0.046
0.823MetArg: 0.823 ± 0.044
1.43MetSer: 1.43 ± 0.052
0.958MetThr: 0.958 ± 0.045
1.434MetVal: 1.434 ± 0.064
0.147MetTrp: 0.147 ± 0.018
0.49MetTyr: 0.49 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.551AsnAla: 3.551 ± 0.13
0.58AsnCys: 0.58 ± 0.033
3.105AsnAsp: 3.105 ± 0.096
3.364AsnGlu: 3.364 ± 0.09
3.537AsnPhe: 3.537 ± 0.105
3.002AsnGly: 3.002 ± 0.107
1.605AsnHis: 1.605 ± 0.058
7.208AsnIle: 7.208 ± 0.158
5.434AsnLys: 5.434 ± 0.126
7.808AsnLeu: 7.808 ± 0.164
1.233AsnMet: 1.233 ± 0.058
5.762AsnAsn: 5.762 ± 0.162
2.629AsnPro: 2.629 ± 0.088
3.028AsnGln: 3.028 ± 0.089
1.912AsnArg: 1.912 ± 0.07
4.145AsnSer: 4.145 ± 0.102
3.223AsnThr: 3.223 ± 0.122
2.705AsnVal: 2.705 ± 0.082
0.488AsnTrp: 0.488 ± 0.033
2.856AsnTyr: 2.856 ± 0.095
0.0AsnXaa: 0.0 ± 0.0
Pro
2.097ProAla: 2.097 ± 0.066
0.283ProCys: 0.283 ± 0.028
1.621ProAsp: 1.621 ± 0.061
2.458ProGlu: 2.458 ± 0.067
1.623ProPhe: 1.623 ± 0.057
1.856ProGly: 1.856 ± 0.073
0.843ProHis: 0.843 ± 0.047
3.115ProIle: 3.115 ± 0.078
2.498ProLys: 2.498 ± 0.073
3.39ProLeu: 3.39 ± 0.081
0.606ProMet: 0.606 ± 0.036
2.215ProAsn: 2.215 ± 0.071
0.97ProPro: 0.97 ± 0.052
1.498ProGln: 1.498 ± 0.067
1.006ProArg: 1.006 ± 0.044
2.257ProSer: 2.257 ± 0.072
1.928ProThr: 1.928 ± 0.053
1.862ProVal: 1.862 ± 0.081
0.245ProTrp: 0.245 ± 0.024
1.161ProTyr: 1.161 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.444GlnAla: 3.444 ± 0.108
0.249GlnCys: 0.249 ± 0.025
2.113GlnAsp: 2.113 ± 0.071
3.287GlnGlu: 3.287 ± 0.098
1.761GlnPhe: 1.761 ± 0.061
1.98GlnGly: 1.98 ± 0.068
0.93GlnHis: 0.93 ± 0.045
3.846GlnIle: 3.846 ± 0.094
2.964GlnLys: 2.964 ± 0.084
4.129GlnLeu: 4.129 ± 0.101
0.771GlnMet: 0.771 ± 0.031
2.647GlnAsn: 2.647 ± 0.084
1.331GlnPro: 1.331 ± 0.057
2.577GlnGln: 2.577 ± 0.117
1.38GlnArg: 1.38 ± 0.06
2.151GlnSer: 2.151 ± 0.076
2.022GlnThr: 2.022 ± 0.075
2.436GlnVal: 2.436 ± 0.082
0.235GlnTrp: 0.235 ± 0.02
1.285GlnTyr: 1.285 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.257ArgAla: 2.257 ± 0.08
0.269ArgCys: 0.269 ± 0.025
1.723ArgAsp: 1.723 ± 0.064
2.295ArgGlu: 2.295 ± 0.088
1.731ArgPhe: 1.731 ± 0.072
1.823ArgGly: 1.823 ± 0.077
0.711ArgHis: 0.711 ± 0.037
3.177ArgIle: 3.177 ± 0.089
2.472ArgLys: 2.472 ± 0.076
3.557ArgLeu: 3.557 ± 0.089
0.87ArgMet: 0.87 ± 0.049
2.05ArgAsn: 2.05 ± 0.059
1.121ArgPro: 1.121 ± 0.053
1.339ArgGln: 1.339 ± 0.057
1.285ArgArg: 1.285 ± 0.068
2.058ArgSer: 2.058 ± 0.075
1.599ArgThr: 1.599 ± 0.057
1.92ArgVal: 1.92 ± 0.072
0.257ArgTrp: 0.257 ± 0.019
1.165ArgTyr: 1.165 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.645SerAla: 3.645 ± 0.099
0.663SerCys: 0.663 ± 0.036
2.619SerAsp: 2.619 ± 0.083
3.125SerGlu: 3.125 ± 0.095
3.526SerPhe: 3.526 ± 0.108
3.786SerGly: 3.786 ± 0.105
1.313SerHis: 1.313 ± 0.048
5.89SerIle: 5.89 ± 0.131
5.169SerLys: 5.169 ± 0.102
7.439SerLeu: 7.439 ± 0.15
1.335SerMet: 1.335 ± 0.05
4.41SerAsn: 4.41 ± 0.112
2.205SerPro: 2.205 ± 0.074
2.492SerGln: 2.492 ± 0.073
2.125SerArg: 2.125 ± 0.063
4.924SerSer: 4.924 ± 0.128
3.438SerThr: 3.438 ± 0.115
2.96SerVal: 2.96 ± 0.085
0.562SerTrp: 0.562 ± 0.035
2.561SerTyr: 2.561 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
4.119ThrAla: 4.119 ± 0.155
0.416ThrCys: 0.416 ± 0.028
2.396ThrAsp: 2.396 ± 0.071
3.111ThrGlu: 3.111 ± 0.092
2.129ThrPhe: 2.129 ± 0.072
3.008ThrGly: 3.008 ± 0.157
1.149ThrHis: 1.149 ± 0.044
4.693ThrIle: 4.693 ± 0.109
4.004ThrLys: 4.004 ± 0.087
5.503ThrLeu: 5.503 ± 0.135
0.884ThrMet: 0.884 ± 0.044
3.364ThrAsn: 3.364 ± 0.116
2.326ThrPro: 2.326 ± 0.069
2.404ThrGln: 2.404 ± 0.062
1.665ThrArg: 1.665 ± 0.053
3.522ThrSer: 3.522 ± 0.124
3.298ThrThr: 3.298 ± 0.148
2.818ThrVal: 2.818 ± 0.105
0.366ThrTrp: 0.366 ± 0.031
1.627ThrTyr: 1.627 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.081ValAla: 4.081 ± 0.11
0.518ValCys: 0.518 ± 0.03
2.765ValAsp: 2.765 ± 0.078
3.394ValGlu: 3.394 ± 0.111
2.044ValPhe: 2.044 ± 0.079
3.31ValGly: 3.31 ± 0.093
0.845ValHis: 0.845 ± 0.047
5.605ValIle: 5.605 ± 0.122
3.938ValLys: 3.938 ± 0.085
4.948ValLeu: 4.948 ± 0.105
1.337ValMet: 1.337 ± 0.06
3.448ValAsn: 3.448 ± 0.109
1.797ValPro: 1.797 ± 0.055
1.578ValGln: 1.578 ± 0.068
1.836ValArg: 1.836 ± 0.062
3.51ValSer: 3.51 ± 0.093
3.283ValThr: 3.283 ± 0.102
3.372ValVal: 3.372 ± 0.117
0.374ValTrp: 0.374 ± 0.029
1.629ValTyr: 1.629 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.438TrpAla: 0.438 ± 0.028
0.102TrpCys: 0.102 ± 0.016
0.335TrpAsp: 0.335 ± 0.03
0.366TrpGlu: 0.366 ± 0.028
0.398TrpPhe: 0.398 ± 0.035
0.386TrpGly: 0.386 ± 0.029
0.263TrpHis: 0.263 ± 0.022
0.57TrpIle: 0.57 ± 0.041
0.438TrpLys: 0.438 ± 0.028
1.068TrpLeu: 1.068 ± 0.051
0.161TrpMet: 0.161 ± 0.017
0.478TrpAsn: 0.478 ± 0.036
0.273TrpPro: 0.273 ± 0.025
0.564TrpGln: 0.564 ± 0.036
0.315TrpArg: 0.315 ± 0.028
0.43TrpSer: 0.43 ± 0.027
0.225TrpThr: 0.225 ± 0.02
0.452TrpVal: 0.452 ± 0.026
0.106TrpTrp: 0.106 ± 0.014
0.287TrpTyr: 0.287 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.267TyrAla: 2.267 ± 0.072
0.374TyrCys: 0.374 ± 0.027
1.783TyrAsp: 1.783 ± 0.075
1.89TyrGlu: 1.89 ± 0.075
1.898TyrPhe: 1.898 ± 0.067
1.924TyrGly: 1.924 ± 0.068
1.006TyrHis: 1.006 ± 0.048
2.942TyrIle: 2.942 ± 0.086
2.581TyrLys: 2.581 ± 0.091
4.31TyrLeu: 4.31 ± 0.107
0.55TyrMet: 0.55 ± 0.034
2.733TyrAsn: 2.733 ± 0.083
1.335TyrPro: 1.335 ± 0.052
1.807TyrGln: 1.807 ± 0.074
1.273TyrArg: 1.273 ± 0.053
2.301TyrSer: 2.301 ± 0.077
1.735TyrThr: 1.735 ± 0.06
1.558TyrVal: 1.558 ± 0.056
0.299TyrTrp: 0.299 ± 0.023
1.709TyrTyr: 1.709 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1519 proteins (502053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski