Amino acid dipepetide frequency for Apple-associated luteovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.86AlaAla: 3.86 ± 0.954
0.702AlaCys: 0.702 ± 0.514
3.158AlaAsp: 3.158 ± 1.022
6.316AlaGlu: 6.316 ± 1.77
2.456AlaPhe: 2.456 ± 0.529
3.86AlaGly: 3.86 ± 1.308
2.105AlaHis: 2.105 ± 0.882
5.263AlaIle: 5.263 ± 0.787
2.456AlaLys: 2.456 ± 0.871
3.509AlaLeu: 3.509 ± 1.218
2.105AlaMet: 2.105 ± 0.928
1.053AlaAsn: 1.053 ± 0.466
5.614AlaPro: 5.614 ± 1.502
2.105AlaGln: 2.105 ± 0.552
10.526AlaArg: 10.526 ± 1.336
4.561AlaSer: 4.561 ± 1.813
3.509AlaThr: 3.509 ± 0.802
3.509AlaVal: 3.509 ± 0.865
1.053AlaTrp: 1.053 ± 0.69
3.86AlaTyr: 3.86 ± 1.373
0.0AlaXaa: 0.0 ± 0.0
Cys
1.053CysAla: 1.053 ± 0.655
0.351CysCys: 0.351 ± 0.387
0.0CysAsp: 0.0 ± 0.0
1.053CysGlu: 1.053 ± 0.515
0.351CysPhe: 0.351 ± 0.318
1.754CysGly: 1.754 ± 0.873
0.351CysHis: 0.351 ± 0.318
0.0CysIle: 0.0 ± 0.0
1.754CysLys: 1.754 ± 0.617
2.105CysLeu: 2.105 ± 1.069
0.0CysMet: 0.0 ± 0.0
1.404CysAsn: 1.404 ± 0.42
1.053CysPro: 1.053 ± 0.694
0.351CysGln: 0.351 ± 0.268
1.053CysArg: 1.053 ± 0.615
1.053CysSer: 1.053 ± 0.694
0.0CysThr: 0.0 ± 0.0
1.754CysVal: 1.754 ± 0.638
0.351CysTrp: 0.351 ± 0.387
1.053CysTyr: 1.053 ± 0.617
0.0CysXaa: 0.0 ± 0.0
Asp
4.561AspAla: 4.561 ± 1.614
1.053AspCys: 1.053 ± 0.98
3.509AspAsp: 3.509 ± 1.031
5.263AspGlu: 5.263 ± 1.658
2.807AspPhe: 2.807 ± 0.757
1.754AspGly: 1.754 ± 0.549
0.0AspHis: 0.0 ± 0.0
3.158AspIle: 3.158 ± 0.791
4.211AspLys: 4.211 ± 1.848
5.614AspLeu: 5.614 ± 0.771
1.754AspMet: 1.754 ± 0.627
2.807AspAsn: 2.807 ± 1.076
2.105AspPro: 2.105 ± 0.667
2.105AspGln: 2.105 ± 0.84
0.702AspArg: 0.702 ± 0.333
3.86AspSer: 3.86 ± 1.494
3.509AspThr: 3.509 ± 1.235
2.456AspVal: 2.456 ± 0.717
0.351AspTrp: 0.351 ± 0.268
2.105AspTyr: 2.105 ± 0.793
0.0AspXaa: 0.0 ± 0.0
Glu
2.105GluAla: 2.105 ± 0.939
0.0GluCys: 0.0 ± 0.0
5.614GluAsp: 5.614 ± 1.362
5.263GluGlu: 5.263 ± 1.389
3.86GluPhe: 3.86 ± 0.848
2.105GluGly: 2.105 ± 0.71
2.456GluHis: 2.456 ± 1.029
0.702GluIle: 0.702 ± 0.537
4.561GluLys: 4.561 ± 1.856
6.316GluLeu: 6.316 ± 1.66
0.702GluMet: 0.702 ± 0.918
1.754GluAsn: 1.754 ± 0.549
4.211GluPro: 4.211 ± 0.949
0.702GluGln: 0.702 ± 0.537
3.509GluArg: 3.509 ± 1.42
1.754GluSer: 1.754 ± 0.616
2.456GluThr: 2.456 ± 0.966
3.86GluVal: 3.86 ± 1.007
0.702GluTrp: 0.702 ± 0.362
2.807GluTyr: 2.807 ± 0.603
0.0GluXaa: 0.0 ± 0.0
Phe
2.456PheAla: 2.456 ± 0.966
0.351PheCys: 0.351 ± 0.268
2.105PheAsp: 2.105 ± 0.667
1.053PheGlu: 1.053 ± 0.504
1.754PhePhe: 1.754 ± 0.627
2.456PheGly: 2.456 ± 0.656
1.754PheHis: 1.754 ± 0.396
3.158PheIle: 3.158 ± 0.811
2.807PheLys: 2.807 ± 0.978
3.509PheLeu: 3.509 ± 1.365
1.404PheMet: 1.404 ± 0.42
1.754PheAsn: 1.754 ± 0.531
2.105PhePro: 2.105 ± 0.567
1.053PheGln: 1.053 ± 0.659
1.053PheArg: 1.053 ± 0.498
4.561PheSer: 4.561 ± 1.23
1.754PheThr: 1.754 ± 0.959
2.105PheVal: 2.105 ± 1.187
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
2.807GlyAla: 2.807 ± 0.959
0.702GlyCys: 0.702 ± 0.461
2.807GlyAsp: 2.807 ± 1.076
2.807GlyGlu: 2.807 ± 0.947
2.456GlyPhe: 2.456 ± 1.141
3.86GlyGly: 3.86 ± 0.769
1.404GlyHis: 1.404 ± 0.42
1.754GlyIle: 1.754 ± 0.396
2.807GlyLys: 2.807 ± 0.742
3.86GlyLeu: 3.86 ± 1.348
1.754GlyMet: 1.754 ± 0.789
1.754GlyAsn: 1.754 ± 0.634
3.158GlyPro: 3.158 ± 1.145
2.807GlyGln: 2.807 ± 0.368
5.965GlyArg: 5.965 ± 1.497
5.965GlySer: 5.965 ± 2.981
2.105GlyThr: 2.105 ± 0.848
4.912GlyVal: 4.912 ± 1.579
1.404GlyTrp: 1.404 ± 0.624
4.211GlyTyr: 4.211 ± 1.181
0.0GlyXaa: 0.0 ± 0.0
His
2.456HisAla: 2.456 ± 0.855
0.0HisCys: 0.0 ± 0.0
0.702HisAsp: 0.702 ± 0.362
0.351HisGlu: 0.351 ± 0.464
0.0HisPhe: 0.0 ± 0.0
1.754HisGly: 1.754 ± 0.857
0.0HisHis: 0.0 ± 0.0
1.754HisIle: 1.754 ± 0.576
2.105HisLys: 2.105 ± 0.71
3.86HisLeu: 3.86 ± 0.797
0.0HisMet: 0.0 ± 0.0
1.053HisAsn: 1.053 ± 0.498
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.456HisArg: 2.456 ± 0.609
2.456HisSer: 2.456 ± 0.894
0.702HisThr: 0.702 ± 0.995
1.754HisVal: 1.754 ± 1.022
0.0HisTrp: 0.0 ± 0.0
0.702HisTyr: 0.702 ± 0.362
0.0HisXaa: 0.0 ± 0.0
Ile
3.158IleAla: 3.158 ± 0.8
1.754IleCys: 1.754 ± 0.823
1.404IleAsp: 1.404 ± 0.42
2.807IleGlu: 2.807 ± 1.076
1.053IlePhe: 1.053 ± 0.594
2.105IleGly: 2.105 ± 0.857
2.456IleHis: 2.456 ± 0.72
3.86IleIle: 3.86 ± 1.322
4.211IleLys: 4.211 ± 0.879
3.509IleLeu: 3.509 ± 1.126
0.702IleMet: 0.702 ± 0.333
1.404IleAsn: 1.404 ± 0.721
2.807IlePro: 2.807 ± 0.806
1.404IleGln: 1.404 ± 0.409
4.211IleArg: 4.211 ± 0.687
4.561IleSer: 4.561 ± 1.332
4.211IleThr: 4.211 ± 1.008
3.158IleVal: 3.158 ± 1.663
0.0IleTrp: 0.0 ± 0.0
1.053IleTyr: 1.053 ± 0.504
0.0IleXaa: 0.0 ± 0.0
Lys
3.509LysAla: 3.509 ± 1.395
1.404LysCys: 1.404 ± 0.721
2.456LysAsp: 2.456 ± 0.842
2.807LysGlu: 2.807 ± 1.123
2.807LysPhe: 2.807 ± 0.802
2.807LysGly: 2.807 ± 0.919
2.105LysHis: 2.105 ± 0.614
4.912LysIle: 4.912 ± 1.095
1.754LysLys: 1.754 ± 0.617
2.807LysLeu: 2.807 ± 0.698
1.754LysMet: 1.754 ± 0.617
4.561LysAsn: 4.561 ± 0.834
3.509LysPro: 3.509 ± 0.892
1.404LysGln: 1.404 ± 0.892
2.105LysArg: 2.105 ± 0.752
3.509LysSer: 3.509 ± 1.098
3.509LysThr: 3.509 ± 0.975
4.211LysVal: 4.211 ± 1.466
1.404LysTrp: 1.404 ± 0.667
0.351LysTyr: 0.351 ± 0.318
0.351LysXaa: 0.351 ± 0.318
Leu
3.158LeuAla: 3.158 ± 1.181
1.053LeuCys: 1.053 ± 0.504
5.263LeuAsp: 5.263 ± 1.211
7.368LeuGlu: 7.368 ± 1.562
1.754LeuPhe: 1.754 ± 0.572
7.368LeuGly: 7.368 ± 1.293
1.754LeuHis: 1.754 ± 1.044
3.158LeuIle: 3.158 ± 0.645
4.912LeuLys: 4.912 ± 0.873
7.368LeuLeu: 7.368 ± 2.062
1.754LeuMet: 1.754 ± 1.136
3.158LeuAsn: 3.158 ± 1.071
3.509LeuPro: 3.509 ± 0.825
5.263LeuGln: 5.263 ± 1.059
8.07LeuArg: 8.07 ± 1.399
13.333LeuSer: 13.333 ± 1.514
6.316LeuThr: 6.316 ± 1.56
2.105LeuVal: 2.105 ± 0.721
1.404LeuTrp: 1.404 ± 0.767
1.053LeuTyr: 1.053 ± 0.466
0.0LeuXaa: 0.0 ± 0.0
Met
2.105MetAla: 2.105 ± 1.069
2.105MetCys: 2.105 ± 0.486
1.754MetAsp: 1.754 ± 0.855
0.702MetGlu: 0.702 ± 0.333
0.702MetPhe: 0.702 ± 0.362
1.404MetGly: 1.404 ± 0.666
0.702MetHis: 0.702 ± 0.537
0.351MetIle: 0.351 ± 0.268
2.105MetLys: 2.105 ± 1.074
2.807MetLeu: 2.807 ± 0.741
1.053MetMet: 1.053 ± 0.504
1.053MetAsn: 1.053 ± 0.752
1.053MetPro: 1.053 ± 0.877
0.702MetGln: 0.702 ± 0.459
2.105MetArg: 2.105 ± 0.922
1.404MetSer: 1.404 ± 0.871
0.702MetThr: 0.702 ± 0.362
2.105MetVal: 2.105 ± 0.882
0.702MetTrp: 0.702 ± 0.362
0.351MetTyr: 0.351 ± 0.387
0.0MetXaa: 0.0 ± 0.0
Asn
3.86AsnAla: 3.86 ± 1.377
0.0AsnCys: 0.0 ± 0.0
1.404AsnAsp: 1.404 ± 1.271
0.702AsnGlu: 0.702 ± 0.592
1.053AsnPhe: 1.053 ± 0.498
3.86AsnGly: 3.86 ± 1.443
0.0AsnHis: 0.0 ± 0.0
1.754AsnIle: 1.754 ± 0.356
1.754AsnLys: 1.754 ± 0.965
2.807AsnLeu: 2.807 ± 0.851
1.053AsnMet: 1.053 ± 0.659
2.807AsnAsn: 2.807 ± 0.851
0.702AsnPro: 0.702 ± 0.356
0.702AsnGln: 0.702 ± 0.514
3.158AsnArg: 3.158 ± 0.907
3.158AsnSer: 3.158 ± 1.17
2.105AsnThr: 2.105 ± 0.614
2.807AsnVal: 2.807 ± 1.076
0.351AsnTrp: 0.351 ± 0.387
1.754AsnTyr: 1.754 ± 0.637
0.0AsnXaa: 0.0 ± 0.0
Pro
5.263ProAla: 5.263 ± 1.992
0.351ProCys: 0.351 ± 0.387
2.456ProAsp: 2.456 ± 0.624
2.456ProGlu: 2.456 ± 0.563
1.404ProPhe: 1.404 ± 0.666
2.807ProGly: 2.807 ± 1.519
0.702ProHis: 0.702 ± 0.459
1.754ProIle: 1.754 ± 0.566
3.86ProLys: 3.86 ± 1.173
4.211ProLeu: 4.211 ± 1.12
1.404ProMet: 1.404 ± 0.46
1.404ProAsn: 1.404 ± 0.574
4.211ProPro: 4.211 ± 1.237
1.754ProGln: 1.754 ± 0.572
5.614ProArg: 5.614 ± 1.312
7.719ProSer: 7.719 ± 1.484
5.614ProThr: 5.614 ± 1.192
5.965ProVal: 5.965 ± 1.122
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.509GlnAla: 3.509 ± 0.825
1.754GlnCys: 1.754 ± 0.792
1.754GlnAsp: 1.754 ± 0.616
1.754GlnGlu: 1.754 ± 0.832
2.807GlnPhe: 2.807 ± 1.202
3.158GlnGly: 3.158 ± 0.645
1.404GlnHis: 1.404 ± 0.493
1.053GlnIle: 1.053 ± 0.79
0.702GlnLys: 0.702 ± 0.461
2.105GlnLeu: 2.105 ± 0.854
1.404GlnMet: 1.404 ± 0.489
0.0GlnAsn: 0.0 ± 0.0
0.702GlnPro: 0.702 ± 0.461
1.754GlnGln: 1.754 ± 0.627
0.702GlnArg: 0.702 ± 0.461
1.404GlnSer: 1.404 ± 0.861
1.754GlnThr: 1.754 ± 0.785
2.807GlnVal: 2.807 ± 1.11
0.702GlnTrp: 0.702 ± 0.612
1.754GlnTyr: 1.754 ± 0.396
0.0GlnXaa: 0.0 ± 0.0
Arg
11.228ArgAla: 11.228 ± 1.885
1.053ArgCys: 1.053 ± 0.694
3.158ArgAsp: 3.158 ± 0.524
4.211ArgGlu: 4.211 ± 1.466
3.509ArgPhe: 3.509 ± 1.11
3.86ArgGly: 3.86 ± 1.889
1.754ArgHis: 1.754 ± 0.953
2.456ArgIle: 2.456 ± 1.402
3.158ArgLys: 3.158 ± 0.923
7.368ArgLeu: 7.368 ± 1.345
2.105ArgMet: 2.105 ± 0.892
2.456ArgAsn: 2.456 ± 1.111
2.807ArgPro: 2.807 ± 0.779
2.807ArgGln: 2.807 ± 1.106
10.877ArgArg: 10.877 ± 4.118
7.018ArgSer: 7.018 ± 2.008
4.912ArgThr: 4.912 ± 1.586
4.211ArgVal: 4.211 ± 0.82
1.404ArgTrp: 1.404 ± 0.615
2.807ArgTyr: 2.807 ± 1.076
0.0ArgXaa: 0.0 ± 0.0
Ser
7.719SerAla: 7.719 ± 1.158
1.053SerCys: 1.053 ± 0.79
6.316SerAsp: 6.316 ± 1.42
1.754SerGlu: 1.754 ± 0.677
3.509SerPhe: 3.509 ± 1.268
7.018SerGly: 7.018 ± 2.094
0.351SerHis: 0.351 ± 0.387
4.561SerIle: 4.561 ± 0.941
3.158SerLys: 3.158 ± 0.832
8.772SerLeu: 8.772 ± 2.072
2.456SerMet: 2.456 ± 1.236
1.404SerAsn: 1.404 ± 0.551
5.965SerPro: 5.965 ± 1.168
3.158SerGln: 3.158 ± 1.448
7.018SerArg: 7.018 ± 3.3
11.579SerSer: 11.579 ± 5.375
4.561SerThr: 4.561 ± 1.865
3.86SerVal: 3.86 ± 1.258
1.754SerTrp: 1.754 ± 1.029
2.456SerTyr: 2.456 ± 0.63
0.0SerXaa: 0.0 ± 0.0
Thr
3.509ThrAla: 3.509 ± 0.791
0.702ThrCys: 0.702 ± 0.673
4.912ThrAsp: 4.912 ± 1.624
1.404ThrGlu: 1.404 ± 0.899
1.053ThrPhe: 1.053 ± 0.655
3.509ThrGly: 3.509 ± 0.876
1.404ThrHis: 1.404 ± 0.633
1.404ThrIle: 1.404 ± 0.724
1.404ThrLys: 1.404 ± 0.402
7.368ThrLeu: 7.368 ± 2.861
2.105ThrMet: 2.105 ± 0.865
2.105ThrAsn: 2.105 ± 1.243
6.316ThrPro: 6.316 ± 1.813
2.456ThrGln: 2.456 ± 0.624
5.263ThrArg: 5.263 ± 1.392
4.561ThrSer: 4.561 ± 2.075
3.86ThrThr: 3.86 ± 1.929
3.509ThrVal: 3.509 ± 0.702
0.351ThrTrp: 0.351 ± 0.387
0.702ThrTyr: 0.702 ± 0.503
0.0ThrXaa: 0.0 ± 0.0
Val
3.86ValAla: 3.86 ± 0.878
1.754ValCys: 1.754 ± 0.566
4.211ValAsp: 4.211 ± 1.61
4.211ValGlu: 4.211 ± 1.369
1.754ValPhe: 1.754 ± 0.965
2.456ValGly: 2.456 ± 1.008
0.702ValHis: 0.702 ± 0.995
4.912ValIle: 4.912 ± 0.935
2.807ValLys: 2.807 ± 1.064
6.316ValLeu: 6.316 ± 1.243
0.702ValMet: 0.702 ± 0.362
1.053ValAsn: 1.053 ± 0.624
7.719ValPro: 7.719 ± 1.017
0.702ValGln: 0.702 ± 0.362
7.018ValArg: 7.018 ± 1.671
3.86ValSer: 3.86 ± 0.643
3.158ValThr: 3.158 ± 0.951
6.667ValVal: 6.667 ± 1.603
0.351ValTrp: 0.351 ± 0.318
1.404ValTyr: 1.404 ± 0.42
0.0ValXaa: 0.0 ± 0.0
Trp
0.702TrpAla: 0.702 ± 0.333
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.754TrpGlu: 1.754 ± 0.835
0.702TrpPhe: 0.702 ± 0.333
0.0TrpGly: 0.0 ± 0.0
0.351TrpHis: 0.351 ± 0.268
0.351TrpIle: 0.351 ± 0.387
0.702TrpLys: 0.702 ± 0.514
1.754TrpLeu: 1.754 ± 0.507
0.702TrpMet: 0.702 ± 0.461
0.351TrpAsn: 0.351 ± 0.318
1.053TrpPro: 1.053 ± 0.464
0.702TrpGln: 0.702 ± 0.356
0.702TrpArg: 0.702 ± 0.673
0.351TrpSer: 0.351 ± 0.464
0.702TrpThr: 0.702 ± 0.612
1.404TrpVal: 1.404 ± 0.844
0.0TrpTrp: 0.0 ± 0.0
0.351TrpTyr: 0.351 ± 0.318
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.702TyrAla: 0.702 ± 0.82
0.702TyrCys: 0.702 ± 0.333
0.702TyrAsp: 0.702 ± 0.333
1.404TyrGlu: 1.404 ± 0.724
1.404TyrPhe: 1.404 ± 0.721
1.404TyrGly: 1.404 ± 0.721
0.351TyrHis: 0.351 ± 0.268
3.509TyrIle: 3.509 ± 1.67
3.158TyrLys: 3.158 ± 0.759
3.158TyrLeu: 3.158 ± 1.302
0.702TyrMet: 0.702 ± 0.362
2.456TyrAsn: 2.456 ± 0.842
0.351TyrPro: 0.351 ± 0.268
1.053TyrGln: 1.053 ± 0.594
1.053TyrArg: 1.053 ± 0.659
1.754TyrSer: 1.754 ± 0.946
2.456TyrThr: 2.456 ± 0.636
2.105TyrVal: 2.105 ± 0.565
0.351TyrTrp: 0.351 ± 0.268
0.351TyrTyr: 0.351 ± 0.54
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.351XaaVal: 0.351 ± 0.318
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski