Amino acid dipepetide frequency for Coniochaeta ligniaria NRRL 30616

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.619AlaAla: 10.619 ± 0.061	1.189AlaCys: 1.189 ± 0.016	4.704AlaAsp: 4.704 ± 0.027	5.384AlaGlu: 5.384 ± 0.041	3.12AlaPhe: 3.12 ± 0.027	6.678AlaGly: 6.678 ± 0.043	1.864AlaHis: 1.864 ± 0.02	4.046AlaIle: 4.046 ± 0.031	4.133AlaLys: 4.133 ± 0.035	7.928AlaLeu: 7.928 ± 0.046	2.048AlaMet: 2.048 ± 0.02	2.878AlaAsn: 2.878 ± 0.023	5.173AlaPro: 5.173 ± 0.039	3.395AlaGln: 3.395 ± 0.028	5.403AlaArg: 5.403 ± 0.034	7.49AlaSer: 7.49 ± 0.042	5.687AlaThr: 5.687 ± 0.039	6.144AlaVal: 6.144 ± 0.041	1.29AlaTrp: 1.29 ± 0.016	2.217AlaTyr: 2.217 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.039CysAla: 1.039 ± 0.013	0.304CysCys: 0.304 ± 0.007	0.694CysAsp: 0.694 ± 0.01	0.588CysGlu: 0.588 ± 0.011	0.57CysPhe: 0.57 ± 0.01	1.05CysGly: 1.05 ± 0.015	0.368CysHis: 0.368 ± 0.008	0.679CysIle: 0.679 ± 0.01	0.513CysLys: 0.513 ± 0.011	1.333CysLeu: 1.333 ± 0.016	0.278CysMet: 0.278 ± 0.007	0.439CysAsn: 0.439 ± 0.009	0.777CysPro: 0.777 ± 0.014	0.477CysGln: 0.477 ± 0.009	0.903CysArg: 0.903 ± 0.013	1.001CysSer: 1.001 ± 0.014	0.756CysThr: 0.756 ± 0.013	0.865CysVal: 0.865 ± 0.014	0.244CysTrp: 0.244 ± 0.007	0.385CysTyr: 0.385 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.971AspAla: 4.971 ± 0.034	0.659AspCys: 0.659 ± 0.01	4.543AspAsp: 4.543 ± 0.045	4.422AspGlu: 4.422 ± 0.039	2.175AspPhe: 2.175 ± 0.021	4.439AspGly: 4.439 ± 0.027	1.285AspHis: 1.285 ± 0.018	2.885AspIle: 2.885 ± 0.026	2.385AspLys: 2.385 ± 0.023	4.961AspLeu: 4.961 ± 0.03	1.339AspMet: 1.339 ± 0.015	1.853AspAsn: 1.853 ± 0.021	3.392AspPro: 3.392 ± 0.025	1.816AspGln: 1.816 ± 0.02	3.142AspArg: 3.142 ± 0.027	3.894AspSer: 3.894 ± 0.029	2.998AspThr: 2.998 ± 0.024	3.876AspVal: 3.876 ± 0.028	0.924AspTrp: 0.924 ± 0.014	1.594AspTyr: 1.594 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.499GluAla: 5.499 ± 0.039	0.623GluCys: 0.623 ± 0.01	4.094GluAsp: 4.094 ± 0.036	5.257GluGlu: 5.257 ± 0.057	1.796GluPhe: 1.796 ± 0.019	3.886GluGly: 3.886 ± 0.032	1.382GluHis: 1.382 ± 0.016	2.678GluIle: 2.678 ± 0.025	3.311GluLys: 3.311 ± 0.034	5.059GluLeu: 5.059 ± 0.033	1.412GluMet: 1.412 ± 0.016	1.885GluAsn: 1.885 ± 0.017	2.787GluPro: 2.787 ± 0.038	2.312GluGln: 2.312 ± 0.024	3.888GluArg: 3.888 ± 0.029	3.772GluSer: 3.772 ± 0.029	3.393GluThr: 3.393 ± 0.03	3.678GluVal: 3.678 ± 0.032	0.885GluTrp: 0.885 ± 0.014	1.562GluTyr: 1.562 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.158PheAla: 3.158 ± 0.026	0.576PheCys: 0.576 ± 0.009	2.225PheAsp: 2.225 ± 0.02	2.007PheGlu: 2.007 ± 0.018	1.562PhePhe: 1.562 ± 0.019	2.909PheGly: 2.909 ± 0.03	0.866PheHis: 0.866 ± 0.012	1.598PheIle: 1.598 ± 0.019	1.386PheLys: 1.386 ± 0.017	3.388PheLeu: 3.388 ± 0.029	0.73PheMet: 0.73 ± 0.011	1.336PheAsn: 1.336 ± 0.016	1.92PhePro: 1.92 ± 0.018	1.281PheGln: 1.281 ± 0.016	2.02PheArg: 2.02 ± 0.019	2.771PheSer: 2.771 ± 0.025	2.08PheThr: 2.08 ± 0.021	2.436PheVal: 2.436 ± 0.023	0.663PheTrp: 0.663 ± 0.012	1.041PheTyr: 1.041 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.903GlyAla: 5.903 ± 0.046	0.986GlyCys: 0.986 ± 0.016	3.858GlyAsp: 3.858 ± 0.028	3.865GlyGlu: 3.865 ± 0.032	2.76GlyPhe: 2.76 ± 0.025	6.748GlyGly: 6.748 ± 0.059	1.778GlyHis: 1.778 ± 0.018	3.32GlyIle: 3.32 ± 0.028	3.4GlyLys: 3.4 ± 0.03	6.293GlyLeu: 6.293 ± 0.037	1.683GlyMet: 1.683 ± 0.019	2.489GlyAsn: 2.489 ± 0.026	3.671GlyPro: 3.671 ± 0.029	2.708GlyGln: 2.708 ± 0.029	4.637GlyArg: 4.637 ± 0.034	5.886GlySer: 5.886 ± 0.037	4.355GlyThr: 4.355 ± 0.035	4.719GlyVal: 4.719 ± 0.038	1.272GlyTrp: 1.272 ± 0.017	2.182GlyTyr: 2.182 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.89HisAla: 1.89 ± 0.019	0.366HisCys: 0.366 ± 0.008	1.364HisAsp: 1.364 ± 0.015	1.232HisGlu: 1.232 ± 0.016	0.898HisPhe: 0.898 ± 0.014	1.848HisGly: 1.848 ± 0.02	0.941HisHis: 0.941 ± 0.015	1.151HisIle: 1.151 ± 0.012	0.904HisLys: 0.904 ± 0.012	2.253HisLeu: 2.253 ± 0.02	0.529HisMet: 0.529 ± 0.009	0.823HisAsn: 0.823 ± 0.013	1.714HisPro: 1.714 ± 0.018	0.999HisGln: 0.999 ± 0.015	1.632HisArg: 1.632 ± 0.019	1.751HisSer: 1.751 ± 0.017	1.288HisThr: 1.288 ± 0.015	1.53HisVal: 1.53 ± 0.017	0.351HisTrp: 0.351 ± 0.008	0.687HisTyr: 0.687 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.947IleAla: 3.947 ± 0.03	0.726IleCys: 0.726 ± 0.013	2.607IleAsp: 2.607 ± 0.023	2.476IleGlu: 2.476 ± 0.023	1.802IlePhe: 1.802 ± 0.02	3.0IleGly: 3.0 ± 0.027	1.089IleHis: 1.089 ± 0.016	2.163IleIle: 2.163 ± 0.021	1.913IleLys: 1.913 ± 0.022	4.143IleLeu: 4.143 ± 0.032	0.952IleMet: 0.952 ± 0.013	1.606IleAsn: 1.606 ± 0.016	2.834IlePro: 2.834 ± 0.02	1.655IleGln: 1.655 ± 0.018	2.698IleArg: 2.698 ± 0.025	3.424IleSer: 3.424 ± 0.023	2.716IleThr: 2.716 ± 0.025	3.045IleVal: 3.045 ± 0.025	0.708IleTrp: 0.708 ± 0.012	1.313IleTyr: 1.313 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.236LysAla: 4.236 ± 0.038	0.486LysCys: 0.486 ± 0.009	2.627LysAsp: 2.627 ± 0.026	3.033LysGlu: 3.033 ± 0.035	1.33LysPhe: 1.33 ± 0.014	2.901LysGly: 2.901 ± 0.025	1.085LysHis: 1.085 ± 0.013	1.99LysIle: 1.99 ± 0.022	3.043LysLys: 3.043 ± 0.048	3.819LysLeu: 3.819 ± 0.029	0.945LysMet: 0.945 ± 0.013	1.477LysAsn: 1.477 ± 0.016	2.677LysPro: 2.677 ± 0.027	1.671LysGln: 1.671 ± 0.017	3.218LysArg: 3.218 ± 0.027	3.106LysSer: 3.106 ± 0.026	2.802LysThr: 2.802 ± 0.025	2.734LysVal: 2.734 ± 0.023	0.657LysTrp: 0.657 ± 0.01	1.243LysTyr: 1.243 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.412LeuAla: 8.412 ± 0.039	1.28LeuCys: 1.28 ± 0.015	5.25LeuAsp: 5.25 ± 0.033	5.236LeuGlu: 5.236 ± 0.036	3.234LeuPhe: 3.234 ± 0.027	6.195LeuGly: 6.195 ± 0.039	2.185LeuHis: 2.185 ± 0.02	3.597LeuIle: 3.597 ± 0.027	3.828LeuLys: 3.828 ± 0.029	8.425LeuLeu: 8.425 ± 0.051	1.758LeuMet: 1.758 ± 0.018	2.86LeuAsn: 2.86 ± 0.022	5.686LeuPro: 5.686 ± 0.038	3.62LeuGln: 3.62 ± 0.03	5.93LeuArg: 5.93 ± 0.039	7.07LeuSer: 7.07 ± 0.04	4.858LeuThr: 4.858 ± 0.032	5.751LeuVal: 5.751 ± 0.036	1.253LeuTrp: 1.253 ± 0.017	2.32LeuTyr: 2.32 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.352MetAla: 2.352 ± 0.024	0.265MetCys: 0.265 ± 0.007	1.28MetAsp: 1.28 ± 0.014	1.215MetGlu: 1.215 ± 0.015	0.739MetPhe: 0.739 ± 0.01	1.474MetGly: 1.474 ± 0.018	0.47MetHis: 0.47 ± 0.009	0.902MetIle: 0.902 ± 0.013	0.895MetLys: 0.895 ± 0.014	1.848MetLeu: 1.848 ± 0.018	0.572MetMet: 0.572 ± 0.011	0.704MetAsn: 0.704 ± 0.011	1.292MetPro: 1.292 ± 0.016	0.796MetGln: 0.796 ± 0.014	1.312MetArg: 1.312 ± 0.016	1.846MetSer: 1.846 ± 0.017	1.343MetThr: 1.343 ± 0.016	1.365MetVal: 1.365 ± 0.016	0.273MetTrp: 0.273 ± 0.007	0.52MetTyr: 0.52 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.022	0.466AsnCys: 0.466 ± 0.01	1.791AsnAsp: 1.791 ± 0.017	1.694AsnGlu: 1.694 ± 0.018	1.26AsnPhe: 1.26 ± 0.013	2.864AsnGly: 2.864 ± 0.029	0.814AsnHis: 0.814 ± 0.011	1.774AsnIle: 1.774 ± 0.018	1.387AsnLys: 1.387 ± 0.015	3.01AsnLeu: 3.01 ± 0.026	0.8AsnMet: 0.8 ± 0.011	1.387AsnAsn: 1.387 ± 0.02	2.362AsnPro: 2.362 ± 0.022	1.195AsnGln: 1.195 ± 0.016	1.844AsnArg: 1.844 ± 0.019	2.402AsnSer: 2.402 ± 0.023	2.096AsnThr: 2.096 ± 0.022	2.143AsnVal: 2.143 ± 0.019	0.55AsnTrp: 0.55 ± 0.009	0.965AsnTyr: 0.965 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.896ProAla: 5.896 ± 0.045	0.616ProCys: 0.616 ± 0.012	3.44ProAsp: 3.44 ± 0.026	3.722ProGlu: 3.722 ± 0.037	2.019ProPhe: 2.019 ± 0.02	4.404ProGly: 4.404 ± 0.036	1.353ProHis: 1.353 ± 0.017	2.323ProIle: 2.323 ± 0.022	2.583ProLys: 2.583 ± 0.025	4.903ProLeu: 4.903 ± 0.034	1.053ProMet: 1.053 ± 0.015	2.075ProAsn: 2.075 ± 0.02	5.571ProPro: 5.571 ± 0.072	2.468ProGln: 2.468 ± 0.029	3.689ProArg: 3.689 ± 0.031	5.981ProSer: 5.981 ± 0.047	4.175ProThr: 4.175 ± 0.033	3.835ProVal: 3.835 ± 0.031	0.827ProTrp: 0.827 ± 0.012	1.546ProTyr: 1.546 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.551GlnAla: 3.551 ± 0.032	0.474GlnCys: 0.474 ± 0.009	2.003GlnAsp: 2.003 ± 0.019	2.18GlnGlu: 2.18 ± 0.02	1.204GlnPhe: 1.204 ± 0.016	2.467GlnGly: 2.467 ± 0.022	1.126GlnHis: 1.126 ± 0.016	1.683GlnIle: 1.683 ± 0.017	1.726GlnLys: 1.726 ± 0.018	3.422GlnLeu: 3.422 ± 0.027	0.841GlnMet: 0.841 ± 0.016	1.317GlnAsn: 1.317 ± 0.014	2.65GlnPro: 2.65 ± 0.033	2.507GlnGln: 2.507 ± 0.056	2.594GlnArg: 2.594 ± 0.024	2.89GlnSer: 2.89 ± 0.026	2.299GlnThr: 2.299 ± 0.023	2.164GlnVal: 2.164 ± 0.021	0.557GlnTrp: 0.557 ± 0.009	1.09GlnTyr: 1.09 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.047ArgAla: 5.047 ± 0.033	0.819ArgCys: 0.819 ± 0.014	3.584ArgAsp: 3.584 ± 0.03	3.843ArgGlu: 3.843 ± 0.029	2.133ArgPhe: 2.133 ± 0.019	4.063ArgGly: 4.063 ± 0.033	1.767ArgHis: 1.767 ± 0.019	2.743ArgIle: 2.743 ± 0.021	3.299ArgLys: 3.299 ± 0.028	5.781ArgLeu: 5.781 ± 0.038	1.34ArgMet: 1.34 ± 0.016	2.137ArgAsn: 2.137 ± 0.019	3.856ArgPro: 3.856 ± 0.033	2.733ArgGln: 2.733 ± 0.024	5.65ArgArg: 5.65 ± 0.048	4.721ArgSer: 4.721 ± 0.034	3.48ArgThr: 3.48 ± 0.028	3.63ArgVal: 3.63 ± 0.025	1.021ArgTrp: 1.021 ± 0.014	1.71ArgTyr: 1.71 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.859SerAla: 6.859 ± 0.041	0.975SerCys: 0.975 ± 0.014	4.037SerAsp: 4.037 ± 0.029	3.681SerGlu: 3.681 ± 0.028	2.886SerPhe: 2.886 ± 0.024	5.695SerGly: 5.695 ± 0.041	1.899SerHis: 1.899 ± 0.016	3.545SerIle: 3.545 ± 0.025	3.274SerLys: 3.274 ± 0.027	6.963SerLeu: 6.963 ± 0.035	1.618SerMet: 1.618 ± 0.017	2.637SerAsn: 2.637 ± 0.022	5.59SerPro: 5.59 ± 0.051	3.051SerGln: 3.051 ± 0.026	5.067SerArg: 5.067 ± 0.035	8.555SerSer: 8.555 ± 0.072	5.628SerThr: 5.628 ± 0.049	4.662SerVal: 4.662 ± 0.027	1.141SerTrp: 1.141 ± 0.014	2.032SerTyr: 2.032 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.725ThrAla: 5.725 ± 0.036	0.871ThrCys: 0.871 ± 0.014	2.942ThrAsp: 2.942 ± 0.02	3.031ThrGlu: 3.031 ± 0.03	2.226ThrPhe: 2.226 ± 0.019	4.41ThrGly: 4.41 ± 0.037	1.302ThrHis: 1.302 ± 0.015	2.888ThrIle: 2.888 ± 0.024	2.475ThrLys: 2.475 ± 0.022	5.246ThrLeu: 5.246 ± 0.035	1.196ThrMet: 1.196 ± 0.014	1.999ThrAsn: 1.999 ± 0.02	4.51ThrPro: 4.51 ± 0.036	2.037ThrGln: 2.037 ± 0.02	3.261ThrArg: 3.261 ± 0.024	5.502ThrSer: 5.502 ± 0.051	4.78ThrThr: 4.78 ± 0.048	4.122ThrVal: 4.122 ± 0.036	0.914ThrTrp: 0.914 ± 0.013	1.638ThrTyr: 1.638 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.926ValAla: 5.926 ± 0.035	0.915ValCys: 0.915 ± 0.014	3.901ValAsp: 3.901 ± 0.027	3.967ValGlu: 3.967 ± 0.032	2.524ValPhe: 2.524 ± 0.025	4.373ValGly: 4.373 ± 0.037	1.435ValHis: 1.435 ± 0.016	2.822ValIle: 2.822 ± 0.022	2.827ValLys: 2.827 ± 0.027	5.933ValLeu: 5.933 ± 0.034	1.371ValMet: 1.371 ± 0.014	2.132ValAsn: 2.132 ± 0.021	3.832ValPro: 3.832 ± 0.027	2.359ValGln: 2.359 ± 0.02	3.79ValArg: 3.79 ± 0.026	4.721ValSer: 4.721 ± 0.029	3.735ValThr: 3.735 ± 0.031	4.877ValVal: 4.877 ± 0.034	0.978ValTrp: 0.978 ± 0.014	1.799ValTyr: 1.799 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.239TrpAla: 1.239 ± 0.016	0.226TrpCys: 0.226 ± 0.005	0.948TrpAsp: 0.948 ± 0.015	0.865TrpGlu: 0.865 ± 0.012	0.571TrpPhe: 0.571 ± 0.009	0.982TrpGly: 0.982 ± 0.014	0.386TrpHis: 0.386 ± 0.009	0.745TrpIle: 0.745 ± 0.012	0.758TrpLys: 0.758 ± 0.011	1.438TrpLeu: 1.438 ± 0.017	0.386TrpMet: 0.386 ± 0.007	0.62TrpAsn: 0.62 ± 0.01	0.69TrpPro: 0.69 ± 0.011	0.592TrpGln: 0.592 ± 0.01	1.034TrpArg: 1.034 ± 0.015	1.075TrpSer: 1.075 ± 0.015	1.014TrpThr: 1.014 ± 0.013	0.946TrpVal: 0.946 ± 0.013	0.301TrpTrp: 0.301 ± 0.007	0.448TrpTyr: 0.448 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.205TyrAla: 2.205 ± 0.021	0.44TyrCys: 0.44 ± 0.009	1.659TyrAsp: 1.659 ± 0.016	1.46TyrGlu: 1.46 ± 0.016	1.146TyrPhe: 1.146 ± 0.014	2.13TyrGly: 2.13 ± 0.021	0.755TyrHis: 0.755 ± 0.011	1.287TyrIle: 1.287 ± 0.016	1.039TyrLys: 1.039 ± 0.015	2.601TyrLeu: 2.601 ± 0.022	0.607TyrMet: 0.607 ± 0.009	1.067TyrAsn: 1.067 ± 0.013	1.496TyrPro: 1.496 ± 0.016	1.076TyrGln: 1.076 ± 0.016	1.646TyrArg: 1.646 ± 0.017	1.935TyrSer: 1.935 ± 0.019	1.592TyrThr: 1.592 ± 0.016	1.695TyrVal: 1.695 ± 0.019	0.456TyrTrp: 0.456 ± 0.01	0.946TyrTyr: 0.946 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.018XaaXaa: 0.018 ± 0.019

Statistics based on 13658 proteins (6049712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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