Amino acid dipepetide frequency for Thermolongibacillus altinsuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.889AlaAla: 5.889 ± 0.114	0.676AlaCys: 0.676 ± 0.027	3.17AlaAsp: 3.17 ± 0.064	5.003AlaGlu: 5.003 ± 0.085	3.367AlaPhe: 3.367 ± 0.074	4.842AlaGly: 4.842 ± 0.081	1.594AlaHis: 1.594 ± 0.046	6.268AlaIle: 6.268 ± 0.085	5.65AlaLys: 5.65 ± 0.089	8.025AlaLeu: 8.025 ± 0.113	2.226AlaMet: 2.226 ± 0.054	2.81AlaAsn: 2.81 ± 0.065	2.134AlaPro: 2.134 ± 0.055	2.547AlaGln: 2.547 ± 0.059	3.145AlaArg: 3.145 ± 0.059	3.743AlaSer: 3.743 ± 0.059	3.604AlaThr: 3.604 ± 0.072	5.524AlaVal: 5.524 ± 0.094	0.66AlaTrp: 0.66 ± 0.03	2.548AlaTyr: 2.548 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.544CysAla: 0.544 ± 0.029	0.122CysCys: 0.122 ± 0.013	0.451CysAsp: 0.451 ± 0.024	0.579CysGlu: 0.579 ± 0.029	0.371CysPhe: 0.371 ± 0.023	0.706CysGly: 0.706 ± 0.034	0.225CysHis: 0.225 ± 0.016	0.526CysIle: 0.526 ± 0.026	0.38CysLys: 0.38 ± 0.021	0.751CysLeu: 0.751 ± 0.031	0.204CysMet: 0.204 ± 0.018	0.293CysAsn: 0.293 ± 0.018	0.445CysPro: 0.445 ± 0.023	0.283CysGln: 0.283 ± 0.022	0.367CysArg: 0.367 ± 0.024	0.519CysSer: 0.519 ± 0.022	0.435CysThr: 0.435 ± 0.022	0.455CysVal: 0.455 ± 0.025	0.064CysTrp: 0.064 ± 0.007	0.276CysTyr: 0.276 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.065AspAla: 3.065 ± 0.062	0.41AspCys: 0.41 ± 0.023	2.229AspAsp: 2.229 ± 0.055	4.874AspGlu: 4.874 ± 0.084	2.123AspPhe: 2.123 ± 0.052	3.181AspGly: 3.181 ± 0.075	1.199AspHis: 1.199 ± 0.038	3.539AspIle: 3.539 ± 0.073	2.121AspLys: 2.121 ± 0.049	4.766AspLeu: 4.766 ± 0.081	1.073AspMet: 1.073 ± 0.035	1.139AspAsn: 1.139 ± 0.039	2.055AspPro: 2.055 ± 0.053	1.703AspGln: 1.703 ± 0.056	2.41AspArg: 2.41 ± 0.058	1.869AspSer: 1.869 ± 0.05	1.88AspThr: 1.88 ± 0.053	4.201AspVal: 4.201 ± 0.073	0.58AspTrp: 0.58 ± 0.031	1.952AspTyr: 1.952 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.2GluAla: 6.2 ± 0.098	0.441GluCys: 0.441 ± 0.027	3.114GluAsp: 3.114 ± 0.063	7.71GluGlu: 7.71 ± 0.139	2.425GluPhe: 2.425 ± 0.054	4.174GluGly: 4.174 ± 0.075	1.903GluHis: 1.903 ± 0.047	5.812GluIle: 5.812 ± 0.096	7.623GluLys: 7.623 ± 0.112	7.03GluLeu: 7.03 ± 0.115	2.58GluMet: 2.58 ± 0.054	3.35GluAsn: 3.35 ± 0.062	2.056GluPro: 2.056 ± 0.054	4.698GluGln: 4.698 ± 0.099	4.675GluArg: 4.675 ± 0.091	2.743GluSer: 2.743 ± 0.065	4.051GluThr: 4.051 ± 0.074	5.112GluVal: 5.112 ± 0.092	0.959GluTrp: 0.959 ± 0.033	2.228GluTyr: 2.228 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.47PheAla: 3.47 ± 0.067	0.373PheCys: 0.373 ± 0.02	2.204PheAsp: 2.204 ± 0.045	2.756PheGlu: 2.756 ± 0.055	2.539PhePhe: 2.539 ± 0.068	3.309PheGly: 3.309 ± 0.072	1.174PheHis: 1.174 ± 0.035	3.771PheIle: 3.771 ± 0.078	2.068PheLys: 2.068 ± 0.054	4.782PheLeu: 4.782 ± 0.095	1.181PheMet: 1.181 ± 0.04	1.427PheAsn: 1.427 ± 0.044	1.754PhePro: 1.754 ± 0.045	1.713PheGln: 1.713 ± 0.048	1.779PheArg: 1.779 ± 0.054	3.036PheSer: 3.036 ± 0.063	2.403PheThr: 2.403 ± 0.058	3.542PheVal: 3.542 ± 0.066	0.482PheTrp: 0.482 ± 0.027	1.696PheTyr: 1.696 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.796GlyAla: 4.796 ± 0.102	0.651GlyCys: 0.651 ± 0.029	2.999GlyAsp: 2.999 ± 0.056	4.614GlyGlu: 4.614 ± 0.078	3.255GlyPhe: 3.255 ± 0.073	4.525GlyGly: 4.525 ± 0.096	1.354GlyHis: 1.354 ± 0.043	5.631GlyIle: 5.631 ± 0.094	5.263GlyLys: 5.263 ± 0.081	6.066GlyLeu: 6.066 ± 0.102	2.095GlyMet: 2.095 ± 0.053	2.397GlyAsn: 2.397 ± 0.064	1.682GlyPro: 1.682 ± 0.043	2.13GlyGln: 2.13 ± 0.053	2.814GlyArg: 2.814 ± 0.071	3.241GlySer: 3.241 ± 0.061	3.803GlyThr: 3.803 ± 0.077	5.058GlyVal: 5.058 ± 0.075	0.768GlyTrp: 0.768 ± 0.034	2.653GlyTyr: 2.653 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.472HisAla: 1.472 ± 0.046	0.239HisCys: 0.239 ± 0.017	1.035HisAsp: 1.035 ± 0.037	1.658HisGlu: 1.658 ± 0.038	1.134HisPhe: 1.134 ± 0.036	1.498HisGly: 1.498 ± 0.046	0.821HisHis: 0.821 ± 0.035	1.722HisIle: 1.722 ± 0.04	1.01HisLys: 1.01 ± 0.036	2.558HisLeu: 2.558 ± 0.054	0.582HisMet: 0.582 ± 0.022	0.689HisAsn: 0.689 ± 0.029	1.356HisPro: 1.356 ± 0.042	0.893HisGln: 0.893 ± 0.037	1.166HisArg: 1.166 ± 0.039	1.241HisSer: 1.241 ± 0.035	1.001HisThr: 1.001 ± 0.035	1.793HisVal: 1.793 ± 0.041	0.263HisTrp: 0.263 ± 0.016	1.0HisTyr: 1.0 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.554IleAla: 6.554 ± 0.106	0.714IleCys: 0.714 ± 0.026	4.336IleAsp: 4.336 ± 0.08	6.422IleGlu: 6.422 ± 0.094	3.229IlePhe: 3.229 ± 0.067	6.027IleGly: 6.027 ± 0.099	1.864IleHis: 1.864 ± 0.048	5.477IleIle: 5.477 ± 0.106	4.124IleLys: 4.124 ± 0.071	6.537IleLeu: 6.537 ± 0.105	1.562IleMet: 1.562 ± 0.045	2.68IleAsn: 2.68 ± 0.052	3.463IlePro: 3.463 ± 0.069	3.045IleGln: 3.045 ± 0.058	3.701IleArg: 3.701 ± 0.071	4.432IleSer: 4.432 ± 0.081	3.885IleThr: 3.885 ± 0.068	6.353IleVal: 6.353 ± 0.094	0.676IleTrp: 0.676 ± 0.033	2.473IleTyr: 2.473 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.038LysAla: 5.038 ± 0.088	0.378LysCys: 0.378 ± 0.023	3.071LysAsp: 3.071 ± 0.067	7.377LysGlu: 7.377 ± 0.108	1.834LysPhe: 1.834 ± 0.049	4.55LysGly: 4.55 ± 0.069	1.439LysHis: 1.439 ± 0.039	4.844LysIle: 4.844 ± 0.083	6.454LysLys: 6.454 ± 0.096	5.674LysLeu: 5.674 ± 0.09	2.236LysMet: 2.236 ± 0.052	3.024LysAsn: 3.024 ± 0.073	2.278LysPro: 2.278 ± 0.055	3.827LysGln: 3.827 ± 0.079	4.049LysArg: 4.049 ± 0.072	2.78LysSer: 2.78 ± 0.058	3.691LysThr: 3.691 ± 0.066	4.705LysVal: 4.705 ± 0.087	0.951LysTrp: 0.951 ± 0.035	2.201LysTyr: 2.201 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.07LeuAla: 8.07 ± 0.105	0.745LeuCys: 0.745 ± 0.028	4.5LeuAsp: 4.5 ± 0.075	6.882LeuGlu: 6.882 ± 0.125	4.972LeuPhe: 4.972 ± 0.109	6.205LeuGly: 6.205 ± 0.095	2.249LeuHis: 2.249 ± 0.051	6.876LeuIle: 6.876 ± 0.112	6.872LeuLys: 6.872 ± 0.093	10.472LeuLeu: 10.472 ± 0.136	2.342LeuMet: 2.342 ± 0.056	3.813LeuAsn: 3.813 ± 0.071	4.039LeuPro: 4.039 ± 0.076	4.02LeuGln: 4.02 ± 0.074	4.404LeuArg: 4.404 ± 0.074	6.191LeuSer: 6.191 ± 0.094	5.462LeuThr: 5.462 ± 0.071	6.348LeuVal: 6.348 ± 0.087	0.833LeuTrp: 0.833 ± 0.035	3.251LeuTyr: 3.251 ± 0.068	0.001LeuXaa: 0.001 ± 0.001
Met	2.134MetAla: 2.134 ± 0.05	0.149MetCys: 0.149 ± 0.014	1.248MetAsp: 1.248 ± 0.041	2.038MetGlu: 2.038 ± 0.048	1.13MetPhe: 1.13 ± 0.042	1.595MetGly: 1.595 ± 0.048	0.415MetHis: 0.415 ± 0.022	2.324MetIle: 2.324 ± 0.056	2.703MetLys: 2.703 ± 0.057	2.519MetLeu: 2.519 ± 0.067	1.015MetMet: 1.015 ± 0.044	1.607MetAsn: 1.607 ± 0.041	1.038MetPro: 1.038 ± 0.045	0.908MetGln: 0.908 ± 0.042	1.304MetArg: 1.304 ± 0.045	1.473MetSer: 1.473 ± 0.045	1.609MetThr: 1.609 ± 0.047	1.671MetVal: 1.671 ± 0.044	0.218MetTrp: 0.218 ± 0.016	0.764MetTyr: 0.764 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.599AsnAla: 2.599 ± 0.056	0.269AsnCys: 0.269 ± 0.018	2.073AsnAsp: 2.073 ± 0.053	3.69AsnGlu: 3.69 ± 0.072	1.393AsnPhe: 1.393 ± 0.041	3.204AsnGly: 3.204 ± 0.075	0.968AsnHis: 0.968 ± 0.032	3.195AsnIle: 3.195 ± 0.065	2.414AsnLys: 2.414 ± 0.06	3.11AsnLeu: 3.11 ± 0.058	1.067AsnMet: 1.067 ± 0.037	1.47AsnAsn: 1.47 ± 0.05	2.033AsnPro: 2.033 ± 0.055	1.426AsnGln: 1.426 ± 0.043	1.921AsnArg: 1.921 ± 0.046	1.553AsnSer: 1.553 ± 0.044	1.689AsnThr: 1.689 ± 0.049	3.116AsnVal: 3.116 ± 0.068	0.42AsnTrp: 0.42 ± 0.023	1.301AsnTyr: 1.301 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.123ProAla: 2.123 ± 0.047	0.256ProCys: 0.256 ± 0.016	1.8ProAsp: 1.8 ± 0.051	2.736ProGlu: 2.736 ± 0.07	2.175ProPhe: 2.175 ± 0.058	2.11ProGly: 2.11 ± 0.06	1.016ProHis: 1.016 ± 0.037	3.039ProIle: 3.039 ± 0.055	2.609ProLys: 2.609 ± 0.049	3.937ProLeu: 3.937 ± 0.081	0.888ProMet: 0.888 ± 0.038	1.924ProAsn: 1.924 ± 0.05	1.141ProPro: 1.141 ± 0.044	1.118ProGln: 1.118 ± 0.033	1.261ProArg: 1.261 ± 0.038	2.375ProSer: 2.375 ± 0.057	2.119ProThr: 2.119 ± 0.057	2.654ProVal: 2.654 ± 0.057	0.397ProTrp: 0.397 ± 0.022	1.598ProTyr: 1.598 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	3.041GlnAla: 3.041 ± 0.067	0.278GlnCys: 0.278 ± 0.021	1.333GlnAsp: 1.333 ± 0.043	2.921GlnGlu: 2.921 ± 0.072	1.813GlnPhe: 1.813 ± 0.043	2.03GlnGly: 2.03 ± 0.054	0.917GlnHis: 0.917 ± 0.033	2.826GlnIle: 2.826 ± 0.069	3.174GlnLys: 3.174 ± 0.07	4.84GlnLeu: 4.84 ± 0.087	1.344GlnMet: 1.344 ± 0.042	1.426GlnAsn: 1.426 ± 0.044	1.379GlnPro: 1.379 ± 0.056	2.285GlnGln: 2.285 ± 0.065	1.76GlnArg: 1.76 ± 0.053	2.029GlnSer: 2.029 ± 0.049	2.219GlnThr: 2.219 ± 0.063	2.189GlnVal: 2.189 ± 0.054	0.5GlnTrp: 0.5 ± 0.022	1.487GlnTyr: 1.487 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.981ArgAla: 2.981 ± 0.064	0.367ArgCys: 0.367 ± 0.025	2.115ArgAsp: 2.115 ± 0.048	3.852ArgGlu: 3.852 ± 0.084	2.267ArgPhe: 2.267 ± 0.046	2.682ArgGly: 2.682 ± 0.057	1.01ArgHis: 1.01 ± 0.033	3.485ArgIle: 3.485 ± 0.07	3.645ArgLys: 3.645 ± 0.073	4.938ArgLeu: 4.938 ± 0.086	1.503ArgMet: 1.503 ± 0.041	1.967ArgAsn: 1.967 ± 0.048	1.595ArgPro: 1.595 ± 0.045	1.96ArgGln: 1.96 ± 0.047	2.213ArgArg: 2.213 ± 0.057	2.329ArgSer: 2.329 ± 0.059	2.267ArgThr: 2.267 ± 0.052	2.908ArgVal: 2.908 ± 0.068	0.557ArgTrp: 0.557 ± 0.024	1.893ArgTyr: 1.893 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.273SerAla: 3.273 ± 0.071	0.41SerCys: 0.41 ± 0.022	2.317SerAsp: 2.317 ± 0.057	3.591SerGlu: 3.591 ± 0.067	3.292SerPhe: 3.292 ± 0.071	3.684SerGly: 3.684 ± 0.071	1.152SerHis: 1.152 ± 0.035	4.283SerIle: 4.283 ± 0.075	3.018SerLys: 3.018 ± 0.066	5.99SerLeu: 5.99 ± 0.098	1.459SerMet: 1.459 ± 0.043	1.842SerAsn: 1.842 ± 0.043	2.075SerPro: 2.075 ± 0.049	1.619SerGln: 1.619 ± 0.047	2.074SerArg: 2.074 ± 0.057	3.14SerSer: 3.14 ± 0.067	2.455SerThr: 2.455 ± 0.055	3.749SerVal: 3.749 ± 0.075	0.528SerTrp: 0.528 ± 0.024	1.938SerTyr: 1.938 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.679ThrAla: 3.679 ± 0.063	0.396ThrCys: 0.396 ± 0.022	2.292ThrAsp: 2.292 ± 0.057	3.425ThrGlu: 3.425 ± 0.067	2.75ThrPhe: 2.75 ± 0.064	3.686ThrGly: 3.686 ± 0.07	1.028ThrHis: 1.028 ± 0.034	4.701ThrIle: 4.701 ± 0.081	3.568ThrLys: 3.568 ± 0.062	5.093ThrLeu: 5.093 ± 0.081	1.398ThrMet: 1.398 ± 0.043	2.478ThrAsn: 2.478 ± 0.059	2.114ThrPro: 2.114 ± 0.048	1.175ThrGln: 1.175 ± 0.04	1.779ThrArg: 1.779 ± 0.046	2.645ThrSer: 2.645 ± 0.06	2.747ThrThr: 2.747 ± 0.071	4.184ThrVal: 4.184 ± 0.085	0.495ThrTrp: 0.495 ± 0.025	1.956ThrTyr: 1.956 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.521ValAla: 5.521 ± 0.098	0.68ValCys: 0.68 ± 0.03	3.685ValAsp: 3.685 ± 0.072	4.988ValGlu: 4.988 ± 0.084	3.101ValPhe: 3.101 ± 0.067	4.64ValGly: 4.64 ± 0.084	1.648ValHis: 1.648 ± 0.047	5.777ValIle: 5.777 ± 0.082	4.831ValLys: 4.831 ± 0.071	6.89ValLeu: 6.89 ± 0.104	1.835ValMet: 1.835 ± 0.046	2.817ValAsn: 2.817 ± 0.06	2.979ValPro: 2.979 ± 0.062	2.799ValGln: 2.799 ± 0.057	3.306ValArg: 3.306 ± 0.072	4.178ValSer: 4.178 ± 0.066	4.026ValThr: 4.026 ± 0.071	5.575ValVal: 5.575 ± 0.097	0.685ValTrp: 0.685 ± 0.032	2.525ValTyr: 2.525 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.655TrpAla: 0.655 ± 0.035	0.076TrpCys: 0.076 ± 0.01	0.445TrpAsp: 0.445 ± 0.024	0.683TrpGlu: 0.683 ± 0.03	0.527TrpPhe: 0.527 ± 0.029	0.618TrpGly: 0.618 ± 0.029	0.253TrpHis: 0.253 ± 0.021	0.942TrpIle: 0.942 ± 0.034	0.828TrpLys: 0.828 ± 0.037	1.258TrpLeu: 1.258 ± 0.044	0.407TrpMet: 0.407 ± 0.021	0.528TrpAsn: 0.528 ± 0.027	0.275TrpPro: 0.275 ± 0.02	0.39TrpGln: 0.39 ± 0.025	0.476TrpArg: 0.476 ± 0.024	0.535TrpSer: 0.535 ± 0.027	0.547TrpThr: 0.547 ± 0.025	0.624TrpVal: 0.624 ± 0.028	0.152TrpTrp: 0.152 ± 0.013	0.351TrpTyr: 0.351 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.323TyrAla: 2.323 ± 0.056	0.365TyrCys: 0.365 ± 0.021	1.953TyrAsp: 1.953 ± 0.052	3.084TyrGlu: 3.084 ± 0.065	1.765TyrPhe: 1.765 ± 0.052	2.528TyrGly: 2.528 ± 0.058	0.903TyrHis: 0.903 ± 0.034	2.519TyrIle: 2.519 ± 0.055	2.042TyrLys: 2.042 ± 0.054	3.311TyrLeu: 3.311 ± 0.067	0.866TyrMet: 0.866 ± 0.031	1.228TyrAsn: 1.228 ± 0.041	1.385TyrPro: 1.385 ± 0.043	1.25TyrGln: 1.25 ± 0.037	1.929TyrArg: 1.929 ± 0.044	1.837TyrSer: 1.837 ± 0.04	1.696TyrThr: 1.696 ± 0.05	2.722TyrVal: 2.722 ± 0.052	0.384TyrTrp: 0.384 ± 0.021	1.433TyrTyr: 1.433 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.004

Statistics based on 2961 proteins (844262 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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