Amino acid dipepetide frequency for Aeromonas phage D3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.981AlaAla: 4.981 ± 0.42
0.583AlaCys: 0.583 ± 0.088
3.851AlaAsp: 3.851 ± 0.248
4.325AlaGlu: 4.325 ± 0.291
2.758AlaPhe: 2.758 ± 0.242
4.362AlaGly: 4.362 ± 0.335
1.008AlaHis: 1.008 ± 0.111
4.495AlaIle: 4.495 ± 0.258
4.362AlaLys: 4.362 ± 0.288
5.346AlaLeu: 5.346 ± 0.338
2.782AlaMet: 2.782 ± 0.256
3.584AlaAsn: 3.584 ± 0.214
2.333AlaPro: 2.333 ± 0.253
1.847AlaGln: 1.847 ± 0.148
3.292AlaArg: 3.292 ± 0.217
3.73AlaSer: 3.73 ± 0.263
3.949AlaThr: 3.949 ± 0.401
4.362AlaVal: 4.362 ± 0.27
0.85AlaTrp: 0.85 ± 0.112
2.078AlaTyr: 2.078 ± 0.179
0.0AlaXaa: 0.0 ± 0.0
Cys
0.51CysAla: 0.51 ± 0.073
0.109CysCys: 0.109 ± 0.035
0.583CysAsp: 0.583 ± 0.089
0.547CysGlu: 0.547 ± 0.081
0.462CysPhe: 0.462 ± 0.072
0.644CysGly: 0.644 ± 0.083
0.219CysHis: 0.219 ± 0.053
0.486CysIle: 0.486 ± 0.083
0.607CysLys: 0.607 ± 0.073
0.693CysLeu: 0.693 ± 0.092
0.231CysMet: 0.231 ± 0.057
0.413CysAsn: 0.413 ± 0.066
0.401CysPro: 0.401 ± 0.068
0.231CysGln: 0.231 ± 0.061
0.644CysArg: 0.644 ± 0.098
0.632CysSer: 0.632 ± 0.098
0.486CysThr: 0.486 ± 0.088
0.705CysVal: 0.705 ± 0.097
0.121CysTrp: 0.121 ± 0.041
0.413CysTyr: 0.413 ± 0.068
0.0CysXaa: 0.0 ± 0.0
Asp
3.73AspAla: 3.73 ± 0.225
0.68AspCys: 0.68 ± 0.102
3.487AspAsp: 3.487 ± 0.225
4.179AspGlu: 4.179 ± 0.274
2.916AspPhe: 2.916 ± 0.181
4.69AspGly: 4.69 ± 0.246
1.142AspHis: 1.142 ± 0.115
4.544AspIle: 4.544 ± 0.24
3.778AspLys: 3.778 ± 0.186
6.196AspLeu: 6.196 ± 0.272
2.053AspMet: 2.053 ± 0.191
3.402AspAsn: 3.402 ± 0.194
3.195AspPro: 3.195 ± 0.219
2.248AspGln: 2.248 ± 0.185
2.879AspArg: 2.879 ± 0.191
3.122AspSer: 3.122 ± 0.203
3.317AspThr: 3.317 ± 0.179
4.823AspVal: 4.823 ± 0.241
0.984AspTrp: 0.984 ± 0.108
2.491AspTyr: 2.491 ± 0.161
0.0AspXaa: 0.0 ± 0.0
Glu
3.693GluAla: 3.693 ± 0.263
0.62GluCys: 0.62 ± 0.098
3.511GluAsp: 3.511 ± 0.231
5.358GluGlu: 5.358 ± 0.409
3.122GluPhe: 3.122 ± 0.205
4.398GluGly: 4.398 ± 0.221
1.494GluHis: 1.494 ± 0.135
4.665GluIle: 4.665 ± 0.262
3.633GluLys: 3.633 ± 0.238
6.986GluLeu: 6.986 ± 0.388
2.308GluMet: 2.308 ± 0.168
2.819GluAsn: 2.819 ± 0.197
2.163GluPro: 2.163 ± 0.185
2.442GluGln: 2.442 ± 0.208
3.499GluArg: 3.499 ± 0.247
3.863GluSer: 3.863 ± 0.224
3.706GluThr: 3.706 ± 0.182
5.188GluVal: 5.188 ± 0.266
0.814GluTrp: 0.814 ± 0.089
2.661GluTyr: 2.661 ± 0.167
0.0GluXaa: 0.0 ± 0.0
Phe
2.551PheAla: 2.551 ± 0.184
0.401PheCys: 0.401 ± 0.066
3.402PheAsp: 3.402 ± 0.175
2.892PheGlu: 2.892 ± 0.191
2.138PhePhe: 2.138 ± 0.19
3.645PheGly: 3.645 ± 0.212
0.838PheHis: 0.838 ± 0.104
2.867PheIle: 2.867 ± 0.218
3.341PheLys: 3.341 ± 0.19
3.207PheLeu: 3.207 ± 0.225
1.264PheMet: 1.264 ± 0.117
3.28PheAsn: 3.28 ± 0.568
1.64PhePro: 1.64 ± 0.147
1.421PheGln: 1.421 ± 0.116
2.078PheArg: 2.078 ± 0.216
3.049PheSer: 3.049 ± 0.21
2.879PheThr: 2.879 ± 0.208
2.831PheVal: 2.831 ± 0.188
0.486PheTrp: 0.486 ± 0.071
1.932PheTyr: 1.932 ± 0.173
0.0PheXaa: 0.0 ± 0.0
Gly
4.009GlyAla: 4.009 ± 0.264
0.571GlyCys: 0.571 ± 0.088
4.082GlyAsp: 4.082 ± 0.225
4.58GlyGlu: 4.58 ± 0.237
3.475GlyPhe: 3.475 ± 0.204
4.605GlyGly: 4.605 ± 0.347
1.239GlyHis: 1.239 ± 0.127
4.204GlyIle: 4.204 ± 0.213
4.92GlyLys: 4.92 ± 0.295
5.528GlyLeu: 5.528 ± 0.276
2.491GlyMet: 2.491 ± 0.21
3.511GlyAsn: 3.511 ± 0.222
1.847GlyPro: 1.847 ± 0.15
1.992GlyGln: 1.992 ± 0.16
3.317GlyArg: 3.317 ± 0.205
4.155GlySer: 4.155 ± 0.273
4.702GlyThr: 4.702 ± 0.397
4.726GlyVal: 4.726 ± 0.225
1.13GlyTrp: 1.13 ± 0.173
3.159GlyTyr: 3.159 ± 0.213
0.0GlyXaa: 0.0 ± 0.0
His
1.081HisAla: 1.081 ± 0.108
0.207HisCys: 0.207 ± 0.052
1.434HisAsp: 1.434 ± 0.13
1.264HisGlu: 1.264 ± 0.122
1.178HisPhe: 1.178 ± 0.126
1.227HisGly: 1.227 ± 0.132
0.559HisHis: 0.559 ± 0.086
1.178HisIle: 1.178 ± 0.135
1.118HisLys: 1.118 ± 0.12
1.677HisLeu: 1.677 ± 0.128
0.535HisMet: 0.535 ± 0.071
1.008HisAsn: 1.008 ± 0.104
1.106HisPro: 1.106 ± 0.111
0.753HisGln: 0.753 ± 0.093
0.923HisArg: 0.923 ± 0.12
1.118HisSer: 1.118 ± 0.134
1.166HisThr: 1.166 ± 0.122
1.543HisVal: 1.543 ± 0.131
0.279HisTrp: 0.279 ± 0.058
0.875HisTyr: 0.875 ± 0.111
0.0HisXaa: 0.0 ± 0.0
Ile
4.69IleAla: 4.69 ± 0.236
0.632IleCys: 0.632 ± 0.092
4.422IleAsp: 4.422 ± 0.249
4.41IleGlu: 4.41 ± 0.232
2.235IlePhe: 2.235 ± 0.173
4.021IleGly: 4.021 ± 0.269
1.215IleHis: 1.215 ± 0.126
3.438IleIle: 3.438 ± 0.22
4.398IleLys: 4.398 ± 0.249
4.106IleLeu: 4.106 ± 0.305
1.689IleMet: 1.689 ± 0.15
4.058IleAsn: 4.058 ± 0.241
3.305IlePro: 3.305 ± 0.21
2.078IleGln: 2.078 ± 0.161
3.256IleArg: 3.256 ± 0.231
4.264IleSer: 4.264 ± 0.265
4.483IleThr: 4.483 ± 0.29
3.73IleVal: 3.73 ± 0.211
0.486IleTrp: 0.486 ± 0.088
2.041IleTyr: 2.041 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
4.811LysAla: 4.811 ± 0.338
0.45LysCys: 0.45 ± 0.073
4.471LysAsp: 4.471 ± 0.266
5.078LysGlu: 5.078 ± 0.282
2.527LysPhe: 2.527 ± 0.19
4.131LysGly: 4.131 ± 0.203
1.494LysHis: 1.494 ± 0.162
3.232LysIle: 3.232 ± 0.198
3.548LysLys: 3.548 ± 0.275
5.625LysLeu: 5.625 ± 0.265
2.041LysMet: 2.041 ± 0.189
2.794LysAsn: 2.794 ± 0.173
2.6LysPro: 2.6 ± 0.184
2.065LysGln: 2.065 ± 0.194
3.074LysArg: 3.074 ± 0.226
3.171LysSer: 3.171 ± 0.183
3.778LysThr: 3.778 ± 0.207
4.738LysVal: 4.738 ± 0.271
0.668LysTrp: 0.668 ± 0.128
2.454LysTyr: 2.454 ± 0.175
0.0LysXaa: 0.0 ± 0.0
Leu
5.382LeuAla: 5.382 ± 0.278
0.778LeuCys: 0.778 ± 0.096
6.002LeuAsp: 6.002 ± 0.262
5.844LeuGlu: 5.844 ± 0.319
3.961LeuPhe: 3.961 ± 0.226
5.261LeuGly: 5.261 ± 0.328
1.458LeuHis: 1.458 ± 0.137
4.75LeuIle: 4.75 ± 0.323
5.163LeuLys: 5.163 ± 0.254
5.698LeuLeu: 5.698 ± 0.334
2.43LeuMet: 2.43 ± 0.209
4.653LeuAsn: 4.653 ± 0.225
3.256LeuPro: 3.256 ± 0.202
2.381LeuGln: 2.381 ± 0.163
4.228LeuArg: 4.228 ± 0.205
5.115LeuSer: 5.115 ± 0.253
5.832LeuThr: 5.832 ± 0.34
5.977LeuVal: 5.977 ± 0.298
0.632LeuTrp: 0.632 ± 0.101
2.977LeuTyr: 2.977 ± 0.194
0.0LeuXaa: 0.0 ± 0.0
Met
2.078MetAla: 2.078 ± 0.195
0.328MetCys: 0.328 ± 0.058
2.017MetAsp: 2.017 ± 0.166
1.968MetGlu: 1.968 ± 0.138
2.369MetPhe: 2.369 ± 0.546
1.92MetGly: 1.92 ± 0.188
0.522MetHis: 0.522 ± 0.074
1.98MetIle: 1.98 ± 0.178
2.078MetLys: 2.078 ± 0.157
2.333MetLeu: 2.333 ± 0.192
0.911MetMet: 0.911 ± 0.106
2.005MetAsn: 2.005 ± 0.165
0.984MetPro: 0.984 ± 0.1
0.826MetGln: 0.826 ± 0.118
1.093MetArg: 1.093 ± 0.129
2.709MetSer: 2.709 ± 0.224
2.175MetThr: 2.175 ± 0.179
2.163MetVal: 2.163 ± 0.166
0.377MetTrp: 0.377 ± 0.071
1.178MetTyr: 1.178 ± 0.145
0.0MetXaa: 0.0 ± 0.0
Asn
3.827AsnAla: 3.827 ± 0.225
0.437AsnCys: 0.437 ± 0.082
3.135AsnAsp: 3.135 ± 0.203
3.232AsnGlu: 3.232 ± 0.234
2.369AsnPhe: 2.369 ± 0.147
4.167AsnGly: 4.167 ± 0.263
1.178AsnHis: 1.178 ± 0.122
2.916AsnIle: 2.916 ± 0.187
3.718AsnLys: 3.718 ± 0.254
4.349AsnLeu: 4.349 ± 0.267
1.664AsnMet: 1.664 ± 0.197
3.049AsnAsn: 3.049 ± 0.257
3.074AsnPro: 3.074 ± 0.202
2.235AsnGln: 2.235 ± 0.337
2.454AsnArg: 2.454 ± 0.175
2.867AsnSer: 2.867 ± 0.199
3.45AsnThr: 3.45 ± 0.233
3.45AsnVal: 3.45 ± 0.244
0.632AsnTrp: 0.632 ± 0.142
2.163AsnTyr: 2.163 ± 0.168
0.0AsnXaa: 0.0 ± 0.0
Pro
2.989ProAla: 2.989 ± 0.194
0.243ProCys: 0.243 ± 0.052
2.709ProAsp: 2.709 ± 0.219
2.989ProGlu: 2.989 ± 0.195
1.847ProPhe: 1.847 ± 0.151
3.28ProGly: 3.28 ± 0.201
0.778ProHis: 0.778 ± 0.095
2.442ProIle: 2.442 ± 0.192
2.515ProLys: 2.515 ± 0.157
2.649ProLeu: 2.649 ± 0.184
1.203ProMet: 1.203 ± 0.179
2.199ProAsn: 2.199 ± 0.193
1.178ProPro: 1.178 ± 0.131
1.093ProGln: 1.093 ± 0.133
1.628ProArg: 1.628 ± 0.127
2.551ProSer: 2.551 ± 0.175
2.624ProThr: 2.624 ± 0.186
3.608ProVal: 3.608 ± 0.307
0.462ProTrp: 0.462 ± 0.075
1.482ProTyr: 1.482 ± 0.169
0.0ProXaa: 0.0 ± 0.0
Gln
2.442GlnAla: 2.442 ± 0.197
0.243GlnCys: 0.243 ± 0.056
2.114GlnAsp: 2.114 ± 0.195
2.223GlnGlu: 2.223 ± 0.186
1.519GlnPhe: 1.519 ± 0.111
2.248GlnGly: 2.248 ± 0.192
0.729GlnHis: 0.729 ± 0.099
1.871GlnIle: 1.871 ± 0.157
1.446GlnLys: 1.446 ± 0.142
3.171GlnLeu: 3.171 ± 0.225
0.875GlnMet: 0.875 ± 0.131
1.47GlnAsn: 1.47 ± 0.137
1.421GlnPro: 1.421 ± 0.222
1.446GlnGln: 1.446 ± 0.257
1.628GlnArg: 1.628 ± 0.16
2.102GlnSer: 2.102 ± 0.146
1.786GlnThr: 1.786 ± 0.165
2.43GlnVal: 2.43 ± 0.174
0.425GlnTrp: 0.425 ± 0.07
1.446GlnTyr: 1.446 ± 0.123
0.0GlnXaa: 0.0 ± 0.0
Arg
3.001ArgAla: 3.001 ± 0.213
0.583ArgCys: 0.583 ± 0.108
3.11ArgAsp: 3.11 ± 0.204
3.049ArgGlu: 3.049 ± 0.213
2.187ArgPhe: 2.187 ± 0.16
2.916ArgGly: 2.916 ± 0.236
1.106ArgHis: 1.106 ± 0.103
3.475ArgIle: 3.475 ± 0.183
2.892ArgLys: 2.892 ± 0.187
4.192ArgLeu: 4.192 ± 0.222
1.507ArgMet: 1.507 ± 0.169
2.381ArgAsn: 2.381 ± 0.181
1.664ArgPro: 1.664 ± 0.143
1.895ArgGln: 1.895 ± 0.188
2.235ArgArg: 2.235 ± 0.169
2.673ArgSer: 2.673 ± 0.198
2.977ArgThr: 2.977 ± 0.199
3.268ArgVal: 3.268 ± 0.191
0.535ArgTrp: 0.535 ± 0.077
2.102ArgTyr: 2.102 ± 0.165
0.0ArgXaa: 0.0 ± 0.0
Ser
3.681SerAla: 3.681 ± 0.325
0.607SerCys: 0.607 ± 0.104
3.693SerAsp: 3.693 ± 0.247
3.426SerGlu: 3.426 ± 0.18
3.122SerPhe: 3.122 ± 0.206
4.228SerGly: 4.228 ± 0.249
1.312SerHis: 1.312 ± 0.117
4.192SerIle: 4.192 ± 0.282
3.621SerLys: 3.621 ± 0.217
5.078SerLeu: 5.078 ± 0.292
2.43SerMet: 2.43 ± 0.221
3.305SerAsn: 3.305 ± 0.309
2.466SerPro: 2.466 ± 0.173
1.907SerGln: 1.907 ± 0.163
2.661SerArg: 2.661 ± 0.181
3.329SerSer: 3.329 ± 0.223
3.11SerThr: 3.11 ± 0.165
4.641SerVal: 4.641 ± 0.236
0.705SerTrp: 0.705 ± 0.096
2.369SerTyr: 2.369 ± 0.196
0.0SerXaa: 0.0 ± 0.0
Thr
3.888ThrAla: 3.888 ± 0.248
0.535ThrCys: 0.535 ± 0.076
3.985ThrAsp: 3.985 ± 0.216
4.106ThrGlu: 4.106 ± 0.189
2.819ThrPhe: 2.819 ± 0.181
5.188ThrGly: 5.188 ± 0.428
1.3ThrHis: 1.3 ± 0.157
4.046ThrIle: 4.046 ± 0.234
3.596ThrLys: 3.596 ± 0.241
5.516ThrLeu: 5.516 ± 0.313
1.774ThrMet: 1.774 ± 0.158
3.098ThrAsn: 3.098 ± 0.249
3.183ThrPro: 3.183 ± 0.265
1.98ThrGln: 1.98 ± 0.164
2.649ThrArg: 2.649 ± 0.19
3.463ThrSer: 3.463 ± 0.227
4.301ThrThr: 4.301 ± 0.287
4.933ThrVal: 4.933 ± 0.393
0.85ThrTrp: 0.85 ± 0.116
2.126ThrTyr: 2.126 ± 0.196
0.0ThrXaa: 0.0 ± 0.0
Val
4.641ValAla: 4.641 ± 0.318
0.68ValCys: 0.68 ± 0.093
4.24ValAsp: 4.24 ± 0.228
4.617ValGlu: 4.617 ± 0.33
2.794ValPhe: 2.794 ± 0.21
4.653ValGly: 4.653 ± 0.222
1.434ValHis: 1.434 ± 0.124
5.139ValIle: 5.139 ± 0.286
5.006ValLys: 5.006 ± 0.328
5.261ValLeu: 5.261 ± 0.271
2.175ValMet: 2.175 ± 0.168
4.009ValAsn: 4.009 ± 0.267
2.673ValPro: 2.673 ± 0.162
2.551ValGln: 2.551 ± 0.171
3.426ValArg: 3.426 ± 0.169
4.981ValSer: 4.981 ± 0.254
5.103ValThr: 5.103 ± 0.405
5.115ValVal: 5.115 ± 0.365
0.765ValTrp: 0.765 ± 0.102
2.564ValTyr: 2.564 ± 0.205
0.0ValXaa: 0.0 ± 0.0
Trp
0.571TrpAla: 0.571 ± 0.081
0.121TrpCys: 0.121 ± 0.037
0.984TrpAsp: 0.984 ± 0.167
0.814TrpGlu: 0.814 ± 0.092
0.632TrpPhe: 0.632 ± 0.085
0.559TrpGly: 0.559 ± 0.076
0.207TrpHis: 0.207 ± 0.047
0.753TrpIle: 0.753 ± 0.114
0.693TrpLys: 0.693 ± 0.096
1.008TrpLeu: 1.008 ± 0.105
0.522TrpMet: 0.522 ± 0.068
0.911TrpAsn: 0.911 ± 0.298
0.243TrpPro: 0.243 ± 0.055
0.182TrpGln: 0.182 ± 0.044
0.656TrpArg: 0.656 ± 0.098
0.705TrpSer: 0.705 ± 0.089
0.765TrpThr: 0.765 ± 0.102
0.948TrpVal: 0.948 ± 0.11
0.158TrpTrp: 0.158 ± 0.037
0.462TrpTyr: 0.462 ± 0.071
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.321TyrAla: 2.321 ± 0.187
0.328TyrCys: 0.328 ± 0.054
2.624TyrAsp: 2.624 ± 0.209
2.041TyrGlu: 2.041 ± 0.158
1.725TyrPhe: 1.725 ± 0.161
2.102TyrGly: 2.102 ± 0.175
0.996TyrHis: 0.996 ± 0.112
2.284TyrIle: 2.284 ± 0.178
2.321TyrLys: 2.321 ± 0.168
3.159TyrLeu: 3.159 ± 0.204
1.118TyrMet: 1.118 ± 0.123
2.418TyrAsn: 2.418 ± 0.186
1.737TyrPro: 1.737 ± 0.135
1.458TyrGln: 1.458 ± 0.147
2.126TyrArg: 2.126 ± 0.192
2.284TyrSer: 2.284 ± 0.195
2.746TyrThr: 2.746 ± 0.225
2.649TyrVal: 2.649 ± 0.223
0.535TyrTrp: 0.535 ± 0.072
1.543TyrTyr: 1.543 ± 0.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 267 proteins (82310 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski