Amino acid dipepetide frequency for [Clostridium] populeti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.409AlaAla: 5.409 ± 0.079	0.928AlaCys: 0.928 ± 0.031	3.608AlaAsp: 3.608 ± 0.06	4.536AlaGlu: 4.536 ± 0.076	2.82AlaPhe: 2.82 ± 0.049	5.03AlaGly: 5.03 ± 0.07	0.863AlaHis: 0.863 ± 0.027	4.966AlaIle: 4.966 ± 0.069	4.386AlaLys: 4.386 ± 0.063	5.598AlaLeu: 5.598 ± 0.065	1.801AlaMet: 1.801 ± 0.042	2.692AlaAsn: 2.692 ± 0.051	1.596AlaPro: 1.596 ± 0.041	1.819AlaGln: 1.819 ± 0.04	2.163AlaArg: 2.163 ± 0.044	3.775AlaSer: 3.775 ± 0.064	3.122AlaThr: 3.122 ± 0.074	5.243AlaVal: 5.243 ± 0.082	0.479AlaTrp: 0.479 ± 0.02	2.589AlaTyr: 2.589 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.797CysAla: 0.797 ± 0.031	0.294CysCys: 0.294 ± 0.017	0.79CysAsp: 0.79 ± 0.029	0.891CysGlu: 0.891 ± 0.026	0.727CysPhe: 0.727 ± 0.024	1.235CysGly: 1.235 ± 0.031	0.278CysHis: 0.278 ± 0.014	1.29CysIle: 1.29 ± 0.031	0.93CysLys: 0.93 ± 0.028	1.095CysLeu: 1.095 ± 0.031	0.451CysMet: 0.451 ± 0.02	0.742CysAsn: 0.742 ± 0.024	0.52CysPro: 0.52 ± 0.02	0.466CysGln: 0.466 ± 0.017	0.495CysArg: 0.495 ± 0.019	1.028CysSer: 1.028 ± 0.03	0.717CysThr: 0.717 ± 0.027	0.919CysVal: 0.919 ± 0.028	0.121CysTrp: 0.121 ± 0.011	0.633CysTyr: 0.633 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.27AspAla: 3.27 ± 0.057	0.785AspCys: 0.785 ± 0.026	2.363AspAsp: 2.363 ± 0.052	4.152AspGlu: 4.152 ± 0.062	2.779AspPhe: 2.779 ± 0.049	3.633AspGly: 3.633 ± 0.065	0.664AspHis: 0.664 ± 0.024	4.759AspIle: 4.759 ± 0.074	3.957AspLys: 3.957 ± 0.056	4.331AspLeu: 4.331 ± 0.058	1.591AspMet: 1.591 ± 0.033	2.611AspAsn: 2.611 ± 0.055	1.313AspPro: 1.313 ± 0.037	1.302AspGln: 1.302 ± 0.033	1.727AspArg: 1.727 ± 0.036	3.389AspSer: 3.389 ± 0.064	2.933AspThr: 2.933 ± 0.052	3.442AspVal: 3.442 ± 0.051	0.612AspTrp: 0.612 ± 0.022	2.74AspTyr: 2.74 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.903GluAla: 4.903 ± 0.068	0.835GluCys: 0.835 ± 0.026	4.062GluAsp: 4.062 ± 0.057	7.58GluGlu: 7.58 ± 0.095	2.927GluPhe: 2.927 ± 0.05	4.219GluGly: 4.219 ± 0.071	1.236GluHis: 1.236 ± 0.031	6.326GluIle: 6.326 ± 0.075	7.289GluLys: 7.289 ± 0.098	7.212GluLeu: 7.212 ± 0.086	2.312GluMet: 2.312 ± 0.043	4.608GluAsn: 4.608 ± 0.076	1.829GluPro: 1.829 ± 0.042	3.295GluGln: 3.295 ± 0.061	2.931GluArg: 2.931 ± 0.059	3.753GluSer: 3.753 ± 0.057	3.811GluThr: 3.811 ± 0.065	4.835GluVal: 4.835 ± 0.073	0.677GluTrp: 0.677 ± 0.025	3.478GluTyr: 3.478 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.537PheAla: 2.537 ± 0.049	0.745PheCys: 0.745 ± 0.025	2.547PheAsp: 2.547 ± 0.051	2.945PheGlu: 2.945 ± 0.058	1.952PhePhe: 1.952 ± 0.047	2.809PheGly: 2.809 ± 0.051	0.862PheHis: 0.862 ± 0.028	3.468PheIle: 3.468 ± 0.057	2.312PheLys: 2.312 ± 0.047	3.964PheLeu: 3.964 ± 0.073	1.135PheMet: 1.135 ± 0.035	1.942PheAsn: 1.942 ± 0.041	1.268PhePro: 1.268 ± 0.033	1.792PheGln: 1.792 ± 0.039	1.432PheArg: 1.432 ± 0.038	3.336PheSer: 3.336 ± 0.05	2.36PheThr: 2.36 ± 0.047	2.873PheVal: 2.873 ± 0.048	0.427PheTrp: 0.427 ± 0.019	2.038PheTyr: 2.038 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.072GlyAla: 4.072 ± 0.078	1.046GlyCys: 1.046 ± 0.034	3.136GlyAsp: 3.136 ± 0.06	4.512GlyGlu: 4.512 ± 0.064	3.032GlyPhe: 3.032 ± 0.053	4.36GlyGly: 4.36 ± 0.08	1.012GlyHis: 1.012 ± 0.031	6.136GlyIle: 6.136 ± 0.075	5.353GlyLys: 5.353 ± 0.078	5.139GlyLeu: 5.139 ± 0.079	2.053GlyMet: 2.053 ± 0.046	3.403GlyAsn: 3.403 ± 0.066	1.053GlyPro: 1.053 ± 0.031	1.873GlyGln: 1.873 ± 0.032	2.338GlyArg: 2.338 ± 0.046	3.976GlySer: 3.976 ± 0.063	4.465GlyThr: 4.465 ± 0.074	4.599GlyVal: 4.599 ± 0.063	0.6GlyTrp: 0.6 ± 0.024	3.125GlyTyr: 3.125 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.873HisAla: 0.873 ± 0.03	0.268HisCys: 0.268 ± 0.014	0.735HisAsp: 0.735 ± 0.033	0.921HisGlu: 0.921 ± 0.027	0.883HisPhe: 0.883 ± 0.026	1.079HisGly: 1.079 ± 0.029	0.364HisHis: 0.364 ± 0.023	1.405HisIle: 1.405 ± 0.034	1.014HisLys: 1.014 ± 0.028	1.333HisLeu: 1.333 ± 0.037	0.457HisMet: 0.457 ± 0.018	0.793HisAsn: 0.793 ± 0.025	0.732HisPro: 0.732 ± 0.025	0.529HisGln: 0.529 ± 0.021	0.567HisArg: 0.567 ± 0.022	0.988HisSer: 0.988 ± 0.029	0.891HisThr: 0.891 ± 0.028	0.942HisVal: 0.942 ± 0.027	0.158HisTrp: 0.158 ± 0.011	0.776HisTyr: 0.776 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.288IleAla: 5.288 ± 0.069	1.358IleCys: 1.358 ± 0.035	4.239IleAsp: 4.239 ± 0.062	6.191IleGlu: 6.191 ± 0.09	3.188IlePhe: 3.188 ± 0.058	5.284IleGly: 5.284 ± 0.074	1.457IleHis: 1.457 ± 0.037	6.584IleIle: 6.584 ± 0.1	5.577IleLys: 5.577 ± 0.067	7.5IleLeu: 7.5 ± 0.096	2.155IleMet: 2.155 ± 0.04	4.011IleAsn: 4.011 ± 0.07	3.074IlePro: 3.074 ± 0.051	3.046IleGln: 3.046 ± 0.047	3.182IleArg: 3.182 ± 0.054	6.108IleSer: 6.108 ± 0.072	4.918IleThr: 4.918 ± 0.07	5.508IleVal: 5.508 ± 0.077	0.694IleTrp: 0.694 ± 0.025	3.268IleTyr: 3.268 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.697LysAla: 4.697 ± 0.076	0.822LysCys: 0.822 ± 0.03	3.963LysAsp: 3.963 ± 0.051	7.48LysGlu: 7.48 ± 0.089	2.271LysPhe: 2.271 ± 0.042	4.196LysGly: 4.196 ± 0.053	1.017LysHis: 1.017 ± 0.033	6.155LysIle: 6.155 ± 0.073	6.961LysLys: 6.961 ± 0.077	6.13LysLeu: 6.13 ± 0.067	2.299LysMet: 2.299 ± 0.041	4.536LysAsn: 4.536 ± 0.061	1.934LysPro: 1.934 ± 0.038	2.785LysGln: 2.785 ± 0.051	3.052LysArg: 3.052 ± 0.056	4.097LysSer: 4.097 ± 0.065	3.885LysThr: 3.885 ± 0.055	4.924LysVal: 4.924 ± 0.068	0.718LysTrp: 0.718 ± 0.027	3.264LysTyr: 3.264 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.753LeuAla: 5.753 ± 0.078	1.342LeuCys: 1.342 ± 0.034	4.778LeuAsp: 4.778 ± 0.061	6.951LeuGlu: 6.951 ± 0.086	3.932LeuPhe: 3.932 ± 0.073	5.4LeuGly: 5.4 ± 0.07	1.36LeuHis: 1.36 ± 0.034	6.44LeuIle: 6.44 ± 0.089	6.497LeuLys: 6.497 ± 0.072	8.363LeuLeu: 8.363 ± 0.116	2.212LeuMet: 2.212 ± 0.035	4.626LeuAsn: 4.626 ± 0.06	3.003LeuPro: 3.003 ± 0.05	2.927LeuGln: 2.927 ± 0.048	3.108LeuArg: 3.108 ± 0.058	6.524LeuSer: 6.524 ± 0.072	4.85LeuThr: 4.85 ± 0.06	5.515LeuVal: 5.515 ± 0.075	0.695LeuTrp: 0.695 ± 0.026	3.54LeuTyr: 3.54 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.903MetAla: 1.903 ± 0.04	0.323MetCys: 0.323 ± 0.016	1.689MetAsp: 1.689 ± 0.033	2.567MetGlu: 2.567 ± 0.047	0.987MetPhe: 0.987 ± 0.027	1.79MetGly: 1.79 ± 0.046	0.379MetHis: 0.379 ± 0.017	2.158MetIle: 2.158 ± 0.045	2.591MetLys: 2.591 ± 0.047	2.515MetLeu: 2.515 ± 0.051	0.749MetMet: 0.749 ± 0.025	1.646MetAsn: 1.646 ± 0.035	0.97MetPro: 0.97 ± 0.031	0.979MetGln: 0.979 ± 0.033	0.959MetArg: 0.959 ± 0.032	1.711MetSer: 1.711 ± 0.035	1.499MetThr: 1.499 ± 0.036	1.769MetVal: 1.769 ± 0.036	0.177MetTrp: 0.177 ± 0.012	0.866MetTyr: 0.866 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.237AsnAla: 3.237 ± 0.051	0.791AsnCys: 0.791 ± 0.028	2.298AsnAsp: 2.298 ± 0.046	3.675AsnGlu: 3.675 ± 0.063	1.979AsnPhe: 1.979 ± 0.042	3.848AsnGly: 3.848 ± 0.074	0.924AsnHis: 0.924 ± 0.026	4.411AsnIle: 4.411 ± 0.068	3.647AsnLys: 3.647 ± 0.058	4.304AsnLeu: 4.304 ± 0.064	1.537AsnMet: 1.537 ± 0.035	2.773AsnAsn: 2.773 ± 0.06	2.019AsnPro: 2.019 ± 0.041	2.262AsnGln: 2.262 ± 0.048	2.175AsnArg: 2.175 ± 0.043	3.272AsnSer: 3.272 ± 0.056	2.963AsnThr: 2.963 ± 0.053	3.326AsnVal: 3.326 ± 0.051	0.483AsnTrp: 0.483 ± 0.02	2.418AsnTyr: 2.418 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	1.867ProAla: 1.867 ± 0.047	0.4ProCys: 0.4 ± 0.018	1.906ProAsp: 1.906 ± 0.044	2.73ProGlu: 2.73 ± 0.055	1.44ProPhe: 1.44 ± 0.033	1.818ProGly: 1.818 ± 0.04	0.477ProHis: 0.477 ± 0.022	2.223ProIle: 2.223 ± 0.043	1.816ProLys: 1.816 ± 0.039	2.379ProLeu: 2.379 ± 0.047	0.743ProMet: 0.743 ± 0.029	1.442ProAsn: 1.442 ± 0.036	0.651ProPro: 0.651 ± 0.027	0.936ProGln: 0.936 ± 0.026	0.767ProArg: 0.767 ± 0.027	1.803ProSer: 1.803 ± 0.046	1.806ProThr: 1.806 ± 0.067	2.809ProVal: 2.809 ± 0.064	0.272ProTrp: 0.272 ± 0.015	1.432ProTyr: 1.432 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.003GlnAla: 2.003 ± 0.046	0.43GlnCys: 0.43 ± 0.018	1.614GlnAsp: 1.614 ± 0.037	2.794GlnGlu: 2.794 ± 0.054	1.402GlnPhe: 1.402 ± 0.033	1.906GlnGly: 1.906 ± 0.039	0.471GlnHis: 0.471 ± 0.019	2.938GlnIle: 2.938 ± 0.052	2.906GlnLys: 2.906 ± 0.057	3.323GlnLeu: 3.323 ± 0.053	1.131GlnMet: 1.131 ± 0.031	1.947GlnAsn: 1.947 ± 0.043	0.888GlnPro: 0.888 ± 0.027	1.31GlnGln: 1.31 ± 0.038	1.362GlnArg: 1.362 ± 0.038	1.928GlnSer: 1.928 ± 0.046	1.74GlnThr: 1.74 ± 0.035	2.28GlnVal: 2.28 ± 0.042	0.331GlnTrp: 0.331 ± 0.014	1.767GlnTyr: 1.767 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.939ArgAla: 1.939 ± 0.04	0.47ArgCys: 0.47 ± 0.021	1.69ArgAsp: 1.69 ± 0.041	3.053ArgGlu: 3.053 ± 0.059	1.574ArgPhe: 1.574 ± 0.039	2.025ArgGly: 2.025 ± 0.04	0.566ArgHis: 0.566 ± 0.021	3.272ArgIle: 3.272 ± 0.061	3.139ArgLys: 3.139 ± 0.053	3.251ArgLeu: 3.251 ± 0.055	1.175ArgMet: 1.175 ± 0.036	2.157ArgAsn: 2.157 ± 0.041	0.976ArgPro: 0.976 ± 0.028	1.324ArgGln: 1.324 ± 0.032	1.549ArgArg: 1.549 ± 0.034	1.839ArgSer: 1.839 ± 0.038	1.91ArgThr: 1.91 ± 0.038	2.266ArgVal: 2.266 ± 0.046	0.349ArgTrp: 0.349 ± 0.017	1.625ArgTyr: 1.625 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	3.866SerAla: 3.866 ± 0.064	0.917SerCys: 0.917 ± 0.025	3.393SerAsp: 3.393 ± 0.057	4.482SerGlu: 4.482 ± 0.064	3.101SerPhe: 3.101 ± 0.048	4.88SerGly: 4.88 ± 0.077	1.035SerHis: 1.035 ± 0.029	5.444SerIle: 5.444 ± 0.073	4.366SerLys: 4.366 ± 0.069	5.446SerLeu: 5.446 ± 0.076	1.799SerMet: 1.799 ± 0.039	3.238SerAsn: 3.238 ± 0.061	1.689SerPro: 1.689 ± 0.042	2.147SerGln: 2.147 ± 0.042	2.265SerArg: 2.265 ± 0.042	4.532SerSer: 4.532 ± 0.095	3.518SerThr: 3.518 ± 0.068	4.389SerVal: 4.389 ± 0.069	0.592SerTrp: 0.592 ± 0.025	2.994SerTyr: 2.994 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.003ThrAla: 4.003 ± 0.074	0.694ThrCys: 0.694 ± 0.022	2.985ThrAsp: 2.985 ± 0.054	3.91ThrGlu: 3.91 ± 0.063	2.244ThrPhe: 2.244 ± 0.044	4.36ThrGly: 4.36 ± 0.067	0.786ThrHis: 0.786 ± 0.021	4.877ThrIle: 4.877 ± 0.064	3.699ThrLys: 3.699 ± 0.052	4.68ThrLeu: 4.68 ± 0.069	1.361ThrMet: 1.361 ± 0.033	2.676ThrAsn: 2.676 ± 0.052	2.37ThrPro: 2.37 ± 0.096	1.492ThrGln: 1.492 ± 0.037	1.661ThrArg: 1.661 ± 0.039	3.586ThrSer: 3.586 ± 0.066	3.138ThrThr: 3.138 ± 0.064	4.281ThrVal: 4.281 ± 0.078	0.47ThrTrp: 0.47 ± 0.018	2.478ThrTyr: 2.478 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.019ValAla: 4.019 ± 0.067	1.045ValCys: 1.045 ± 0.03	3.521ValAsp: 3.521 ± 0.058	4.851ValGlu: 4.851 ± 0.069	3.031ValPhe: 3.031 ± 0.052	3.878ValGly: 3.878 ± 0.077	1.01ValHis: 1.01 ± 0.031	5.65ValIle: 5.65 ± 0.076	5.126ValLys: 5.126 ± 0.065	6.524ValLeu: 6.524 ± 0.086	1.802ValMet: 1.802 ± 0.037	3.529ValAsn: 3.529 ± 0.056	2.254ValPro: 2.254 ± 0.044	2.082ValGln: 2.082 ± 0.046	2.337ValArg: 2.337 ± 0.049	4.938ValSer: 4.938 ± 0.068	4.385ValThr: 4.385 ± 0.081	4.917ValVal: 4.917 ± 0.074	0.585ValTrp: 0.585 ± 0.022	2.754ValTyr: 2.754 ± 0.043	0.001ValXaa: 0.001 ± 0.001
Trp	0.462TrpAla: 0.462 ± 0.02	0.161TrpCys: 0.161 ± 0.012	0.542TrpAsp: 0.542 ± 0.023	0.66TrpGlu: 0.66 ± 0.025	0.402TrpPhe: 0.402 ± 0.017	0.642TrpGly: 0.642 ± 0.023	0.147TrpHis: 0.147 ± 0.012	0.691TrpIle: 0.691 ± 0.023	0.786TrpLys: 0.786 ± 0.024	0.755TrpLeu: 0.755 ± 0.026	0.3TrpMet: 0.3 ± 0.017	0.642TrpAsn: 0.642 ± 0.024	0.185TrpPro: 0.185 ± 0.012	0.264TrpGln: 0.264 ± 0.015	0.327TrpArg: 0.327 ± 0.016	0.57TrpSer: 0.57 ± 0.02	0.415TrpThr: 0.415 ± 0.02	0.47TrpVal: 0.47 ± 0.019	0.11TrpTrp: 0.11 ± 0.01	0.404TrpTyr: 0.404 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.047	0.759TyrCys: 0.759 ± 0.026	2.492TyrAsp: 2.492 ± 0.054	3.236TyrGlu: 3.236 ± 0.059	2.077TyrPhe: 2.077 ± 0.046	2.889TyrGly: 2.889 ± 0.045	0.8TyrHis: 0.8 ± 0.03	3.437TyrIle: 3.437 ± 0.049	2.835TyrLys: 2.835 ± 0.047	3.977TyrLeu: 3.977 ± 0.062	1.164TyrMet: 1.164 ± 0.032	2.327TyrAsn: 2.327 ± 0.044	1.394TyrPro: 1.394 ± 0.036	1.841TyrGln: 1.841 ± 0.041	1.754TyrArg: 1.754 ± 0.041	2.94TyrSer: 2.94 ± 0.058	2.425TyrThr: 2.425 ± 0.05	2.928TyrVal: 2.928 ± 0.059	0.387TyrTrp: 0.387 ± 0.021	2.204TyrTyr: 2.204 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 3680 proteins (1277886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---