Amino acid dipepetide frequency for Mycobacterium phage Dallas

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.312AlaAla: 11.312 ± 0.805
0.962AlaCys: 0.962 ± 0.157
6.476AlaAsp: 6.476 ± 0.413
7.353AlaGlu: 7.353 ± 0.537
3.479AlaPhe: 3.479 ± 0.298
7.636AlaGly: 7.636 ± 0.658
1.951AlaHis: 1.951 ± 0.266
4.779AlaIle: 4.779 ± 0.385
4.072AlaLys: 4.072 ± 0.38
8.852AlaLeu: 8.852 ± 0.59
3.196AlaMet: 3.196 ± 0.368
2.743AlaAsn: 2.743 ± 0.281
3.846AlaPro: 3.846 ± 0.316
2.885AlaGln: 2.885 ± 0.286
6.957AlaArg: 6.957 ± 0.466
4.949AlaSer: 4.949 ± 0.402
5.119AlaThr: 5.119 ± 0.361
6.533AlaVal: 6.533 ± 0.371
1.923AlaTrp: 1.923 ± 0.253
2.715AlaTyr: 2.715 ± 0.285
0.0AlaXaa: 0.0 ± 0.0
Cys
0.905CysAla: 0.905 ± 0.17
0.085CysCys: 0.085 ± 0.044
1.16CysAsp: 1.16 ± 0.204
1.357CysGlu: 1.357 ± 0.215
0.424CysPhe: 0.424 ± 0.122
1.697CysGly: 1.697 ± 0.235
0.396CysHis: 0.396 ± 0.137
0.566CysIle: 0.566 ± 0.135
0.679CysLys: 0.679 ± 0.145
0.99CysLeu: 0.99 ± 0.211
0.311CysMet: 0.311 ± 0.114
0.65CysAsn: 0.65 ± 0.152
0.735CysPro: 0.735 ± 0.158
0.396CysGln: 0.396 ± 0.109
1.046CysArg: 1.046 ± 0.208
0.537CysSer: 0.537 ± 0.12
0.82CysThr: 0.82 ± 0.16
0.679CysVal: 0.679 ± 0.141
0.17CysTrp: 0.17 ± 0.073
0.481CysTyr: 0.481 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
6.137AspAla: 6.137 ± 0.457
1.046AspCys: 1.046 ± 0.17
5.062AspAsp: 5.062 ± 0.419
5.288AspGlu: 5.288 ± 0.488
2.262AspPhe: 2.262 ± 0.243
6.9AspGly: 6.9 ± 0.472
1.81AspHis: 1.81 ± 0.247
3.365AspIle: 3.365 ± 0.348
2.404AspLys: 2.404 ± 0.251
5.684AspLeu: 5.684 ± 0.317
1.018AspMet: 1.018 ± 0.136
2.262AspAsn: 2.262 ± 0.234
3.479AspPro: 3.479 ± 0.311
1.867AspGln: 1.867 ± 0.207
4.101AspArg: 4.101 ± 0.288
3.054AspSer: 3.054 ± 0.275
3.252AspThr: 3.252 ± 0.339
4.242AspVal: 4.242 ± 0.373
2.234AspTrp: 2.234 ± 0.273
2.319AspTyr: 2.319 ± 0.248
0.0AspXaa: 0.0 ± 0.0
Glu
7.24GluAla: 7.24 ± 0.395
1.216GluCys: 1.216 ± 0.194
4.214GluAsp: 4.214 ± 0.411
5.175GluGlu: 5.175 ± 0.473
2.715GluPhe: 2.715 ± 0.284
4.101GluGly: 4.101 ± 0.334
1.131GluHis: 1.131 ± 0.171
3.959GluIle: 3.959 ± 0.272
2.517GluLys: 2.517 ± 0.308
6.448GluLeu: 6.448 ± 0.559
2.574GluMet: 2.574 ± 0.269
1.386GluAsn: 1.386 ± 0.202
3.281GluPro: 3.281 ± 0.327
2.206GluGln: 2.206 ± 0.221
5.147GluArg: 5.147 ± 0.466
3.139GluSer: 3.139 ± 0.297
3.479GluThr: 3.479 ± 0.307
4.836GluVal: 4.836 ± 0.405
1.301GluTrp: 1.301 ± 0.22
2.545GluTyr: 2.545 ± 0.294
0.0GluXaa: 0.0 ± 0.0
Phe
2.347PheAla: 2.347 ± 0.227
0.396PheCys: 0.396 ± 0.104
2.262PheAsp: 2.262 ± 0.257
2.489PheGlu: 2.489 ± 0.224
0.99PhePhe: 0.99 ± 0.165
3.111PheGly: 3.111 ± 0.397
0.537PheHis: 0.537 ± 0.128
1.499PheIle: 1.499 ± 0.186
1.018PheLys: 1.018 ± 0.16
2.602PheLeu: 2.602 ± 0.265
0.792PheMet: 0.792 ± 0.134
1.273PheAsn: 1.273 ± 0.247
1.838PhePro: 1.838 ± 0.258
0.905PheGln: 0.905 ± 0.182
2.064PheArg: 2.064 ± 0.244
1.895PheSer: 1.895 ± 0.234
2.064PheThr: 2.064 ± 0.216
2.262PheVal: 2.262 ± 0.259
0.594PheTrp: 0.594 ± 0.144
0.735PheTyr: 0.735 ± 0.144
0.0PheXaa: 0.0 ± 0.0
Gly
6.957GlyAla: 6.957 ± 0.58
1.357GlyCys: 1.357 ± 0.207
5.939GlyAsp: 5.939 ± 0.354
5.6GlyGlu: 5.6 ± 0.412
3.139GlyPhe: 3.139 ± 0.346
7.919GlyGly: 7.919 ± 1.468
2.319GlyHis: 2.319 ± 0.264
3.988GlyIle: 3.988 ± 0.369
3.592GlyLys: 3.592 ± 0.331
7.692GlyLeu: 7.692 ± 0.59
2.064GlyMet: 2.064 ± 0.249
3.054GlyAsn: 3.054 ± 0.338
3.45GlyPro: 3.45 ± 0.346
2.743GlyGln: 2.743 ± 0.392
5.713GlyArg: 5.713 ± 0.352
4.921GlySer: 4.921 ± 0.304
4.553GlyThr: 4.553 ± 0.349
5.288GlyVal: 5.288 ± 0.383
1.838GlyTrp: 1.838 ± 0.272
3.252GlyTyr: 3.252 ± 0.276
0.0GlyXaa: 0.0 ± 0.0
His
1.357HisAla: 1.357 ± 0.185
0.452HisCys: 0.452 ± 0.118
1.753HisAsp: 1.753 ± 0.219
1.499HisGlu: 1.499 ± 0.187
0.509HisPhe: 0.509 ± 0.125
2.036HisGly: 2.036 ± 0.263
0.877HisHis: 0.877 ± 0.176
1.018HisIle: 1.018 ± 0.206
0.679HisLys: 0.679 ± 0.129
2.46HisLeu: 2.46 ± 0.267
0.537HisMet: 0.537 ± 0.134
0.622HisAsn: 0.622 ± 0.117
1.442HisPro: 1.442 ± 0.217
0.848HisGln: 0.848 ± 0.134
1.584HisArg: 1.584 ± 0.21
0.82HisSer: 0.82 ± 0.151
0.962HisThr: 0.962 ± 0.141
1.244HisVal: 1.244 ± 0.161
0.82HisTrp: 0.82 ± 0.139
0.679HisTyr: 0.679 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.317IleAla: 5.317 ± 0.38
0.622IleCys: 0.622 ± 0.149
3.903IleAsp: 3.903 ± 0.414
3.705IleGlu: 3.705 ± 0.297
1.103IlePhe: 1.103 ± 0.178
3.818IleGly: 3.818 ± 0.468
1.131IleHis: 1.131 ± 0.173
1.867IleIle: 1.867 ± 0.229
1.753IleLys: 1.753 ± 0.222
3.818IleLeu: 3.818 ± 0.281
0.933IleMet: 0.933 ± 0.167
1.81IleAsn: 1.81 ± 0.202
3.196IlePro: 3.196 ± 0.253
1.357IleGln: 1.357 ± 0.195
3.026IleArg: 3.026 ± 0.293
2.178IleSer: 2.178 ± 0.21
2.941IleThr: 2.941 ± 0.258
3.733IleVal: 3.733 ± 0.381
0.848IleTrp: 0.848 ± 0.137
1.216IleTyr: 1.216 ± 0.199
0.0IleXaa: 0.0 ± 0.0
Lys
4.157LysAla: 4.157 ± 0.404
0.679LysCys: 0.679 ± 0.141
1.98LysAsp: 1.98 ± 0.273
1.923LysGlu: 1.923 ± 0.235
1.103LysPhe: 1.103 ± 0.162
3.252LysGly: 3.252 ± 0.316
0.905LysHis: 0.905 ± 0.17
1.414LysIle: 1.414 ± 0.219
1.923LysLys: 1.923 ± 0.325
3.592LysLeu: 3.592 ± 0.336
1.442LysMet: 1.442 ± 0.214
0.877LysAsn: 0.877 ± 0.153
2.771LysPro: 2.771 ± 0.279
1.16LysGln: 1.16 ± 0.174
2.856LysArg: 2.856 ± 0.338
2.093LysSer: 2.093 ± 0.308
1.81LysThr: 1.81 ± 0.223
3.111LysVal: 3.111 ± 0.323
1.131LysTrp: 1.131 ± 0.17
1.273LysTyr: 1.273 ± 0.208
0.0LysXaa: 0.0 ± 0.0
Leu
8.824LeuAla: 8.824 ± 0.459
0.82LeuCys: 0.82 ± 0.142
5.854LeuAsp: 5.854 ± 0.374
5.317LeuGlu: 5.317 ± 0.418
2.489LeuPhe: 2.489 ± 0.26
6.561LeuGly: 6.561 ± 0.544
1.895LeuHis: 1.895 ± 0.194
3.139LeuIle: 3.139 ± 0.318
3.394LeuLys: 3.394 ± 0.296
6.109LeuLeu: 6.109 ± 0.463
1.98LeuMet: 1.98 ± 0.223
3.422LeuAsn: 3.422 ± 0.282
4.61LeuPro: 4.61 ± 0.342
2.687LeuGln: 2.687 ± 0.257
5.486LeuArg: 5.486 ± 0.462
5.204LeuSer: 5.204 ± 0.38
5.402LeuThr: 5.402 ± 0.339
5.09LeuVal: 5.09 ± 0.349
1.499LeuTrp: 1.499 ± 0.199
2.234LeuTyr: 2.234 ± 0.297
0.0LeuXaa: 0.0 ± 0.0
Met
2.489MetAla: 2.489 ± 0.246
0.17MetCys: 0.17 ± 0.083
1.499MetAsp: 1.499 ± 0.216
1.244MetGlu: 1.244 ± 0.2
0.735MetPhe: 0.735 ± 0.142
1.612MetGly: 1.612 ± 0.2
0.368MetHis: 0.368 ± 0.093
1.442MetIle: 1.442 ± 0.19
1.188MetLys: 1.188 ± 0.207
1.555MetLeu: 1.555 ± 0.219
0.537MetMet: 0.537 ± 0.112
1.018MetAsn: 1.018 ± 0.164
1.131MetPro: 1.131 ± 0.17
0.735MetGln: 0.735 ± 0.172
1.188MetArg: 1.188 ± 0.17
2.63MetSer: 2.63 ± 0.269
2.234MetThr: 2.234 ± 0.29
1.301MetVal: 1.301 ± 0.191
0.452MetTrp: 0.452 ± 0.091
0.481MetTyr: 0.481 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
3.563AsnAla: 3.563 ± 0.296
0.283AsnCys: 0.283 ± 0.079
1.867AsnAsp: 1.867 ± 0.175
1.64AsnGlu: 1.64 ± 0.197
1.131AsnPhe: 1.131 ± 0.144
3.563AsnGly: 3.563 ± 0.279
0.764AsnHis: 0.764 ± 0.12
1.386AsnIle: 1.386 ± 0.214
1.16AsnLys: 1.16 ± 0.188
2.687AsnLeu: 2.687 ± 0.284
0.509AsnMet: 0.509 ± 0.128
0.65AsnAsn: 0.65 ± 0.117
2.602AsnPro: 2.602 ± 0.282
1.046AsnGln: 1.046 ± 0.187
2.545AsnArg: 2.545 ± 0.263
1.527AsnSer: 1.527 ± 0.2
1.442AsnThr: 1.442 ± 0.223
2.376AsnVal: 2.376 ± 0.276
0.848AsnTrp: 0.848 ± 0.158
0.99AsnTyr: 0.99 ± 0.161
0.0AsnXaa: 0.0 ± 0.0
Pro
4.977ProAla: 4.977 ± 0.45
0.848ProCys: 0.848 ± 0.202
3.62ProAsp: 3.62 ± 0.279
4.412ProGlu: 4.412 ± 0.417
1.725ProPhe: 1.725 ± 0.249
5.458ProGly: 5.458 ± 0.542
1.018ProHis: 1.018 ± 0.147
2.262ProIle: 2.262 ± 0.212
2.291ProLys: 2.291 ± 0.263
3.988ProLeu: 3.988 ± 0.335
0.905ProMet: 0.905 ± 0.173
2.178ProAsn: 2.178 ± 0.265
3.083ProPro: 3.083 ± 0.365
1.273ProGln: 1.273 ± 0.201
3.196ProArg: 3.196 ± 0.301
2.347ProSer: 2.347 ± 0.266
2.913ProThr: 2.913 ± 0.278
4.129ProVal: 4.129 ± 0.298
1.414ProTrp: 1.414 ± 0.202
1.612ProTyr: 1.612 ± 0.222
0.0ProXaa: 0.0 ± 0.0
Gln
3.422GlnAla: 3.422 ± 0.325
0.509GlnCys: 0.509 ± 0.128
1.386GlnAsp: 1.386 ± 0.198
2.008GlnGlu: 2.008 ± 0.246
1.357GlnPhe: 1.357 ± 0.191
2.347GlnGly: 2.347 ± 0.314
0.509GlnHis: 0.509 ± 0.124
1.923GlnIle: 1.923 ± 0.225
1.669GlnLys: 1.669 ± 0.326
2.404GlnLeu: 2.404 ± 0.264
0.933GlnMet: 0.933 ± 0.16
0.99GlnAsn: 0.99 ± 0.163
1.81GlnPro: 1.81 ± 0.239
1.131GlnGln: 1.131 ± 0.178
2.093GlnArg: 2.093 ± 0.229
1.64GlnSer: 1.64 ± 0.224
1.584GlnThr: 1.584 ± 0.24
2.262GlnVal: 2.262 ± 0.25
0.792GlnTrp: 0.792 ± 0.155
0.679GlnTyr: 0.679 ± 0.121
0.0GlnXaa: 0.0 ± 0.0
Arg
6.335ArgAla: 6.335 ± 0.488
1.075ArgCys: 1.075 ± 0.194
4.214ArgAsp: 4.214 ± 0.349
4.072ArgGlu: 4.072 ± 0.393
2.064ArgPhe: 2.064 ± 0.21
5.006ArgGly: 5.006 ± 0.364
1.499ArgHis: 1.499 ± 0.198
3.761ArgIle: 3.761 ± 0.412
2.941ArgLys: 2.941 ± 0.295
4.808ArgLeu: 4.808 ± 0.396
1.951ArgMet: 1.951 ± 0.238
1.951ArgAsn: 1.951 ± 0.224
3.45ArgPro: 3.45 ± 0.366
2.969ArgGln: 2.969 ± 0.29
5.006ArgArg: 5.006 ± 0.454
3.281ArgSer: 3.281 ± 0.295
3.365ArgThr: 3.365 ± 0.441
5.034ArgVal: 5.034 ± 0.387
2.206ArgTrp: 2.206 ± 0.289
2.376ArgTyr: 2.376 ± 0.278
0.0ArgXaa: 0.0 ± 0.0
Ser
5.543SerAla: 5.543 ± 0.418
0.848SerCys: 0.848 ± 0.154
3.676SerAsp: 3.676 ± 0.331
4.129SerGlu: 4.129 ± 0.368
1.386SerPhe: 1.386 ± 0.216
4.864SerGly: 4.864 ± 0.478
1.244SerHis: 1.244 ± 0.183
2.913SerIle: 2.913 ± 0.235
1.64SerLys: 1.64 ± 0.222
4.355SerLeu: 4.355 ± 0.345
1.386SerMet: 1.386 ± 0.197
1.838SerAsn: 1.838 ± 0.243
2.658SerPro: 2.658 ± 0.288
1.301SerGln: 1.301 ± 0.177
3.45SerArg: 3.45 ± 0.346
3.111SerSer: 3.111 ± 0.381
3.026SerThr: 3.026 ± 0.29
3.479SerVal: 3.479 ± 0.324
1.555SerTrp: 1.555 ± 0.231
1.64SerTyr: 1.64 ± 0.204
0.0SerXaa: 0.0 ± 0.0
Thr
4.723ThrAla: 4.723 ± 0.409
0.962ThrCys: 0.962 ± 0.195
3.563ThrAsp: 3.563 ± 0.338
3.167ThrGlu: 3.167 ± 0.281
1.895ThrPhe: 1.895 ± 0.228
5.175ThrGly: 5.175 ± 0.361
1.244ThrHis: 1.244 ± 0.191
2.941ThrIle: 2.941 ± 0.297
1.923ThrLys: 1.923 ± 0.253
5.034ThrLeu: 5.034 ± 0.378
0.764ThrMet: 0.764 ± 0.13
1.612ThrAsn: 1.612 ± 0.26
4.157ThrPro: 4.157 ± 0.383
1.584ThrGln: 1.584 ± 0.227
2.913ThrArg: 2.913 ± 0.278
3.224ThrSer: 3.224 ± 0.362
2.856ThrThr: 2.856 ± 0.4
4.553ThrVal: 4.553 ± 0.41
1.527ThrTrp: 1.527 ± 0.214
1.725ThrTyr: 1.725 ± 0.252
0.0ThrXaa: 0.0 ± 0.0
Val
7.183ValAla: 7.183 ± 0.462
0.82ValCys: 0.82 ± 0.168
5.741ValAsp: 5.741 ± 0.408
4.949ValGlu: 4.949 ± 0.419
1.669ValPhe: 1.669 ± 0.219
5.402ValGly: 5.402 ± 0.503
1.442ValHis: 1.442 ± 0.202
3.705ValIle: 3.705 ± 0.314
2.743ValLys: 2.743 ± 0.225
4.666ValLeu: 4.666 ± 0.396
1.188ValMet: 1.188 ± 0.17
2.432ValAsn: 2.432 ± 0.273
3.648ValPro: 3.648 ± 0.33
2.404ValGln: 2.404 ± 0.25
4.61ValArg: 4.61 ± 0.39
4.44ValSer: 4.44 ± 0.346
4.61ValThr: 4.61 ± 0.446
5.515ValVal: 5.515 ± 0.43
0.99ValTrp: 0.99 ± 0.133
1.895ValTyr: 1.895 ± 0.248
0.0ValXaa: 0.0 ± 0.0
Trp
1.923TrpAla: 1.923 ± 0.21
0.481TrpCys: 0.481 ± 0.126
1.442TrpAsp: 1.442 ± 0.184
1.216TrpGlu: 1.216 ± 0.182
0.707TrpPhe: 0.707 ± 0.143
1.753TrpGly: 1.753 ± 0.186
0.735TrpHis: 0.735 ± 0.148
1.131TrpIle: 1.131 ± 0.159
0.735TrpLys: 0.735 ± 0.124
1.923TrpLeu: 1.923 ± 0.227
0.566TrpMet: 0.566 ± 0.132
0.82TrpAsn: 0.82 ± 0.14
1.046TrpPro: 1.046 ± 0.173
0.764TrpGln: 0.764 ± 0.144
1.895TrpArg: 1.895 ± 0.249
1.81TrpSer: 1.81 ± 0.213
1.414TrpThr: 1.414 ± 0.192
1.895TrpVal: 1.895 ± 0.231
0.735TrpTrp: 0.735 ± 0.146
0.65TrpTyr: 0.65 ± 0.142
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.026TyrAla: 3.026 ± 0.334
0.452TyrCys: 0.452 ± 0.119
2.178TyrAsp: 2.178 ± 0.249
2.064TyrGlu: 2.064 ± 0.251
0.792TyrPhe: 0.792 ± 0.165
3.196TyrGly: 3.196 ± 0.296
0.424TyrHis: 0.424 ± 0.115
1.216TyrIle: 1.216 ± 0.201
1.131TyrLys: 1.131 ± 0.171
2.347TyrLeu: 2.347 ± 0.284
0.396TyrMet: 0.396 ± 0.101
0.99TyrAsn: 0.99 ± 0.146
1.414TyrPro: 1.414 ± 0.213
1.188TyrGln: 1.188 ± 0.187
2.489TyrArg: 2.489 ± 0.301
1.244TyrSer: 1.244 ± 0.179
1.697TyrThr: 1.697 ± 0.227
2.489TyrVal: 2.489 ± 0.278
0.764TyrTrp: 0.764 ± 0.156
0.962TyrTyr: 0.962 ± 0.19
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 241 proteins (35361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski