Amino acid dipepetide frequency for Candidatus Vecturithrix granuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.319AlaAla: 7.319 ± 0.083	0.952AlaCys: 0.952 ± 0.02	3.843AlaAsp: 3.843 ± 0.047	5.662AlaGlu: 5.662 ± 0.056	3.654AlaPhe: 3.654 ± 0.042	5.587AlaGly: 5.587 ± 0.049	1.623AlaHis: 1.623 ± 0.027	6.043AlaIle: 6.043 ± 0.059	3.832AlaLys: 3.832 ± 0.043	8.937AlaLeu: 8.937 ± 0.076	2.297AlaMet: 2.297 ± 0.033	2.594AlaAsn: 2.594 ± 0.038	2.674AlaPro: 2.674 ± 0.037	3.714AlaGln: 3.714 ± 0.05	4.139AlaArg: 4.139 ± 0.049	4.328AlaSer: 4.328 ± 0.044	3.909AlaThr: 3.909 ± 0.046	5.453AlaVal: 5.453 ± 0.055	0.972AlaTrp: 0.972 ± 0.023	2.773AlaTyr: 2.773 ± 0.044	0.001AlaXaa: 0.001 ± 0.001
Cys	0.83CysAla: 0.83 ± 0.02	0.175CysCys: 0.175 ± 0.009	0.548CysAsp: 0.548 ± 0.016	0.644CysGlu: 0.644 ± 0.019	0.47CysPhe: 0.47 ± 0.013	1.001CysGly: 1.001 ± 0.022	0.34CysHis: 0.34 ± 0.011	0.634CysIle: 0.634 ± 0.016	0.397CysLys: 0.397 ± 0.012	1.126CysLeu: 1.126 ± 0.021	0.233CysMet: 0.233 ± 0.01	0.311CysAsn: 0.311 ± 0.013	0.604CysPro: 0.604 ± 0.021	0.613CysGln: 0.613 ± 0.016	0.631CysArg: 0.631 ± 0.017	0.668CysSer: 0.668 ± 0.016	0.543CysThr: 0.543 ± 0.018	0.696CysVal: 0.696 ± 0.019	0.168CysTrp: 0.168 ± 0.008	0.398CysTyr: 0.398 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.066AspAla: 4.066 ± 0.046	0.445AspCys: 0.445 ± 0.016	2.498AspAsp: 2.498 ± 0.047	3.474AspGlu: 3.474 ± 0.04	2.42AspPhe: 2.42 ± 0.032	3.181AspGly: 3.181 ± 0.041	1.139AspHis: 1.139 ± 0.02	3.777AspIle: 3.777 ± 0.048	1.97AspLys: 1.97 ± 0.034	5.31AspLeu: 5.31 ± 0.055	1.268AspMet: 1.268 ± 0.023	1.48AspAsn: 1.48 ± 0.029	2.451AspPro: 2.451 ± 0.039	2.161AspGln: 2.161 ± 0.034	2.586AspArg: 2.586 ± 0.038	2.177AspSer: 2.177 ± 0.028	2.417AspThr: 2.417 ± 0.033	3.829AspVal: 3.829 ± 0.04	0.697AspTrp: 0.697 ± 0.019	1.874AspTyr: 1.874 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.382GluAla: 5.382 ± 0.051	0.594GluCys: 0.594 ± 0.018	3.035GluAsp: 3.035 ± 0.038	5.068GluGlu: 5.068 ± 0.078	2.846GluPhe: 2.846 ± 0.036	3.597GluGly: 3.597 ± 0.046	1.905GluHis: 1.905 ± 0.032	5.167GluIle: 5.167 ± 0.055	4.258GluLys: 4.258 ± 0.051	6.756GluLeu: 6.756 ± 0.065	1.875GluMet: 1.875 ± 0.033	2.731GluAsn: 2.731 ± 0.034	2.226GluPro: 2.226 ± 0.033	4.148GluGln: 4.148 ± 0.058	3.993GluArg: 3.993 ± 0.044	2.99GluSer: 2.99 ± 0.034	3.862GluThr: 3.862 ± 0.048	4.165GluVal: 4.165 ± 0.044	0.767GluTrp: 0.767 ± 0.019	2.375GluTyr: 2.375 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.499PheAla: 3.499 ± 0.043	0.613PheCys: 0.613 ± 0.014	2.609PheAsp: 2.609 ± 0.032	2.857PheGlu: 2.857 ± 0.039	2.26PhePhe: 2.26 ± 0.041	3.133PheGly: 3.133 ± 0.042	1.141PheHis: 1.141 ± 0.021	2.722PheIle: 2.722 ± 0.034	1.741PheLys: 1.741 ± 0.029	5.05PheLeu: 5.05 ± 0.068	1.076PheMet: 1.076 ± 0.025	1.365PheAsn: 1.365 ± 0.025	2.143PhePro: 2.143 ± 0.033	2.095PheGln: 2.095 ± 0.033	2.284PheArg: 2.284 ± 0.034	3.117PheSer: 3.117 ± 0.042	2.621PheThr: 2.621 ± 0.034	2.934PheVal: 2.934 ± 0.036	0.684PheTrp: 0.684 ± 0.018	1.584PheTyr: 1.584 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.925GlyAla: 4.925 ± 0.055	0.917GlyCys: 0.917 ± 0.019	3.016GlyAsp: 3.016 ± 0.039	4.074GlyGlu: 4.074 ± 0.043	3.225GlyPhe: 3.225 ± 0.04	4.591GlyGly: 4.591 ± 0.052	1.358GlyHis: 1.358 ± 0.024	5.681GlyIle: 5.681 ± 0.054	4.263GlyLys: 4.263 ± 0.048	6.478GlyLeu: 6.478 ± 0.061	1.989GlyMet: 1.989 ± 0.032	2.376GlyAsn: 2.376 ± 0.034	1.69GlyPro: 1.69 ± 0.032	2.647GlyGln: 2.647 ± 0.036	3.115GlyArg: 3.115 ± 0.041	3.573GlySer: 3.573 ± 0.046	3.758GlyThr: 3.758 ± 0.052	5.12GlyVal: 5.12 ± 0.058	0.908GlyTrp: 0.908 ± 0.023	2.643GlyTyr: 2.643 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	1.824HisAla: 1.824 ± 0.031	0.285HisCys: 0.285 ± 0.011	1.241HisAsp: 1.241 ± 0.025	1.555HisGlu: 1.555 ± 0.029	1.124HisPhe: 1.124 ± 0.022	1.519HisGly: 1.519 ± 0.027	0.697HisHis: 0.697 ± 0.019	1.762HisIle: 1.762 ± 0.027	0.999HisLys: 0.999 ± 0.02	2.63HisLeu: 2.63 ± 0.035	0.218HisMet: 0.218 ± 0.01	0.797HisAsn: 0.797 ± 0.02	1.431HisPro: 1.431 ± 0.026	1.097HisGln: 1.097 ± 0.024	1.177HisArg: 1.177 ± 0.024	1.22HisSer: 1.22 ± 0.026	1.27HisThr: 1.27 ± 0.026	1.539HisVal: 1.539 ± 0.031	0.3HisTrp: 0.3 ± 0.012	0.887HisTyr: 0.887 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.387IleAla: 6.387 ± 0.056	0.795IleCys: 0.795 ± 0.019	3.715IleAsp: 3.715 ± 0.039	4.812IleGlu: 4.812 ± 0.046	3.308IlePhe: 3.308 ± 0.048	5.179IleGly: 5.179 ± 0.049	1.686IleHis: 1.686 ± 0.027	4.56IleIle: 4.56 ± 0.051	3.033IleLys: 3.033 ± 0.038	7.717IleLeu: 7.717 ± 0.067	1.512IleMet: 1.512 ± 0.026	2.217IleAsn: 2.217 ± 0.032	3.896IlePro: 3.896 ± 0.048	3.107IleGln: 3.107 ± 0.037	3.61IleArg: 3.61 ± 0.041	4.316IleSer: 4.316 ± 0.045	4.019IleThr: 4.019 ± 0.049	5.076IleVal: 5.076 ± 0.053	0.763IleTrp: 0.763 ± 0.016	2.169IleTyr: 2.169 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.994LysAla: 3.994 ± 0.049	0.388LysCys: 0.388 ± 0.016	2.48LysAsp: 2.48 ± 0.035	3.575LysGlu: 3.575 ± 0.044	1.864LysPhe: 1.864 ± 0.027	3.019LysGly: 3.019 ± 0.043	1.248LysHis: 1.248 ± 0.025	3.994LysIle: 3.994 ± 0.04	3.223LysLys: 3.223 ± 0.04	4.53LysLeu: 4.53 ± 0.044	1.399LysMet: 1.399 ± 0.025	2.147LysAsn: 2.147 ± 0.03	2.077LysPro: 2.077 ± 0.035	2.538LysGln: 2.538 ± 0.034	2.7LysArg: 2.7 ± 0.036	2.512LysSer: 2.512 ± 0.032	3.334LysThr: 3.334 ± 0.045	3.053LysVal: 3.053 ± 0.038	0.545LysTrp: 0.545 ± 0.017	1.79LysTyr: 1.79 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	8.854LeuAla: 8.854 ± 0.07	1.268LeuCys: 1.268 ± 0.024	5.179LeuAsp: 5.179 ± 0.051	6.842LeuGlu: 6.842 ± 0.065	4.687LeuPhe: 4.687 ± 0.054	6.65LeuGly: 6.65 ± 0.069	2.515LeuHis: 2.515 ± 0.034	6.796LeuIle: 6.796 ± 0.062	5.53LeuLys: 5.53 ± 0.049	11.237LeuLeu: 11.237 ± 0.1	2.459LeuMet: 2.459 ± 0.034	3.845LeuAsn: 3.845 ± 0.044	4.965LeuPro: 4.965 ± 0.056	4.984LeuGln: 4.984 ± 0.062	5.767LeuArg: 5.767 ± 0.057	6.728LeuSer: 6.728 ± 0.066	6.037LeuThr: 6.037 ± 0.058	6.312LeuVal: 6.312 ± 0.057	1.256LeuTrp: 1.256 ± 0.029	3.217LeuTyr: 3.217 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.031	0.194MetCys: 0.194 ± 0.008	1.008MetAsp: 1.008 ± 0.023	1.341MetGlu: 1.341 ± 0.024	1.052MetPhe: 1.052 ± 0.02	1.513MetGly: 1.513 ± 0.027	0.417MetHis: 0.417 ± 0.014	1.897MetIle: 1.897 ± 0.033	1.748MetLys: 1.748 ± 0.03	2.718MetLeu: 2.718 ± 0.036	0.745MetMet: 0.745 ± 0.017	1.164MetAsn: 1.164 ± 0.022	1.09MetPro: 1.09 ± 0.025	1.115MetGln: 1.115 ± 0.024	1.276MetArg: 1.276 ± 0.024	1.473MetSer: 1.473 ± 0.024	1.631MetThr: 1.631 ± 0.029	1.575MetVal: 1.575 ± 0.022	0.176MetTrp: 0.176 ± 0.009	0.722MetTyr: 0.722 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.915AsnAla: 2.915 ± 0.033	0.344AsnCys: 0.344 ± 0.013	1.557AsnAsp: 1.557 ± 0.029	1.88AsnGlu: 1.88 ± 0.03	1.547AsnPhe: 1.547 ± 0.026	2.201AsnGly: 2.201 ± 0.032	0.738AsnHis: 0.738 ± 0.018	2.896AsnIle: 2.896 ± 0.04	1.421AsnLys: 1.421 ± 0.026	3.966AsnLeu: 3.966 ± 0.054	0.951AsnMet: 0.951 ± 0.023	1.24AsnAsn: 1.24 ± 0.028	2.202AsnPro: 2.202 ± 0.034	1.452AsnGln: 1.452 ± 0.024	1.768AsnArg: 1.768 ± 0.029	1.839AsnSer: 1.839 ± 0.029	2.065AsnThr: 2.065 ± 0.027	2.503AsnVal: 2.503 ± 0.036	0.488AsnTrp: 0.488 ± 0.014	1.262AsnTyr: 1.262 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.212ProAla: 3.212 ± 0.043	0.42ProCys: 0.42 ± 0.014	2.862ProAsp: 2.862 ± 0.041	4.045ProGlu: 4.045 ± 0.044	2.083ProPhe: 2.083 ± 0.026	3.137ProGly: 3.137 ± 0.042	1.003ProHis: 1.003 ± 0.021	2.701ProIle: 2.701 ± 0.03	1.835ProLys: 1.835 ± 0.031	4.24ProLeu: 4.24 ± 0.047	0.923ProMet: 0.923 ± 0.02	1.46ProAsn: 1.46 ± 0.027	1.902ProPro: 1.902 ± 0.029	1.981ProGln: 1.981 ± 0.032	1.767ProArg: 1.767 ± 0.031	2.257ProSer: 2.257 ± 0.036	2.337ProThr: 2.337 ± 0.039	3.247ProVal: 3.247 ± 0.035	0.54ProTrp: 0.54 ± 0.016	1.574ProTyr: 1.574 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.053	0.42GlnCys: 0.42 ± 0.014	2.097GlnAsp: 2.097 ± 0.03	4.06GlnGlu: 4.06 ± 0.05	1.815GlnPhe: 1.815 ± 0.03	2.956GlnGly: 2.956 ± 0.041	1.348GlnHis: 1.348 ± 0.028	3.374GlnIle: 3.374 ± 0.043	2.867GlnLys: 2.867 ± 0.034	4.156GlnLeu: 4.156 ± 0.053	1.114GlnMet: 1.114 ± 0.024	1.714GlnAsn: 1.714 ± 0.031	1.798GlnPro: 1.798 ± 0.032	3.31GlnGln: 3.31 ± 0.059	2.835GlnArg: 2.835 ± 0.037	2.217GlnSer: 2.217 ± 0.034	2.699GlnThr: 2.699 ± 0.041	2.87GlnVal: 2.87 ± 0.042	0.521GlnTrp: 0.521 ± 0.017	1.575GlnTyr: 1.575 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.553ArgAla: 3.553 ± 0.04	0.609ArgCys: 0.609 ± 0.015	2.597ArgAsp: 2.597 ± 0.034	3.888ArgGlu: 3.888 ± 0.046	2.511ArgPhe: 2.511 ± 0.035	2.948ArgGly: 2.948 ± 0.033	1.2ArgHis: 1.2 ± 0.024	3.857ArgIle: 3.857 ± 0.042	3.056ArgLys: 3.056 ± 0.039	5.428ArgLeu: 5.428 ± 0.049	1.369ArgMet: 1.369 ± 0.023	1.853ArgAsn: 1.853 ± 0.031	1.826ArgPro: 1.826 ± 0.027	2.821ArgGln: 2.821 ± 0.039	2.874ArgArg: 2.874 ± 0.037	2.729ArgSer: 2.729 ± 0.037	2.675ArgThr: 2.675 ± 0.033	3.315ArgVal: 3.315 ± 0.044	0.704ArgTrp: 0.704 ± 0.017	2.05ArgTyr: 2.05 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.287SerAla: 4.287 ± 0.049	0.577SerCys: 0.577 ± 0.018	2.733SerAsp: 2.733 ± 0.037	3.496SerGlu: 3.496 ± 0.041	2.601SerPhe: 2.601 ± 0.038	4.562SerGly: 4.562 ± 0.056	1.28SerHis: 1.28 ± 0.025	3.657SerIle: 3.657 ± 0.04	2.367SerLys: 2.367 ± 0.035	6.048SerLeu: 6.048 ± 0.057	1.386SerMet: 1.386 ± 0.025	1.692SerAsn: 1.692 ± 0.026	2.58SerPro: 2.58 ± 0.037	2.566SerGln: 2.566 ± 0.035	2.727SerArg: 2.727 ± 0.035	3.547SerSer: 3.547 ± 0.046	2.935SerThr: 2.935 ± 0.038	3.873SerVal: 3.873 ± 0.041	0.712SerTrp: 0.712 ± 0.019	1.834SerTyr: 1.834 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.321ThrAla: 4.321 ± 0.048	0.617ThrCys: 0.617 ± 0.018	2.514ThrAsp: 2.514 ± 0.036	3.229ThrGlu: 3.229 ± 0.039	2.607ThrPhe: 2.607 ± 0.032	4.132ThrGly: 4.132 ± 0.055	1.307ThrHis: 1.307 ± 0.027	4.249ThrIle: 4.249 ± 0.047	2.094ThrLys: 2.094 ± 0.028	6.539ThrLeu: 6.539 ± 0.059	1.291ThrMet: 1.291 ± 0.025	1.787ThrAsn: 1.787 ± 0.027	3.247ThrPro: 3.247 ± 0.053	2.27ThrGln: 2.27 ± 0.037	2.73ThrArg: 2.73 ± 0.036	3.146ThrSer: 3.146 ± 0.035	3.214ThrThr: 3.214 ± 0.05	3.786ThrVal: 3.786 ± 0.043	0.688ThrTrp: 0.688 ± 0.019	1.972ThrTyr: 1.972 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.09ValAla: 5.09 ± 0.053	0.862ValCys: 0.862 ± 0.02	3.176ValAsp: 3.176 ± 0.043	4.355ValGlu: 4.355 ± 0.051	3.208ValPhe: 3.208 ± 0.038	4.279ValGly: 4.279 ± 0.051	1.365ValHis: 1.365 ± 0.026	5.14ValIle: 5.14 ± 0.055	3.614ValLys: 3.614 ± 0.041	7.174ValLeu: 7.174 ± 0.058	1.807ValMet: 1.807 ± 0.031	2.63ValAsn: 2.63 ± 0.034	2.674ValPro: 2.674 ± 0.038	2.682ValGln: 2.682 ± 0.035	3.189ValArg: 3.189 ± 0.034	4.182ValSer: 4.182 ± 0.05	3.803ValThr: 3.803 ± 0.048	4.977ValVal: 4.977 ± 0.056	0.76ValTrp: 0.76 ± 0.019	2.163ValTyr: 2.163 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.762TrpAla: 0.762 ± 0.019	0.135TrpCys: 0.135 ± 0.008	0.626TrpAsp: 0.626 ± 0.021	0.789TrpGlu: 0.789 ± 0.022	0.587TrpPhe: 0.587 ± 0.013	0.833TrpGly: 0.833 ± 0.02	0.292TrpHis: 0.292 ± 0.012	0.869TrpIle: 0.869 ± 0.022	0.758TrpLys: 0.758 ± 0.021	1.299TrpLeu: 1.299 ± 0.024	0.343TrpMet: 0.343 ± 0.012	0.607TrpAsn: 0.607 ± 0.017	0.406TrpPro: 0.406 ± 0.015	0.729TrpGln: 0.729 ± 0.018	0.679TrpArg: 0.679 ± 0.018	0.655TrpSer: 0.655 ± 0.018	0.624TrpThr: 0.624 ± 0.019	0.716TrpVal: 0.716 ± 0.017	0.194TrpTrp: 0.194 ± 0.01	0.444TrpTyr: 0.444 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.831TyrAla: 2.831 ± 0.038	0.423TyrCys: 0.423 ± 0.013	1.887TyrAsp: 1.887 ± 0.032	2.091TyrGlu: 2.091 ± 0.029	1.658TyrPhe: 1.658 ± 0.028	2.331TyrGly: 2.331 ± 0.038	0.971TyrHis: 0.971 ± 0.022	2.101TyrIle: 2.101 ± 0.026	1.403TyrLys: 1.403 ± 0.029	3.786TyrLeu: 3.786 ± 0.049	0.684TyrMet: 0.684 ± 0.017	1.225TyrAsn: 1.225 ± 0.025	1.643TyrPro: 1.643 ± 0.031	1.891TyrGln: 1.891 ± 0.033	2.014TyrArg: 2.014 ± 0.03	1.786TyrSer: 1.786 ± 0.031	1.986TyrThr: 1.986 ± 0.032	2.092TyrVal: 2.092 ± 0.031	0.504TyrTrp: 0.504 ± 0.015	1.381TyrTyr: 1.381 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7048 proteins (2347583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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