Amino acid dipepetide frequency for Koongol virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.94AlaAla: 1.94 ± 2.163
1.663AlaCys: 1.663 ± 1.284
3.049AlaAsp: 3.049 ± 1.07
3.049AlaGlu: 3.049 ± 0.563
1.94AlaPhe: 1.94 ± 0.455
1.663AlaGly: 1.663 ± 0.513
1.386AlaHis: 1.386 ± 0.294
4.435AlaIle: 4.435 ± 1.691
6.375AlaLys: 6.375 ± 5.467
5.266AlaLeu: 5.266 ± 0.865
1.386AlaMet: 1.386 ± 0.301
2.772AlaAsn: 2.772 ± 0.561
1.109AlaPro: 1.109 ± 0.702
1.386AlaGln: 1.386 ± 0.659
2.494AlaArg: 2.494 ± 0.481
2.494AlaSer: 2.494 ± 0.481
3.88AlaThr: 3.88 ± 1.167
2.494AlaVal: 2.494 ± 0.709
0.831AlaTrp: 0.831 ± 0.441
1.94AlaTyr: 1.94 ± 0.663
0.0AlaXaa: 0.0 ± 0.0
Cys
2.217CysAla: 2.217 ± 0.526
0.0CysCys: 0.0 ± 0.0
0.277CysAsp: 0.277 ± 0.153
1.663CysGlu: 1.663 ± 0.321
1.386CysPhe: 1.386 ± 0.606
2.494CysGly: 2.494 ± 1.722
0.831CysHis: 0.831 ± 0.16
3.326CysIle: 3.326 ± 1.38
2.217CysLys: 2.217 ± 1.441
1.94CysLeu: 1.94 ± 1.161
1.109CysMet: 1.109 ± 0.342
1.663CysAsn: 1.663 ± 0.513
1.386CysPro: 1.386 ± 0.294
2.217CysGln: 2.217 ± 1.047
0.277CysArg: 0.277 ± 0.153
0.554CysSer: 0.554 ± 0.565
1.386CysThr: 1.386 ± 1.002
1.109CysVal: 1.109 ± 0.721
0.0CysTrp: 0.0 ± 0.0
1.386CysTyr: 1.386 ± 0.606
0.0CysXaa: 0.0 ± 0.0
Asp
2.494AspAla: 2.494 ± 1.244
1.109AspCys: 1.109 ± 0.342
3.326AspAsp: 3.326 ± 0.79
3.326AspGlu: 3.326 ± 1.508
4.435AspPhe: 4.435 ± 0.388
2.494AspGly: 2.494 ± 0.397
0.554AspHis: 0.554 ± 0.307
5.266AspIle: 5.266 ± 1.192
4.157AspLys: 4.157 ± 1.126
6.652AspLeu: 6.652 ± 0.593
1.94AspMet: 1.94 ± 0.408
3.326AspAsn: 3.326 ± 0.745
2.217AspPro: 2.217 ± 0.405
2.217AspGln: 2.217 ± 0.526
3.326AspArg: 3.326 ± 0.642
2.772AspSer: 2.772 ± 1.148
2.494AspThr: 2.494 ± 0.996
3.603AspVal: 3.603 ± 0.399
0.554AspTrp: 0.554 ± 0.565
3.049AspTyr: 3.049 ± 1.301
0.0AspXaa: 0.0 ± 0.0
Glu
2.494GluAla: 2.494 ± 1.168
0.277GluCys: 0.277 ± 0.153
5.82GluAsp: 5.82 ± 1.37
4.712GluGlu: 4.712 ± 0.968
3.049GluPhe: 3.049 ± 1.301
1.94GluGly: 1.94 ± 0.455
2.494GluHis: 2.494 ± 0.709
7.761GluIle: 7.761 ± 1.052
4.989GluLys: 4.989 ± 1.46
5.82GluLeu: 5.82 ± 0.697
2.772GluMet: 2.772 ± 1.941
2.494GluAsn: 2.494 ± 1.38
1.663GluPro: 1.663 ± 0.92
2.217GluGln: 2.217 ± 0.526
3.88GluArg: 3.88 ± 1.759
1.94GluSer: 1.94 ± 0.453
3.88GluThr: 3.88 ± 0.753
3.049GluVal: 3.049 ± 1.07
0.277GluTrp: 0.277 ± 0.153
1.94GluTyr: 1.94 ± 0.408
0.0GluXaa: 0.0 ± 0.0
Phe
3.326PheAla: 3.326 ± 0.745
1.663PheCys: 1.663 ± 0.321
1.94PheAsp: 1.94 ± 0.453
3.88PheGlu: 3.88 ± 0.907
2.494PhePhe: 2.494 ± 0.73
2.772PheGly: 2.772 ± 0.295
0.831PheHis: 0.831 ± 0.16
3.603PheIle: 3.603 ± 0.896
4.989PheLys: 4.989 ± 0.605
3.88PheLeu: 3.88 ± 0.947
1.109PheMet: 1.109 ± 0.263
2.494PheAsn: 2.494 ± 0.659
1.109PhePro: 1.109 ± 0.614
1.663PheGln: 1.663 ± 0.545
0.831PheArg: 0.831 ± 0.46
4.435PheSer: 4.435 ± 1.053
4.989PheThr: 4.989 ± 0.688
2.494PheVal: 2.494 ± 0.73
0.277PheTrp: 0.277 ± 0.153
1.109PheTyr: 1.109 ± 0.263
0.0PheXaa: 0.0 ± 0.0
Gly
1.386GlyAla: 1.386 ± 1.318
2.494GlyCys: 2.494 ± 0.943
2.772GlyAsp: 2.772 ± 0.8
3.049GlyGlu: 3.049 ± 1.098
1.109GlyPhe: 1.109 ± 0.342
1.94GlyGly: 1.94 ± 1.013
1.109GlyHis: 1.109 ± 0.614
4.435GlyIle: 4.435 ± 1.049
3.603GlyLys: 3.603 ± 0.399
2.494GlyLeu: 2.494 ± 0.709
0.277GlyMet: 0.277 ± 0.282
1.663GlyAsn: 1.663 ± 0.513
1.386GlyPro: 1.386 ± 0.606
1.94GlyGln: 1.94 ± 0.453
1.663GlyArg: 1.663 ± 0.92
3.603GlySer: 3.603 ± 1.283
3.326GlyThr: 3.326 ± 1.613
1.109GlyVal: 1.109 ± 0.342
0.831GlyTrp: 0.831 ± 0.441
1.663GlyTyr: 1.663 ± 0.545
0.0GlyXaa: 0.0 ± 0.0
His
1.386HisAla: 1.386 ± 0.606
0.831HisCys: 0.831 ± 0.441
0.277HisAsp: 0.277 ± 0.282
0.831HisGlu: 0.831 ± 0.16
1.663HisPhe: 1.663 ± 0.321
0.554HisGly: 0.554 ± 0.307
0.554HisHis: 0.554 ± 0.307
1.663HisIle: 1.663 ± 0.92
3.049HisLys: 3.049 ± 0.668
3.326HisLeu: 3.326 ± 0.297
0.554HisMet: 0.554 ± 0.565
0.831HisAsn: 0.831 ± 0.699
0.831HisPro: 0.831 ± 0.441
0.831HisGln: 0.831 ± 0.441
1.386HisArg: 1.386 ± 0.561
1.94HisSer: 1.94 ± 1.074
0.831HisThr: 0.831 ± 0.16
1.109HisVal: 1.109 ± 0.263
0.0HisTrp: 0.0 ± 0.0
0.277HisTyr: 0.277 ± 0.282
0.0HisXaa: 0.0 ± 0.0
Ile
5.543IleAla: 5.543 ± 1.07
2.772IleCys: 2.772 ± 1.213
5.543IleAsp: 5.543 ± 2.297
3.326IleGlu: 3.326 ± 0.263
4.712IlePhe: 4.712 ± 0.323
3.049IleGly: 3.049 ± 0.668
1.94IleHis: 1.94 ± 0.408
3.603IleIle: 3.603 ± 1.848
7.761IleLys: 7.761 ± 2.779
9.146IleLeu: 9.146 ± 1.081
2.494IleMet: 2.494 ± 0.659
4.712IleAsn: 4.712 ± 0.917
4.712IlePro: 4.712 ± 0.537
3.049IleGln: 3.049 ± 1.198
2.772IleArg: 2.772 ± 0.295
5.82IleSer: 5.82 ± 0.336
4.989IleThr: 4.989 ± 1.417
4.435IleVal: 4.435 ± 0.837
0.554IleTrp: 0.554 ± 0.307
2.217IleTyr: 2.217 ± 0.684
0.0IleXaa: 0.0 ± 0.0
Lys
4.435LysAla: 4.435 ± 2.547
1.663LysCys: 1.663 ± 1.695
4.989LysAsp: 4.989 ± 1.539
8.038LysGlu: 8.038 ± 2.369
3.049LysPhe: 3.049 ± 1.098
2.772LysGly: 2.772 ± 0.8
2.217LysHis: 2.217 ± 0.845
5.82LysIle: 5.82 ± 0.65
6.929LysLys: 6.929 ± 2.044
6.652LysLeu: 6.652 ± 1.09
1.94LysMet: 1.94 ± 0.898
4.157LysAsn: 4.157 ± 0.882
3.049LysPro: 3.049 ± 1.446
2.217LysGln: 2.217 ± 0.405
3.049LysArg: 3.049 ± 1.098
6.375LysSer: 6.375 ± 0.669
6.652LysThr: 6.652 ± 1.325
4.712LysVal: 4.712 ± 0.537
1.109LysTrp: 1.109 ± 0.263
3.049LysTyr: 3.049 ± 0.253
0.0LysXaa: 0.0 ± 0.0
Leu
4.989LeuAla: 4.989 ± 1.636
1.663LeuCys: 1.663 ± 0.882
5.543LeuAsp: 5.543 ± 0.593
5.543LeuGlu: 5.543 ± 1.934
3.88LeuPhe: 3.88 ± 0.753
2.772LeuGly: 2.772 ± 1.602
3.049LeuHis: 3.049 ± 0.563
6.098LeuIle: 6.098 ± 1.331
6.652LeuLys: 6.652 ± 1.579
6.652LeuLeu: 6.652 ± 1.579
3.603LeuMet: 3.603 ± 0.718
4.989LeuAsn: 4.989 ± 1.523
3.88LeuPro: 3.88 ± 0.126
3.603LeuGln: 3.603 ± 0.484
3.049LeuArg: 3.049 ± 0.961
5.82LeuSer: 5.82 ± 1.365
8.869LeuThr: 8.869 ± 0.493
6.375LeuVal: 6.375 ± 1.248
0.554LeuTrp: 0.554 ± 0.72
3.603LeuTyr: 3.603 ± 1.703
0.0LeuXaa: 0.0 ± 0.0
Met
1.94MetAla: 1.94 ± 3.149
1.386MetCys: 1.386 ± 0.4
1.386MetAsp: 1.386 ± 0.767
1.663MetGlu: 1.663 ± 0.92
1.663MetPhe: 1.663 ± 0.547
1.663MetGly: 1.663 ± 1.388
0.0MetHis: 0.0 ± 0.0
2.494MetIle: 2.494 ± 0.41
3.049MetLys: 3.049 ± 0.668
2.772MetLeu: 2.772 ± 1.148
0.554MetMet: 0.554 ± 0.307
0.831MetAsn: 0.831 ± 0.46
1.386MetPro: 1.386 ± 0.606
1.94MetGln: 1.94 ± 0.774
2.217MetArg: 2.217 ± 0.638
1.663MetSer: 1.663 ± 0.321
1.94MetThr: 1.94 ± 0.453
1.663MetVal: 1.663 ± 0.547
0.277MetTrp: 0.277 ± 0.282
0.554MetTyr: 0.554 ± 0.307
0.0MetXaa: 0.0 ± 0.0
Asn
3.326AsnAla: 3.326 ± 0.679
1.109AsnCys: 1.109 ± 0.721
3.603AsnAsp: 3.603 ± 0.718
1.386AsnGlu: 1.386 ± 0.294
2.494AsnPhe: 2.494 ± 0.481
0.831AsnGly: 0.831 ± 0.441
2.217AsnHis: 2.217 ± 0.861
2.217AsnIle: 2.217 ± 1.047
3.049AsnLys: 3.049 ± 0.668
6.098AsnLeu: 6.098 ± 1.888
1.386AsnMet: 1.386 ± 0.767
3.049AsnAsn: 3.049 ± 1.07
4.435AsnPro: 4.435 ± 1.277
1.94AsnGln: 1.94 ± 0.663
0.831AsnArg: 0.831 ± 0.16
2.217AsnSer: 2.217 ± 0.526
2.772AsnThr: 2.772 ± 0.588
1.663AsnVal: 1.663 ± 0.92
0.554AsnTrp: 0.554 ± 0.171
3.603AsnTyr: 3.603 ± 0.921
0.0AsnXaa: 0.0 ± 0.0
Pro
2.494ProAla: 2.494 ± 0.41
0.554ProCys: 0.554 ± 0.565
2.217ProAsp: 2.217 ± 0.526
2.217ProGlu: 2.217 ± 0.405
1.94ProPhe: 1.94 ± 0.774
3.049ProGly: 3.049 ± 0.563
0.831ProHis: 0.831 ± 0.16
3.326ProIle: 3.326 ± 0.637
2.772ProLys: 2.772 ± 1.213
3.326ProLeu: 3.326 ± 0.263
1.109ProMet: 1.109 ± 0.615
1.663ProAsn: 1.663 ± 0.545
0.0ProPro: 0.0 ± 0.0
1.109ProGln: 1.109 ± 0.342
2.217ProArg: 2.217 ± 0.405
1.663ProSer: 1.663 ± 1.388
2.494ProThr: 2.494 ± 0.659
1.94ProVal: 1.94 ± 0.694
0.554ProTrp: 0.554 ± 0.307
1.386ProTyr: 1.386 ± 0.4
0.0ProXaa: 0.0 ± 0.0
Gln
1.94GlnAla: 1.94 ± 0.408
0.554GlnCys: 0.554 ± 0.307
2.494GlnAsp: 2.494 ± 0.943
1.94GlnGlu: 1.94 ± 0.663
1.109GlnPhe: 1.109 ± 0.263
1.94GlnGly: 1.94 ± 0.663
0.554GlnHis: 0.554 ± 0.171
2.772GlnIle: 2.772 ± 0.8
2.494GlnLys: 2.494 ± 0.481
2.772GlnLeu: 2.772 ± 0.855
0.831GlnMet: 0.831 ± 0.46
2.494GlnAsn: 2.494 ± 0.943
1.94GlnPro: 1.94 ± 0.408
1.386GlnGln: 1.386 ± 0.742
2.494GlnArg: 2.494 ± 0.996
2.217GlnSer: 2.217 ± 1.047
3.88GlnThr: 3.88 ± 0.747
2.494GlnVal: 2.494 ± 0.41
0.554GlnTrp: 0.554 ± 0.307
2.772GlnTyr: 2.772 ± 2.152
0.0GlnXaa: 0.0 ± 0.0
Arg
1.109ArgAla: 1.109 ± 0.263
2.494ArgCys: 2.494 ± 0.619
3.049ArgAsp: 3.049 ± 0.944
3.603ArgGlu: 3.603 ± 1.226
3.326ArgPhe: 3.326 ± 0.79
1.386ArgGly: 1.386 ± 0.659
0.277ArgHis: 0.277 ± 0.153
4.989ArgIle: 4.989 ± 1.845
3.049ArgLys: 3.049 ± 0.668
3.326ArgLeu: 3.326 ± 0.679
1.386ArgMet: 1.386 ± 1.098
1.386ArgAsn: 1.386 ± 0.767
0.277ArgPro: 0.277 ± 0.153
1.386ArgGln: 1.386 ± 0.742
1.94ArgArg: 1.94 ± 1.074
1.386ArgSer: 1.386 ± 0.4
2.772ArgThr: 2.772 ± 0.8
1.663ArgVal: 1.663 ± 0.545
0.831ArgTrp: 0.831 ± 0.694
1.94ArgTyr: 1.94 ± 1.074
0.0ArgXaa: 0.0 ± 0.0
Ser
3.88SerAla: 3.88 ± 0.526
1.663SerCys: 1.663 ± 0.513
2.217SerAsp: 2.217 ± 0.638
3.603SerGlu: 3.603 ± 0.993
2.217SerPhe: 2.217 ± 0.684
2.494SerGly: 2.494 ± 1.725
0.831SerHis: 0.831 ± 0.16
5.82SerIle: 5.82 ± 1.446
3.88SerLys: 3.88 ± 1.548
6.375SerLeu: 6.375 ± 1.454
2.772SerMet: 2.772 ± 0.8
2.772SerAsn: 2.772 ± 0.561
2.217SerPro: 2.217 ± 0.526
3.326SerGln: 3.326 ± 0.642
2.772SerArg: 2.772 ± 1.246
4.157SerSer: 4.157 ± 0.94
5.266SerThr: 5.266 ± 1.266
1.94SerVal: 1.94 ± 0.408
0.0SerTrp: 0.0 ± 0.0
1.386SerTyr: 1.386 ± 0.294
0.0SerXaa: 0.0 ± 0.0
Thr
3.88ThrAla: 3.88 ± 0.126
1.94ThrCys: 1.94 ± 0.774
4.435ThrAsp: 4.435 ± 1.343
4.435ThrGlu: 4.435 ± 0.388
4.989ThrPhe: 4.989 ± 1.075
3.603ThrGly: 3.603 ± 2.043
1.386ThrHis: 1.386 ± 0.606
7.761ThrIle: 7.761 ± 1.076
4.157ThrLys: 4.157 ± 1.2
5.543ThrLeu: 5.543 ± 2.245
1.386ThrMet: 1.386 ± 0.577
3.326ThrAsn: 3.326 ± 0.745
1.94ThrPro: 1.94 ± 1.161
3.049ThrGln: 3.049 ± 0.596
3.603ThrArg: 3.603 ± 0.921
4.989ThrSer: 4.989 ± 0.605
4.157ThrThr: 4.157 ± 2.205
2.217ThrVal: 2.217 ± 0.684
1.386ThrTrp: 1.386 ± 0.953
3.88ThrTyr: 3.88 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
1.94ValAla: 1.94 ± 0.574
2.217ValCys: 2.217 ± 1.047
2.772ValAsp: 2.772 ± 0.8
2.772ValGlu: 2.772 ± 2.86
2.217ValPhe: 2.217 ± 0.638
2.494ValGly: 2.494 ± 1.38
1.109ValHis: 1.109 ± 0.263
3.326ValIle: 3.326 ± 0.297
3.603ValLys: 3.603 ± 0.956
3.049ValLeu: 3.049 ± 0.596
2.217ValMet: 2.217 ± 0.524
1.386ValAsn: 1.386 ± 0.742
1.386ValPro: 1.386 ± 0.4
2.217ValGln: 2.217 ± 0.638
1.109ValArg: 1.109 ± 1.439
2.494ValSer: 2.494 ± 0.659
4.157ValThr: 4.157 ± 0.244
1.94ValVal: 1.94 ± 0.408
0.0ValTrp: 0.0 ± 0.0
4.157ValTyr: 4.157 ± 1.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.554TrpAla: 0.554 ± 0.804
0.554TrpCys: 0.554 ± 0.171
1.109TrpAsp: 1.109 ± 0.263
0.277TrpGlu: 0.277 ± 0.153
0.554TrpPhe: 0.554 ± 0.171
0.277TrpGly: 0.277 ± 0.282
0.0TrpHis: 0.0 ± 0.0
0.554TrpIle: 0.554 ± 0.804
0.0TrpLys: 0.0 ± 0.0
0.831TrpLeu: 0.831 ± 0.16
0.554TrpMet: 0.554 ± 0.72
0.277TrpAsn: 0.277 ± 0.153
0.277TrpPro: 0.277 ± 0.282
0.554TrpGln: 0.554 ± 0.307
0.554TrpArg: 0.554 ± 0.171
1.663TrpSer: 1.663 ± 0.545
0.554TrpThr: 0.554 ± 0.171
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.277TrpTyr: 0.277 ± 0.282
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.277TyrAla: 0.277 ± 0.153
0.831TyrCys: 0.831 ± 0.441
2.494TyrAsp: 2.494 ± 1.244
4.157TyrGlu: 4.157 ± 1.205
1.663TyrPhe: 1.663 ± 0.92
1.663TyrGly: 1.663 ± 0.513
0.554TyrHis: 0.554 ± 0.565
3.88TyrIle: 3.88 ± 1.548
6.098TyrLys: 6.098 ± 0.816
5.266TyrLeu: 5.266 ± 1.193
1.386TyrMet: 1.386 ± 0.767
2.494TyrAsn: 2.494 ± 0.481
1.663TyrPro: 1.663 ± 0.545
1.386TyrGln: 1.386 ± 0.294
1.386TyrArg: 1.386 ± 0.4
1.386TyrSer: 1.386 ± 0.953
2.772TyrThr: 2.772 ± 1.148
0.554TyrVal: 0.554 ± 0.307
0.277TyrTrp: 0.277 ± 0.153
0.831TyrTyr: 0.831 ± 0.441
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski