Amino acid dipepetide frequency for Lacinutrix sp. Bg11-31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.084AlaAla: 4.084 ± 0.101
0.537AlaCys: 0.537 ± 0.025
3.217AlaAsp: 3.217 ± 0.098
3.924AlaGlu: 3.924 ± 0.081
3.55AlaPhe: 3.55 ± 0.069
3.953AlaGly: 3.953 ± 0.123
1.031AlaHis: 1.031 ± 0.032
5.853AlaIle: 5.853 ± 0.085
4.998AlaLys: 4.998 ± 0.094
6.554AlaLeu: 6.554 ± 0.097
1.463AlaMet: 1.463 ± 0.045
3.973AlaAsn: 3.973 ± 0.065
1.812AlaPro: 1.812 ± 0.059
2.391AlaGln: 2.391 ± 0.053
1.793AlaArg: 1.793 ± 0.045
4.212AlaSer: 4.212 ± 0.067
4.12AlaThr: 4.12 ± 0.139
3.954AlaVal: 3.954 ± 0.081
0.543AlaTrp: 0.543 ± 0.024
2.366AlaTyr: 2.366 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.457CysAla: 0.457 ± 0.022
0.106CysCys: 0.106 ± 0.01
0.509CysAsp: 0.509 ± 0.033
0.469CysGlu: 0.469 ± 0.023
0.455CysPhe: 0.455 ± 0.021
0.652CysGly: 0.652 ± 0.033
0.173CysHis: 0.173 ± 0.013
0.609CysIle: 0.609 ± 0.026
0.559CysLys: 0.559 ± 0.025
0.615CysLeu: 0.615 ± 0.021
0.138CysMet: 0.138 ± 0.012
0.534CysAsn: 0.534 ± 0.026
0.343CysPro: 0.343 ± 0.023
0.204CysGln: 0.204 ± 0.02
0.149CysArg: 0.149 ± 0.014
0.553CysSer: 0.553 ± 0.026
0.451CysThr: 0.451 ± 0.04
0.465CysVal: 0.465 ± 0.022
0.07CysTrp: 0.07 ± 0.011
0.33CysTyr: 0.33 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.138AspAla: 4.138 ± 0.163
0.5AspCys: 0.5 ± 0.031
3.045AspAsp: 3.045 ± 0.065
3.561AspGlu: 3.561 ± 0.087
3.642AspPhe: 3.642 ± 0.063
3.798AspGly: 3.798 ± 0.113
0.805AspHis: 0.805 ± 0.03
4.69AspIle: 4.69 ± 0.079
4.084AspLys: 4.084 ± 0.066
5.333AspLeu: 5.333 ± 0.078
1.052AspMet: 1.052 ± 0.031
3.724AspAsn: 3.724 ± 0.081
1.452AspPro: 1.452 ± 0.056
1.32AspGln: 1.32 ± 0.043
1.579AspArg: 1.579 ± 0.041
3.428AspSer: 3.428 ± 0.084
3.204AspThr: 3.204 ± 0.098
3.863AspVal: 3.863 ± 0.096
0.664AspTrp: 0.664 ± 0.031
2.971AspTyr: 2.971 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.763GluAla: 4.763 ± 0.08
0.378GluCys: 0.378 ± 0.022
3.934GluAsp: 3.934 ± 0.07
4.325GluGlu: 4.325 ± 0.101
2.961GluPhe: 2.961 ± 0.061
3.522GluGly: 3.522 ± 0.063
1.096GluHis: 1.096 ± 0.035
5.367GluIle: 5.367 ± 0.08
5.421GluLys: 5.421 ± 0.106
5.877GluLeu: 5.877 ± 0.083
1.456GluMet: 1.456 ± 0.044
4.791GluAsn: 4.791 ± 0.078
1.436GluPro: 1.436 ± 0.037
2.153GluGln: 2.153 ± 0.055
2.217GluArg: 2.217 ± 0.053
3.454GluSer: 3.454 ± 0.055
4.422GluThr: 4.422 ± 0.075
4.049GluVal: 4.049 ± 0.072
0.554GluTrp: 0.554 ± 0.029
2.28GluTyr: 2.28 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.936PheAla: 2.936 ± 0.063
0.468PheCys: 0.468 ± 0.02
3.165PheAsp: 3.165 ± 0.062
3.262PheGlu: 3.262 ± 0.061
2.657PhePhe: 2.657 ± 0.067
3.616PheGly: 3.616 ± 0.063
0.752PheHis: 0.752 ± 0.027
4.071PheIle: 4.071 ± 0.072
4.275PheLys: 4.275 ± 0.08
4.542PheLeu: 4.542 ± 0.078
1.041PheMet: 1.041 ± 0.033
3.887PheAsn: 3.887 ± 0.068
1.618PhePro: 1.618 ± 0.044
1.494PheGln: 1.494 ± 0.043
1.402PheArg: 1.402 ± 0.037
4.203PheSer: 4.203 ± 0.083
3.291PheThr: 3.291 ± 0.066
3.001PheVal: 3.001 ± 0.066
0.536PheTrp: 0.536 ± 0.022
2.199PheTyr: 2.199 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.955GlyAla: 3.955 ± 0.071
0.648GlyCys: 0.648 ± 0.043
3.56GlyAsp: 3.56 ± 0.098
3.569GlyGlu: 3.569 ± 0.054
3.645GlyPhe: 3.645 ± 0.062
4.282GlyGly: 4.282 ± 0.086
1.025GlyHis: 1.025 ± 0.036
5.022GlyIle: 5.022 ± 0.074
4.699GlyLys: 4.699 ± 0.088
5.637GlyLeu: 5.637 ± 0.083
1.454GlyMet: 1.454 ± 0.038
3.833GlyAsn: 3.833 ± 0.1
1.191GlyPro: 1.191 ± 0.038
1.734GlyGln: 1.734 ± 0.046
1.894GlyArg: 1.894 ± 0.046
3.856GlySer: 3.856 ± 0.069
4.25GlyThr: 4.25 ± 0.167
4.169GlyVal: 4.169 ± 0.061
0.636GlyTrp: 0.636 ± 0.026
2.661GlyTyr: 2.661 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.94HisAla: 0.94 ± 0.031
0.159HisCys: 0.159 ± 0.013
0.832HisAsp: 0.832 ± 0.031
0.902HisGlu: 0.902 ± 0.032
1.118HisPhe: 1.118 ± 0.036
0.922HisGly: 0.922 ± 0.032
0.396HisHis: 0.396 ± 0.02
1.354HisIle: 1.354 ± 0.037
1.218HisLys: 1.218 ± 0.04
1.612HisLeu: 1.612 ± 0.042
0.3HisMet: 0.3 ± 0.019
1.003HisAsn: 1.003 ± 0.03
0.766HisPro: 0.766 ± 0.031
0.576HisGln: 0.576 ± 0.028
0.536HisArg: 0.536 ± 0.023
1.009HisSer: 1.009 ± 0.036
0.87HisThr: 0.87 ± 0.026
0.915HisVal: 0.915 ± 0.03
0.196HisTrp: 0.196 ± 0.011
0.857HisTyr: 0.857 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.743IleAla: 5.743 ± 0.084
0.649IleCys: 0.649 ± 0.026
5.364IleAsp: 5.364 ± 0.083
5.839IleGlu: 5.839 ± 0.087
3.601IlePhe: 3.601 ± 0.064
5.085IleGly: 5.085 ± 0.087
1.227IleHis: 1.227 ± 0.037
6.765IleIle: 6.765 ± 0.104
6.529IleLys: 6.529 ± 0.086
7.106IleLeu: 7.106 ± 0.105
1.35IleMet: 1.35 ± 0.039
5.218IleAsn: 5.218 ± 0.09
3.09IlePro: 3.09 ± 0.078
2.362IleGln: 2.362 ± 0.047
2.18IleArg: 2.18 ± 0.048
5.769IleSer: 5.769 ± 0.079
5.429IleThr: 5.429 ± 0.099
5.017IleVal: 5.017 ± 0.082
0.668IleTrp: 0.668 ± 0.027
2.789IleTyr: 2.789 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
5.435LysAla: 5.435 ± 0.09
0.371LysCys: 0.371 ± 0.017
4.694LysAsp: 4.694 ± 0.091
6.13LysGlu: 6.13 ± 0.117
2.918LysPhe: 2.918 ± 0.063
4.524LysGly: 4.524 ± 0.083
1.635LysHis: 1.635 ± 0.042
6.188LysIle: 6.188 ± 0.092
7.116LysLys: 7.116 ± 0.12
6.981LysLeu: 6.981 ± 0.107
2.04LysMet: 2.04 ± 0.04
5.572LysAsn: 5.572 ± 0.093
2.561LysPro: 2.561 ± 0.057
3.029LysGln: 3.029 ± 0.069
2.98LysArg: 2.98 ± 0.058
4.703LysSer: 4.703 ± 0.082
5.337LysThr: 5.337 ± 0.077
4.676LysVal: 4.676 ± 0.082
0.778LysTrp: 0.778 ± 0.028
3.008LysTyr: 3.008 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
5.616LeuAla: 5.616 ± 0.069
0.738LeuCys: 0.738 ± 0.034
5.33LeuAsp: 5.33 ± 0.081
6.318LeuGlu: 6.318 ± 0.083
4.991LeuPhe: 4.991 ± 0.101
5.563LeuGly: 5.563 ± 0.073
1.428LeuHis: 1.428 ± 0.047
7.232LeuIle: 7.232 ± 0.118
8.263LeuLys: 8.263 ± 0.117
8.555LeuLeu: 8.555 ± 0.122
1.928LeuMet: 1.928 ± 0.043
6.067LeuAsn: 6.067 ± 0.098
3.246LeuPro: 3.246 ± 0.06
2.933LeuGln: 2.933 ± 0.065
2.786LeuArg: 2.786 ± 0.058
6.53LeuSer: 6.53 ± 0.097
5.279LeuThr: 5.279 ± 0.107
5.417LeuVal: 5.417 ± 0.079
0.722LeuTrp: 0.722 ± 0.03
3.064LeuTyr: 3.064 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.46MetAla: 1.46 ± 0.041
0.121MetCys: 0.121 ± 0.011
1.004MetAsp: 1.004 ± 0.031
1.225MetGlu: 1.225 ± 0.036
0.833MetPhe: 0.833 ± 0.028
1.082MetGly: 1.082 ± 0.033
0.42MetHis: 0.42 ± 0.023
1.391MetIle: 1.391 ± 0.037
2.071MetLys: 2.071 ± 0.053
1.959MetLeu: 1.959 ± 0.045
0.516MetMet: 0.516 ± 0.027
1.226MetAsn: 1.226 ± 0.034
0.832MetPro: 0.832 ± 0.026
0.835MetGln: 0.835 ± 0.026
0.748MetArg: 0.748 ± 0.032
1.416MetSer: 1.416 ± 0.043
1.058MetThr: 1.058 ± 0.035
1.277MetVal: 1.277 ± 0.036
0.158MetTrp: 0.158 ± 0.013
0.688MetTyr: 0.688 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.31AsnAla: 4.31 ± 0.069
0.558AsnCys: 0.558 ± 0.034
3.551AsnAsp: 3.551 ± 0.078
3.944AsnGlu: 3.944 ± 0.081
3.07AsnPhe: 3.07 ± 0.064
4.272AsnGly: 4.272 ± 0.096
1.018AsnHis: 1.018 ± 0.035
5.452AsnIle: 5.452 ± 0.09
5.146AsnLys: 5.146 ± 0.097
5.657AsnLeu: 5.657 ± 0.082
1.254AsnMet: 1.254 ± 0.034
4.846AsnAsn: 4.846 ± 0.101
2.691AsnPro: 2.691 ± 0.065
2.194AsnGln: 2.194 ± 0.058
2.021AsnArg: 2.021 ± 0.046
4.156AsnSer: 4.156 ± 0.087
4.804AsnThr: 4.804 ± 0.087
3.953AsnVal: 3.953 ± 0.075
0.777AsnTrp: 0.777 ± 0.026
3.12AsnTyr: 3.12 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.663ProAla: 1.663 ± 0.057
0.206ProCys: 0.206 ± 0.013
1.73ProAsp: 1.73 ± 0.036
2.594ProGlu: 2.594 ± 0.051
1.819ProPhe: 1.819 ± 0.042
1.66ProGly: 1.66 ± 0.046
0.502ProHis: 0.502 ± 0.025
2.623ProIle: 2.623 ± 0.053
2.578ProLys: 2.578 ± 0.065
2.787ProLeu: 2.787 ± 0.048
0.626ProMet: 0.626 ± 0.024
2.289ProAsn: 2.289 ± 0.056
0.686ProPro: 0.686 ± 0.037
0.99ProGln: 0.99 ± 0.032
0.78ProArg: 0.78 ± 0.03
1.982ProSer: 1.982 ± 0.062
2.089ProThr: 2.089 ± 0.062
2.076ProVal: 2.076 ± 0.063
0.274ProTrp: 0.274 ± 0.017
1.289ProTyr: 1.289 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.074GlnAla: 2.074 ± 0.066
0.192GlnCys: 0.192 ± 0.013
1.83GlnAsp: 1.83 ± 0.051
2.172GlnGlu: 2.172 ± 0.058
1.74GlnPhe: 1.74 ± 0.042
1.734GlnGly: 1.734 ± 0.046
0.555GlnHis: 0.555 ± 0.023
2.474GlnIle: 2.474 ± 0.048
2.436GlnLys: 2.436 ± 0.053
3.246GlnLeu: 3.246 ± 0.058
0.745GlnMet: 0.745 ± 0.027
2.071GlnAsn: 2.071 ± 0.044
1.0GlnPro: 1.0 ± 0.037
1.283GlnGln: 1.283 ± 0.045
1.053GlnArg: 1.053 ± 0.039
1.84GlnSer: 1.84 ± 0.04
2.064GlnThr: 2.064 ± 0.091
1.973GlnVal: 1.973 ± 0.043
0.315GlnTrp: 0.315 ± 0.017
1.252GlnTyr: 1.252 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.011ArgAla: 2.011 ± 0.052
0.18ArgCys: 0.18 ± 0.012
1.675ArgAsp: 1.675 ± 0.042
1.927ArgGlu: 1.927 ± 0.051
1.721ArgPhe: 1.721 ± 0.043
1.702ArgGly: 1.702 ± 0.046
0.555ArgHis: 0.555 ± 0.022
2.505ArgIle: 2.505 ± 0.053
2.469ArgLys: 2.469 ± 0.056
2.936ArgLeu: 2.936 ± 0.064
0.69ArgMet: 0.69 ± 0.028
1.804ArgAsn: 1.804 ± 0.045
0.919ArgPro: 0.919 ± 0.032
1.003ArgGln: 1.003 ± 0.034
1.119ArgArg: 1.119 ± 0.042
1.64ArgSer: 1.64 ± 0.046
1.76ArgThr: 1.76 ± 0.048
1.982ArgVal: 1.982 ± 0.043
0.293ArgTrp: 0.293 ± 0.017
1.365ArgTyr: 1.365 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
3.867SerAla: 3.867 ± 0.06
0.677SerCys: 0.677 ± 0.029
3.437SerAsp: 3.437 ± 0.09
3.868SerGlu: 3.868 ± 0.062
3.789SerPhe: 3.789 ± 0.077
4.605SerGly: 4.605 ± 0.096
1.057SerHis: 1.057 ± 0.03
5.691SerIle: 5.691 ± 0.076
5.373SerLys: 5.373 ± 0.08
5.773SerLeu: 5.773 ± 0.088
1.122SerMet: 1.122 ± 0.033
4.277SerAsn: 4.277 ± 0.083
1.914SerPro: 1.914 ± 0.051
2.114SerGln: 2.114 ± 0.048
1.985SerArg: 1.985 ± 0.048
4.293SerSer: 4.293 ± 0.083
3.919SerThr: 3.919 ± 0.082
4.094SerVal: 4.094 ± 0.09
0.656SerTrp: 0.656 ± 0.027
2.667SerTyr: 2.667 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.94ThrAla: 3.94 ± 0.118
0.414ThrCys: 0.414 ± 0.033
3.589ThrAsp: 3.589 ± 0.143
3.835ThrGlu: 3.835 ± 0.065
3.349ThrPhe: 3.349 ± 0.062
4.056ThrGly: 4.056 ± 0.097
1.0ThrHis: 1.0 ± 0.03
5.834ThrIle: 5.834 ± 0.138
4.703ThrLys: 4.703 ± 0.078
5.977ThrLeu: 5.977 ± 0.108
1.001ThrMet: 1.001 ± 0.035
4.148ThrAsn: 4.148 ± 0.113
2.365ThrPro: 2.365 ± 0.061
2.008ThrGln: 2.008 ± 0.052
1.586ThrArg: 1.586 ± 0.044
4.181ThrSer: 4.181 ± 0.097
4.41ThrThr: 4.41 ± 0.205
4.436ThrVal: 4.436 ± 0.234
0.571ThrTrp: 0.571 ± 0.033
2.548ThrTyr: 2.548 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
4.112ValAla: 4.112 ± 0.076
0.522ValCys: 0.522 ± 0.026
3.756ValAsp: 3.756 ± 0.127
3.99ValGlu: 3.99 ± 0.068
3.552ValPhe: 3.552 ± 0.061
3.735ValGly: 3.735 ± 0.068
0.883ValHis: 0.883 ± 0.034
5.077ValIle: 5.077 ± 0.093
4.557ValLys: 4.557 ± 0.072
6.128ValLeu: 6.128 ± 0.094
1.214ValMet: 1.214 ± 0.036
3.804ValAsn: 3.804 ± 0.068
1.868ValPro: 1.868 ± 0.056
1.662ValGln: 1.662 ± 0.055
1.733ValArg: 1.733 ± 0.04
4.595ValSer: 4.595 ± 0.08
4.093ValThr: 4.093 ± 0.207
4.136ValVal: 4.136 ± 0.081
0.505ValTrp: 0.505 ± 0.023
2.303ValTyr: 2.303 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.524TrpAla: 0.524 ± 0.026
0.093TrpCys: 0.093 ± 0.009
0.549TrpAsp: 0.549 ± 0.027
0.623TrpGlu: 0.623 ± 0.032
0.557TrpPhe: 0.557 ± 0.025
0.453TrpGly: 0.453 ± 0.024
0.191TrpHis: 0.191 ± 0.012
0.706TrpIle: 0.706 ± 0.026
0.742TrpLys: 0.742 ± 0.03
0.948TrpLeu: 0.948 ± 0.03
0.266TrpMet: 0.266 ± 0.016
0.671TrpAsn: 0.671 ± 0.027
0.186TrpPro: 0.186 ± 0.014
0.373TrpGln: 0.373 ± 0.021
0.342TrpArg: 0.342 ± 0.018
0.638TrpSer: 0.638 ± 0.027
0.552TrpThr: 0.552 ± 0.03
0.563TrpVal: 0.563 ± 0.024
0.128TrpTrp: 0.128 ± 0.013
0.382TrpTyr: 0.382 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.301TyrAla: 2.301 ± 0.048
0.326TyrCys: 0.326 ± 0.019
2.084TyrAsp: 2.084 ± 0.051
1.979TyrGlu: 1.979 ± 0.05
2.448TyrPhe: 2.448 ± 0.053
2.504TyrGly: 2.504 ± 0.051
0.732TyrHis: 0.732 ± 0.029
2.874TyrIle: 2.874 ± 0.053
3.436TyrLys: 3.436 ± 0.062
3.783TyrLeu: 3.783 ± 0.067
0.661TyrMet: 0.661 ± 0.024
3.055TyrAsn: 3.055 ± 0.067
1.269TyrPro: 1.269 ± 0.041
1.392TyrGln: 1.392 ± 0.041
1.373TyrArg: 1.373 ± 0.039
2.721TyrSer: 2.721 ± 0.059
2.55TyrThr: 2.55 ± 0.097
2.207TyrVal: 2.207 ± 0.044
0.445TyrTrp: 0.445 ± 0.022
1.791TyrTyr: 1.791 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3170 proteins (1077573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski