Amino acid dipepetide frequency for Tetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) (Pediococcus halophilus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.112AlaAla: 5.112 ± 0.105
0.544AlaCys: 0.544 ± 0.026
3.916AlaAsp: 3.916 ± 0.079
4.507AlaGlu: 4.507 ± 0.081
3.243AlaPhe: 3.243 ± 0.066
4.948AlaGly: 4.948 ± 0.106
1.18AlaHis: 1.18 ± 0.039
5.676AlaIle: 5.676 ± 0.104
4.974AlaLys: 4.974 ± 0.091
6.815AlaLeu: 6.815 ± 0.103
2.095AlaMet: 2.095 ± 0.055
3.218AlaAsn: 3.218 ± 0.07
2.028AlaPro: 2.028 ± 0.055
3.207AlaGln: 3.207 ± 0.069
2.63AlaArg: 2.63 ± 0.06
4.232AlaSer: 4.232 ± 0.085
3.645AlaThr: 3.645 ± 0.074
4.856AlaVal: 4.856 ± 0.09
0.553AlaTrp: 0.553 ± 0.029
2.289AlaTyr: 2.289 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.399CysAla: 0.399 ± 0.024
0.072CysCys: 0.072 ± 0.009
0.338CysAsp: 0.338 ± 0.02
0.372CysGlu: 0.372 ± 0.022
0.297CysPhe: 0.297 ± 0.021
0.596CysGly: 0.596 ± 0.032
0.183CysHis: 0.183 ± 0.017
0.405CysIle: 0.405 ± 0.026
0.315CysLys: 0.315 ± 0.022
0.588CysLeu: 0.588 ± 0.031
0.129CysMet: 0.129 ± 0.013
0.212CysAsn: 0.212 ± 0.018
0.261CysPro: 0.261 ± 0.023
0.269CysGln: 0.269 ± 0.021
0.244CysArg: 0.244 ± 0.021
0.408CysSer: 0.408 ± 0.024
0.28CysThr: 0.28 ± 0.02
0.422CysVal: 0.422 ± 0.027
0.05CysTrp: 0.05 ± 0.008
0.254CysTyr: 0.254 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.478AspAla: 3.478 ± 0.076
0.298AspCys: 0.298 ± 0.022
3.379AspAsp: 3.379 ± 0.091
5.11AspGlu: 5.11 ± 0.097
2.984AspPhe: 2.984 ± 0.065
3.365AspGly: 3.365 ± 0.071
1.169AspHis: 1.169 ± 0.035
4.385AspIle: 4.385 ± 0.081
3.919AspLys: 3.919 ± 0.078
5.467AspLeu: 5.467 ± 0.096
1.498AspMet: 1.498 ± 0.047
2.522AspAsn: 2.522 ± 0.067
2.088AspPro: 2.088 ± 0.063
2.561AspGln: 2.561 ± 0.064
2.273AspArg: 2.273 ± 0.055
3.124AspSer: 3.124 ± 0.07
3.061AspThr: 3.061 ± 0.064
3.899AspVal: 3.899 ± 0.086
0.719AspTrp: 0.719 ± 0.039
2.884AspTyr: 2.884 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.193GluAla: 5.193 ± 0.097
0.354GluCys: 0.354 ± 0.024
4.693GluAsp: 4.693 ± 0.098
7.275GluGlu: 7.275 ± 0.13
2.55GluPhe: 2.55 ± 0.064
3.906GluGly: 3.906 ± 0.083
1.198GluHis: 1.198 ± 0.043
5.628GluIle: 5.628 ± 0.105
6.944GluLys: 6.944 ± 0.122
6.787GluLeu: 6.787 ± 0.111
2.318GluMet: 2.318 ± 0.059
4.627GluAsn: 4.627 ± 0.086
1.834GluPro: 1.834 ± 0.054
3.724GluGln: 3.724 ± 0.074
2.856GluArg: 2.856 ± 0.065
3.376GluSer: 3.376 ± 0.069
3.921GluThr: 3.921 ± 0.083
4.953GluVal: 4.953 ± 0.091
0.614GluTrp: 0.614 ± 0.031
2.225GluTyr: 2.225 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.178PheAla: 3.178 ± 0.071
0.355PheCys: 0.355 ± 0.024
2.87PheAsp: 2.87 ± 0.065
2.826PheGlu: 2.826 ± 0.068
2.421PhePhe: 2.421 ± 0.064
3.028PheGly: 3.028 ± 0.065
0.86PheHis: 0.86 ± 0.037
3.655PheIle: 3.655 ± 0.08
2.326PheLys: 2.326 ± 0.066
4.727PheLeu: 4.727 ± 0.104
1.128PheMet: 1.128 ± 0.04
2.117PheAsn: 2.117 ± 0.05
1.651PhePro: 1.651 ± 0.054
1.746PheGln: 1.746 ± 0.05
1.473PheArg: 1.473 ± 0.047
3.595PheSer: 3.595 ± 0.08
2.559PheThr: 2.559 ± 0.067
3.177PheVal: 3.177 ± 0.08
0.465PheTrp: 0.465 ± 0.029
1.966PheTyr: 1.966 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.425GlyAla: 4.425 ± 0.1
0.393GlyCys: 0.393 ± 0.027
3.124GlyAsp: 3.124 ± 0.069
3.988GlyGlu: 3.988 ± 0.072
3.253GlyPhe: 3.253 ± 0.075
4.247GlyGly: 4.247 ± 0.092
1.126GlyHis: 1.126 ± 0.04
5.585GlyIle: 5.585 ± 0.092
4.752GlyLys: 4.752 ± 0.079
6.091GlyLeu: 6.091 ± 0.114
1.914GlyMet: 1.914 ± 0.05
2.831GlyAsn: 2.831 ± 0.057
1.473GlyPro: 1.473 ± 0.047
2.436GlyGln: 2.436 ± 0.063
2.332GlyArg: 2.332 ± 0.073
3.705GlySer: 3.705 ± 0.081
3.733GlyThr: 3.733 ± 0.076
4.579GlyVal: 4.579 ± 0.097
0.699GlyTrp: 0.699 ± 0.037
2.648GlyTyr: 2.648 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.135HisAla: 1.135 ± 0.041
0.165HisCys: 0.165 ± 0.016
0.922HisAsp: 0.922 ± 0.041
1.146HisGlu: 1.146 ± 0.041
1.079HisPhe: 1.079 ± 0.036
1.137HisGly: 1.137 ± 0.04
0.454HisHis: 0.454 ± 0.026
1.21HisIle: 1.21 ± 0.035
0.993HisLys: 0.993 ± 0.034
2.074HisLeu: 2.074 ± 0.053
0.462HisMet: 0.462 ± 0.021
0.662HisAsn: 0.662 ± 0.03
0.922HisPro: 0.922 ± 0.036
0.857HisGln: 0.857 ± 0.033
0.785HisArg: 0.785 ± 0.037
1.069HisSer: 1.069 ± 0.038
0.91HisThr: 0.91 ± 0.038
1.074HisVal: 1.074 ± 0.038
0.28HisTrp: 0.28 ± 0.022
0.918HisTyr: 0.918 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.03IleAla: 6.03 ± 0.098
0.559IleCys: 0.559 ± 0.029
4.962IleAsp: 4.962 ± 0.084
5.241IleGlu: 5.241 ± 0.084
3.591IlePhe: 3.591 ± 0.085
5.342IleGly: 5.342 ± 0.092
1.398IleHis: 1.398 ± 0.043
5.483IleIle: 5.483 ± 0.097
4.411IleLys: 4.411 ± 0.09
7.07IleLeu: 7.07 ± 0.114
1.631IleMet: 1.631 ± 0.053
3.476IleAsn: 3.476 ± 0.069
2.993IlePro: 2.993 ± 0.073
3.05IleGln: 3.05 ± 0.073
2.79IleArg: 2.79 ± 0.067
4.849IleSer: 4.849 ± 0.083
4.177IleThr: 4.177 ± 0.077
5.032IleVal: 5.032 ± 0.086
0.605IleTrp: 0.605 ± 0.034
2.715IleTyr: 2.715 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.657LysAla: 4.657 ± 0.086
0.243LysCys: 0.243 ± 0.019
4.252LysAsp: 4.252 ± 0.091
7.103LysGlu: 7.103 ± 0.095
2.002LysPhe: 2.002 ± 0.059
3.844LysGly: 3.844 ± 0.082
1.089LysHis: 1.089 ± 0.035
5.091LysIle: 5.091 ± 0.093
6.902LysLys: 6.902 ± 0.121
5.342LysLeu: 5.342 ± 0.094
2.126LysMet: 2.126 ± 0.052
4.286LysAsn: 4.286 ± 0.09
1.749LysPro: 1.749 ± 0.057
3.813LysGln: 3.813 ± 0.08
3.218LysArg: 3.218 ± 0.073
3.306LysSer: 3.306 ± 0.062
3.987LysThr: 3.987 ± 0.079
4.396LysVal: 4.396 ± 0.087
0.565LysTrp: 0.565 ± 0.027
2.294LysTyr: 2.294 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.714LeuAla: 7.714 ± 0.108
0.617LeuCys: 0.617 ± 0.03
5.657LeuAsp: 5.657 ± 0.085
6.306LeuGlu: 6.306 ± 0.1
4.626LeuPhe: 4.626 ± 0.101
6.031LeuGly: 6.031 ± 0.102
1.655LeuHis: 1.655 ± 0.049
6.732LeuIle: 6.732 ± 0.112
6.298LeuLys: 6.298 ± 0.099
9.822LeuLeu: 9.822 ± 0.155
2.341LeuMet: 2.341 ± 0.06
4.578LeuAsn: 4.578 ± 0.084
3.848LeuPro: 3.848 ± 0.077
4.204LeuGln: 4.204 ± 0.082
3.483LeuArg: 3.483 ± 0.073
6.753LeuSer: 6.753 ± 0.104
5.79LeuThr: 5.79 ± 0.092
6.08LeuVal: 6.08 ± 0.08
0.713LeuTrp: 0.713 ± 0.034
3.143LeuTyr: 3.143 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.888MetAla: 1.888 ± 0.052
0.121MetCys: 0.121 ± 0.013
1.733MetAsp: 1.733 ± 0.056
1.767MetGlu: 1.767 ± 0.055
0.91MetPhe: 0.91 ± 0.038
1.638MetGly: 1.638 ± 0.055
0.461MetHis: 0.461 ± 0.027
2.154MetIle: 2.154 ± 0.055
2.172MetLys: 2.172 ± 0.061
2.329MetLeu: 2.329 ± 0.064
0.795MetMet: 0.795 ± 0.035
1.544MetAsn: 1.544 ± 0.049
0.893MetPro: 0.893 ± 0.028
1.2MetGln: 1.2 ± 0.054
0.935MetArg: 0.935 ± 0.038
1.821MetSer: 1.821 ± 0.052
1.755MetThr: 1.755 ± 0.047
1.696MetVal: 1.696 ± 0.045
0.161MetTrp: 0.161 ± 0.017
0.781MetTyr: 0.781 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.045AsnAla: 3.045 ± 0.075
0.286AsnCys: 0.286 ± 0.021
2.859AsnAsp: 2.859 ± 0.062
3.912AsnGlu: 3.912 ± 0.086
2.228AsnPhe: 2.228 ± 0.057
3.26AsnGly: 3.26 ± 0.081
1.11AsnHis: 1.11 ± 0.038
3.612AsnIle: 3.612 ± 0.075
3.278AsnLys: 3.278 ± 0.079
4.239AsnLeu: 4.239 ± 0.076
1.264AsnMet: 1.264 ± 0.046
2.433AsnAsn: 2.433 ± 0.071
1.849AsnPro: 1.849 ± 0.053
2.566AsnGln: 2.566 ± 0.063
1.881AsnArg: 1.881 ± 0.051
2.516AsnSer: 2.516 ± 0.074
2.397AsnThr: 2.397 ± 0.056
3.147AsnVal: 3.147 ± 0.073
0.559AsnTrp: 0.559 ± 0.03
2.146AsnTyr: 2.146 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.189ProAla: 2.189 ± 0.059
0.171ProCys: 0.171 ± 0.018
1.905ProAsp: 1.905 ± 0.054
3.084ProGlu: 3.084 ± 0.077
1.78ProPhe: 1.78 ± 0.047
1.925ProGly: 1.925 ± 0.052
0.613ProHis: 0.613 ± 0.031
2.551ProIle: 2.551 ± 0.061
2.174ProLys: 2.174 ± 0.051
3.243ProLeu: 3.243 ± 0.066
0.85ProMet: 0.85 ± 0.035
1.635ProAsn: 1.635 ± 0.055
0.617ProPro: 0.617 ± 0.03
1.413ProGln: 1.413 ± 0.049
0.954ProArg: 0.954 ± 0.038
1.941ProSer: 1.941 ± 0.05
2.02ProThr: 2.02 ± 0.053
2.343ProVal: 2.343 ± 0.06
0.313ProTrp: 0.313 ± 0.022
1.291ProTyr: 1.291 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.666GlnAla: 3.666 ± 0.074
0.18GlnCys: 0.18 ± 0.018
2.287GlnAsp: 2.287 ± 0.057
4.016GlnGlu: 4.016 ± 0.098
1.781GlnPhe: 1.781 ± 0.047
2.415GlnGly: 2.415 ± 0.059
0.723GlnHis: 0.723 ± 0.033
3.041GlnIle: 3.041 ± 0.067
3.795GlnLys: 3.795 ± 0.088
4.901GlnLeu: 4.901 ± 0.092
1.318GlnMet: 1.318 ± 0.048
2.308GlnAsn: 2.308 ± 0.058
1.316GlnPro: 1.316 ± 0.047
2.465GlnGln: 2.465 ± 0.079
1.907GlnArg: 1.907 ± 0.054
2.343GlnSer: 2.343 ± 0.065
2.792GlnThr: 2.792 ± 0.06
2.83GlnVal: 2.83 ± 0.059
0.458GlnTrp: 0.458 ± 0.029
1.445GlnTyr: 1.445 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.154ArgAla: 2.154 ± 0.06
0.264ArgCys: 0.264 ± 0.021
1.856ArgAsp: 1.856 ± 0.053
2.569ArgGlu: 2.569 ± 0.069
1.873ArgPhe: 1.873 ± 0.049
2.158ArgGly: 2.158 ± 0.048
0.699ArgHis: 0.699 ± 0.031
2.748ArgIle: 2.748 ± 0.068
3.175ArgLys: 3.175 ± 0.079
3.799ArgLeu: 3.799 ± 0.08
1.104ArgMet: 1.104 ± 0.049
1.855ArgAsn: 1.855 ± 0.058
1.315ArgPro: 1.315 ± 0.047
1.902ArgGln: 1.902 ± 0.056
1.848ArgArg: 1.848 ± 0.053
2.242ArgSer: 2.242 ± 0.057
1.917ArgThr: 1.917 ± 0.05
2.509ArgVal: 2.509 ± 0.063
0.375ArgTrp: 0.375 ± 0.021
1.692ArgTyr: 1.692 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.759SerAla: 3.759 ± 0.073
0.39SerCys: 0.39 ± 0.024
3.332SerAsp: 3.332 ± 0.067
4.078SerGlu: 4.078 ± 0.083
3.267SerPhe: 3.267 ± 0.078
4.275SerGly: 4.275 ± 0.085
1.135SerHis: 1.135 ± 0.037
4.473SerIle: 4.473 ± 0.084
3.573SerLys: 3.573 ± 0.067
6.026SerLeu: 6.026 ± 0.108
1.623SerMet: 1.623 ± 0.047
2.637SerAsn: 2.637 ± 0.065
1.827SerPro: 1.827 ± 0.048
2.695SerGln: 2.695 ± 0.072
2.103SerArg: 2.103 ± 0.057
4.056SerSer: 4.056 ± 0.087
3.225SerThr: 3.225 ± 0.067
4.005SerVal: 4.005 ± 0.081
0.657SerTrp: 0.657 ± 0.025
2.601SerTyr: 2.601 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.96ThrAla: 3.96 ± 0.078
0.302ThrCys: 0.302 ± 0.023
3.203ThrAsp: 3.203 ± 0.069
3.803ThrGlu: 3.803 ± 0.074
2.69ThrPhe: 2.69 ± 0.063
3.748ThrGly: 3.748 ± 0.07
1.008ThrHis: 1.008 ± 0.038
4.719ThrIle: 4.719 ± 0.09
3.626ThrLys: 3.626 ± 0.07
5.414ThrLeu: 5.414 ± 0.087
1.419ThrMet: 1.419 ± 0.046
2.638ThrAsn: 2.638 ± 0.053
2.282ThrPro: 2.282 ± 0.06
2.239ThrGln: 2.239 ± 0.06
1.878ThrArg: 1.878 ± 0.054
3.4ThrSer: 3.4 ± 0.064
3.228ThrThr: 3.228 ± 0.073
4.042ThrVal: 4.042 ± 0.073
0.456ThrTrp: 0.456 ± 0.026
1.885ThrTyr: 1.885 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.014ValAla: 5.014 ± 0.089
0.442ValCys: 0.442 ± 0.024
4.063ValAsp: 4.063 ± 0.082
4.748ValGlu: 4.748 ± 0.085
2.968ValPhe: 2.968 ± 0.074
4.461ValGly: 4.461 ± 0.084
1.096ValHis: 1.096 ± 0.041
5.21ValIle: 5.21 ± 0.088
4.027ValLys: 4.027 ± 0.081
6.403ValLeu: 6.403 ± 0.106
1.694ValMet: 1.694 ± 0.052
3.045ValAsn: 3.045 ± 0.072
2.384ValPro: 2.384 ± 0.058
2.559ValGln: 2.559 ± 0.068
2.335ValArg: 2.335 ± 0.059
4.401ValSer: 4.401 ± 0.081
4.16ValThr: 4.16 ± 0.07
4.845ValVal: 4.845 ± 0.095
0.48ValTrp: 0.48 ± 0.025
2.28ValTyr: 2.28 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.487TrpAla: 0.487 ± 0.028
0.058TrpCys: 0.058 ± 0.009
0.47TrpAsp: 0.47 ± 0.025
0.587TrpGlu: 0.587 ± 0.03
0.47TrpPhe: 0.47 ± 0.032
0.58TrpGly: 0.58 ± 0.032
0.225TrpHis: 0.225 ± 0.018
0.641TrpIle: 0.641 ± 0.03
0.584TrpLys: 0.584 ± 0.027
1.147TrpLeu: 1.147 ± 0.045
0.24TrpMet: 0.24 ± 0.019
0.43TrpAsn: 0.43 ± 0.041
0.214TrpPro: 0.214 ± 0.017
0.712TrpGln: 0.712 ± 0.032
0.393TrpArg: 0.393 ± 0.023
0.504TrpSer: 0.504 ± 0.031
0.451TrpThr: 0.451 ± 0.026
0.541TrpVal: 0.541 ± 0.028
0.114TrpTrp: 0.114 ± 0.014
0.34TrpTyr: 0.34 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.186TyrAla: 2.186 ± 0.058
0.282TyrCys: 0.282 ± 0.02
2.362TyrAsp: 2.362 ± 0.065
2.543TyrGlu: 2.543 ± 0.058
2.111TyrPhe: 2.111 ± 0.052
2.427TyrGly: 2.427 ± 0.057
0.873TyrHis: 0.873 ± 0.031
2.408TyrIle: 2.408 ± 0.053
2.025TyrLys: 2.025 ± 0.06
4.106TyrLeu: 4.106 ± 0.08
0.803TyrMet: 0.803 ± 0.036
1.531TyrAsn: 1.531 ± 0.045
1.468TyrPro: 1.468 ± 0.044
2.368TyrGln: 2.368 ± 0.07
1.735TyrArg: 1.735 ± 0.049
2.096TyrSer: 2.096 ± 0.056
1.934TyrThr: 1.934 ± 0.05
2.19TyrVal: 2.19 ± 0.051
0.35TyrTrp: 0.35 ± 0.024
1.638TyrTyr: 1.638 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2507 proteins (720916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski