Amino acid dipepetide frequency for Cowpea mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.66AlaAla: 4.66 ± 1.459
1.997AlaCys: 1.997 ± 0.627
1.997AlaAsp: 1.997 ± 0.627
3.329AlaGlu: 3.329 ± 1.04
1.997AlaPhe: 1.997 ± 0.78
3.995AlaGly: 3.995 ± 1.466
1.332AlaHis: 1.332 ± 1.011
3.995AlaIle: 3.995 ± 1.595
2.663AlaLys: 2.663 ± 0.798
6.658AlaLeu: 6.658 ± 1.732
1.332AlaMet: 1.332 ± 0.676
3.995AlaAsn: 3.995 ± 1.529
3.329AlaPro: 3.329 ± 0.931
1.332AlaGln: 1.332 ± 0.637
2.663AlaArg: 2.663 ± 0.533
5.992AlaSer: 5.992 ± 1.771
6.658AlaThr: 6.658 ± 3.05
5.326AlaVal: 5.326 ± 1.452
0.666AlaTrp: 0.666 ± 0.682
3.995AlaTyr: 3.995 ± 2.149
0.0AlaXaa: 0.0 ± 0.0
Cys
1.332CysAla: 1.332 ± 0.617
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.666CysGlu: 0.666 ± 0.559
0.0CysPhe: 0.0 ± 0.0
1.332CysGly: 1.332 ± 0.637
0.0CysHis: 0.0 ± 0.0
1.332CysIle: 1.332 ± 0.617
0.666CysLys: 0.666 ± 0.485
1.997CysLeu: 1.997 ± 0.953
0.0CysMet: 0.0 ± 0.0
0.666CysAsn: 0.666 ± 0.485
0.0CysPro: 0.0 ± 0.0
1.332CysGln: 1.332 ± 0.961
1.332CysArg: 1.332 ± 0.637
1.332CysSer: 1.332 ± 1.276
0.666CysThr: 0.666 ± 0.69
1.997CysVal: 1.997 ± 0.904
0.666CysTrp: 0.666 ± 0.69
0.666CysTyr: 0.666 ± 1.112
0.0CysXaa: 0.0 ± 0.0
Asp
5.992AspAla: 5.992 ± 1.767
0.666AspCys: 0.666 ± 0.485
1.332AspAsp: 1.332 ± 0.97
1.332AspGlu: 1.332 ± 0.637
1.332AspPhe: 1.332 ± 0.834
0.666AspGly: 0.666 ± 0.485
0.0AspHis: 0.0 ± 0.0
0.666AspIle: 0.666 ± 0.559
0.666AspLys: 0.666 ± 0.787
1.332AspLeu: 1.332 ± 0.617
2.663AspMet: 2.663 ± 1.32
1.997AspAsn: 1.997 ± 1.677
3.329AspPro: 3.329 ± 1.658
1.997AspGln: 1.997 ± 1.004
1.332AspArg: 1.332 ± 0.617
4.66AspSer: 4.66 ± 1.162
1.997AspThr: 1.997 ± 0.627
1.997AspVal: 1.997 ± 0.627
0.0AspTrp: 0.0 ± 0.0
1.332AspTyr: 1.332 ± 0.617
0.0AspXaa: 0.0 ± 0.0
Glu
2.663GluAla: 2.663 ± 0.789
0.0GluCys: 0.0 ± 0.0
0.666GluAsp: 0.666 ± 0.682
1.332GluGlu: 1.332 ± 0.97
1.997GluPhe: 1.997 ± 0.904
1.332GluGly: 1.332 ± 0.97
1.997GluHis: 1.997 ± 0.904
1.997GluIle: 1.997 ± 1.072
3.329GluLys: 3.329 ± 1.487
1.332GluLeu: 1.332 ± 0.617
0.666GluMet: 0.666 ± 0.961
0.0GluAsn: 0.0 ± 0.0
3.995GluPro: 3.995 ± 1.268
0.666GluGln: 0.666 ± 1.112
3.329GluArg: 3.329 ± 1.487
1.997GluSer: 1.997 ± 1.072
0.666GluThr: 0.666 ± 0.69
4.66GluVal: 4.66 ± 1.676
0.666GluTrp: 0.666 ± 0.682
1.997GluTyr: 1.997 ± 1.227
0.0GluXaa: 0.0 ± 0.0
Phe
3.329PheAla: 3.329 ± 1.072
1.997PheCys: 1.997 ± 1.163
1.997PheAsp: 1.997 ± 1.455
3.995PheGlu: 3.995 ± 1.305
0.0PhePhe: 0.0 ± 0.0
2.663PheGly: 2.663 ± 1.274
0.0PheHis: 0.0 ± 0.0
0.666PheIle: 0.666 ± 0.485
0.666PheLys: 0.666 ± 0.485
2.663PheLeu: 2.663 ± 1.881
0.666PheMet: 0.666 ± 0.485
2.663PheAsn: 2.663 ± 1.478
1.332PhePro: 1.332 ± 0.637
0.0PheGln: 0.0 ± 0.0
1.997PheArg: 1.997 ± 1.227
1.332PheSer: 1.332 ± 0.676
0.666PheThr: 0.666 ± 0.485
4.66PheVal: 4.66 ± 2.128
0.0PheTrp: 0.0 ± 0.0
1.332PheTyr: 1.332 ± 0.97
0.0PheXaa: 0.0 ± 0.0
Gly
1.997GlyAla: 1.997 ± 1.072
1.997GlyCys: 1.997 ± 1.278
3.995GlyAsp: 3.995 ± 1.493
1.997GlyGlu: 1.997 ± 1.363
4.66GlyPhe: 4.66 ± 2.101
5.326GlyGly: 5.326 ± 2.12
1.997GlyHis: 1.997 ± 1.004
3.329GlyIle: 3.329 ± 1.846
5.326GlyLys: 5.326 ± 1.527
2.663GlyLeu: 2.663 ± 1.274
0.666GlyMet: 0.666 ± 0.69
2.663GlyAsn: 2.663 ± 1.389
1.997GlyPro: 1.997 ± 0.78
1.997GlyGln: 1.997 ± 0.959
5.992GlyArg: 5.992 ± 1.324
6.658GlySer: 6.658 ± 1.878
2.663GlyThr: 2.663 ± 1.06
9.321GlyVal: 9.321 ± 1.867
2.663GlyTrp: 2.663 ± 1.352
1.997GlyTyr: 1.997 ± 0.627
0.0GlyXaa: 0.0 ± 0.0
His
0.666HisAla: 0.666 ± 0.682
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.666HisGlu: 0.666 ± 0.69
1.332HisPhe: 1.332 ± 1.072
3.329HisGly: 3.329 ± 1.046
3.329HisHis: 3.329 ± 1.436
0.666HisIle: 0.666 ± 0.682
1.332HisLys: 1.332 ± 0.617
3.329HisLeu: 3.329 ± 1.291
0.0HisMet: 0.0 ± 0.0
0.666HisAsn: 0.666 ± 0.485
0.666HisPro: 0.666 ± 0.485
0.0HisGln: 0.0 ± 0.0
0.666HisArg: 0.666 ± 0.69
5.326HisSer: 5.326 ± 2.337
2.663HisThr: 2.663 ± 0.789
2.663HisVal: 2.663 ± 1.234
0.0HisTrp: 0.0 ± 0.0
0.666HisTyr: 0.666 ± 0.69
0.0HisXaa: 0.0 ± 0.0
Ile
3.995IleAla: 3.995 ± 1.456
0.666IleCys: 0.666 ± 0.69
1.332IleAsp: 1.332 ± 0.617
0.666IleGlu: 0.666 ± 0.682
1.332IlePhe: 1.332 ± 0.676
2.663IleGly: 2.663 ± 1.303
0.0IleHis: 0.0 ± 0.0
0.666IleIle: 0.666 ± 0.559
3.995IleLys: 3.995 ± 1.206
3.329IleLeu: 3.329 ± 2.403
1.997IleMet: 1.997 ± 1.096
3.995IleAsn: 3.995 ± 2.435
2.663IlePro: 2.663 ± 1.353
2.663IleGln: 2.663 ± 0.798
5.326IleArg: 5.326 ± 1.75
3.995IleSer: 3.995 ± 1.271
6.658IleThr: 6.658 ± 2.595
2.663IleVal: 2.663 ± 1.129
0.666IleTrp: 0.666 ± 0.69
2.663IleTyr: 2.663 ± 1.138
0.0IleXaa: 0.0 ± 0.0
Lys
2.663LysAla: 2.663 ± 1.234
0.0LysCys: 0.0 ± 0.0
1.997LysAsp: 1.997 ± 1.455
0.666LysGlu: 0.666 ± 0.682
1.332LysPhe: 1.332 ± 1.364
3.995LysGly: 3.995 ± 1.808
1.332LysHis: 1.332 ± 0.617
1.997LysIle: 1.997 ± 0.959
2.663LysLys: 2.663 ± 1.234
4.66LysLeu: 4.66 ± 2.048
0.666LysMet: 0.666 ± 0.485
1.997LysAsn: 1.997 ± 0.82
3.995LysPro: 3.995 ± 1.503
1.997LysGln: 1.997 ± 0.82
3.329LysArg: 3.329 ± 1.751
3.329LysSer: 3.329 ± 1.354
0.666LysThr: 0.666 ± 0.559
3.329LysVal: 3.329 ± 1.297
0.666LysTrp: 0.666 ± 0.682
1.332LysTyr: 1.332 ± 0.97
0.0LysXaa: 0.0 ± 0.0
Leu
7.989LeuAla: 7.989 ± 1.854
0.666LeuCys: 0.666 ± 0.69
1.332LeuAsp: 1.332 ± 0.787
3.329LeuGlu: 3.329 ± 2.426
1.332LeuPhe: 1.332 ± 0.637
5.326LeuGly: 5.326 ± 2.597
3.329LeuHis: 3.329 ± 1.088
6.658LeuIle: 6.658 ± 2.741
3.329LeuLys: 3.329 ± 1.04
11.984LeuLeu: 11.984 ± 6.65
2.663LeuMet: 2.663 ± 0.796
5.326LeuAsn: 5.326 ± 0.731
1.332LeuPro: 1.332 ± 0.676
5.326LeuGln: 5.326 ± 0.993
4.66LeuArg: 4.66 ± 1.516
9.321LeuSer: 9.321 ± 3.724
4.66LeuThr: 4.66 ± 1.314
7.989LeuVal: 7.989 ± 2.324
2.663LeuTrp: 2.663 ± 1.351
3.329LeuTyr: 3.329 ± 1.795
0.0LeuXaa: 0.0 ± 0.0
Met
1.332MetAla: 1.332 ± 0.691
0.0MetCys: 0.0 ± 0.0
1.332MetAsp: 1.332 ± 0.834
1.332MetGlu: 1.332 ± 0.676
0.0MetPhe: 0.0 ± 0.0
2.663MetGly: 2.663 ± 1.94
0.0MetHis: 0.0 ± 0.0
2.663MetIle: 2.663 ± 1.565
1.332MetLys: 1.332 ± 0.637
2.663MetLeu: 2.663 ± 1.329
0.0MetMet: 0.0 ± 0.0
1.332MetAsn: 1.332 ± 0.617
0.666MetPro: 0.666 ± 0.682
0.666MetGln: 0.666 ± 0.69
1.332MetArg: 1.332 ± 0.676
3.995MetSer: 3.995 ± 0.93
0.666MetThr: 0.666 ± 0.682
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.666MetTyr: 0.666 ± 0.559
0.0MetXaa: 0.0 ± 0.0
Asn
5.992AsnAla: 5.992 ± 1.88
1.332AsnCys: 1.332 ± 0.637
1.332AsnAsp: 1.332 ± 0.874
0.666AsnGlu: 0.666 ± 0.682
1.997AsnPhe: 1.997 ± 1.115
3.329AsnGly: 3.329 ± 1.04
0.666AsnHis: 0.666 ± 1.112
2.663AsnIle: 2.663 ± 1.484
1.997AsnLys: 1.997 ± 0.82
5.326AsnLeu: 5.326 ± 1.64
1.332AsnMet: 1.332 ± 0.728
3.329AsnAsn: 3.329 ± 1.936
3.995AsnPro: 3.995 ± 1.881
3.329AsnGln: 3.329 ± 1.337
1.332AsnArg: 1.332 ± 1.364
2.663AsnSer: 2.663 ± 1.317
4.66AsnThr: 4.66 ± 1.746
2.663AsnVal: 2.663 ± 1.234
0.666AsnTrp: 0.666 ± 0.559
0.666AsnTyr: 0.666 ± 0.559
0.0AsnXaa: 0.0 ± 0.0
Pro
4.66ProAla: 4.66 ± 1.316
0.0ProCys: 0.0 ± 0.0
2.663ProAsp: 2.663 ± 1.234
3.329ProGlu: 3.329 ± 1.747
1.332ProPhe: 1.332 ± 0.617
1.332ProGly: 1.332 ± 0.676
2.663ProHis: 2.663 ± 1.915
5.992ProIle: 5.992 ± 1.63
1.997ProLys: 1.997 ± 1.238
5.992ProLeu: 5.992 ± 1.899
0.666ProMet: 0.666 ± 0.682
1.332ProAsn: 1.332 ± 1.118
5.992ProPro: 5.992 ± 1.785
1.997ProGln: 1.997 ± 1.263
5.326ProArg: 5.326 ± 1.906
7.989ProSer: 7.989 ± 4.244
2.663ProThr: 2.663 ± 0.875
5.992ProVal: 5.992 ± 1.648
0.666ProTrp: 0.666 ± 0.682
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
0.666GlnAla: 0.666 ± 0.485
1.332GlnCys: 1.332 ± 0.97
0.0GlnAsp: 0.0 ± 0.0
1.332GlnGlu: 1.332 ± 1.364
2.663GlnPhe: 2.663 ± 1.274
2.663GlnGly: 2.663 ± 1.366
1.997GlnHis: 1.997 ± 0.959
2.663GlnIle: 2.663 ± 0.758
1.332GlnLys: 1.332 ± 0.617
5.326GlnLeu: 5.326 ± 1.215
0.0GlnMet: 0.0 ± 0.0
1.997GlnAsn: 1.997 ± 1.039
2.663GlnPro: 2.663 ± 0.866
3.329GlnGln: 3.329 ± 1.063
2.663GlnArg: 2.663 ± 1.484
1.997GlnSer: 1.997 ± 1.452
3.329GlnThr: 3.329 ± 2.095
3.995GlnVal: 3.995 ± 2.681
1.332GlnTrp: 1.332 ± 0.961
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.329ArgAla: 3.329 ± 1.525
1.332ArgCys: 1.332 ± 1.118
2.663ArgAsp: 2.663 ± 0.866
1.332ArgGlu: 1.332 ± 0.637
3.995ArgPhe: 3.995 ± 0.856
4.66ArgGly: 4.66 ± 2.146
1.332ArgHis: 1.332 ± 0.637
2.663ArgIle: 2.663 ± 0.758
5.326ArgLys: 5.326 ± 1.228
6.658ArgLeu: 6.658 ± 1.529
1.332ArgMet: 1.332 ± 0.66
3.995ArgAsn: 3.995 ± 1.25
3.329ArgPro: 3.329 ± 1.833
1.997ArgGln: 1.997 ± 1.004
4.66ArgArg: 4.66 ± 2.128
6.658ArgSer: 6.658 ± 3.082
4.66ArgThr: 4.66 ± 1.316
3.995ArgVal: 3.995 ± 2.012
0.0ArgTrp: 0.0 ± 0.0
2.663ArgTyr: 2.663 ± 0.758
0.0ArgXaa: 0.0 ± 0.0
Ser
3.995SerAla: 3.995 ± 2.025
0.0SerCys: 0.0 ± 0.0
3.995SerAsp: 3.995 ± 1.596
1.997SerGlu: 1.997 ± 2.57
1.997SerPhe: 1.997 ± 0.953
8.655SerGly: 8.655 ± 1.827
3.329SerHis: 3.329 ± 1.998
2.663SerIle: 2.663 ± 2.552
3.329SerLys: 3.329 ± 0.931
10.652SerLeu: 10.652 ± 2.609
0.666SerMet: 0.666 ± 0.69
3.329SerAsn: 3.329 ± 1.422
9.321SerPro: 9.321 ± 5.595
1.332SerGln: 1.332 ± 0.961
6.658SerArg: 6.658 ± 2.274
5.992SerSer: 5.992 ± 2.338
8.655SerThr: 8.655 ± 2.288
4.66SerVal: 4.66 ± 2.162
1.997SerTrp: 1.997 ± 1.455
4.66SerTyr: 4.66 ± 1.474
0.0SerXaa: 0.0 ± 0.0
Thr
4.66ThrAla: 4.66 ± 1.455
0.666ThrCys: 0.666 ± 0.485
1.997ThrAsp: 1.997 ± 1.05
1.997ThrGlu: 1.997 ± 0.82
2.663ThrPhe: 2.663 ± 0.866
7.324ThrGly: 7.324 ± 0.722
2.663ThrHis: 2.663 ± 1.329
3.329ThrIle: 3.329 ± 2.136
1.332ThrLys: 1.332 ± 0.617
5.992ThrLeu: 5.992 ± 3.034
2.663ThrMet: 2.663 ± 1.329
3.329ThrAsn: 3.329 ± 1.929
5.992ThrPro: 5.992 ± 1.822
3.995ThrGln: 3.995 ± 2.055
3.995ThrArg: 3.995 ± 1.693
6.658ThrSer: 6.658 ± 2.613
6.658ThrThr: 6.658 ± 2.011
2.663ThrVal: 2.663 ± 1.028
0.666ThrTrp: 0.666 ± 0.485
1.332ThrTyr: 1.332 ± 1.072
0.0ThrXaa: 0.0 ± 0.0
Val
5.326ValAla: 5.326 ± 1.812
1.332ValCys: 1.332 ± 0.637
3.329ValAsp: 3.329 ± 1.658
3.995ValGlu: 3.995 ± 1.305
1.332ValPhe: 1.332 ± 0.637
5.326ValGly: 5.326 ± 1.05
1.332ValHis: 1.332 ± 0.637
5.326ValIle: 5.326 ± 2.225
0.666ValLys: 0.666 ± 0.485
2.663ValLeu: 2.663 ± 1.915
1.997ValMet: 1.997 ± 0.78
5.326ValAsn: 5.326 ± 1.479
7.989ValPro: 7.989 ± 2.491
4.66ValGln: 4.66 ± 1.74
5.992ValArg: 5.992 ± 1.024
5.326ValSer: 5.326 ± 3.005
6.658ValThr: 6.658 ± 1.947
6.658ValVal: 6.658 ± 3.238
0.0ValTrp: 0.0 ± 0.0
2.663ValTyr: 2.663 ± 1.138
0.0ValXaa: 0.0 ± 0.0
Trp
1.332TrpAla: 1.332 ± 1.364
0.666TrpCys: 0.666 ± 0.69
0.666TrpAsp: 0.666 ± 0.485
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.332TrpGly: 1.332 ± 0.691
0.0TrpHis: 0.0 ± 0.0
0.666TrpIle: 0.666 ± 0.682
0.666TrpLys: 0.666 ± 0.559
3.329TrpLeu: 3.329 ± 1.419
0.666TrpMet: 0.666 ± 0.69
0.666TrpAsn: 0.666 ± 0.485
0.0TrpPro: 0.0 ± 0.0
1.332TrpGln: 1.332 ± 0.676
0.0TrpArg: 0.0 ± 0.0
1.997TrpSer: 1.997 ± 1.363
1.332TrpThr: 1.332 ± 0.676
0.666TrpVal: 0.666 ± 0.559
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.332TyrAla: 1.332 ± 1.155
1.332TyrCys: 1.332 ± 1.072
2.663TyrAsp: 2.663 ± 1.234
1.332TyrGlu: 1.332 ± 1.072
1.332TyrPhe: 1.332 ± 1.317
1.997TyrGly: 1.997 ± 0.539
0.666TyrHis: 0.666 ± 0.485
1.997TyrIle: 1.997 ± 1.434
0.0TyrLys: 0.0 ± 0.0
3.995TyrLeu: 3.995 ± 1.578
1.332TyrMet: 1.332 ± 0.787
1.332TyrAsn: 1.332 ± 0.97
0.0TyrPro: 0.0 ± 0.0
1.332TyrGln: 1.332 ± 0.97
3.995TyrArg: 3.995 ± 1.298
0.666TyrSer: 0.666 ± 0.559
3.329TyrThr: 3.329 ± 1.354
1.997TyrVal: 1.997 ± 1.039
1.332TyrTrp: 1.332 ± 0.617
1.332TyrTyr: 1.332 ± 0.97
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski