Amino acid dipepetide frequency for Gordonia phage GTE2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.628AlaAla: 10.628 ± 1.488
0.586AlaCys: 0.586 ± 0.202
5.571AlaAsp: 5.571 ± 0.896
5.937AlaGlu: 5.937 ± 0.687
3.298AlaPhe: 3.298 ± 0.869
8.796AlaGly: 8.796 ± 1.007
1.466AlaHis: 1.466 ± 0.329
4.911AlaIle: 4.911 ± 0.634
4.178AlaLys: 4.178 ± 0.594
8.722AlaLeu: 8.722 ± 0.881
2.639AlaMet: 2.639 ± 0.439
3.005AlaAsn: 3.005 ± 0.531
5.717AlaPro: 5.717 ± 0.643
2.712AlaGln: 2.712 ± 0.406
6.157AlaArg: 6.157 ± 0.674
5.717AlaSer: 5.717 ± 0.907
5.864AlaThr: 5.864 ± 0.657
6.597AlaVal: 6.597 ± 1.242
2.565AlaTrp: 2.565 ± 0.436
2.785AlaTyr: 2.785 ± 0.312
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.281
0.147CysCys: 0.147 ± 0.09
0.953CysAsp: 0.953 ± 0.246
0.44CysGlu: 0.44 ± 0.177
0.66CysPhe: 0.66 ± 0.209
1.026CysGly: 1.026 ± 0.305
0.22CysHis: 0.22 ± 0.139
0.147CysIle: 0.147 ± 0.098
0.366CysLys: 0.366 ± 0.182
0.66CysLeu: 0.66 ± 0.224
0.147CysMet: 0.147 ± 0.115
0.147CysAsn: 0.147 ± 0.1
0.66CysPro: 0.66 ± 0.226
0.22CysGln: 0.22 ± 0.125
0.66CysArg: 0.66 ± 0.236
0.733CysSer: 0.733 ± 0.247
0.513CysThr: 0.513 ± 0.219
0.44CysVal: 0.44 ± 0.204
0.147CysTrp: 0.147 ± 0.095
0.44CysTyr: 0.44 ± 0.174
0.0CysXaa: 0.0 ± 0.0
Asp
5.717AspAla: 5.717 ± 0.601
0.806AspCys: 0.806 ± 0.253
3.885AspAsp: 3.885 ± 0.728
5.644AspGlu: 5.644 ± 0.763
2.199AspPhe: 2.199 ± 0.436
4.838AspGly: 4.838 ± 0.777
1.393AspHis: 1.393 ± 0.37
2.565AspIle: 2.565 ± 0.38
2.565AspLys: 2.565 ± 0.367
6.157AspLeu: 6.157 ± 0.909
1.832AspMet: 1.832 ± 0.424
1.466AspAsn: 1.466 ± 0.265
4.031AspPro: 4.031 ± 0.596
2.052AspGln: 2.052 ± 0.333
3.811AspArg: 3.811 ± 0.445
3.958AspSer: 3.958 ± 0.619
3.005AspThr: 3.005 ± 0.58
3.445AspVal: 3.445 ± 0.538
1.099AspTrp: 1.099 ± 0.252
1.979AspTyr: 1.979 ± 0.489
0.0AspXaa: 0.0 ± 0.0
Glu
6.89GluAla: 6.89 ± 0.787
0.66GluCys: 0.66 ± 0.259
4.618GluAsp: 4.618 ± 0.709
4.691GluGlu: 4.691 ± 0.761
1.686GluPhe: 1.686 ± 0.277
4.105GluGly: 4.105 ± 0.524
1.319GluHis: 1.319 ± 0.312
2.492GluIle: 2.492 ± 0.42
2.346GluLys: 2.346 ± 0.414
4.911GluLeu: 4.911 ± 0.86
1.832GluMet: 1.832 ± 0.344
1.613GluAsn: 1.613 ± 0.302
2.346GluPro: 2.346 ± 0.493
2.712GluGln: 2.712 ± 0.439
4.764GluArg: 4.764 ± 0.815
3.079GluSer: 3.079 ± 0.498
3.079GluThr: 3.079 ± 0.437
4.764GluVal: 4.764 ± 0.643
1.173GluTrp: 1.173 ± 0.323
2.199GluTyr: 2.199 ± 0.41
0.0GluXaa: 0.0 ± 0.0
Phe
2.932PheAla: 2.932 ± 0.497
0.586PheCys: 0.586 ± 0.265
2.639PheAsp: 2.639 ± 0.437
1.613PheGlu: 1.613 ± 0.362
0.806PhePhe: 0.806 ± 0.204
1.979PheGly: 1.979 ± 0.344
0.513PheHis: 0.513 ± 0.171
2.126PheIle: 2.126 ± 0.45
1.832PheLys: 1.832 ± 0.402
1.832PheLeu: 1.832 ± 0.339
0.586PheMet: 0.586 ± 0.202
1.026PheAsn: 1.026 ± 0.245
1.686PhePro: 1.686 ± 0.396
0.953PheGln: 0.953 ± 0.266
2.346PheArg: 2.346 ± 0.516
2.126PheSer: 2.126 ± 0.756
2.492PheThr: 2.492 ± 0.493
1.906PheVal: 1.906 ± 0.28
0.513PheTrp: 0.513 ± 0.176
0.513PheTyr: 0.513 ± 0.212
0.0PheXaa: 0.0 ± 0.0
Gly
7.77GlyAla: 7.77 ± 0.73
0.66GlyCys: 0.66 ± 0.254
6.01GlyAsp: 6.01 ± 0.817
4.398GlyGlu: 4.398 ± 0.605
3.005GlyPhe: 3.005 ± 0.401
7.183GlyGly: 7.183 ± 0.952
1.979GlyHis: 1.979 ± 0.41
4.251GlyIle: 4.251 ± 0.734
4.105GlyLys: 4.105 ± 0.582
5.131GlyLeu: 5.131 ± 0.692
2.346GlyMet: 2.346 ± 0.361
3.079GlyAsn: 3.079 ± 0.48
3.079GlyPro: 3.079 ± 0.732
3.885GlyGln: 3.885 ± 0.639
5.204GlyArg: 5.204 ± 0.663
6.23GlySer: 6.23 ± 0.999
5.424GlyThr: 5.424 ± 0.842
5.131GlyVal: 5.131 ± 0.699
2.492GlyTrp: 2.492 ± 0.408
2.712GlyTyr: 2.712 ± 0.453
0.0GlyXaa: 0.0 ± 0.0
His
1.613HisAla: 1.613 ± 0.284
0.147HisCys: 0.147 ± 0.113
1.613HisAsp: 1.613 ± 0.365
1.319HisGlu: 1.319 ± 0.313
0.733HisPhe: 0.733 ± 0.239
1.246HisGly: 1.246 ± 0.361
0.44HisHis: 0.44 ± 0.153
0.586HisIle: 0.586 ± 0.207
0.953HisLys: 0.953 ± 0.243
1.832HisLeu: 1.832 ± 0.407
0.953HisMet: 0.953 ± 0.267
1.026HisAsn: 1.026 ± 0.293
1.466HisPro: 1.466 ± 0.299
0.513HisGln: 0.513 ± 0.203
1.466HisArg: 1.466 ± 0.301
1.246HisSer: 1.246 ± 0.346
2.052HisThr: 2.052 ± 0.364
1.173HisVal: 1.173 ± 0.27
0.513HisTrp: 0.513 ± 0.186
0.44HisTyr: 0.44 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
4.618IleAla: 4.618 ± 0.675
0.147IleCys: 0.147 ± 0.129
3.225IleAsp: 3.225 ± 0.494
3.225IleGlu: 3.225 ± 0.504
1.319IlePhe: 1.319 ± 0.283
4.325IleGly: 4.325 ± 0.952
1.026IleHis: 1.026 ± 0.204
2.199IleIle: 2.199 ± 0.529
2.199IleLys: 2.199 ± 0.691
2.346IleLeu: 2.346 ± 0.349
0.586IleMet: 0.586 ± 0.175
1.613IleAsn: 1.613 ± 0.325
2.859IlePro: 2.859 ± 0.513
1.246IleGln: 1.246 ± 0.306
3.225IleArg: 3.225 ± 0.457
3.225IleSer: 3.225 ± 0.418
2.639IleThr: 2.639 ± 0.407
3.738IleVal: 3.738 ± 0.596
0.953IleTrp: 0.953 ± 0.228
1.686IleTyr: 1.686 ± 0.444
0.0IleXaa: 0.0 ± 0.0
Lys
4.984LysAla: 4.984 ± 0.583
0.44LysCys: 0.44 ± 0.215
2.126LysAsp: 2.126 ± 0.365
2.859LysGlu: 2.859 ± 0.401
1.686LysPhe: 1.686 ± 0.398
4.325LysGly: 4.325 ± 0.408
0.806LysHis: 0.806 ± 0.239
1.466LysIle: 1.466 ± 0.328
2.419LysLys: 2.419 ± 0.373
4.544LysLeu: 4.544 ± 0.478
1.026LysMet: 1.026 ± 0.294
2.272LysAsn: 2.272 ± 0.378
2.346LysPro: 2.346 ± 0.431
2.126LysGln: 2.126 ± 0.472
3.152LysArg: 3.152 ± 0.499
3.079LysSer: 3.079 ± 0.493
2.785LysThr: 2.785 ± 0.477
2.785LysVal: 2.785 ± 0.52
0.953LysTrp: 0.953 ± 0.271
1.393LysTyr: 1.393 ± 0.294
0.0LysXaa: 0.0 ± 0.0
Leu
8.063LeuAla: 8.063 ± 0.917
0.66LeuCys: 0.66 ± 0.298
4.618LeuAsp: 4.618 ± 0.564
5.351LeuGlu: 5.351 ± 0.77
1.539LeuPhe: 1.539 ± 0.359
6.23LeuGly: 6.23 ± 0.823
1.979LeuHis: 1.979 ± 0.441
3.225LeuIle: 3.225 ± 0.555
4.471LeuLys: 4.471 ± 0.515
7.916LeuLeu: 7.916 ± 0.794
2.199LeuMet: 2.199 ± 0.33
2.199LeuAsn: 2.199 ± 0.445
4.911LeuPro: 4.911 ± 0.573
2.346LeuGln: 2.346 ± 0.409
6.377LeuArg: 6.377 ± 0.601
5.204LeuSer: 5.204 ± 0.761
4.691LeuThr: 4.691 ± 0.642
5.791LeuVal: 5.791 ± 0.545
1.613LeuTrp: 1.613 ± 0.431
2.126LeuTyr: 2.126 ± 0.357
0.0LeuXaa: 0.0 ± 0.0
Met
3.225MetAla: 3.225 ± 0.381
0.073MetCys: 0.073 ± 0.075
1.173MetAsp: 1.173 ± 0.315
1.173MetGlu: 1.173 ± 0.281
1.099MetPhe: 1.099 ± 0.278
1.393MetGly: 1.393 ± 0.318
0.66MetHis: 0.66 ± 0.246
2.126MetIle: 2.126 ± 0.417
0.953MetLys: 0.953 ± 0.285
2.126MetLeu: 2.126 ± 0.412
0.66MetMet: 0.66 ± 0.168
1.026MetAsn: 1.026 ± 0.265
1.539MetPro: 1.539 ± 0.316
1.393MetGln: 1.393 ± 0.229
1.319MetArg: 1.319 ± 0.255
2.126MetSer: 2.126 ± 0.444
1.613MetThr: 1.613 ± 0.265
1.906MetVal: 1.906 ± 0.341
0.66MetTrp: 0.66 ± 0.228
0.293MetTyr: 0.293 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
3.372AsnAla: 3.372 ± 0.509
0.366AsnCys: 0.366 ± 0.165
1.906AsnAsp: 1.906 ± 0.384
1.613AsnGlu: 1.613 ± 0.291
1.319AsnPhe: 1.319 ± 0.325
3.152AsnGly: 3.152 ± 0.647
0.513AsnHis: 0.513 ± 0.209
0.953AsnIle: 0.953 ± 0.404
1.246AsnLys: 1.246 ± 0.315
1.979AsnLeu: 1.979 ± 0.388
0.953AsnMet: 0.953 ± 0.197
0.66AsnAsn: 0.66 ± 0.244
3.738AsnPro: 3.738 ± 0.646
1.099AsnGln: 1.099 ± 0.25
2.565AsnArg: 2.565 ± 0.462
1.759AsnSer: 1.759 ± 0.334
1.393AsnThr: 1.393 ± 0.345
2.346AsnVal: 2.346 ± 0.42
0.586AsnTrp: 0.586 ± 0.226
1.026AsnTyr: 1.026 ± 0.248
0.0AsnXaa: 0.0 ± 0.0
Pro
5.424ProAla: 5.424 ± 0.639
0.586ProCys: 0.586 ± 0.238
3.665ProAsp: 3.665 ± 0.688
3.738ProGlu: 3.738 ± 0.648
1.539ProPhe: 1.539 ± 0.398
5.937ProGly: 5.937 ± 0.725
1.026ProHis: 1.026 ± 0.221
2.126ProIle: 2.126 ± 0.356
3.079ProLys: 3.079 ± 0.56
4.031ProLeu: 4.031 ± 0.561
1.466ProMet: 1.466 ± 0.315
1.613ProAsn: 1.613 ± 0.35
1.979ProPro: 1.979 ± 0.388
2.272ProGln: 2.272 ± 0.386
2.492ProArg: 2.492 ± 0.392
3.738ProSer: 3.738 ± 0.603
3.298ProThr: 3.298 ± 0.53
4.031ProVal: 4.031 ± 0.511
1.246ProTrp: 1.246 ± 0.281
1.173ProTyr: 1.173 ± 0.289
0.0ProXaa: 0.0 ± 0.0
Gln
3.152GlnAla: 3.152 ± 0.621
0.513GlnCys: 0.513 ± 0.277
1.832GlnAsp: 1.832 ± 0.305
2.052GlnGlu: 2.052 ± 0.324
1.539GlnPhe: 1.539 ± 0.344
2.492GlnGly: 2.492 ± 0.511
1.026GlnHis: 1.026 ± 0.317
2.199GlnIle: 2.199 ± 0.437
1.613GlnLys: 1.613 ± 0.342
3.152GlnLeu: 3.152 ± 0.342
0.66GlnMet: 0.66 ± 0.241
1.026GlnAsn: 1.026 ± 0.431
2.199GlnPro: 2.199 ± 0.427
1.319GlnGln: 1.319 ± 0.385
2.639GlnArg: 2.639 ± 0.416
2.199GlnSer: 2.199 ± 0.405
1.539GlnThr: 1.539 ± 0.297
2.859GlnVal: 2.859 ± 0.365
0.88GlnTrp: 0.88 ± 0.203
1.099GlnTyr: 1.099 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
6.01ArgAla: 6.01 ± 0.809
0.806ArgCys: 0.806 ± 0.303
4.178ArgAsp: 4.178 ± 0.569
4.105ArgGlu: 4.105 ± 0.411
1.979ArgPhe: 1.979 ± 0.425
5.497ArgGly: 5.497 ± 0.785
1.246ArgHis: 1.246 ± 0.27
2.419ArgIle: 2.419 ± 0.421
4.618ArgLys: 4.618 ± 0.589
4.984ArgLeu: 4.984 ± 0.599
1.613ArgMet: 1.613 ± 0.376
1.759ArgAsn: 1.759 ± 0.343
2.859ArgPro: 2.859 ± 0.502
2.639ArgGln: 2.639 ± 0.454
3.958ArgArg: 3.958 ± 0.552
3.811ArgSer: 3.811 ± 0.587
3.298ArgThr: 3.298 ± 0.494
5.497ArgVal: 5.497 ± 1.008
1.759ArgTrp: 1.759 ± 0.532
1.759ArgTyr: 1.759 ± 0.329
0.0ArgXaa: 0.0 ± 0.0
Ser
6.01SerAla: 6.01 ± 0.929
0.366SerCys: 0.366 ± 0.173
3.079SerAsp: 3.079 ± 0.403
3.298SerGlu: 3.298 ± 0.683
1.613SerPhe: 1.613 ± 0.378
7.183SerGly: 7.183 ± 0.942
1.393SerHis: 1.393 ± 0.361
3.811SerIle: 3.811 ± 0.505
2.199SerLys: 2.199 ± 0.46
5.497SerLeu: 5.497 ± 0.678
1.979SerMet: 1.979 ± 0.316
2.199SerAsn: 2.199 ± 0.355
3.592SerPro: 3.592 ± 0.609
2.199SerGln: 2.199 ± 0.56
4.031SerArg: 4.031 ± 0.523
2.932SerSer: 2.932 ± 0.564
3.592SerThr: 3.592 ± 0.641
3.445SerVal: 3.445 ± 0.495
1.613SerTrp: 1.613 ± 0.325
1.539SerTyr: 1.539 ± 0.34
0.0SerXaa: 0.0 ± 0.0
Thr
6.157ThrAla: 6.157 ± 0.753
0.44ThrCys: 0.44 ± 0.205
3.005ThrAsp: 3.005 ± 0.755
2.492ThrGlu: 2.492 ± 0.442
1.393ThrPhe: 1.393 ± 0.266
5.644ThrGly: 5.644 ± 0.658
1.246ThrHis: 1.246 ± 0.332
3.079ThrIle: 3.079 ± 0.509
3.298ThrLys: 3.298 ± 0.685
4.691ThrLeu: 4.691 ± 0.576
1.686ThrMet: 1.686 ± 0.314
2.126ThrAsn: 2.126 ± 0.32
4.031ThrPro: 4.031 ± 0.551
1.539ThrGln: 1.539 ± 0.348
3.665ThrArg: 3.665 ± 0.519
2.785ThrSer: 2.785 ± 0.428
4.105ThrThr: 4.105 ± 0.828
5.791ThrVal: 5.791 ± 0.612
1.099ThrTrp: 1.099 ± 0.253
1.393ThrTyr: 1.393 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
6.597ValAla: 6.597 ± 0.702
0.733ValCys: 0.733 ± 0.237
4.764ValAsp: 4.764 ± 0.592
4.178ValGlu: 4.178 ± 0.527
1.979ValPhe: 1.979 ± 0.334
5.058ValGly: 5.058 ± 0.802
1.539ValHis: 1.539 ± 0.353
3.811ValIle: 3.811 ± 0.539
2.859ValLys: 2.859 ± 0.411
6.157ValLeu: 6.157 ± 0.634
1.759ValMet: 1.759 ± 0.433
2.859ValAsn: 2.859 ± 0.482
3.665ValPro: 3.665 ± 0.544
2.565ValGln: 2.565 ± 0.32
3.738ValArg: 3.738 ± 0.549
4.325ValSer: 4.325 ± 0.62
5.717ValThr: 5.717 ± 0.651
4.691ValVal: 4.691 ± 0.763
1.832ValTrp: 1.832 ± 0.341
2.052ValTyr: 2.052 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
2.419TrpAla: 2.419 ± 0.404
0.513TrpCys: 0.513 ± 0.212
1.466TrpAsp: 1.466 ± 0.321
1.099TrpGlu: 1.099 ± 0.23
0.586TrpPhe: 0.586 ± 0.234
1.319TrpGly: 1.319 ± 0.476
0.733TrpHis: 0.733 ± 0.192
0.513TrpIle: 0.513 ± 0.185
1.026TrpLys: 1.026 ± 0.255
2.419TrpLeu: 2.419 ± 0.42
0.44TrpMet: 0.44 ± 0.2
1.246TrpAsn: 1.246 ± 0.405
0.733TrpPro: 0.733 ± 0.214
1.393TrpGln: 1.393 ± 0.419
1.099TrpArg: 1.099 ± 0.281
1.393TrpSer: 1.393 ± 0.287
0.88TrpThr: 0.88 ± 0.206
1.979TrpVal: 1.979 ± 0.344
0.366TrpTrp: 0.366 ± 0.161
0.806TrpTyr: 0.806 ± 0.233
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.539TyrAla: 1.539 ± 0.267
0.22TyrCys: 0.22 ± 0.113
2.126TyrAsp: 2.126 ± 0.38
2.052TyrGlu: 2.052 ± 0.372
1.026TyrPhe: 1.026 ± 0.246
2.346TyrGly: 2.346 ± 0.406
0.806TyrHis: 0.806 ± 0.3
1.393TyrIle: 1.393 ± 0.34
1.246TyrLys: 1.246 ± 0.292
2.492TyrLeu: 2.492 ± 0.444
1.099TyrMet: 1.099 ± 0.278
0.586TyrAsn: 0.586 ± 0.187
1.026TyrPro: 1.026 ± 0.267
0.806TyrGln: 0.806 ± 0.181
2.126TyrArg: 2.126 ± 0.402
1.906TyrSer: 1.906 ± 0.383
1.686TyrThr: 1.686 ± 0.363
2.565TyrVal: 2.565 ± 0.5
0.366TyrTrp: 0.366 ± 0.162
0.806TyrTyr: 0.806 ± 0.278
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski