Amino acid dipepetide frequency for Pyrenophora seminiperda CCB06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.036AlaAla: 9.036 ± 0.075	1.096AlaCys: 1.096 ± 0.017	4.232AlaAsp: 4.232 ± 0.035	5.125AlaGlu: 5.125 ± 0.047	3.125AlaPhe: 3.125 ± 0.029	5.6AlaGly: 5.6 ± 0.048	1.948AlaHis: 1.948 ± 0.022	4.244AlaIle: 4.244 ± 0.032	4.525AlaLys: 4.525 ± 0.038	7.58AlaLeu: 7.58 ± 0.048	2.102AlaMet: 2.102 ± 0.02	3.159AlaAsn: 3.159 ± 0.027	5.22AlaPro: 5.22 ± 0.053	3.636AlaGln: 3.636 ± 0.036	5.005AlaArg: 5.005 ± 0.044	7.456AlaSer: 7.456 ± 0.05	5.629AlaThr: 5.629 ± 0.038	5.283AlaVal: 5.283 ± 0.043	1.179AlaTrp: 1.179 ± 0.018	2.316AlaTyr: 2.316 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.015	0.271CysCys: 0.271 ± 0.009	0.646CysAsp: 0.646 ± 0.012	0.615CysGlu: 0.615 ± 0.012	0.535CysPhe: 0.535 ± 0.009	0.923CysGly: 0.923 ± 0.017	0.317CysHis: 0.317 ± 0.01	0.725CysIle: 0.725 ± 0.013	0.557CysLys: 0.557 ± 0.011	1.153CysLeu: 1.153 ± 0.02	0.289CysMet: 0.289 ± 0.008	0.465CysAsn: 0.465 ± 0.012	0.671CysPro: 0.671 ± 0.015	0.444CysGln: 0.444 ± 0.013	0.703CysArg: 0.703 ± 0.013	0.908CysSer: 0.908 ± 0.016	0.769CysThr: 0.769 ± 0.015	0.796CysVal: 0.796 ± 0.015	0.192CysTrp: 0.192 ± 0.007	0.355CysTyr: 0.355 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.02AspAla: 5.02 ± 0.038	0.614AspCys: 0.614 ± 0.012	4.222AspAsp: 4.222 ± 0.052	4.41AspGlu: 4.41 ± 0.043	2.197AspPhe: 2.197 ± 0.023	3.799AspGly: 3.799 ± 0.034	1.188AspHis: 1.188 ± 0.017	2.973AspIle: 2.973 ± 0.029	2.507AspLys: 2.507 ± 0.03	4.621AspLeu: 4.621 ± 0.04	1.459AspMet: 1.459 ± 0.02	1.872AspAsn: 1.872 ± 0.02	3.087AspPro: 3.087 ± 0.027	1.819AspGln: 1.819 ± 0.019	2.893AspArg: 2.893 ± 0.029	3.806AspSer: 3.806 ± 0.035	3.156AspThr: 3.156 ± 0.032	3.734AspVal: 3.734 ± 0.037	0.894AspTrp: 0.894 ± 0.013	1.611AspTyr: 1.611 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.426GluAla: 5.426 ± 0.048	0.607GluCys: 0.607 ± 0.013	4.167GluAsp: 4.167 ± 0.037	5.588GluGlu: 5.588 ± 0.065	1.81GluPhe: 1.81 ± 0.021	3.75GluGly: 3.75 ± 0.033	1.536GluHis: 1.536 ± 0.021	2.814GluIle: 2.814 ± 0.029	3.928GluLys: 3.928 ± 0.039	5.046GluLeu: 5.046 ± 0.041	1.498GluMet: 1.498 ± 0.017	2.167GluAsn: 2.167 ± 0.022	2.736GluPro: 2.736 ± 0.04	2.695GluGln: 2.695 ± 0.028	4.016GluArg: 4.016 ± 0.042	3.962GluSer: 3.962 ± 0.041	3.297GluThr: 3.297 ± 0.032	3.459GluVal: 3.459 ± 0.032	0.885GluTrp: 0.885 ± 0.014	1.684GluTyr: 1.684 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.029	0.547PheCys: 0.547 ± 0.011	2.23PheAsp: 2.23 ± 0.023	2.075PheGlu: 2.075 ± 0.022	1.571PhePhe: 1.571 ± 0.023	2.755PheGly: 2.755 ± 0.03	0.858PheHis: 0.858 ± 0.014	1.702PheIle: 1.702 ± 0.023	1.537PheLys: 1.537 ± 0.019	3.252PheLeu: 3.252 ± 0.029	0.79PheMet: 0.79 ± 0.016	1.432PheAsn: 1.432 ± 0.019	1.879PhePro: 1.879 ± 0.022	1.351PheGln: 1.351 ± 0.018	1.882PheArg: 1.882 ± 0.022	2.895PheSer: 2.895 ± 0.029	2.25PheThr: 2.25 ± 0.023	2.324PheVal: 2.324 ± 0.026	0.61PheTrp: 0.61 ± 0.013	1.047PheTyr: 1.047 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.305GlyAla: 5.305 ± 0.041	0.861GlyCys: 0.861 ± 0.015	3.454GlyAsp: 3.454 ± 0.033	3.648GlyGlu: 3.648 ± 0.031	2.661GlyPhe: 2.661 ± 0.027	5.97GlyGly: 5.97 ± 0.067	1.639GlyHis: 1.639 ± 0.021	3.331GlyIle: 3.331 ± 0.035	3.645GlyLys: 3.645 ± 0.033	5.69GlyLeu: 5.69 ± 0.041	1.723GlyMet: 1.723 ± 0.024	2.491GlyAsn: 2.491 ± 0.027	3.174GlyPro: 3.174 ± 0.032	2.523GlyGln: 2.523 ± 0.027	4.008GlyArg: 4.008 ± 0.038	5.268GlySer: 5.268 ± 0.045	3.99GlyThr: 3.99 ± 0.038	4.245GlyVal: 4.245 ± 0.042	1.168GlyTrp: 1.168 ± 0.019	2.111GlyTyr: 2.111 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.066HisAla: 2.066 ± 0.023	0.354HisCys: 0.354 ± 0.01	1.382HisAsp: 1.382 ± 0.021	1.351HisGlu: 1.351 ± 0.019	0.94HisPhe: 0.94 ± 0.015	1.737HisGly: 1.737 ± 0.021	0.939HisHis: 0.939 ± 0.018	1.259HisIle: 1.259 ± 0.018	0.99HisLys: 0.99 ± 0.015	2.264HisLeu: 2.264 ± 0.024	0.565HisMet: 0.565 ± 0.013	0.906HisAsn: 0.906 ± 0.016	1.657HisPro: 1.657 ± 0.021	1.051HisGln: 1.051 ± 0.017	1.525HisArg: 1.525 ± 0.02	1.919HisSer: 1.919 ± 0.024	1.474HisThr: 1.474 ± 0.021	1.649HisVal: 1.649 ± 0.018	0.347HisTrp: 0.347 ± 0.009	0.729HisTyr: 0.729 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.265IleAla: 4.265 ± 0.036	0.7IleCys: 0.7 ± 0.013	2.755IleAsp: 2.755 ± 0.028	2.831IleGlu: 2.831 ± 0.033	1.864IlePhe: 1.864 ± 0.024	3.031IleGly: 3.031 ± 0.034	1.193IleHis: 1.193 ± 0.018	2.381IleIle: 2.381 ± 0.029	2.288IleLys: 2.288 ± 0.023	4.256IleLeu: 4.256 ± 0.037	1.095IleMet: 1.095 ± 0.018	1.803IleAsn: 1.803 ± 0.021	2.984IlePro: 2.984 ± 0.025	1.858IleGln: 1.858 ± 0.022	2.676IleArg: 2.676 ± 0.027	3.675IleSer: 3.675 ± 0.03	2.944IleThr: 2.944 ± 0.026	3.063IleVal: 3.063 ± 0.034	0.684IleTrp: 0.684 ± 0.014	1.39IleTyr: 1.39 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.549LysAla: 4.549 ± 0.041	0.528LysCys: 0.528 ± 0.013	2.949LysAsp: 2.949 ± 0.032	3.65LysGlu: 3.65 ± 0.037	1.463LysPhe: 1.463 ± 0.019	3.18LysGly: 3.18 ± 0.03	1.27LysHis: 1.27 ± 0.02	2.274LysIle: 2.274 ± 0.025	3.81LysLys: 3.81 ± 0.051	4.26LysLeu: 4.26 ± 0.038	1.169LysMet: 1.169 ± 0.017	1.886LysAsn: 1.886 ± 0.021	2.906LysPro: 2.906 ± 0.032	2.079LysGln: 2.079 ± 0.028	3.618LysArg: 3.618 ± 0.04	3.608LysSer: 3.608 ± 0.034	3.08LysThr: 3.08 ± 0.029	2.918LysVal: 2.918 ± 0.031	0.71LysTrp: 0.71 ± 0.012	1.414LysTyr: 1.414 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.611LeuAla: 7.611 ± 0.05	1.18LeuCys: 1.18 ± 0.02	4.936LeuAsp: 4.936 ± 0.036	5.205LeuGlu: 5.205 ± 0.049	3.172LeuPhe: 3.172 ± 0.035	5.56LeuGly: 5.56 ± 0.04	2.296LeuHis: 2.296 ± 0.026	3.734LeuIle: 3.734 ± 0.031	4.236LeuLys: 4.236 ± 0.038	7.976LeuLeu: 7.976 ± 0.062	1.74LeuMet: 1.74 ± 0.021	3.12LeuAsn: 3.12 ± 0.028	5.586LeuPro: 5.586 ± 0.044	3.839LeuGln: 3.839 ± 0.033	5.535LeuArg: 5.535 ± 0.042	6.922LeuSer: 6.922 ± 0.046	4.781LeuThr: 4.781 ± 0.034	5.231LeuVal: 5.231 ± 0.043	1.125LeuTrp: 1.125 ± 0.018	2.325LeuTyr: 2.325 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.247MetAla: 2.247 ± 0.026	0.286MetCys: 0.286 ± 0.009	1.327MetAsp: 1.327 ± 0.019	1.336MetGlu: 1.336 ± 0.019	0.782MetPhe: 0.782 ± 0.013	1.545MetGly: 1.545 ± 0.025	0.581MetHis: 0.581 ± 0.013	0.963MetIle: 0.963 ± 0.015	1.094MetLys: 1.094 ± 0.015	1.988MetLeu: 1.988 ± 0.023	0.623MetMet: 0.623 ± 0.013	0.873MetAsn: 0.873 ± 0.014	1.438MetPro: 1.438 ± 0.022	1.023MetGln: 1.023 ± 0.019	1.413MetArg: 1.413 ± 0.02	2.007MetSer: 2.007 ± 0.021	1.405MetThr: 1.405 ± 0.017	1.396MetVal: 1.396 ± 0.018	0.281MetTrp: 0.281 ± 0.008	0.625MetTyr: 0.625 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.324AsnAla: 3.324 ± 0.029	0.444AsnCys: 0.444 ± 0.01	2.011AsnAsp: 2.011 ± 0.024	2.019AsnGlu: 2.019 ± 0.022	1.412AsnPhe: 1.412 ± 0.019	2.975AsnGly: 2.975 ± 0.032	0.889AsnHis: 0.889 ± 0.016	2.01AsnIle: 2.01 ± 0.022	1.77AsnLys: 1.77 ± 0.022	3.142AsnLeu: 3.142 ± 0.025	0.991AsnMet: 0.991 ± 0.018	1.623AsnAsn: 1.623 ± 0.025	2.385AsnPro: 2.385 ± 0.025	1.339AsnGln: 1.339 ± 0.018	1.905AsnArg: 1.905 ± 0.024	2.775AsnSer: 2.775 ± 0.029	2.422AsnThr: 2.422 ± 0.023	2.425AsnVal: 2.425 ± 0.027	0.564AsnTrp: 0.564 ± 0.011	1.068AsnTyr: 1.068 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.461ProAla: 5.461 ± 0.054	0.532ProCys: 0.532 ± 0.012	3.012ProAsp: 3.012 ± 0.029	3.573ProGlu: 3.573 ± 0.037	2.036ProPhe: 2.036 ± 0.026	3.664ProGly: 3.664 ± 0.036	1.508ProHis: 1.508 ± 0.022	2.622ProIle: 2.622 ± 0.024	2.954ProLys: 2.954 ± 0.031	4.739ProLeu: 4.739 ± 0.036	1.2ProMet: 1.2 ± 0.018	2.354ProAsn: 2.354 ± 0.026	5.566ProPro: 5.566 ± 0.087	2.614ProGln: 2.614 ± 0.038	3.472ProArg: 3.472 ± 0.038	6.068ProSer: 6.068 ± 0.06	4.518ProThr: 4.518 ± 0.041	3.621ProVal: 3.621 ± 0.037	0.708ProTrp: 0.708 ± 0.015	1.582ProTyr: 1.582 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.591GlnAla: 3.591 ± 0.033	0.452GlnCys: 0.452 ± 0.01	2.144GlnAsp: 2.144 ± 0.024	2.473GlnGlu: 2.473 ± 0.027	1.269GlnPhe: 1.269 ± 0.018	2.472GlnGly: 2.472 ± 0.027	1.274GlnHis: 1.274 ± 0.021	1.851GlnIle: 1.851 ± 0.02	2.115GlnLys: 2.115 ± 0.028	3.482GlnLeu: 3.482 ± 0.03	0.916GlnMet: 0.916 ± 0.017	1.571GlnAsn: 1.571 ± 0.021	2.686GlnPro: 2.686 ± 0.037	2.713GlnGln: 2.713 ± 0.052	2.78GlnArg: 2.78 ± 0.028	3.147GlnSer: 3.147 ± 0.034	2.372GlnThr: 2.372 ± 0.024	2.196GlnVal: 2.196 ± 0.021	0.55GlnTrp: 0.55 ± 0.011	1.252GlnTyr: 1.252 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.712ArgAla: 4.712 ± 0.04	0.711ArgCys: 0.711 ± 0.015	3.227ArgAsp: 3.227 ± 0.033	3.781ArgGlu: 3.781 ± 0.036	2.05ArgPhe: 2.05 ± 0.028	3.652ArgGly: 3.652 ± 0.041	1.594ArgHis: 1.594 ± 0.021	2.965ArgIle: 2.965 ± 0.029	3.655ArgLys: 3.655 ± 0.04	5.214ArgLeu: 5.214 ± 0.038	1.389ArgMet: 1.389 ± 0.021	2.386ArgAsn: 2.386 ± 0.023	3.53ArgPro: 3.53 ± 0.038	2.646ArgGln: 2.646 ± 0.03	4.953ArgArg: 4.953 ± 0.056	4.697ArgSer: 4.697 ± 0.046	3.435ArgThr: 3.435 ± 0.035	3.263ArgVal: 3.263 ± 0.029	0.879ArgTrp: 0.879 ± 0.016	1.693ArgTyr: 1.693 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.675SerAla: 6.675 ± 0.046	0.86SerCys: 0.86 ± 0.017	4.098SerAsp: 4.098 ± 0.036	3.952SerGlu: 3.952 ± 0.04	2.932SerPhe: 2.932 ± 0.025	5.229SerGly: 5.229 ± 0.042	2.027SerHis: 2.027 ± 0.024	3.886SerIle: 3.886 ± 0.036	3.8SerLys: 3.8 ± 0.031	6.86SerLeu: 6.86 ± 0.051	1.792SerMet: 1.792 ± 0.024	3.035SerAsn: 3.035 ± 0.031	5.635SerPro: 5.635 ± 0.056	3.189SerGln: 3.189 ± 0.033	4.833SerArg: 4.833 ± 0.047	8.436SerSer: 8.436 ± 0.079	5.729SerThr: 5.729 ± 0.046	4.419SerVal: 4.419 ± 0.04	1.04SerTrp: 1.04 ± 0.017	2.131SerTyr: 2.131 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.448ThrAla: 5.448 ± 0.044	0.811ThrCys: 0.811 ± 0.016	2.891ThrAsp: 2.891 ± 0.028	3.1ThrGlu: 3.1 ± 0.032	2.287ThrPhe: 2.287 ± 0.024	4.079ThrGly: 4.079 ± 0.041	1.462ThrHis: 1.462 ± 0.017	3.106ThrIle: 3.106 ± 0.028	2.865ThrLys: 2.865 ± 0.028	5.373ThrLeu: 5.373 ± 0.038	1.448ThrMet: 1.448 ± 0.019	2.3ThrAsn: 2.3 ± 0.024	4.885ThrPro: 4.885 ± 0.046	2.295ThrGln: 2.295 ± 0.023	3.278ThrArg: 3.278 ± 0.031	5.526ThrSer: 5.526 ± 0.044	4.778ThrThr: 4.778 ± 0.049	3.709ThrVal: 3.709 ± 0.039	0.885ThrTrp: 0.885 ± 0.014	1.701ThrTyr: 1.701 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.306ValAla: 5.306 ± 0.046	0.816ValCys: 0.816 ± 0.017	3.639ValAsp: 3.639 ± 0.029	3.926ValGlu: 3.926 ± 0.041	2.3ValPhe: 2.3 ± 0.026	4.068ValGly: 4.068 ± 0.041	1.459ValHis: 1.459 ± 0.021	2.755ValIle: 2.755 ± 0.028	3.018ValLys: 3.018 ± 0.031	5.364ValLeu: 5.364 ± 0.038	1.368ValMet: 1.368 ± 0.019	2.195ValAsn: 2.195 ± 0.021	3.614ValPro: 3.614 ± 0.034	2.483ValGln: 2.483 ± 0.024	3.372ValArg: 3.372 ± 0.03	4.423ValSer: 4.423 ± 0.038	3.527ValThr: 3.527 ± 0.031	4.249ValVal: 4.249 ± 0.038	0.863ValTrp: 0.863 ± 0.014	1.726ValTyr: 1.726 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.016	0.21TrpCys: 0.21 ± 0.008	0.882TrpAsp: 0.882 ± 0.016	0.834TrpGlu: 0.834 ± 0.015	0.529TrpPhe: 0.529 ± 0.012	0.919TrpGly: 0.919 ± 0.017	0.364TrpHis: 0.364 ± 0.01	0.737TrpIle: 0.737 ± 0.016	0.806TrpLys: 0.806 ± 0.012	1.276TrpLeu: 1.276 ± 0.017	0.372TrpMet: 0.372 ± 0.009	0.643TrpAsn: 0.643 ± 0.014	0.597TrpPro: 0.597 ± 0.013	0.575TrpGln: 0.575 ± 0.011	0.932TrpArg: 0.932 ± 0.015	1.027TrpSer: 1.027 ± 0.016	0.904TrpThr: 0.904 ± 0.016	0.879TrpVal: 0.879 ± 0.016	0.278TrpTrp: 0.278 ± 0.01	0.427TrpTyr: 0.427 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.025	0.425TyrCys: 0.425 ± 0.01	1.675TyrAsp: 1.675 ± 0.02	1.578TyrGlu: 1.578 ± 0.023	1.173TyrPhe: 1.173 ± 0.017	1.996TyrGly: 1.996 ± 0.026	0.762TyrHis: 0.762 ± 0.014	1.406TyrIle: 1.406 ± 0.019	1.223TyrLys: 1.223 ± 0.017	2.577TyrLeu: 2.577 ± 0.03	0.704TyrMet: 0.704 ± 0.012	1.213TyrAsn: 1.213 ± 0.018	1.569TyrPro: 1.569 ± 0.024	1.134TyrGln: 1.134 ± 0.018	1.631TyrArg: 1.631 ± 0.023	2.032TyrSer: 2.032 ± 0.026	1.767TyrThr: 1.767 ± 0.023	1.613TyrVal: 1.613 ± 0.019	0.452TyrTrp: 0.452 ± 0.011	0.958TyrTyr: 0.958 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 8702 proteins (4318722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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