Amino acid dipepetide frequency for Steinernema carpocapsae (Entomopathogenic nematode)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.275AlaAla: 6.275 ± 0.035	1.333AlaCys: 1.333 ± 0.014	3.363AlaAsp: 3.363 ± 0.021	4.681AlaGlu: 4.681 ± 0.045	3.18AlaPhe: 3.18 ± 0.018	3.548AlaGly: 3.548 ± 0.023	1.507AlaHis: 1.507 ± 0.016	3.669AlaIle: 3.669 ± 0.017	4.196AlaLys: 4.196 ± 0.023	6.251AlaLeu: 6.251 ± 0.032	1.761AlaMet: 1.761 ± 0.014	2.892AlaAsn: 2.892 ± 0.021	3.807AlaPro: 3.807 ± 0.031	2.688AlaGln: 2.688 ± 0.022	3.595AlaArg: 3.595 ± 0.021	5.817AlaSer: 5.817 ± 0.038	4.121AlaThr: 4.121 ± 0.023	4.809AlaVal: 4.809 ± 0.026	0.667AlaTrp: 0.667 ± 0.008	1.8AlaTyr: 1.8 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.394CysAla: 1.394 ± 0.014	0.686CysCys: 0.686 ± 0.012	1.154CysAsp: 1.154 ± 0.015	1.246CysGlu: 1.246 ± 0.016	1.105CysPhe: 1.105 ± 0.012	1.466CysGly: 1.466 ± 0.018	0.569CysHis: 0.569 ± 0.01	1.016CysIle: 1.016 ± 0.013	1.103CysLys: 1.103 ± 0.014	1.969CysLeu: 1.969 ± 0.015	0.489CysMet: 0.489 ± 0.007	0.879CysAsn: 0.879 ± 0.01	1.264CysPro: 1.264 ± 0.023	0.867CysGln: 0.867 ± 0.013	1.339CysArg: 1.339 ± 0.013	1.856CysSer: 1.856 ± 0.019	1.036CysThr: 1.036 ± 0.011	1.464CysVal: 1.464 ± 0.014	0.251CysTrp: 0.251 ± 0.005	0.666CysTyr: 0.666 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.467AspAla: 3.467 ± 0.024	1.06AspCys: 1.06 ± 0.013	3.451AspAsp: 3.451 ± 0.029	4.105AspGlu: 4.105 ± 0.03	2.493AspPhe: 2.493 ± 0.017	3.226AspGly: 3.226 ± 0.043	1.268AspHis: 1.268 ± 0.013	2.506AspIle: 2.506 ± 0.017	2.677AspLys: 2.677 ± 0.019	4.782AspLeu: 4.782 ± 0.023	1.169AspMet: 1.169 ± 0.01	1.927AspAsn: 1.927 ± 0.017	2.571AspPro: 2.571 ± 0.02	1.946AspGln: 1.946 ± 0.014	3.059AspArg: 3.059 ± 0.02	4.048AspSer: 4.048 ± 0.025	2.117AspThr: 2.117 ± 0.016	3.519AspVal: 3.519 ± 0.021	0.621AspTrp: 0.621 ± 0.008	1.697AspTyr: 1.697 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.881GluAla: 4.881 ± 0.039	1.195GluCys: 1.195 ± 0.015	3.932GluAsp: 3.932 ± 0.025	6.109GluGlu: 6.109 ± 0.095	2.555GluPhe: 2.555 ± 0.018	3.05GluGly: 3.05 ± 0.02	1.453GluHis: 1.453 ± 0.012	3.491GluIle: 3.491 ± 0.024	4.863GluLys: 4.863 ± 0.085	5.208GluLeu: 5.208 ± 0.03	1.797GluMet: 1.797 ± 0.016	3.226GluAsn: 3.226 ± 0.02	2.815GluPro: 2.815 ± 0.057	2.521GluGln: 2.521 ± 0.019	3.962GluArg: 3.962 ± 0.028	4.389GluSer: 4.389 ± 0.029	3.383GluThr: 3.383 ± 0.021	3.775GluVal: 3.775 ± 0.038	0.698GluTrp: 0.698 ± 0.008	1.647GluTyr: 1.647 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.247PheAla: 3.247 ± 0.018	1.266PheCys: 1.266 ± 0.014	2.55PheAsp: 2.55 ± 0.018	2.796PheGlu: 2.796 ± 0.031	2.346PhePhe: 2.346 ± 0.017	3.051PheGly: 3.051 ± 0.021	1.139PheHis: 1.139 ± 0.012	2.255PheIle: 2.255 ± 0.017	2.211PheLys: 2.211 ± 0.017	4.41PheLeu: 4.41 ± 0.025	1.108PheMet: 1.108 ± 0.01	1.899PheAsn: 1.899 ± 0.013	2.028PhePro: 2.028 ± 0.02	1.682PheGln: 1.682 ± 0.013	2.49PheArg: 2.49 ± 0.016	3.561PheSer: 3.561 ± 0.021	2.324PheThr: 2.324 ± 0.016	3.385PheVal: 3.385 ± 0.02	0.624PheTrp: 0.624 ± 0.007	1.567PheTyr: 1.567 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.566GlyAla: 3.566 ± 0.026	1.188GlyCys: 1.188 ± 0.015	2.844GlyAsp: 2.844 ± 0.023	3.199GlyGlu: 3.199 ± 0.025	2.757GlyPhe: 2.757 ± 0.02	4.028GlyGly: 4.028 ± 0.048	1.43GlyHis: 1.43 ± 0.013	2.981GlyIle: 2.981 ± 0.018	3.18GlyLys: 3.18 ± 0.027	4.341GlyLeu: 4.341 ± 0.026	1.296GlyMet: 1.296 ± 0.014	2.529GlyAsn: 2.529 ± 0.023	2.514GlyPro: 2.514 ± 0.036	2.129GlyGln: 2.129 ± 0.02	3.454GlyArg: 3.454 ± 0.024	4.73GlySer: 4.73 ± 0.043	3.02GlyThr: 3.02 ± 0.02	3.412GlyVal: 3.412 ± 0.023	0.639GlyTrp: 0.639 ± 0.007	1.892GlyTyr: 1.892 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.411HisAla: 1.411 ± 0.017	0.588HisCys: 0.588 ± 0.009	1.128HisAsp: 1.128 ± 0.01	1.371HisGlu: 1.371 ± 0.012	1.315HisPhe: 1.315 ± 0.016	1.407HisGly: 1.407 ± 0.016	0.846HisHis: 0.846 ± 0.013	1.212HisIle: 1.212 ± 0.01	1.233HisLys: 1.233 ± 0.011	2.383HisLeu: 2.383 ± 0.017	0.583HisMet: 0.583 ± 0.007	0.999HisAsn: 0.999 ± 0.01	1.333HisPro: 1.333 ± 0.017	1.003HisGln: 1.003 ± 0.01	1.642HisArg: 1.642 ± 0.014	1.885HisSer: 1.885 ± 0.016	1.054HisThr: 1.054 ± 0.011	1.604HisVal: 1.604 ± 0.02	0.285HisTrp: 0.285 ± 0.005	0.779HisTyr: 0.779 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.765IleAla: 3.765 ± 0.019	1.327IleCys: 1.327 ± 0.014	2.91IleAsp: 2.91 ± 0.022	3.194IleGlu: 3.194 ± 0.022	2.465IlePhe: 2.465 ± 0.016	2.948IleGly: 2.948 ± 0.018	1.282IleHis: 1.282 ± 0.011	2.555IleIle: 2.555 ± 0.02	2.525IleLys: 2.525 ± 0.016	4.736IleLeu: 4.736 ± 0.023	1.184IleMet: 1.184 ± 0.012	2.119IleAsn: 2.119 ± 0.014	2.768IlePro: 2.768 ± 0.018	2.006IleGln: 2.006 ± 0.014	3.029IleArg: 3.029 ± 0.018	4.268IleSer: 4.268 ± 0.024	2.752IleThr: 2.752 ± 0.016	3.677IleVal: 3.677 ± 0.022	0.611IleTrp: 0.611 ± 0.007	1.664IleTyr: 1.664 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.951LysAla: 3.951 ± 0.025	1.276LysCys: 1.276 ± 0.016	2.914LysAsp: 2.914 ± 0.02	4.246LysGlu: 4.246 ± 0.044	2.219LysPhe: 2.219 ± 0.015	2.569LysGly: 2.569 ± 0.017	1.371LysHis: 1.371 ± 0.012	3.289LysIle: 3.289 ± 0.019	5.116LysLys: 5.116 ± 0.061	5.028LysLeu: 5.028 ± 0.033	1.674LysMet: 1.674 ± 0.011	2.971LysAsn: 2.971 ± 0.019	3.224LysPro: 3.224 ± 0.049	2.306LysGln: 2.306 ± 0.018	4.118LysArg: 4.118 ± 0.024	4.262LysSer: 4.262 ± 0.033	3.832LysThr: 3.832 ± 0.03	3.396LysVal: 3.396 ± 0.036	0.725LysTrp: 0.725 ± 0.008	1.578LysTyr: 1.578 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.098LeuAla: 6.098 ± 0.025	1.963LeuCys: 1.963 ± 0.016	4.301LeuAsp: 4.301 ± 0.025	5.414LeuGlu: 5.414 ± 0.031	4.316LeuPhe: 4.316 ± 0.026	4.394LeuGly: 4.394 ± 0.028	2.218LeuHis: 2.218 ± 0.017	4.737LeuIle: 4.737 ± 0.023	5.75LeuLys: 5.75 ± 0.042	8.988LeuLeu: 8.988 ± 0.041	2.209LeuMet: 2.209 ± 0.015	3.989LeuAsn: 3.989 ± 0.021	4.757LeuPro: 4.757 ± 0.046	3.786LeuGln: 3.786 ± 0.024	5.682LeuArg: 5.682 ± 0.028	6.9LeuSer: 6.9 ± 0.03	4.821LeuThr: 4.821 ± 0.025	5.405LeuVal: 5.405 ± 0.024	1.012LeuTrp: 1.012 ± 0.01	2.393LeuTyr: 2.393 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.882MetAla: 1.882 ± 0.014	0.533MetCys: 0.533 ± 0.006	1.393MetAsp: 1.393 ± 0.013	1.608MetGlu: 1.608 ± 0.012	1.097MetPhe: 1.097 ± 0.01	1.21MetGly: 1.21 ± 0.013	0.549MetHis: 0.549 ± 0.007	1.291MetIle: 1.291 ± 0.012	1.59MetLys: 1.59 ± 0.013	2.137MetLeu: 2.137 ± 0.015	0.714MetMet: 0.714 ± 0.009	1.167MetAsn: 1.167 ± 0.01	1.231MetPro: 1.231 ± 0.012	0.974MetGln: 0.974 ± 0.011	1.488MetArg: 1.488 ± 0.012	1.987MetSer: 1.987 ± 0.017	1.556MetThr: 1.556 ± 0.013	1.484MetVal: 1.484 ± 0.012	0.295MetTrp: 0.295 ± 0.005	0.618MetTyr: 0.618 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.164AsnAla: 3.164 ± 0.019	1.018AsnCys: 1.018 ± 0.012	2.299AsnAsp: 2.299 ± 0.018	2.782AsnGlu: 2.782 ± 0.017	1.997AsnPhe: 1.997 ± 0.014	3.193AsnGly: 3.193 ± 0.027	1.025AsnHis: 1.025 ± 0.009	2.142AsnIle: 2.142 ± 0.016	2.138AsnLys: 2.138 ± 0.015	3.901AsnLeu: 3.901 ± 0.022	1.048AsnMet: 1.048 ± 0.011	1.863AsnAsn: 1.863 ± 0.016	2.41AsnPro: 2.41 ± 0.018	1.656AsnGln: 1.656 ± 0.017	2.623AsnArg: 2.623 ± 0.018	3.451AsnSer: 3.451 ± 0.024	2.018AsnThr: 2.018 ± 0.016	3.175AsnVal: 3.175 ± 0.022	0.529AsnTrp: 0.529 ± 0.008	1.36AsnTyr: 1.36 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	3.605ProAla: 3.605 ± 0.029	0.88ProCys: 0.88 ± 0.012	2.501ProAsp: 2.501 ± 0.042	3.677ProGlu: 3.677 ± 0.064	2.104ProPhe: 2.104 ± 0.017	2.924ProGly: 2.924 ± 0.052	1.17ProHis: 1.17 ± 0.015	2.48ProIle: 2.48 ± 0.02	3.363ProLys: 3.363 ± 0.048	4.26ProLeu: 4.26 ± 0.037	1.211ProMet: 1.211 ± 0.013	2.294ProAsn: 2.294 ± 0.019	4.031ProPro: 4.031 ± 0.042	2.23ProGln: 2.23 ± 0.023	2.968ProArg: 2.968 ± 0.023	4.793ProSer: 4.793 ± 0.035	3.398ProThr: 3.398 ± 0.038	3.424ProVal: 3.424 ± 0.03	0.479ProTrp: 0.479 ± 0.007	1.366ProTyr: 1.366 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	2.566GlnAla: 2.566 ± 0.02	0.834GlnCys: 0.834 ± 0.014	1.584GlnAsp: 1.584 ± 0.013	2.399GlnGlu: 2.399 ± 0.022	1.719GlnPhe: 1.719 ± 0.012	1.82GlnGly: 1.82 ± 0.013	0.984GlnHis: 0.984 ± 0.009	2.264GlnIle: 2.264 ± 0.016	2.739GlnLys: 2.739 ± 0.017	3.783GlnLeu: 3.783 ± 0.024	1.26GlnMet: 1.26 ± 0.014	2.033GlnAsn: 2.033 ± 0.016	2.19GlnPro: 2.19 ± 0.029	2.417GlnGln: 2.417 ± 0.036	2.621GlnArg: 2.621 ± 0.016	2.727GlnSer: 2.727 ± 0.018	2.099GlnThr: 2.099 ± 0.017	2.173GlnVal: 2.173 ± 0.016	0.446GlnTrp: 0.446 ± 0.007	1.049GlnTyr: 1.049 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	3.513ArgAla: 3.513 ± 0.02	1.356ArgCys: 1.356 ± 0.016	2.712ArgAsp: 2.712 ± 0.018	3.53ArgGlu: 3.53 ± 0.02	2.876ArgPhe: 2.876 ± 0.019	2.915ArgGly: 2.915 ± 0.024	1.574ArgHis: 1.574 ± 0.013	3.287ArgIle: 3.287 ± 0.018	4.068ArgLys: 4.068 ± 0.02	5.501ArgLeu: 5.501 ± 0.025	1.518ArgMet: 1.518 ± 0.012	2.823ArgAsn: 2.823 ± 0.021	3.115ArgPro: 3.115 ± 0.026	2.488ArgGln: 2.488 ± 0.018	5.544ArgArg: 5.544 ± 0.032	5.308ArgSer: 5.308 ± 0.029	3.295ArgThr: 3.295 ± 0.021	3.347ArgVal: 3.347 ± 0.018	0.69ArgTrp: 0.69 ± 0.009	1.653ArgTyr: 1.653 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	5.806SerAla: 5.806 ± 0.026	1.677SerCys: 1.677 ± 0.017	4.094SerAsp: 4.094 ± 0.024	4.846SerGlu: 4.846 ± 0.06	3.585SerPhe: 3.585 ± 0.024	4.749SerGly: 4.749 ± 0.03	1.827SerHis: 1.827 ± 0.016	3.912SerIle: 3.912 ± 0.025	4.472SerLys: 4.472 ± 0.026	6.873SerLeu: 6.873 ± 0.034	1.861SerMet: 1.861 ± 0.014	3.318SerAsn: 3.318 ± 0.021	4.496SerPro: 4.496 ± 0.034	3.048SerGln: 3.048 ± 0.021	4.742SerArg: 4.742 ± 0.025	8.718SerSer: 8.718 ± 0.066	5.506SerThr: 5.506 ± 0.097	5.17SerVal: 5.17 ± 0.027	0.863SerTrp: 0.863 ± 0.009	2.121SerTyr: 2.121 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	4.07ThrAla: 4.07 ± 0.032	1.235ThrCys: 1.235 ± 0.016	2.727ThrAsp: 2.727 ± 0.034	3.279ThrGlu: 3.279 ± 0.023	2.55ThrPhe: 2.55 ± 0.021	2.937ThrGly: 2.937 ± 0.025	1.224ThrHis: 1.224 ± 0.011	3.084ThrIle: 3.084 ± 0.018	2.983ThrLys: 2.983 ± 0.019	4.986ThrLeu: 4.986 ± 0.032	1.337ThrMet: 1.337 ± 0.011	2.197ThrAsn: 2.197 ± 0.017	3.343ThrPro: 3.343 ± 0.025	1.996ThrGln: 1.996 ± 0.015	2.865ThrArg: 2.865 ± 0.018	5.166ThrSer: 5.166 ± 0.081	4.499ThrThr: 4.499 ± 0.131	4.046ThrVal: 4.046 ± 0.037	0.602ThrTrp: 0.602 ± 0.007	1.503ThrTyr: 1.503 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.792ValAla: 4.792 ± 0.026	1.458ValCys: 1.458 ± 0.015	3.677ValAsp: 3.677 ± 0.022	4.177ValGlu: 4.177 ± 0.038	3.302ValPhe: 3.302 ± 0.019	3.284ValGly: 3.284 ± 0.02	1.618ValHis: 1.618 ± 0.02	3.488ValIle: 3.488 ± 0.02	3.555ValLys: 3.555 ± 0.022	5.949ValLeu: 5.949 ± 0.026	1.504ValMet: 1.504 ± 0.014	2.727ValAsn: 2.727 ± 0.019	3.423ValPro: 3.423 ± 0.031	2.458ValGln: 2.458 ± 0.017	3.388ValArg: 3.388 ± 0.018	4.83ValSer: 4.83 ± 0.025	3.651ValThr: 3.651 ± 0.03	4.844ValVal: 4.844 ± 0.027	0.713ValTrp: 0.713 ± 0.009	1.851ValTyr: 1.851 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.628TrpAla: 0.628 ± 0.008	0.224TrpCys: 0.224 ± 0.005	0.539TrpAsp: 0.539 ± 0.008	0.576TrpGlu: 0.576 ± 0.009	0.535TrpPhe: 0.535 ± 0.007	0.466TrpGly: 0.466 ± 0.007	0.26TrpHis: 0.26 ± 0.005	0.774TrpIle: 0.774 ± 0.009	0.81TrpLys: 0.81 ± 0.009	1.026TrpLeu: 1.026 ± 0.012	0.355TrpMet: 0.355 ± 0.006	0.673TrpAsn: 0.673 ± 0.008	0.491TrpPro: 0.491 ± 0.006	0.417TrpGln: 0.417 ± 0.007	0.737TrpArg: 0.737 ± 0.009	0.91TrpSer: 0.91 ± 0.011	0.759TrpThr: 0.759 ± 0.008	0.612TrpVal: 0.612 ± 0.007	0.165TrpTrp: 0.165 ± 0.004	0.322TrpTyr: 0.322 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.88TyrAla: 1.88 ± 0.02	0.723TyrCys: 0.723 ± 0.01	1.636TyrAsp: 1.636 ± 0.015	1.715TyrGlu: 1.715 ± 0.015	1.421TyrPhe: 1.421 ± 0.011	1.943TyrGly: 1.943 ± 0.017	0.749TyrHis: 0.749 ± 0.008	1.35TyrIle: 1.35 ± 0.012	1.493TyrLys: 1.493 ± 0.011	2.621TyrLeu: 2.621 ± 0.016	0.726TyrMet: 0.726 ± 0.008	1.268TyrAsn: 1.268 ± 0.013	1.346TyrPro: 1.346 ± 0.018	1.091TyrGln: 1.091 ± 0.011	1.764TyrArg: 1.764 ± 0.013	2.077TyrSer: 2.077 ± 0.017	1.389TyrThr: 1.389 ± 0.014	1.968TyrVal: 1.968 ± 0.015	0.365TyrTrp: 0.365 ± 0.006	1.069TyrTyr: 1.069 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 36344 proteins (11325030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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