Amino acid dipepetide frequency for Paracoccus phage vB_PkoS_Pkon1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.281AlaAla: 20.281 ± 1.453
1.074AlaCys: 1.074 ± 0.358
8.797AlaAsp: 8.797 ± 1.003
10.61AlaGlu: 10.61 ± 1.388
3.761AlaPhe: 3.761 ± 0.527
10.879AlaGly: 10.879 ± 1.772
2.216AlaHis: 2.216 ± 0.409
8.26AlaIle: 8.26 ± 1.447
6.783AlaLys: 6.783 ± 0.63
13.431AlaLeu: 13.431 ± 1.057
3.492AlaMet: 3.492 ± 0.477
4.701AlaAsn: 4.701 ± 0.88
4.432AlaPro: 4.432 ± 0.452
4.902AlaGln: 4.902 ± 0.534
8.394AlaArg: 8.394 ± 1.031
5.842AlaSer: 5.842 ± 0.448
6.245AlaThr: 6.245 ± 0.639
9.737AlaVal: 9.737 ± 1.029
1.813AlaTrp: 1.813 ± 0.333
3.559AlaTyr: 3.559 ± 0.539
0.0AlaXaa: 0.0 ± 0.0
Cys
1.41CysAla: 1.41 ± 0.408
0.067CysCys: 0.067 ± 0.076
0.739CysAsp: 0.739 ± 0.193
0.739CysGlu: 0.739 ± 0.28
0.134CysPhe: 0.134 ± 0.091
0.403CysGly: 0.403 ± 0.14
0.067CysHis: 0.067 ± 0.066
0.47CysIle: 0.47 ± 0.217
0.134CysLys: 0.134 ± 0.098
0.672CysLeu: 0.672 ± 0.21
0.067CysMet: 0.067 ± 0.065
0.403CysAsn: 0.403 ± 0.168
0.47CysPro: 0.47 ± 0.206
0.134CysGln: 0.134 ± 0.099
1.142CysArg: 1.142 ± 0.297
0.269CysSer: 0.269 ± 0.129
0.134CysThr: 0.134 ± 0.091
0.604CysVal: 0.604 ± 0.207
0.201CysTrp: 0.201 ± 0.129
0.336CysTyr: 0.336 ± 0.129
0.0CysXaa: 0.0 ± 0.0
Asp
9.2AspAla: 9.2 ± 0.681
0.47AspCys: 0.47 ± 0.186
4.298AspAsp: 4.298 ± 0.582
3.962AspGlu: 3.962 ± 0.6
1.947AspPhe: 1.947 ± 0.453
6.715AspGly: 6.715 ± 0.999
1.276AspHis: 1.276 ± 0.361
2.955AspIle: 2.955 ± 0.481
2.082AspLys: 2.082 ± 0.376
5.91AspLeu: 5.91 ± 0.961
2.082AspMet: 2.082 ± 0.338
1.209AspAsn: 1.209 ± 0.243
4.096AspPro: 4.096 ± 0.45
2.485AspGln: 2.485 ± 0.415
4.969AspArg: 4.969 ± 0.652
1.679AspSer: 1.679 ± 0.29
2.418AspThr: 2.418 ± 0.358
2.35AspVal: 2.35 ± 0.333
1.209AspTrp: 1.209 ± 0.35
1.88AspTyr: 1.88 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
10.342GluAla: 10.342 ± 0.992
0.537GluCys: 0.537 ± 0.169
3.626GluAsp: 3.626 ± 0.649
3.089GluGlu: 3.089 ± 0.43
1.276GluPhe: 1.276 ± 0.276
4.499GluGly: 4.499 ± 0.561
0.873GluHis: 0.873 ± 0.228
3.492GluIle: 3.492 ± 0.564
2.485GluLys: 2.485 ± 0.394
5.574GluLeu: 5.574 ± 0.78
1.679GluMet: 1.679 ± 0.303
1.679GluAsn: 1.679 ± 0.343
2.418GluPro: 2.418 ± 0.429
2.686GluGln: 2.686 ± 0.46
5.507GluArg: 5.507 ± 0.886
2.283GluSer: 2.283 ± 0.445
3.828GluThr: 3.828 ± 0.5
3.694GluVal: 3.694 ± 0.533
1.612GluTrp: 1.612 ± 0.404
1.88GluTyr: 1.88 ± 0.345
0.0GluXaa: 0.0 ± 0.0
Phe
2.82PheAla: 2.82 ± 0.37
0.806PheCys: 0.806 ± 0.292
2.283PheAsp: 2.283 ± 0.341
1.746PheGlu: 1.746 ± 0.26
1.209PhePhe: 1.209 ± 0.315
3.022PheGly: 3.022 ± 0.443
0.47PheHis: 0.47 ± 0.175
1.209PheIle: 1.209 ± 0.318
0.94PheLys: 0.94 ± 0.261
2.149PheLeu: 2.149 ± 0.337
0.537PheMet: 0.537 ± 0.177
0.739PheAsn: 0.739 ± 0.232
0.94PhePro: 0.94 ± 0.281
0.94PheGln: 0.94 ± 0.22
1.41PheArg: 1.41 ± 0.273
2.082PheSer: 2.082 ± 0.344
1.612PheThr: 1.612 ± 0.327
2.149PheVal: 2.149 ± 0.502
0.604PheTrp: 0.604 ± 0.25
0.403PheTyr: 0.403 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
9.805GlyAla: 9.805 ± 1.501
0.336GlyCys: 0.336 ± 0.153
4.432GlyAsp: 4.432 ± 0.475
4.432GlyGlu: 4.432 ± 0.498
3.022GlyPhe: 3.022 ± 0.441
7.924GlyGly: 7.924 ± 0.942
1.142GlyHis: 1.142 ± 0.232
3.962GlyIle: 3.962 ± 0.429
4.298GlyLys: 4.298 ± 0.579
5.574GlyLeu: 5.574 ± 0.832
2.149GlyMet: 2.149 ± 0.405
2.149GlyAsn: 2.149 ± 0.518
2.619GlyPro: 2.619 ± 0.428
3.694GlyGln: 3.694 ± 0.593
5.977GlyArg: 5.977 ± 0.764
4.567GlySer: 4.567 ± 0.515
3.828GlyThr: 3.828 ± 0.598
5.037GlyVal: 5.037 ± 0.563
2.082GlyTrp: 2.082 ± 0.465
1.947GlyTyr: 1.947 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
1.813HisAla: 1.813 ± 0.395
0.0HisCys: 0.0 ± 0.0
0.94HisAsp: 0.94 ± 0.292
0.739HisGlu: 0.739 ± 0.235
0.806HisPhe: 0.806 ± 0.22
1.477HisGly: 1.477 ± 0.327
0.537HisHis: 0.537 ± 0.19
1.074HisIle: 1.074 ± 0.283
0.94HisLys: 0.94 ± 0.297
1.343HisLeu: 1.343 ± 0.354
0.604HisMet: 0.604 ± 0.223
0.403HisAsn: 0.403 ± 0.176
1.142HisPro: 1.142 ± 0.34
0.672HisGln: 0.672 ± 0.196
1.477HisArg: 1.477 ± 0.373
0.873HisSer: 0.873 ± 0.25
1.074HisThr: 1.074 ± 0.229
1.074HisVal: 1.074 ± 0.27
0.403HisTrp: 0.403 ± 0.183
0.269HisTyr: 0.269 ± 0.122
0.0HisXaa: 0.0 ± 0.0
Ile
10.208IleAla: 10.208 ± 1.294
0.672IleCys: 0.672 ± 0.196
3.559IleAsp: 3.559 ± 0.544
4.298IleGlu: 4.298 ± 0.501
0.604IlePhe: 0.604 ± 0.186
4.164IleGly: 4.164 ± 0.414
0.94IleHis: 0.94 ± 0.225
2.149IleIle: 2.149 ± 0.4
2.35IleLys: 2.35 ± 0.382
3.223IleLeu: 3.223 ± 0.486
0.873IleMet: 0.873 ± 0.215
1.477IleAsn: 1.477 ± 0.291
2.283IlePro: 2.283 ± 0.334
1.679IleGln: 1.679 ± 0.3
3.358IleArg: 3.358 ± 0.456
2.888IleSer: 2.888 ± 0.492
4.164IleThr: 4.164 ± 0.838
4.096IleVal: 4.096 ± 0.613
0.94IleTrp: 0.94 ± 0.211
1.343IleTyr: 1.343 ± 0.285
0.0IleXaa: 0.0 ± 0.0
Lys
5.977LysAla: 5.977 ± 0.864
0.336LysCys: 0.336 ± 0.135
2.216LysAsp: 2.216 ± 0.407
1.545LysGlu: 1.545 ± 0.335
1.007LysPhe: 1.007 ± 0.251
3.291LysGly: 3.291 ± 0.707
1.142LysHis: 1.142 ± 0.285
3.425LysIle: 3.425 ± 1.128
1.477LysLys: 1.477 ± 0.511
4.365LysLeu: 4.365 ± 0.539
1.209LysMet: 1.209 ± 0.241
0.537LysAsn: 0.537 ± 0.155
1.947LysPro: 1.947 ± 0.328
1.074LysGln: 1.074 ± 0.293
2.955LysArg: 2.955 ± 0.45
2.552LysSer: 2.552 ± 0.336
1.88LysThr: 1.88 ± 0.429
2.485LysVal: 2.485 ± 0.394
1.276LysTrp: 1.276 ± 0.272
0.94LysTyr: 0.94 ± 0.244
0.0LysXaa: 0.0 ± 0.0
Leu
12.356LeuAla: 12.356 ± 0.723
1.074LeuCys: 1.074 ± 0.31
5.171LeuAsp: 5.171 ± 0.72
4.567LeuGlu: 4.567 ± 0.711
2.015LeuPhe: 2.015 ± 0.307
4.701LeuGly: 4.701 ± 0.547
1.746LeuHis: 1.746 ± 0.363
4.634LeuIle: 4.634 ± 0.527
3.223LeuLys: 3.223 ± 0.498
6.044LeuLeu: 6.044 ± 0.75
2.015LeuMet: 2.015 ± 0.325
2.283LeuAsn: 2.283 ± 0.339
5.305LeuPro: 5.305 ± 0.509
1.612LeuGln: 1.612 ± 0.335
7.253LeuArg: 7.253 ± 0.664
6.245LeuSer: 6.245 ± 0.542
5.104LeuThr: 5.104 ± 0.575
4.365LeuVal: 4.365 ± 0.484
0.806LeuTrp: 0.806 ± 0.231
1.612LeuTyr: 1.612 ± 0.389
0.0LeuXaa: 0.0 ± 0.0
Met
3.291MetAla: 3.291 ± 0.474
0.067MetCys: 0.067 ± 0.061
1.209MetAsp: 1.209 ± 0.312
1.612MetGlu: 1.612 ± 0.329
0.604MetPhe: 0.604 ± 0.174
1.343MetGly: 1.343 ± 0.37
0.403MetHis: 0.403 ± 0.196
0.94MetIle: 0.94 ± 0.282
0.806MetLys: 0.806 ± 0.234
1.88MetLeu: 1.88 ± 0.325
0.403MetMet: 0.403 ± 0.182
1.074MetAsn: 1.074 ± 0.231
1.477MetPro: 1.477 ± 0.341
0.537MetGln: 0.537 ± 0.164
2.283MetArg: 2.283 ± 0.463
2.082MetSer: 2.082 ± 0.376
2.888MetThr: 2.888 ± 0.384
1.074MetVal: 1.074 ± 0.235
0.201MetTrp: 0.201 ± 0.138
0.269MetTyr: 0.269 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
4.365AsnAla: 4.365 ± 0.75
0.134AsnCys: 0.134 ± 0.097
1.813AsnAsp: 1.813 ± 0.332
1.343AsnGlu: 1.343 ± 0.368
0.537AsnPhe: 0.537 ± 0.165
2.753AsnGly: 2.753 ± 0.387
0.269AsnHis: 0.269 ± 0.136
1.88AsnIle: 1.88 ± 0.485
1.007AsnLys: 1.007 ± 0.196
2.283AsnLeu: 2.283 ± 0.325
0.537AsnMet: 0.537 ± 0.202
0.672AsnAsn: 0.672 ± 0.173
1.276AsnPro: 1.276 ± 0.281
0.873AsnGln: 0.873 ± 0.276
2.888AsnArg: 2.888 ± 0.382
1.545AsnSer: 1.545 ± 0.299
1.276AsnThr: 1.276 ± 0.337
1.545AsnVal: 1.545 ± 0.307
0.672AsnTrp: 0.672 ± 0.214
0.336AsnTyr: 0.336 ± 0.151
0.0AsnXaa: 0.0 ± 0.0
Pro
6.447ProAla: 6.447 ± 0.65
0.537ProCys: 0.537 ± 0.225
3.761ProAsp: 3.761 ± 0.501
4.701ProGlu: 4.701 ± 0.64
1.545ProPhe: 1.545 ± 0.334
3.694ProGly: 3.694 ± 0.462
0.739ProHis: 0.739 ± 0.21
2.149ProIle: 2.149 ± 0.389
1.746ProLys: 1.746 ± 0.384
3.358ProLeu: 3.358 ± 0.437
1.007ProMet: 1.007 ± 0.216
1.41ProAsn: 1.41 ± 0.256
2.418ProPro: 2.418 ± 0.612
1.679ProGln: 1.679 ± 0.328
2.753ProArg: 2.753 ± 0.493
2.35ProSer: 2.35 ± 0.46
1.813ProThr: 1.813 ± 0.387
3.626ProVal: 3.626 ± 0.534
0.94ProTrp: 0.94 ± 0.241
1.074ProTyr: 1.074 ± 0.266
0.0ProXaa: 0.0 ± 0.0
Gln
4.365GlnAla: 4.365 ± 0.622
0.336GlnCys: 0.336 ± 0.149
1.813GlnAsp: 1.813 ± 0.427
1.41GlnGlu: 1.41 ± 0.339
1.41GlnPhe: 1.41 ± 0.304
2.082GlnGly: 2.082 ± 0.352
0.47GlnHis: 0.47 ± 0.159
3.358GlnIle: 3.358 ± 0.531
1.88GlnLys: 1.88 ± 0.356
3.089GlnLeu: 3.089 ± 0.449
1.545GlnMet: 1.545 ± 0.339
1.074GlnAsn: 1.074 ± 0.247
1.679GlnPro: 1.679 ± 0.34
2.082GlnGln: 2.082 ± 0.433
2.283GlnArg: 2.283 ± 0.397
1.88GlnSer: 1.88 ± 0.367
1.746GlnThr: 1.746 ± 0.372
1.947GlnVal: 1.947 ± 0.337
0.604GlnTrp: 0.604 ± 0.229
0.604GlnTyr: 0.604 ± 0.174
0.0GlnXaa: 0.0 ± 0.0
Arg
9.939ArgAla: 9.939 ± 1.058
0.873ArgCys: 0.873 ± 0.248
4.164ArgAsp: 4.164 ± 0.58
4.499ArgGlu: 4.499 ± 0.76
2.418ArgPhe: 2.418 ± 0.362
4.701ArgGly: 4.701 ± 0.682
1.612ArgHis: 1.612 ± 0.356
3.559ArgIle: 3.559 ± 0.569
3.626ArgLys: 3.626 ± 0.587
6.313ArgLeu: 6.313 ± 0.652
1.679ArgMet: 1.679 ± 0.361
2.552ArgAsn: 2.552 ± 0.4
4.029ArgPro: 4.029 ± 0.524
3.022ArgGln: 3.022 ± 0.634
5.238ArgArg: 5.238 ± 0.831
4.164ArgSer: 4.164 ± 0.698
3.626ArgThr: 3.626 ± 0.439
3.828ArgVal: 3.828 ± 0.503
1.679ArgTrp: 1.679 ± 0.4
1.813ArgTyr: 1.813 ± 0.318
0.0ArgXaa: 0.0 ± 0.0
Ser
6.917SerAla: 6.917 ± 0.892
0.47SerCys: 0.47 ± 0.153
3.425SerAsp: 3.425 ± 0.509
4.164SerGlu: 4.164 ± 0.506
1.276SerPhe: 1.276 ± 0.268
5.507SerGly: 5.507 ± 0.683
1.209SerHis: 1.209 ± 0.365
3.492SerIle: 3.492 ± 0.441
1.612SerLys: 1.612 ± 0.307
4.231SerLeu: 4.231 ± 0.484
1.612SerMet: 1.612 ± 0.407
1.813SerAsn: 1.813 ± 0.519
2.35SerPro: 2.35 ± 0.382
2.149SerGln: 2.149 ± 0.341
3.492SerArg: 3.492 ± 0.636
3.022SerSer: 3.022 ± 0.467
2.552SerThr: 2.552 ± 0.476
3.022SerVal: 3.022 ± 0.573
0.672SerTrp: 0.672 ± 0.222
1.813SerTyr: 1.813 ± 0.428
0.0SerXaa: 0.0 ± 0.0
Thr
8.059ThrAla: 8.059 ± 1.123
0.067ThrCys: 0.067 ± 0.055
3.358ThrAsp: 3.358 ± 0.409
3.022ThrGlu: 3.022 ± 0.431
1.746ThrPhe: 1.746 ± 0.3
5.574ThrGly: 5.574 ± 0.632
0.873ThrHis: 0.873 ± 0.228
2.619ThrIle: 2.619 ± 0.444
2.216ThrLys: 2.216 ± 0.403
4.432ThrLeu: 4.432 ± 0.529
0.873ThrMet: 0.873 ± 0.232
1.007ThrAsn: 1.007 ± 0.276
3.828ThrPro: 3.828 ± 0.515
1.813ThrGln: 1.813 ± 0.317
3.156ThrArg: 3.156 ± 0.411
3.761ThrSer: 3.761 ± 0.711
3.089ThrThr: 3.089 ± 0.675
4.164ThrVal: 4.164 ± 0.506
0.873ThrTrp: 0.873 ± 0.218
1.209ThrTyr: 1.209 ± 0.27
0.0ThrXaa: 0.0 ± 0.0
Val
6.85ValAla: 6.85 ± 0.656
0.403ValCys: 0.403 ± 0.18
4.096ValAsp: 4.096 ± 0.488
3.761ValGlu: 3.761 ± 0.389
1.477ValPhe: 1.477 ± 0.372
3.828ValGly: 3.828 ± 0.629
0.806ValHis: 0.806 ± 0.246
3.828ValIle: 3.828 ± 0.528
2.552ValLys: 2.552 ± 0.397
4.634ValLeu: 4.634 ± 0.471
1.209ValMet: 1.209 ± 0.214
1.88ValAsn: 1.88 ± 0.32
2.753ValPro: 2.753 ± 0.437
2.552ValGln: 2.552 ± 0.518
4.701ValArg: 4.701 ± 0.712
4.567ValSer: 4.567 ± 0.671
5.305ValThr: 5.305 ± 1.19
3.291ValVal: 3.291 ± 0.503
1.074ValTrp: 1.074 ± 0.388
1.276ValTyr: 1.276 ± 0.245
0.0ValXaa: 0.0 ± 0.0
Trp
1.612TrpAla: 1.612 ± 0.271
0.134TrpCys: 0.134 ± 0.096
1.545TrpAsp: 1.545 ± 0.32
1.209TrpGlu: 1.209 ± 0.306
0.672TrpPhe: 0.672 ± 0.187
1.142TrpGly: 1.142 ± 0.316
0.47TrpHis: 0.47 ± 0.197
0.873TrpIle: 0.873 ± 0.208
0.604TrpLys: 0.604 ± 0.214
1.142TrpLeu: 1.142 ± 0.298
0.403TrpMet: 0.403 ± 0.159
0.537TrpAsn: 0.537 ± 0.196
1.343TrpPro: 1.343 ± 0.395
0.604TrpGln: 0.604 ± 0.169
1.545TrpArg: 1.545 ± 0.311
0.806TrpSer: 0.806 ± 0.357
2.082TrpThr: 2.082 ± 0.421
1.209TrpVal: 1.209 ± 0.35
0.201TrpTrp: 0.201 ± 0.11
0.269TrpTyr: 0.269 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.156TyrAla: 3.156 ± 0.422
0.201TyrCys: 0.201 ± 0.099
1.947TyrAsp: 1.947 ± 0.339
1.612TyrGlu: 1.612 ± 0.317
0.604TyrPhe: 0.604 ± 0.189
1.343TyrGly: 1.343 ± 0.342
0.403TyrHis: 0.403 ± 0.159
0.94TyrIle: 0.94 ± 0.205
0.873TyrLys: 0.873 ± 0.254
2.485TyrLeu: 2.485 ± 0.397
0.403TyrMet: 0.403 ± 0.16
0.403TyrAsn: 0.403 ± 0.155
0.94TyrPro: 0.94 ± 0.22
0.47TyrGln: 0.47 ± 0.159
2.552TyrArg: 2.552 ± 0.446
1.343TyrSer: 1.343 ± 0.297
1.074TyrThr: 1.074 ± 0.22
1.545TyrVal: 1.545 ± 0.339
0.537TyrTrp: 0.537 ± 0.157
0.403TyrTyr: 0.403 ± 0.16
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (14892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski