Amino acid dipepetide frequency for Enterobacteria phage VT2-Sa (Bacteriophage VT2-Sa)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.687AlaAla: 8.687 ± 0.88
1.162AlaCys: 1.162 ± 0.334
4.98AlaAsp: 4.98 ± 0.635
7.913AlaGlu: 7.913 ± 0.786
3.541AlaPhe: 3.541 ± 0.617
7.636AlaGly: 7.636 ± 1.305
1.383AlaHis: 1.383 ± 0.317
4.537AlaIle: 4.537 ± 0.558
4.427AlaLys: 4.427 ± 0.463
7.304AlaLeu: 7.304 ± 0.8
3.209AlaMet: 3.209 ± 0.463
3.099AlaAsn: 3.099 ± 0.414
3.375AlaPro: 3.375 ± 0.453
5.367AlaGln: 5.367 ± 0.664
5.699AlaArg: 5.699 ± 0.621
5.644AlaSer: 5.644 ± 0.492
5.589AlaThr: 5.589 ± 0.871
6.419AlaVal: 6.419 ± 0.608
1.881AlaTrp: 1.881 ± 0.375
2.545AlaTyr: 2.545 ± 0.328
0.0AlaXaa: 0.0 ± 0.0
Cys
1.328CysAla: 1.328 ± 0.332
0.387CysCys: 0.387 ± 0.138
0.664CysAsp: 0.664 ± 0.201
0.775CysGlu: 0.775 ± 0.233
0.387CysPhe: 0.387 ± 0.135
0.941CysGly: 0.941 ± 0.309
0.498CysHis: 0.498 ± 0.192
0.609CysIle: 0.609 ± 0.214
0.553CysLys: 0.553 ± 0.223
0.996CysLeu: 0.996 ± 0.278
0.055CysMet: 0.055 ± 0.048
0.277CysAsn: 0.277 ± 0.133
0.498CysPro: 0.498 ± 0.209
0.332CysGln: 0.332 ± 0.141
1.162CysArg: 1.162 ± 0.28
1.162CysSer: 1.162 ± 0.319
0.553CysThr: 0.553 ± 0.2
0.885CysVal: 0.885 ± 0.261
0.166CysTrp: 0.166 ± 0.095
0.221CysTyr: 0.221 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
6.031AspAla: 6.031 ± 0.575
0.775AspCys: 0.775 ± 0.258
4.039AspAsp: 4.039 ± 0.394
4.205AspGlu: 4.205 ± 0.519
1.715AspPhe: 1.715 ± 0.289
4.869AspGly: 4.869 ± 0.52
0.83AspHis: 0.83 ± 0.291
3.431AspIle: 3.431 ± 0.442
4.095AspLys: 4.095 ± 0.416
3.984AspLeu: 3.984 ± 0.442
1.826AspMet: 1.826 ± 0.279
2.711AspAsn: 2.711 ± 0.396
2.601AspPro: 2.601 ± 0.416
1.549AspGln: 1.549 ± 0.312
3.154AspArg: 3.154 ± 0.375
3.541AspSer: 3.541 ± 0.405
2.656AspThr: 2.656 ± 0.421
3.929AspVal: 3.929 ± 0.421
1.107AspTrp: 1.107 ± 0.328
1.771AspTyr: 1.771 ± 0.32
0.0AspXaa: 0.0 ± 0.0
Glu
6.695GluAla: 6.695 ± 0.65
1.107GluCys: 1.107 ± 0.293
2.103GluAsp: 2.103 ± 0.294
3.929GluGlu: 3.929 ± 0.549
2.379GluPhe: 2.379 ± 0.437
3.873GluGly: 3.873 ± 0.586
1.051GluHis: 1.051 ± 0.214
4.039GluIle: 4.039 ± 0.428
4.925GluLys: 4.925 ± 0.73
5.478GluLeu: 5.478 ± 0.581
2.656GluMet: 2.656 ± 0.442
2.933GluAsn: 2.933 ± 0.52
1.937GluPro: 1.937 ± 0.41
4.316GluGln: 4.316 ± 0.523
5.478GluArg: 5.478 ± 0.638
3.818GluSer: 3.818 ± 0.498
3.929GluThr: 3.929 ± 0.759
3.929GluVal: 3.929 ± 0.567
0.885GluTrp: 0.885 ± 0.209
2.047GluTyr: 2.047 ± 0.321
0.0GluXaa: 0.0 ± 0.0
Phe
2.822PheAla: 2.822 ± 0.457
0.498PheCys: 0.498 ± 0.191
1.826PheAsp: 1.826 ± 0.294
1.439PheGlu: 1.439 ± 0.368
0.941PhePhe: 0.941 ± 0.228
2.213PheGly: 2.213 ± 0.277
0.719PheHis: 0.719 ± 0.185
1.826PheIle: 1.826 ± 0.3
1.715PheLys: 1.715 ± 0.276
1.937PheLeu: 1.937 ± 0.324
1.107PheMet: 1.107 ± 0.231
1.383PheAsn: 1.383 ± 0.25
1.217PhePro: 1.217 ± 0.232
0.996PheGln: 0.996 ± 0.242
2.158PheArg: 2.158 ± 0.409
2.988PheSer: 2.988 ± 0.456
2.545PheThr: 2.545 ± 0.356
2.158PheVal: 2.158 ± 0.326
0.83PheTrp: 0.83 ± 0.195
1.162PheTyr: 1.162 ± 0.233
0.0PheXaa: 0.0 ± 0.0
Gly
6.308GlyAla: 6.308 ± 0.99
0.83GlyCys: 0.83 ± 0.271
4.759GlyAsp: 4.759 ± 0.831
6.363GlyGlu: 6.363 ± 1.507
2.656GlyPhe: 2.656 ± 0.461
5.201GlyGly: 5.201 ± 0.641
1.107GlyHis: 1.107 ± 0.236
3.818GlyIle: 3.818 ± 0.556
4.814GlyLys: 4.814 ± 0.908
4.814GlyLeu: 4.814 ± 0.43
2.601GlyMet: 2.601 ± 0.357
3.043GlyAsn: 3.043 ± 0.368
4.039GlyPro: 4.039 ± 2.319
2.656GlyGln: 2.656 ± 0.38
4.15GlyArg: 4.15 ± 0.541
3.707GlySer: 3.707 ± 0.522
3.763GlyThr: 3.763 ± 0.454
5.201GlyVal: 5.201 ± 0.522
1.162GlyTrp: 1.162 ± 0.237
2.545GlyTyr: 2.545 ± 0.331
0.0GlyXaa: 0.0 ± 0.0
His
1.439HisAla: 1.439 ± 0.245
0.166HisCys: 0.166 ± 0.075
0.996HisAsp: 0.996 ± 0.222
0.941HisGlu: 0.941 ± 0.257
0.775HisPhe: 0.775 ± 0.272
1.881HisGly: 1.881 ± 0.37
0.498HisHis: 0.498 ± 0.142
0.609HisIle: 0.609 ± 0.245
1.051HisLys: 1.051 ± 0.307
1.715HisLeu: 1.715 ± 0.365
0.221HisMet: 0.221 ± 0.111
0.83HisAsn: 0.83 ± 0.18
0.83HisPro: 0.83 ± 0.25
0.719HisGln: 0.719 ± 0.258
0.996HisArg: 0.996 ± 0.257
0.941HisSer: 0.941 ± 0.212
1.273HisThr: 1.273 ± 0.268
0.941HisVal: 0.941 ± 0.249
0.387HisTrp: 0.387 ± 0.198
0.498HisTyr: 0.498 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
4.925IleAla: 4.925 ± 0.529
0.996IleCys: 0.996 ± 0.254
4.205IleAsp: 4.205 ± 0.524
3.099IleGlu: 3.099 ± 0.456
1.051IlePhe: 1.051 ± 0.271
2.988IleGly: 2.988 ± 0.492
0.719IleHis: 0.719 ± 0.15
2.103IleIle: 2.103 ± 0.327
2.933IleLys: 2.933 ± 0.392
3.541IleLeu: 3.541 ± 0.636
1.107IleMet: 1.107 ± 0.207
2.933IleAsn: 2.933 ± 0.396
2.601IlePro: 2.601 ± 0.355
1.771IleGln: 1.771 ± 0.249
4.537IleArg: 4.537 ± 0.418
3.984IleSer: 3.984 ± 0.6
3.818IleThr: 3.818 ± 0.538
1.992IleVal: 1.992 ± 0.398
0.332IleTrp: 0.332 ± 0.192
1.328IleTyr: 1.328 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
6.253LysAla: 6.253 ± 0.613
0.387LysCys: 0.387 ± 0.161
3.209LysAsp: 3.209 ± 0.45
3.818LysGlu: 3.818 ± 0.45
0.996LysPhe: 0.996 ± 0.199
5.865LysGly: 5.865 ± 1.169
1.051LysHis: 1.051 ± 0.235
3.154LysIle: 3.154 ± 0.409
3.541LysLys: 3.541 ± 0.509
4.759LysLeu: 4.759 ± 0.47
1.715LysMet: 1.715 ± 0.289
3.652LysAsn: 3.652 ± 0.421
2.601LysPro: 2.601 ± 0.385
2.933LysGln: 2.933 ± 0.526
3.043LysArg: 3.043 ± 0.379
3.099LysSer: 3.099 ± 0.366
3.486LysThr: 3.486 ± 0.442
3.099LysVal: 3.099 ± 0.465
0.775LysTrp: 0.775 ± 0.239
1.771LysTyr: 1.771 ± 0.343
0.0LysXaa: 0.0 ± 0.0
Leu
7.857LeuAla: 7.857 ± 0.878
1.273LeuCys: 1.273 ± 0.329
3.763LeuAsp: 3.763 ± 0.497
3.984LeuGlu: 3.984 ± 0.576
2.711LeuPhe: 2.711 ± 0.44
3.929LeuGly: 3.929 ± 0.447
1.439LeuHis: 1.439 ± 0.228
3.929LeuIle: 3.929 ± 0.6
4.648LeuLys: 4.648 ± 0.522
6.197LeuLeu: 6.197 ± 0.487
2.103LeuMet: 2.103 ± 0.354
4.371LeuAsn: 4.371 ± 0.527
3.873LeuPro: 3.873 ± 0.423
3.209LeuGln: 3.209 ± 0.771
5.755LeuArg: 5.755 ± 0.611
4.593LeuSer: 4.593 ± 0.42
4.98LeuThr: 4.98 ± 0.501
4.593LeuVal: 4.593 ± 0.451
0.885LeuTrp: 0.885 ± 0.286
2.213LeuTyr: 2.213 ± 0.336
0.0LeuXaa: 0.0 ± 0.0
Met
3.265MetAla: 3.265 ± 0.391
0.111MetCys: 0.111 ± 0.086
1.439MetAsp: 1.439 ± 0.287
1.605MetGlu: 1.605 ± 0.253
0.885MetPhe: 0.885 ± 0.218
1.549MetGly: 1.549 ± 0.339
0.498MetHis: 0.498 ± 0.14
0.996MetIle: 0.996 ± 0.246
2.103MetLys: 2.103 ± 0.326
2.158MetLeu: 2.158 ± 0.294
0.941MetMet: 0.941 ± 0.276
1.494MetAsn: 1.494 ± 0.305
1.826MetPro: 1.826 ± 0.354
1.66MetGln: 1.66 ± 0.239
1.549MetArg: 1.549 ± 0.238
2.047MetSer: 2.047 ± 0.343
2.601MetThr: 2.601 ± 0.365
1.439MetVal: 1.439 ± 0.317
0.221MetTrp: 0.221 ± 0.107
0.609MetTyr: 0.609 ± 0.233
0.0MetXaa: 0.0 ± 0.0
Asn
4.703AsnAla: 4.703 ± 0.749
0.609AsnCys: 0.609 ± 0.206
2.435AsnAsp: 2.435 ± 0.363
2.877AsnGlu: 2.877 ± 0.342
1.051AsnPhe: 1.051 ± 0.209
3.043AsnGly: 3.043 ± 0.539
1.494AsnHis: 1.494 ± 0.342
2.656AsnIle: 2.656 ± 0.362
2.269AsnLys: 2.269 ± 0.326
3.32AsnLeu: 3.32 ± 0.406
1.273AsnMet: 1.273 ± 0.286
1.881AsnAsn: 1.881 ± 0.349
1.937AsnPro: 1.937 ± 0.295
2.047AsnGln: 2.047 ± 0.377
2.711AsnArg: 2.711 ± 0.472
2.711AsnSer: 2.711 ± 0.427
2.711AsnThr: 2.711 ± 0.421
1.992AsnVal: 1.992 ± 0.385
0.387AsnTrp: 0.387 ± 0.116
1.383AsnTyr: 1.383 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
3.652ProAla: 3.652 ± 0.602
0.443ProCys: 0.443 ± 0.159
4.537ProAsp: 4.537 ± 0.513
5.035ProGlu: 5.035 ± 0.814
1.328ProPhe: 1.328 ± 0.241
3.486ProGly: 3.486 ± 0.616
0.664ProHis: 0.664 ± 0.205
1.107ProIle: 1.107 ± 0.289
3.043ProLys: 3.043 ± 0.742
2.711ProLeu: 2.711 ± 0.389
0.941ProMet: 0.941 ± 0.208
0.775ProAsn: 0.775 ± 0.209
1.273ProPro: 1.273 ± 0.266
2.379ProGln: 2.379 ± 0.596
1.826ProArg: 1.826 ± 0.377
2.656ProSer: 2.656 ± 0.389
1.937ProThr: 1.937 ± 0.309
4.316ProVal: 4.316 ± 0.452
0.609ProTrp: 0.609 ± 0.208
1.549ProTyr: 1.549 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
4.869GlnAla: 4.869 ± 0.576
0.775GlnCys: 0.775 ± 0.269
2.435GlnAsp: 2.435 ± 0.376
3.099GlnGlu: 3.099 ± 0.427
1.439GlnPhe: 1.439 ± 0.271
3.209GlnGly: 3.209 ± 0.782
0.775GlnHis: 0.775 ± 0.248
2.545GlnIle: 2.545 ± 0.527
3.375GlnLys: 3.375 ± 0.431
3.375GlnLeu: 3.375 ± 0.359
1.051GlnMet: 1.051 ± 0.249
1.771GlnAsn: 1.771 ± 0.353
1.937GlnPro: 1.937 ± 0.38
3.818GlnGln: 3.818 ± 0.768
3.375GlnArg: 3.375 ± 0.616
2.711GlnSer: 2.711 ± 0.302
1.881GlnThr: 1.881 ± 0.347
2.213GlnVal: 2.213 ± 0.449
0.664GlnTrp: 0.664 ± 0.191
1.273GlnTyr: 1.273 ± 0.262
0.0GlnXaa: 0.0 ± 0.0
Arg
4.648ArgAla: 4.648 ± 0.475
0.166ArgCys: 0.166 ± 0.089
4.039ArgAsp: 4.039 ± 0.586
5.312ArgGlu: 5.312 ± 0.674
2.213ArgPhe: 2.213 ± 0.29
5.035ArgGly: 5.035 ± 0.98
1.826ArgHis: 1.826 ± 0.331
3.486ArgIle: 3.486 ± 0.486
4.482ArgLys: 4.482 ± 0.57
5.423ArgLeu: 5.423 ± 0.416
2.047ArgMet: 2.047 ± 0.32
3.209ArgAsn: 3.209 ± 0.352
2.047ArgPro: 2.047 ± 0.385
3.209ArgGln: 3.209 ± 0.396
5.533ArgArg: 5.533 ± 0.563
3.929ArgSer: 3.929 ± 0.497
3.707ArgThr: 3.707 ± 0.556
3.818ArgVal: 3.818 ± 0.366
1.162ArgTrp: 1.162 ± 0.214
2.103ArgTyr: 2.103 ± 0.447
0.0ArgXaa: 0.0 ± 0.0
Ser
5.81SerAla: 5.81 ± 0.651
0.664SerCys: 0.664 ± 0.221
3.763SerAsp: 3.763 ± 0.42
4.095SerGlu: 4.095 ± 0.527
1.881SerPhe: 1.881 ± 0.351
5.644SerGly: 5.644 ± 0.628
0.775SerHis: 0.775 ± 0.177
2.49SerIle: 2.49 ± 0.352
2.711SerLys: 2.711 ± 0.455
5.533SerLeu: 5.533 ± 0.613
1.66SerMet: 1.66 ± 0.365
2.767SerAsn: 2.767 ± 0.456
3.32SerPro: 3.32 ± 0.412
3.209SerGln: 3.209 ± 0.392
4.482SerArg: 4.482 ± 0.651
2.933SerSer: 2.933 ± 0.634
2.822SerThr: 2.822 ± 0.395
4.15SerVal: 4.15 ± 0.483
0.941SerTrp: 0.941 ± 0.26
1.826SerTyr: 1.826 ± 0.388
0.0SerXaa: 0.0 ± 0.0
Thr
5.533ThrAla: 5.533 ± 0.518
0.609ThrCys: 0.609 ± 0.226
3.541ThrAsp: 3.541 ± 0.429
3.431ThrGlu: 3.431 ± 0.377
2.269ThrPhe: 2.269 ± 0.462
5.755ThrGly: 5.755 ± 0.783
0.83ThrHis: 0.83 ± 0.234
3.32ThrIle: 3.32 ± 0.428
3.154ThrLys: 3.154 ± 0.386
4.98ThrLeu: 4.98 ± 0.492
1.051ThrMet: 1.051 ± 0.21
1.549ThrAsn: 1.549 ± 0.214
3.597ThrPro: 3.597 ± 0.379
1.826ThrGln: 1.826 ± 0.324
3.099ThrArg: 3.099 ± 0.475
3.652ThrSer: 3.652 ± 0.484
3.431ThrThr: 3.431 ± 0.422
4.316ThrVal: 4.316 ± 0.59
0.775ThrTrp: 0.775 ± 0.178
1.107ThrTyr: 1.107 ± 0.243
0.0ThrXaa: 0.0 ± 0.0
Val
5.755ValAla: 5.755 ± 0.561
1.051ValCys: 1.051 ± 0.282
3.763ValAsp: 3.763 ± 0.418
3.541ValGlu: 3.541 ± 0.388
2.269ValPhe: 2.269 ± 0.326
3.541ValGly: 3.541 ± 0.455
0.719ValHis: 0.719 ± 0.179
3.818ValIle: 3.818 ± 0.539
3.32ValLys: 3.32 ± 0.387
5.146ValLeu: 5.146 ± 0.632
1.605ValMet: 1.605 ± 0.276
2.988ValAsn: 2.988 ± 0.392
2.877ValPro: 2.877 ± 0.406
2.047ValGln: 2.047 ± 0.348
4.925ValArg: 4.925 ± 1.065
4.759ValSer: 4.759 ± 0.487
3.984ValThr: 3.984 ± 0.456
4.371ValVal: 4.371 ± 0.529
0.775ValTrp: 0.775 ± 0.195
1.549ValTyr: 1.549 ± 0.272
0.0ValXaa: 0.0 ± 0.0
Trp
0.941TrpAla: 0.941 ± 0.269
0.166TrpCys: 0.166 ± 0.102
0.664TrpAsp: 0.664 ± 0.233
0.609TrpGlu: 0.609 ± 0.149
0.664TrpPhe: 0.664 ± 0.153
0.609TrpGly: 0.609 ± 0.167
0.387TrpHis: 0.387 ± 0.151
0.83TrpIle: 0.83 ± 0.193
1.051TrpLys: 1.051 ± 0.213
1.328TrpLeu: 1.328 ± 0.379
0.885TrpMet: 0.885 ± 0.197
0.664TrpAsn: 0.664 ± 0.198
0.664TrpPro: 0.664 ± 0.216
1.051TrpGln: 1.051 ± 0.202
1.217TrpArg: 1.217 ± 0.264
0.885TrpSer: 0.885 ± 0.224
0.553TrpThr: 0.553 ± 0.175
1.162TrpVal: 1.162 ± 0.269
0.387TrpTrp: 0.387 ± 0.167
0.277TrpTyr: 0.277 ± 0.109
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.877TyrAla: 2.877 ± 0.353
0.277TyrCys: 0.277 ± 0.136
1.715TyrAsp: 1.715 ± 0.316
1.439TyrGlu: 1.439 ± 0.353
1.328TyrPhe: 1.328 ± 0.242
2.269TyrGly: 2.269 ± 0.379
0.443TyrHis: 0.443 ± 0.137
1.66TyrIle: 1.66 ± 0.31
0.996TyrLys: 0.996 ± 0.204
1.605TyrLeu: 1.605 ± 0.325
0.885TyrMet: 0.885 ± 0.23
1.162TyrAsn: 1.162 ± 0.229
1.217TyrPro: 1.217 ± 0.263
1.494TyrGln: 1.494 ± 0.293
2.545TyrArg: 2.545 ± 0.412
1.715TyrSer: 1.715 ± 0.291
1.605TyrThr: 1.605 ± 0.431
1.881TyrVal: 1.881 ± 0.301
0.664TyrTrp: 0.664 ± 0.17
0.996TyrTyr: 0.996 ± 0.215
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (18073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski