Amino acid dipepetide frequency for Rhodoferax sp. IMCC26218

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.609AlaAla: 16.609 ± 0.156
1.421AlaCys: 1.421 ± 0.041
6.173AlaAsp: 6.173 ± 0.07
6.059AlaGlu: 6.059 ± 0.079
4.0AlaPhe: 4.0 ± 0.051
9.703AlaGly: 9.703 ± 0.121
2.856AlaHis: 2.856 ± 0.044
5.235AlaIle: 5.235 ± 0.065
4.375AlaLys: 4.375 ± 0.079
15.096AlaLeu: 15.096 ± 0.126
3.56AlaMet: 3.56 ± 0.051
3.291AlaAsn: 3.291 ± 0.066
5.584AlaPro: 5.584 ± 0.08
6.478AlaGln: 6.478 ± 0.081
7.558AlaArg: 7.558 ± 0.088
7.438AlaSer: 7.438 ± 0.09
6.257AlaThr: 6.257 ± 0.063
8.8AlaVal: 8.8 ± 0.081
1.834AlaTrp: 1.834 ± 0.042
2.532AlaTyr: 2.532 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.283CysAla: 1.283 ± 0.034
0.126CysCys: 0.126 ± 0.009
0.569CysAsp: 0.569 ± 0.02
0.54CysGlu: 0.54 ± 0.021
0.341CysPhe: 0.341 ± 0.015
1.058CysGly: 1.058 ± 0.03
0.348CysHis: 0.348 ± 0.046
0.472CysIle: 0.472 ± 0.018
0.34CysLys: 0.34 ± 0.015
0.998CysLeu: 0.998 ± 0.029
0.245CysMet: 0.245 ± 0.014
0.279CysAsn: 0.279 ± 0.013
0.488CysPro: 0.488 ± 0.021
0.337CysGln: 0.337 ± 0.015
0.496CysArg: 0.496 ± 0.022
0.643CysSer: 0.643 ± 0.026
0.576CysThr: 0.576 ± 0.024
0.808CysVal: 0.808 ± 0.025
0.135CysTrp: 0.135 ± 0.01
0.226CysTyr: 0.226 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.954AspAla: 6.954 ± 0.077
0.521AspCys: 0.521 ± 0.022
2.33AspAsp: 2.33 ± 0.045
2.563AspGlu: 2.563 ± 0.046
2.088AspPhe: 2.088 ± 0.042
4.123AspGly: 4.123 ± 0.062
1.114AspHis: 1.114 ± 0.026
2.626AspIle: 2.626 ± 0.046
1.924AspLys: 1.924 ± 0.036
5.434AspLeu: 5.434 ± 0.063
1.374AspMet: 1.374 ± 0.027
1.343AspAsn: 1.343 ± 0.032
2.503AspPro: 2.503 ± 0.041
1.734AspGln: 1.734 ± 0.04
2.664AspArg: 2.664 ± 0.048
2.683AspSer: 2.683 ± 0.041
2.744AspThr: 2.744 ± 0.055
3.925AspVal: 3.925 ± 0.054
0.924AspTrp: 0.924 ± 0.025
1.413AspTyr: 1.413 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
6.373GluAla: 6.373 ± 0.084
0.416GluCys: 0.416 ± 0.016
2.177GluAsp: 2.177 ± 0.042
2.389GluGlu: 2.389 ± 0.046
1.74GluPhe: 1.74 ± 0.036
3.485GluGly: 3.485 ± 0.058
1.217GluHis: 1.217 ± 0.029
2.544GluIle: 2.544 ± 0.05
2.088GluLys: 2.088 ± 0.045
5.669GluLeu: 5.669 ± 0.073
1.284GluMet: 1.284 ± 0.028
1.237GluAsn: 1.237 ± 0.033
2.199GluPro: 2.199 ± 0.045
2.547GluGln: 2.547 ± 0.047
3.883GluArg: 3.883 ± 0.058
2.657GluSer: 2.657 ± 0.042
2.3GluThr: 2.3 ± 0.036
4.017GluVal: 4.017 ± 0.055
0.685GluTrp: 0.685 ± 0.021
1.001GluTyr: 1.001 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.352PheAla: 4.352 ± 0.065
0.428PheCys: 0.428 ± 0.015
2.397PheAsp: 2.397 ± 0.045
2.056PheGlu: 2.056 ± 0.04
1.375PhePhe: 1.375 ± 0.034
3.308PheGly: 3.308 ± 0.051
0.706PheHis: 0.706 ± 0.021
1.419PheIle: 1.419 ± 0.034
1.405PheLys: 1.405 ± 0.028
2.942PheLeu: 2.942 ± 0.049
0.862PheMet: 0.862 ± 0.023
1.245PheAsn: 1.245 ± 0.03
1.418PhePro: 1.418 ± 0.034
1.189PheGln: 1.189 ± 0.03
1.579PheArg: 1.579 ± 0.033
2.309PheSer: 2.309 ± 0.045
1.896PheThr: 1.896 ± 0.038
2.86PheVal: 2.86 ± 0.048
0.515PheTrp: 0.515 ± 0.022
0.894PheTyr: 0.894 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.813GlyAla: 8.813 ± 0.095
0.933GlyCys: 0.933 ± 0.027
3.833GlyAsp: 3.833 ± 0.071
3.853GlyGlu: 3.853 ± 0.055
3.347GlyPhe: 3.347 ± 0.06
6.587GlyGly: 6.587 ± 0.118
1.945GlyHis: 1.945 ± 0.038
4.003GlyIle: 4.003 ± 0.053
3.489GlyLys: 3.489 ± 0.058
9.057GlyLeu: 9.057 ± 0.094
2.421GlyMet: 2.421 ± 0.046
2.418GlyAsn: 2.418 ± 0.053
2.837GlyPro: 2.837 ± 0.045
3.563GlyGln: 3.563 ± 0.052
4.662GlyArg: 4.662 ± 0.058
4.966GlySer: 4.966 ± 0.088
4.52GlyThr: 4.52 ± 0.091
6.476GlyVal: 6.476 ± 0.078
1.333GlyTrp: 1.333 ± 0.035
2.233GlyTyr: 2.233 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.829HisAla: 2.829 ± 0.053
0.309HisCys: 0.309 ± 0.014
1.114HisAsp: 1.114 ± 0.026
0.994HisGlu: 0.994 ± 0.031
0.965HisPhe: 0.965 ± 0.027
2.023HisGly: 2.023 ± 0.045
0.598HisHis: 0.598 ± 0.02
1.099HisIle: 1.099 ± 0.031
0.734HisLys: 0.734 ± 0.023
2.325HisLeu: 2.325 ± 0.042
0.643HisMet: 0.643 ± 0.021
0.624HisAsn: 0.624 ± 0.019
1.346HisPro: 1.346 ± 0.026
0.854HisGln: 0.854 ± 0.025
1.225HisArg: 1.225 ± 0.032
1.312HisSer: 1.312 ± 0.032
1.323HisThr: 1.323 ± 0.033
1.554HisVal: 1.554 ± 0.035
0.432HisTrp: 0.432 ± 0.018
0.633HisTyr: 0.633 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.012IleAla: 6.012 ± 0.07
0.445IleCys: 0.445 ± 0.017
2.669IleAsp: 2.669 ± 0.05
2.749IleGlu: 2.749 ± 0.055
1.341IlePhe: 1.341 ± 0.035
3.883IleGly: 3.883 ± 0.062
0.946IleHis: 0.946 ± 0.028
1.603IleIle: 1.603 ± 0.035
1.692IleLys: 1.692 ± 0.038
3.63IleLeu: 3.63 ± 0.066
0.798IleMet: 0.798 ± 0.026
1.6IleAsn: 1.6 ± 0.038
2.1IlePro: 2.1 ± 0.037
1.528IleGln: 1.528 ± 0.034
2.488IleArg: 2.488 ± 0.041
2.748IleSer: 2.748 ± 0.049
2.711IleThr: 2.711 ± 0.046
3.145IleVal: 3.145 ± 0.046
0.495IleTrp: 0.495 ± 0.017
1.008IleTyr: 1.008 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.424LysAla: 4.424 ± 0.067
0.215LysCys: 0.215 ± 0.013
1.873LysAsp: 1.873 ± 0.038
1.667LysGlu: 1.667 ± 0.04
1.042LysPhe: 1.042 ± 0.027
2.719LysGly: 2.719 ± 0.052
0.733LysHis: 0.733 ± 0.025
1.692LysIle: 1.692 ± 0.039
1.624LysLys: 1.624 ± 0.041
3.795LysLeu: 3.795 ± 0.057
0.971LysMet: 0.971 ± 0.028
1.163LysAsn: 1.163 ± 0.029
2.406LysPro: 2.406 ± 0.046
1.396LysGln: 1.396 ± 0.032
2.27LysArg: 2.27 ± 0.042
2.173LysSer: 2.173 ± 0.038
2.241LysThr: 2.241 ± 0.04
2.758LysVal: 2.758 ± 0.049
0.373LysTrp: 0.373 ± 0.017
0.748LysTyr: 0.748 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.969LeuAla: 13.969 ± 0.122
1.225LeuCys: 1.225 ± 0.026
5.873LeuAsp: 5.873 ± 0.062
5.393LeuGlu: 5.393 ± 0.078
3.416LeuPhe: 3.416 ± 0.048
8.992LeuGly: 8.992 ± 0.083
2.503LeuHis: 2.503 ± 0.05
4.151LeuIle: 4.151 ± 0.054
4.005LeuLys: 4.005 ± 0.059
11.979LeuLeu: 11.979 ± 0.134
2.718LeuMet: 2.718 ± 0.048
3.096LeuAsn: 3.096 ± 0.044
5.872LeuPro: 5.872 ± 0.073
5.696LeuGln: 5.696 ± 0.093
6.877LeuArg: 6.877 ± 0.082
6.806LeuSer: 6.806 ± 0.074
5.389LeuThr: 5.389 ± 0.07
8.124LeuVal: 8.124 ± 0.088
1.378LeuTrp: 1.378 ± 0.036
2.112LeuTyr: 2.112 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.407MetAla: 3.407 ± 0.053
0.182MetCys: 0.182 ± 0.011
1.4MetAsp: 1.4 ± 0.035
1.302MetGlu: 1.302 ± 0.025
0.701MetPhe: 0.701 ± 0.025
2.214MetGly: 2.214 ± 0.035
0.622MetHis: 0.622 ± 0.02
0.824MetIle: 0.824 ± 0.026
1.058MetLys: 1.058 ± 0.03
2.794MetLeu: 2.794 ± 0.046
0.561MetMet: 0.561 ± 0.019
0.9MetAsn: 0.9 ± 0.023
1.52MetPro: 1.52 ± 0.033
1.388MetGln: 1.388 ± 0.033
1.686MetArg: 1.686 ± 0.037
1.533MetSer: 1.533 ± 0.035
1.458MetThr: 1.458 ± 0.03
2.071MetVal: 2.071 ± 0.038
0.207MetTrp: 0.207 ± 0.01
0.397MetTyr: 0.397 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.774AsnAla: 3.774 ± 0.057
0.317AsnCys: 0.317 ± 0.017
1.359AsnAsp: 1.359 ± 0.035
1.2AsnGlu: 1.2 ± 0.032
1.051AsnPhe: 1.051 ± 0.025
2.422AsnGly: 2.422 ± 0.073
0.608AsnHis: 0.608 ± 0.022
1.355AsnIle: 1.355 ± 0.04
0.988AsnLys: 0.988 ± 0.028
2.94AsnLeu: 2.94 ± 0.046
0.73AsnMet: 0.73 ± 0.023
0.951AsnAsn: 0.951 ± 0.036
1.972AsnPro: 1.972 ± 0.035
1.178AsnGln: 1.178 ± 0.032
1.59AsnArg: 1.59 ± 0.034
1.524AsnSer: 1.524 ± 0.038
1.803AsnThr: 1.803 ± 0.045
2.079AsnVal: 2.079 ± 0.042
0.455AsnTrp: 0.455 ± 0.019
0.723AsnTyr: 0.723 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.095ProAla: 6.095 ± 0.079
0.406ProCys: 0.406 ± 0.019
2.781ProAsp: 2.781 ± 0.043
3.023ProGlu: 3.023 ± 0.05
1.74ProPhe: 1.74 ± 0.039
4.083ProGly: 4.083 ± 0.064
1.091ProHis: 1.091 ± 0.031
1.85ProIle: 1.85 ± 0.036
1.697ProLys: 1.697 ± 0.041
5.114ProLeu: 5.114 ± 0.068
1.383ProMet: 1.383 ± 0.028
1.332ProAsn: 1.332 ± 0.028
2.084ProPro: 2.084 ± 0.048
2.237ProGln: 2.237 ± 0.044
2.353ProArg: 2.353 ± 0.048
2.655ProSer: 2.655 ± 0.044
2.583ProThr: 2.583 ± 0.053
4.189ProVal: 4.189 ± 0.06
0.765ProTrp: 0.765 ± 0.025
1.126ProTyr: 1.126 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
6.591GlnAla: 6.591 ± 0.098
0.432GlnCys: 0.432 ± 0.019
2.05GlnAsp: 2.05 ± 0.039
1.954GlnGlu: 1.954 ± 0.046
1.386GlnPhe: 1.386 ± 0.032
3.524GlnGly: 3.524 ± 0.051
1.091GlnHis: 1.091 ± 0.029
1.943GlnIle: 1.943 ± 0.034
1.39GlnLys: 1.39 ± 0.035
4.616GlnLeu: 4.616 ± 0.064
1.142GlnMet: 1.142 ± 0.029
1.061GlnAsn: 1.061 ± 0.034
2.153GlnPro: 2.153 ± 0.041
2.297GlnGln: 2.297 ± 0.047
3.307GlnArg: 3.307 ± 0.059
2.746GlnSer: 2.746 ± 0.053
2.466GlnThr: 2.466 ± 0.046
3.38GlnVal: 3.38 ± 0.05
0.754GlnTrp: 0.754 ± 0.022
0.873GlnTyr: 0.873 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.702ArgAla: 6.702 ± 0.076
0.567ArgCys: 0.567 ± 0.021
2.997ArgAsp: 2.997 ± 0.054
3.372ArgGlu: 3.372 ± 0.061
2.416ArgPhe: 2.416 ± 0.042
3.882ArgGly: 3.882 ± 0.055
1.5ArgHis: 1.5 ± 0.03
3.099ArgIle: 3.099 ± 0.043
2.105ArgLys: 2.105 ± 0.038
6.925ArgLeu: 6.925 ± 0.092
1.786ArgMet: 1.786 ± 0.033
1.807ArgAsn: 1.807 ± 0.037
2.491ArgPro: 2.491 ± 0.042
2.74ArgGln: 2.74 ± 0.051
3.578ArgArg: 3.578 ± 0.048
3.487ArgSer: 3.487 ± 0.05
2.94ArgThr: 2.94 ± 0.045
4.557ArgVal: 4.557 ± 0.059
1.014ArgTrp: 1.014 ± 0.029
1.607ArgTyr: 1.607 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
7.102SerAla: 7.102 ± 0.08
0.56SerCys: 0.56 ± 0.026
2.883SerAsp: 2.883 ± 0.044
2.746SerGlu: 2.746 ± 0.041
2.216SerPhe: 2.216 ± 0.038
5.766SerGly: 5.766 ± 0.077
1.337SerHis: 1.337 ± 0.029
2.684SerIle: 2.684 ± 0.053
1.965SerLys: 1.965 ± 0.038
6.259SerLeu: 6.259 ± 0.073
1.623SerMet: 1.623 ± 0.036
1.811SerAsn: 1.811 ± 0.053
2.809SerPro: 2.809 ± 0.046
2.384SerGln: 2.384 ± 0.047
3.275SerArg: 3.275 ± 0.051
3.571SerSer: 3.571 ± 0.061
3.448SerThr: 3.448 ± 0.065
4.414SerVal: 4.414 ± 0.06
0.792SerTrp: 0.792 ± 0.027
1.446SerTyr: 1.446 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.266ThrAla: 6.266 ± 0.082
0.486ThrCys: 0.486 ± 0.032
2.604ThrAsp: 2.604 ± 0.047
2.539ThrGlu: 2.539 ± 0.039
1.763ThrPhe: 1.763 ± 0.039
4.866ThrGly: 4.866 ± 0.075
1.261ThrHis: 1.261 ± 0.031
2.212ThrIle: 2.212 ± 0.043
1.474ThrLys: 1.474 ± 0.037
6.722ThrLeu: 6.722 ± 0.082
1.153ThrMet: 1.153 ± 0.028
1.405ThrAsn: 1.405 ± 0.037
3.388ThrPro: 3.388 ± 0.057
2.342ThrGln: 2.342 ± 0.041
3.028ThrArg: 3.028 ± 0.049
2.961ThrSer: 2.961 ± 0.055
3.0ThrThr: 3.0 ± 0.089
4.407ThrVal: 4.407 ± 0.062
0.659ThrTrp: 0.659 ± 0.022
1.09ThrTyr: 1.09 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.302ValAla: 9.302 ± 0.088
0.859ValCys: 0.859 ± 0.027
4.081ValAsp: 4.081 ± 0.05
3.97ValGlu: 3.97 ± 0.056
2.815ValPhe: 2.815 ± 0.047
5.735ValGly: 5.735 ± 0.068
1.649ValHis: 1.649 ± 0.034
3.297ValIle: 3.297 ± 0.051
2.569ValLys: 2.569 ± 0.04
8.758ValLeu: 8.758 ± 0.09
2.024ValMet: 2.024 ± 0.039
2.324ValAsn: 2.324 ± 0.049
3.607ValPro: 3.607 ± 0.055
3.483ValGln: 3.483 ± 0.05
4.577ValArg: 4.577 ± 0.065
4.623ValSer: 4.623 ± 0.069
3.946ValThr: 3.946 ± 0.064
6.449ValVal: 6.449 ± 0.074
1.078ValTrp: 1.078 ± 0.027
1.648ValTyr: 1.648 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.367TrpAla: 1.367 ± 0.031
0.166TrpCys: 0.166 ± 0.01
0.667TrpAsp: 0.667 ± 0.024
0.542TrpGlu: 0.542 ± 0.016
0.505TrpPhe: 0.505 ± 0.019
0.959TrpGly: 0.959 ± 0.028
0.371TrpHis: 0.371 ± 0.017
0.649TrpIle: 0.649 ± 0.022
0.552TrpLys: 0.552 ± 0.019
2.055TrpLeu: 2.055 ± 0.046
0.461TrpMet: 0.461 ± 0.016
0.49TrpAsn: 0.49 ± 0.018
0.654TrpPro: 0.654 ± 0.022
0.777TrpGln: 0.777 ± 0.022
1.01TrpArg: 1.01 ± 0.028
0.897TrpSer: 0.897 ± 0.029
0.724TrpThr: 0.724 ± 0.022
1.064TrpVal: 1.064 ± 0.029
0.255TrpTrp: 0.255 ± 0.014
0.294TrpTyr: 0.294 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.633TyrAla: 2.633 ± 0.041
0.292TyrCys: 0.292 ± 0.014
1.151TyrAsp: 1.151 ± 0.033
0.998TyrGlu: 0.998 ± 0.027
0.908TyrPhe: 0.908 ± 0.026
1.96TyrGly: 1.96 ± 0.041
0.439TyrHis: 0.439 ± 0.018
0.83TyrIle: 0.83 ± 0.024
0.812TyrLys: 0.812 ± 0.022
2.468TyrLeu: 2.468 ± 0.041
0.49TyrMet: 0.49 ± 0.021
0.644TyrAsn: 0.644 ± 0.021
1.157TyrPro: 1.157 ± 0.025
1.008TyrGln: 1.008 ± 0.026
1.465TyrArg: 1.465 ± 0.031
1.357TyrSer: 1.357 ± 0.029
1.299TyrThr: 1.299 ± 0.032
1.716TyrVal: 1.716 ± 0.034
0.379TyrTrp: 0.379 ± 0.017
0.587TyrTyr: 0.587 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4436 proteins (1484475 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski