Amino acid dipepetide frequency for Streptococcus phage Javan207

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.703AlaAla: 1.703 ± 0.547
0.341AlaCys: 0.341 ± 0.221
4.512AlaAsp: 4.512 ± 0.621
6.045AlaGlu: 6.045 ± 0.683
1.788AlaPhe: 1.788 ± 0.395
4.342AlaGly: 4.342 ± 0.903
0.681AlaHis: 0.681 ± 0.229
4.938AlaIle: 4.938 ± 0.614
5.789AlaLys: 5.789 ± 1.264
5.364AlaLeu: 5.364 ± 1.106
2.469AlaMet: 2.469 ± 0.641
3.661AlaAsn: 3.661 ± 0.655
1.532AlaPro: 1.532 ± 0.317
2.469AlaGln: 2.469 ± 0.558
2.469AlaArg: 2.469 ± 0.603
4.512AlaSer: 4.512 ± 0.879
4.682AlaThr: 4.682 ± 0.919
3.405AlaVal: 3.405 ± 0.536
0.851AlaTrp: 0.851 ± 0.304
2.809AlaTyr: 2.809 ± 0.583
0.0AlaXaa: 0.0 ± 0.0
Cys
0.17CysAla: 0.17 ± 0.157
0.0CysCys: 0.0 ± 0.0
0.511CysAsp: 0.511 ± 0.238
0.511CysGlu: 0.511 ± 0.292
0.255CysPhe: 0.255 ± 0.131
0.426CysGly: 0.426 ± 0.21
0.17CysHis: 0.17 ± 0.141
0.681CysIle: 0.681 ± 0.325
0.596CysLys: 0.596 ± 0.22
0.511CysLeu: 0.511 ± 0.243
0.17CysMet: 0.17 ± 0.127
0.17CysAsn: 0.17 ± 0.111
0.17CysPro: 0.17 ± 0.138
0.17CysGln: 0.17 ± 0.15
0.426CysArg: 0.426 ± 0.194
0.511CysSer: 0.511 ± 0.214
0.426CysThr: 0.426 ± 0.181
0.17CysVal: 0.17 ± 0.118
0.0CysTrp: 0.0 ± 0.0
0.17CysTyr: 0.17 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
2.895AspAla: 2.895 ± 0.497
0.511AspCys: 0.511 ± 0.32
4.853AspAsp: 4.853 ± 1.069
5.193AspGlu: 5.193 ± 0.902
3.916AspPhe: 3.916 ± 0.682
6.47AspGly: 6.47 ± 1.145
0.426AspHis: 0.426 ± 0.178
3.576AspIle: 3.576 ± 0.607
6.045AspLys: 6.045 ± 0.815
5.364AspLeu: 5.364 ± 0.666
1.958AspMet: 1.958 ± 0.313
4.086AspAsn: 4.086 ± 0.675
0.851AspPro: 0.851 ± 0.236
1.873AspGln: 1.873 ± 0.53
1.958AspArg: 1.958 ± 0.523
3.661AspSer: 3.661 ± 0.528
3.235AspThr: 3.235 ± 0.62
3.916AspVal: 3.916 ± 0.624
1.362AspTrp: 1.362 ± 0.434
3.746AspTyr: 3.746 ± 0.674
0.0AspXaa: 0.0 ± 0.0
Glu
4.086GluAla: 4.086 ± 0.655
0.766GluCys: 0.766 ± 0.331
4.768GluAsp: 4.768 ± 0.706
7.407GluGlu: 7.407 ± 1.189
3.916GluPhe: 3.916 ± 0.557
3.746GluGly: 3.746 ± 0.61
1.532GluHis: 1.532 ± 0.305
5.534GluIle: 5.534 ± 0.763
6.896GluLys: 6.896 ± 1.012
8.173GluLeu: 8.173 ± 1.31
3.491GluMet: 3.491 ± 0.698
3.916GluAsn: 3.916 ± 0.61
1.618GluPro: 1.618 ± 0.541
2.384GluGln: 2.384 ± 0.476
3.661GluArg: 3.661 ± 0.789
4.427GluSer: 4.427 ± 0.738
4.172GluThr: 4.172 ± 0.798
5.534GluVal: 5.534 ± 0.617
1.532GluTrp: 1.532 ± 0.35
2.98GluTyr: 2.98 ± 0.506
0.0GluXaa: 0.0 ± 0.0
Phe
3.491PheAla: 3.491 ± 0.63
0.085PheCys: 0.085 ± 0.104
2.809PheAsp: 2.809 ± 0.612
3.235PheGlu: 3.235 ± 0.672
1.788PhePhe: 1.788 ± 0.444
2.214PheGly: 2.214 ± 0.495
0.426PheHis: 0.426 ± 0.189
1.532PheIle: 1.532 ± 0.353
3.576PheLys: 3.576 ± 0.617
3.065PheLeu: 3.065 ± 0.738
1.192PheMet: 1.192 ± 0.408
2.639PheAsn: 2.639 ± 0.51
0.766PhePro: 0.766 ± 0.385
1.532PheGln: 1.532 ± 0.438
1.277PheArg: 1.277 ± 0.441
2.98PheSer: 2.98 ± 0.542
2.384PheThr: 2.384 ± 0.504
2.469PheVal: 2.469 ± 0.466
0.341PheTrp: 0.341 ± 0.191
2.043PheTyr: 2.043 ± 0.504
0.0PheXaa: 0.0 ± 0.0
Gly
4.086GlyAla: 4.086 ± 0.857
0.17GlyCys: 0.17 ± 0.134
3.32GlyAsp: 3.32 ± 0.652
4.427GlyGlu: 4.427 ± 0.751
2.128GlyPhe: 2.128 ± 0.464
4.172GlyGly: 4.172 ± 0.79
1.107GlyHis: 1.107 ± 0.342
3.576GlyIle: 3.576 ± 0.492
5.193GlyLys: 5.193 ± 0.723
6.215GlyLeu: 6.215 ± 0.926
1.958GlyMet: 1.958 ± 0.555
2.895GlyAsn: 2.895 ± 0.585
0.936GlyPro: 0.936 ± 0.301
2.384GlyGln: 2.384 ± 0.47
3.576GlyArg: 3.576 ± 0.505
5.278GlySer: 5.278 ± 1.004
3.916GlyThr: 3.916 ± 0.869
4.427GlyVal: 4.427 ± 0.734
0.681GlyTrp: 0.681 ± 0.229
2.895GlyTyr: 2.895 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
0.936HisAla: 0.936 ± 0.239
0.0HisCys: 0.0 ± 0.0
0.766HisAsp: 0.766 ± 0.234
0.851HisGlu: 0.851 ± 0.274
0.596HisPhe: 0.596 ± 0.233
0.766HisGly: 0.766 ± 0.246
0.426HisHis: 0.426 ± 0.193
0.766HisIle: 0.766 ± 0.293
0.851HisLys: 0.851 ± 0.328
0.766HisLeu: 0.766 ± 0.341
0.341HisMet: 0.341 ± 0.18
1.362HisAsn: 1.362 ± 0.303
0.596HisPro: 0.596 ± 0.239
0.426HisGln: 0.426 ± 0.202
0.851HisArg: 0.851 ± 0.256
1.107HisSer: 1.107 ± 0.323
0.511HisThr: 0.511 ± 0.178
1.192HisVal: 1.192 ± 0.325
0.085HisTrp: 0.085 ± 0.077
0.341HisTyr: 0.341 ± 0.164
0.0HisXaa: 0.0 ± 0.0
Ile
5.193IleAla: 5.193 ± 0.655
0.341IleCys: 0.341 ± 0.244
4.001IleAsp: 4.001 ± 0.538
6.555IleGlu: 6.555 ± 0.954
2.043IlePhe: 2.043 ± 0.593
3.491IleGly: 3.491 ± 0.461
0.936IleHis: 0.936 ± 0.285
3.746IleIle: 3.746 ± 0.68
6.045IleLys: 6.045 ± 0.773
4.342IleLeu: 4.342 ± 0.557
1.618IleMet: 1.618 ± 0.455
5.534IleAsn: 5.534 ± 0.794
1.703IlePro: 1.703 ± 0.375
2.214IleGln: 2.214 ± 0.464
2.895IleArg: 2.895 ± 0.568
4.172IleSer: 4.172 ± 0.628
3.405IleThr: 3.405 ± 0.559
2.809IleVal: 2.809 ± 0.646
0.426IleTrp: 0.426 ± 0.192
2.128IleTyr: 2.128 ± 0.45
0.0IleXaa: 0.0 ± 0.0
Lys
6.981LysAla: 6.981 ± 1.317
0.255LysCys: 0.255 ± 0.15
5.874LysAsp: 5.874 ± 0.837
9.109LysGlu: 9.109 ± 1.161
2.639LysPhe: 2.639 ± 0.688
5.193LysGly: 5.193 ± 0.921
0.681LysHis: 0.681 ± 0.244
5.108LysIle: 5.108 ± 0.783
7.066LysLys: 7.066 ± 0.82
6.811LysLeu: 6.811 ± 0.851
1.958LysMet: 1.958 ± 0.44
5.874LysAsn: 5.874 ± 0.639
2.043LysPro: 2.043 ± 0.394
4.086LysGln: 4.086 ± 0.611
2.554LysArg: 2.554 ± 0.492
4.257LysSer: 4.257 ± 0.628
5.619LysThr: 5.619 ± 0.751
5.278LysVal: 5.278 ± 0.657
1.362LysTrp: 1.362 ± 0.369
3.831LysTyr: 3.831 ± 0.555
0.0LysXaa: 0.0 ± 0.0
Leu
5.874LeuAla: 5.874 ± 0.847
0.681LeuCys: 0.681 ± 0.376
5.534LeuAsp: 5.534 ± 0.92
5.874LeuGlu: 5.874 ± 1.055
3.15LeuPhe: 3.15 ± 0.537
3.831LeuGly: 3.831 ± 0.651
1.618LeuHis: 1.618 ± 0.326
5.619LeuIle: 5.619 ± 0.844
8.769LeuLys: 8.769 ± 0.991
6.13LeuLeu: 6.13 ± 0.725
2.299LeuMet: 2.299 ± 0.409
5.108LeuAsn: 5.108 ± 0.684
2.809LeuPro: 2.809 ± 0.515
2.214LeuGln: 2.214 ± 0.43
2.639LeuArg: 2.639 ± 0.634
5.278LeuSer: 5.278 ± 0.679
5.193LeuThr: 5.193 ± 0.807
4.682LeuVal: 4.682 ± 0.609
0.851LeuTrp: 0.851 ± 0.272
2.128LeuTyr: 2.128 ± 0.499
0.0LeuXaa: 0.0 ± 0.0
Met
2.299MetAla: 2.299 ± 0.599
0.085MetCys: 0.085 ± 0.104
1.703MetAsp: 1.703 ± 0.288
2.299MetGlu: 2.299 ± 0.504
1.362MetPhe: 1.362 ± 0.288
1.022MetGly: 1.022 ± 0.258
0.426MetHis: 0.426 ± 0.17
1.703MetIle: 1.703 ± 0.451
2.043MetLys: 2.043 ± 0.398
2.469MetLeu: 2.469 ± 0.533
0.851MetMet: 0.851 ± 0.305
1.873MetAsn: 1.873 ± 0.413
0.681MetPro: 0.681 ± 0.207
1.107MetGln: 1.107 ± 0.353
1.022MetArg: 1.022 ± 0.333
2.214MetSer: 2.214 ± 0.514
2.299MetThr: 2.299 ± 0.465
2.128MetVal: 2.128 ± 0.461
0.255MetTrp: 0.255 ± 0.16
1.277MetTyr: 1.277 ± 0.435
0.0MetXaa: 0.0 ± 0.0
Asn
3.831AsnAla: 3.831 ± 0.897
0.341AsnCys: 0.341 ± 0.17
4.172AsnAsp: 4.172 ± 0.865
3.235AsnGlu: 3.235 ± 0.573
2.214AsnPhe: 2.214 ± 0.569
4.938AsnGly: 4.938 ± 0.8
1.192AsnHis: 1.192 ± 0.289
3.576AsnIle: 3.576 ± 0.564
4.257AsnLys: 4.257 ± 0.49
3.661AsnLeu: 3.661 ± 0.768
1.873AsnMet: 1.873 ± 0.427
3.065AsnAsn: 3.065 ± 0.549
2.128AsnPro: 2.128 ± 0.456
2.299AsnGln: 2.299 ± 0.603
2.214AsnArg: 2.214 ± 0.55
3.235AsnSer: 3.235 ± 0.524
4.086AsnThr: 4.086 ± 0.535
3.916AsnVal: 3.916 ± 0.667
1.022AsnTrp: 1.022 ± 0.365
3.405AsnTyr: 3.405 ± 0.543
0.0AsnXaa: 0.0 ± 0.0
Pro
1.618ProAla: 1.618 ± 0.311
0.17ProCys: 0.17 ± 0.1
2.043ProAsp: 2.043 ± 0.424
2.043ProGlu: 2.043 ± 0.365
0.851ProPhe: 0.851 ± 0.25
0.766ProGly: 0.766 ± 0.233
0.255ProHis: 0.255 ± 0.113
2.214ProIle: 2.214 ± 0.416
1.873ProLys: 1.873 ± 0.419
1.703ProLeu: 1.703 ± 0.333
0.851ProMet: 0.851 ± 0.301
1.447ProAsn: 1.447 ± 0.509
1.107ProPro: 1.107 ± 0.325
0.426ProGln: 0.426 ± 0.168
1.107ProArg: 1.107 ± 0.431
1.532ProSer: 1.532 ± 0.391
2.214ProThr: 2.214 ± 0.623
1.873ProVal: 1.873 ± 0.419
0.085ProTrp: 0.085 ± 0.089
1.107ProTyr: 1.107 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
3.32GlnAla: 3.32 ± 0.737
0.085GlnCys: 0.085 ± 0.106
1.532GlnAsp: 1.532 ± 0.378
2.043GlnGlu: 2.043 ± 0.464
1.873GlnPhe: 1.873 ± 0.482
1.703GlnGly: 1.703 ± 0.468
0.426GlnHis: 0.426 ± 0.176
2.469GlnIle: 2.469 ± 0.392
4.001GlnLys: 4.001 ± 0.693
2.809GlnLeu: 2.809 ± 0.644
1.362GlnMet: 1.362 ± 0.389
1.362GlnAsn: 1.362 ± 0.365
0.851GlnPro: 0.851 ± 0.281
1.788GlnGln: 1.788 ± 0.467
1.532GlnArg: 1.532 ± 0.391
2.299GlnSer: 2.299 ± 0.555
2.554GlnThr: 2.554 ± 0.47
1.447GlnVal: 1.447 ± 0.344
0.511GlnTrp: 0.511 ± 0.2
2.299GlnTyr: 2.299 ± 0.337
0.0GlnXaa: 0.0 ± 0.0
Arg
1.703ArgAla: 1.703 ± 0.332
0.511ArgCys: 0.511 ± 0.221
1.873ArgAsp: 1.873 ± 0.534
3.32ArgGlu: 3.32 ± 0.692
1.618ArgPhe: 1.618 ± 0.47
2.724ArgGly: 2.724 ± 0.51
0.681ArgHis: 0.681 ± 0.198
2.128ArgIle: 2.128 ± 0.572
3.661ArgLys: 3.661 ± 0.849
3.576ArgLeu: 3.576 ± 0.551
1.447ArgMet: 1.447 ± 0.454
2.554ArgAsn: 2.554 ± 0.468
0.936ArgPro: 0.936 ± 0.287
1.022ArgGln: 1.022 ± 0.308
1.192ArgArg: 1.192 ± 0.382
1.873ArgSer: 1.873 ± 0.426
2.128ArgThr: 2.128 ± 0.472
2.809ArgVal: 2.809 ± 0.616
0.766ArgTrp: 0.766 ± 0.213
1.362ArgTyr: 1.362 ± 0.364
0.0ArgXaa: 0.0 ± 0.0
Ser
3.576SerAla: 3.576 ± 0.967
0.511SerCys: 0.511 ± 0.224
5.789SerAsp: 5.789 ± 0.74
5.108SerGlu: 5.108 ± 0.768
2.384SerPhe: 2.384 ± 0.519
5.023SerGly: 5.023 ± 1.115
0.426SerHis: 0.426 ± 0.203
4.172SerIle: 4.172 ± 0.585
4.853SerLys: 4.853 ± 0.661
3.32SerLeu: 3.32 ± 0.489
1.703SerMet: 1.703 ± 0.316
4.086SerAsn: 4.086 ± 0.653
2.043SerPro: 2.043 ± 0.522
2.469SerGln: 2.469 ± 0.608
1.873SerArg: 1.873 ± 0.399
5.108SerSer: 5.108 ± 1.076
4.001SerThr: 4.001 ± 0.995
3.916SerVal: 3.916 ± 0.422
0.936SerTrp: 0.936 ± 0.352
2.809SerTyr: 2.809 ± 0.477
0.0SerXaa: 0.0 ± 0.0
Thr
5.023ThrAla: 5.023 ± 1.109
0.596ThrCys: 0.596 ± 0.255
4.597ThrAsp: 4.597 ± 0.772
3.235ThrGlu: 3.235 ± 0.569
2.384ThrPhe: 2.384 ± 0.588
4.768ThrGly: 4.768 ± 0.854
0.936ThrHis: 0.936 ± 0.288
4.682ThrIle: 4.682 ± 0.627
5.193ThrLys: 5.193 ± 0.664
5.278ThrLeu: 5.278 ± 0.706
1.022ThrMet: 1.022 ± 0.274
2.384ThrAsn: 2.384 ± 0.602
1.703ThrPro: 1.703 ± 0.454
2.895ThrGln: 2.895 ± 0.472
2.299ThrArg: 2.299 ± 0.394
4.257ThrSer: 4.257 ± 1.117
4.938ThrThr: 4.938 ± 1.025
5.789ThrVal: 5.789 ± 1.05
0.596ThrTrp: 0.596 ± 0.244
2.384ThrTyr: 2.384 ± 0.535
0.0ThrXaa: 0.0 ± 0.0
Val
4.597ValAla: 4.597 ± 0.677
0.341ValCys: 0.341 ± 0.183
4.257ValAsp: 4.257 ± 0.58
5.278ValGlu: 5.278 ± 0.965
2.809ValPhe: 2.809 ± 0.586
4.427ValGly: 4.427 ± 0.587
0.426ValHis: 0.426 ± 0.183
4.086ValIle: 4.086 ± 0.616
5.959ValLys: 5.959 ± 0.796
5.789ValLeu: 5.789 ± 0.744
1.362ValMet: 1.362 ± 0.359
3.15ValAsn: 3.15 ± 0.619
1.788ValPro: 1.788 ± 0.36
2.384ValGln: 2.384 ± 0.448
2.043ValArg: 2.043 ± 0.533
3.576ValSer: 3.576 ± 0.605
4.768ValThr: 4.768 ± 0.556
3.831ValVal: 3.831 ± 0.577
0.681ValTrp: 0.681 ± 0.247
2.043ValTyr: 2.043 ± 0.371
0.0ValXaa: 0.0 ± 0.0
Trp
0.681TrpAla: 0.681 ± 0.238
0.255TrpCys: 0.255 ± 0.157
0.426TrpAsp: 0.426 ± 0.211
1.532TrpGlu: 1.532 ± 0.4
0.766TrpPhe: 0.766 ± 0.281
0.766TrpGly: 0.766 ± 0.226
0.17TrpHis: 0.17 ± 0.101
0.426TrpIle: 0.426 ± 0.18
0.851TrpLys: 0.851 ± 0.208
1.107TrpLeu: 1.107 ± 0.344
0.085TrpMet: 0.085 ± 0.105
0.936TrpAsn: 0.936 ± 0.281
0.0TrpPro: 0.0 ± 0.0
0.341TrpGln: 0.341 ± 0.179
0.681TrpArg: 0.681 ± 0.287
1.277TrpSer: 1.277 ± 0.386
1.362TrpThr: 1.362 ± 0.493
0.936TrpVal: 0.936 ± 0.316
0.0TrpTrp: 0.0 ± 0.0
0.596TrpTyr: 0.596 ± 0.294
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.299TyrAla: 2.299 ± 0.51
0.17TyrCys: 0.17 ± 0.121
2.554TyrAsp: 2.554 ± 0.544
3.235TyrGlu: 3.235 ± 0.497
1.362TyrPhe: 1.362 ± 0.427
2.554TyrGly: 2.554 ± 0.529
0.596TyrHis: 0.596 ± 0.243
3.065TyrIle: 3.065 ± 0.665
3.065TyrLys: 3.065 ± 0.479
3.831TyrLeu: 3.831 ± 0.758
1.022TyrMet: 1.022 ± 0.236
2.554TyrAsn: 2.554 ± 0.525
1.022TyrPro: 1.022 ± 0.281
1.788TyrGln: 1.788 ± 0.347
1.703TyrArg: 1.703 ± 0.372
2.554TyrSer: 2.554 ± 0.456
3.065TyrThr: 3.065 ± 0.66
3.065TyrVal: 3.065 ± 0.421
0.851TyrTrp: 0.851 ± 0.396
2.384TyrTyr: 2.384 ± 0.603
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (11747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski