Human papillomavirus 56

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 6

Average proteome isoelectric point is 6.5

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 5 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P36833|VE7_HPV56 Protein E7 OS=Human papillomavirus 56 OX=10596 GN=E7 PE=3 SV=1
MM1 pKa = 7.2HH2 pKa = 7.29GKK4 pKa = 9.63VPTLQDD10 pKa = 3.24VVLEE14 pKa = 4.25LTPQTEE20 pKa = 4.1IDD22 pKa = 3.96LQCNEE27 pKa = 4.41QLDD30 pKa = 4.01SSEE33 pKa = 5.94DD34 pKa = 3.7EE35 pKa = 5.42DD36 pKa = 4.45EE37 pKa = 5.9DD38 pKa = 4.92EE39 pKa = 4.66VDD41 pKa = 4.07HH42 pKa = 6.56LQEE45 pKa = 4.63RR46 pKa = 11.84PQQARR51 pKa = 11.84QAKK54 pKa = 8.5QHH56 pKa = 4.71TCYY59 pKa = 10.48LIHH62 pKa = 6.88VPCCEE67 pKa = 4.19CKK69 pKa = 10.39FVVQLDD75 pKa = 3.73IQSTKK80 pKa = 10.03EE81 pKa = 3.8DD82 pKa = 3.59LRR84 pKa = 11.84VVQQLLMGALTVTCPLCASSNN105 pKa = 3.57

Molecular weight: 11.89 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P36743|VL1_HPV56 Major capsid protein L1 OS=Human papillomavirus 56 OX=10596 GN=L1 PE=3 SV=1
MM1 pKa = 7.71EE2 pKa = 4.95PQFNNPQEE10 pKa = 4.41RR11 pKa = 11.84PRR13 pKa = 11.84SLHH16 pKa = 6.07HH17 pKa = 6.41LSEE20 pKa = 4.29VLEE23 pKa = 4.4IPLIDD28 pKa = 4.1LRR30 pKa = 11.84LSCVYY35 pKa = 10.14CKK37 pKa = 10.6KK38 pKa = 10.18EE39 pKa = 3.67LTRR42 pKa = 11.84AEE44 pKa = 4.61VYY46 pKa = 10.78NFACTEE52 pKa = 4.0LKK54 pKa = 10.39LVYY57 pKa = 10.14RR58 pKa = 11.84DD59 pKa = 3.78DD60 pKa = 3.95FPYY63 pKa = 10.51AVCRR67 pKa = 11.84VCLLFYY73 pKa = 11.04SKK75 pKa = 10.27VRR77 pKa = 11.84KK78 pKa = 8.74YY79 pKa = 10.49RR80 pKa = 11.84YY81 pKa = 9.11YY82 pKa = 10.83DD83 pKa = 3.43YY84 pKa = 11.15SVYY87 pKa = 10.74GATLEE92 pKa = 4.89SITKK96 pKa = 9.82KK97 pKa = 9.82QLCDD101 pKa = 3.61LLIRR105 pKa = 11.84CYY107 pKa = 10.31RR108 pKa = 11.84CQSPLTPEE116 pKa = 4.35EE117 pKa = 4.23KK118 pKa = 10.06QLHH121 pKa = 6.6CDD123 pKa = 2.99RR124 pKa = 11.84KK125 pKa = 10.46RR126 pKa = 11.84RR127 pKa = 11.84FHH129 pKa = 7.03LIAHH133 pKa = 7.01GWTGSCLGCWRR144 pKa = 11.84QTSRR148 pKa = 11.84EE149 pKa = 4.03PRR151 pKa = 11.84EE152 pKa = 4.13STVV155 pKa = 2.8

Molecular weight: 18.52 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

5

0

5

1568

105

534

313.6

35.33

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.612 ± 1.119

2.806 ± 1.274

5.357 ± 0.364

5.357 ± 0.952

3.635 ± 0.585

5.548 ± 1.167

2.551 ± 0.574

4.847 ± 0.748

5.038 ± 1.114

7.398 ± 1.303

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.594 ± 0.438

4.082 ± 0.801

6.633 ± 1.3

4.209 ± 0.883

5.74 ± 0.615

7.972 ± 0.754

8.291 ± 0.791

7.27 ± 0.303

1.467 ± 0.31

4.592 ± 0.723
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski