Amino acid dipepetide frequency for Pedobacter insulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.921AlaAla: 5.921 ± 0.091	0.655AlaCys: 0.655 ± 0.023	4.182AlaAsp: 4.182 ± 0.052	4.423AlaGlu: 4.423 ± 0.071	3.59AlaPhe: 3.59 ± 0.05	5.147AlaGly: 5.147 ± 0.068	1.211AlaHis: 1.211 ± 0.029	5.794AlaIle: 5.794 ± 0.07	5.504AlaLys: 5.504 ± 0.072	6.95AlaLeu: 6.95 ± 0.081	1.7AlaMet: 1.7 ± 0.04	4.44AlaAsn: 4.44 ± 0.068	2.268AlaPro: 2.268 ± 0.039	2.966AlaGln: 2.966 ± 0.046	2.331AlaArg: 2.331 ± 0.041	4.476AlaSer: 4.476 ± 0.071	4.249AlaThr: 4.249 ± 0.085	4.683AlaVal: 4.683 ± 0.069	0.795AlaTrp: 0.795 ± 0.026	3.024AlaTyr: 3.024 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.483CysAla: 0.483 ± 0.02	0.118CysCys: 0.118 ± 0.01	0.368CysAsp: 0.368 ± 0.019	0.416CysGlu: 0.416 ± 0.019	0.413CysPhe: 0.413 ± 0.02	0.59CysGly: 0.59 ± 0.023	0.176CysHis: 0.176 ± 0.014	0.615CysIle: 0.615 ± 0.022	0.506CysLys: 0.506 ± 0.019	0.748CysLeu: 0.748 ± 0.025	0.175CysMet: 0.175 ± 0.011	0.352CysAsn: 0.352 ± 0.016	0.273CysPro: 0.273 ± 0.017	0.209CysGln: 0.209 ± 0.014	0.251CysArg: 0.251 ± 0.013	0.478CysSer: 0.478 ± 0.021	0.398CysThr: 0.398 ± 0.017	0.455CysVal: 0.455 ± 0.017	0.077CysTrp: 0.077 ± 0.008	0.28CysTyr: 0.28 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.569AspAla: 3.569 ± 0.056	0.354AspCys: 0.354 ± 0.018	2.438AspAsp: 2.438 ± 0.049	3.36AspGlu: 3.36 ± 0.061	3.225AspPhe: 3.225 ± 0.056	3.643AspGly: 3.643 ± 0.055	0.978AspHis: 0.978 ± 0.028	3.738AspIle: 3.738 ± 0.052	3.884AspLys: 3.884 ± 0.055	5.126AspLeu: 5.126 ± 0.071	1.115AspMet: 1.115 ± 0.032	2.52AspAsn: 2.52 ± 0.044	2.039AspPro: 2.039 ± 0.038	1.944AspGln: 1.944 ± 0.039	2.079AspArg: 2.079 ± 0.037	2.836AspSer: 2.836 ± 0.056	2.383AspThr: 2.383 ± 0.053	3.254AspVal: 3.254 ± 0.058	0.711AspTrp: 0.711 ± 0.024	2.47AspTyr: 2.47 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.074GluAla: 4.074 ± 0.068	0.286GluCys: 0.286 ± 0.015	2.74GluAsp: 2.74 ± 0.039	3.852GluGlu: 3.852 ± 0.085	2.472GluPhe: 2.472 ± 0.05	3.402GluGly: 3.402 ± 0.053	1.065GluHis: 1.065 ± 0.026	4.7GluIle: 4.7 ± 0.06	4.94GluLys: 4.94 ± 0.073	5.857GluLeu: 5.857 ± 0.065	1.525GluMet: 1.525 ± 0.037	3.581GluAsn: 3.581 ± 0.053	1.584GluPro: 1.584 ± 0.035	2.415GluGln: 2.415 ± 0.049	2.521GluArg: 2.521 ± 0.049	2.801GluSer: 2.801 ± 0.046	2.98GluThr: 2.98 ± 0.052	3.886GluVal: 3.886 ± 0.055	0.634GluTrp: 0.634 ± 0.02	1.85GluTyr: 1.85 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.53PheAla: 3.53 ± 0.061	0.479PheCys: 0.479 ± 0.019	2.879PheAsp: 2.879 ± 0.049	2.973PheGlu: 2.973 ± 0.055	2.529PhePhe: 2.529 ± 0.044	3.614PheGly: 3.614 ± 0.052	0.768PheHis: 0.768 ± 0.024	3.594PheIle: 3.594 ± 0.056	3.676PheLys: 3.676 ± 0.047	4.558PheLeu: 4.558 ± 0.074	1.138PheMet: 1.138 ± 0.029	3.383PheAsn: 3.383 ± 0.054	1.706PhePro: 1.706 ± 0.038	1.372PheGln: 1.372 ± 0.027	1.713PheArg: 1.713 ± 0.036	3.829PheSer: 3.829 ± 0.056	3.117PheThr: 3.117 ± 0.048	2.993PheVal: 2.993 ± 0.049	0.6PheTrp: 0.6 ± 0.024	2.147PheTyr: 2.147 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.647GlyAla: 4.647 ± 0.072	0.568GlyCys: 0.568 ± 0.023	3.246GlyAsp: 3.246 ± 0.055	3.437GlyGlu: 3.437 ± 0.06	3.683GlyPhe: 3.683 ± 0.062	4.831GlyGly: 4.831 ± 0.08	1.109GlyHis: 1.109 ± 0.032	5.313GlyIle: 5.313 ± 0.059	5.617GlyLys: 5.617 ± 0.062	6.279GlyLeu: 6.279 ± 0.072	1.689GlyMet: 1.689 ± 0.046	3.915GlyAsn: 3.915 ± 0.069	1.462GlyPro: 1.462 ± 0.042	2.063GlyGln: 2.063 ± 0.041	2.372GlyArg: 2.372 ± 0.043	4.314GlySer: 4.314 ± 0.066	4.17GlyThr: 4.17 ± 0.071	4.377GlyVal: 4.377 ± 0.06	0.886GlyTrp: 0.886 ± 0.026	3.08GlyTyr: 3.08 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.092HisAla: 1.092 ± 0.031	0.181HisCys: 0.181 ± 0.013	0.824HisAsp: 0.824 ± 0.026	0.902HisGlu: 0.902 ± 0.026	1.103HisPhe: 1.103 ± 0.035	1.096HisGly: 1.096 ± 0.027	0.522HisHis: 0.522 ± 0.02	1.345HisIle: 1.345 ± 0.037	1.082HisLys: 1.082 ± 0.03	1.847HisLeu: 1.847 ± 0.041	0.317HisMet: 0.317 ± 0.017	0.848HisAsn: 0.848 ± 0.027	0.917HisPro: 0.917 ± 0.029	0.831HisGln: 0.831 ± 0.027	0.686HisArg: 0.686 ± 0.026	1.025HisSer: 1.025 ± 0.028	0.987HisThr: 0.987 ± 0.026	0.957HisVal: 0.957 ± 0.027	0.222HisTrp: 0.222 ± 0.015	0.825HisTyr: 0.825 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.339IleAla: 6.339 ± 0.073	0.678IleCys: 0.678 ± 0.022	4.401IleAsp: 4.401 ± 0.058	4.45IleGlu: 4.45 ± 0.069	3.413IlePhe: 3.413 ± 0.06	5.028IleGly: 5.028 ± 0.067	1.273IleHis: 1.273 ± 0.034	5.264IleIle: 5.264 ± 0.07	5.65IleLys: 5.65 ± 0.07	6.564IleLeu: 6.564 ± 0.064	1.412IleMet: 1.412 ± 0.037	4.772IleAsn: 4.772 ± 0.065	3.038IlePro: 3.038 ± 0.048	2.283IleGln: 2.283 ± 0.042	2.707IleArg: 2.707 ± 0.049	5.148IleSer: 5.148 ± 0.071	4.584IleThr: 4.584 ± 0.064	4.464IleVal: 4.464 ± 0.066	0.75IleTrp: 0.75 ± 0.023	2.699IleTyr: 2.699 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.625LysAla: 5.625 ± 0.072	0.306LysCys: 0.306 ± 0.017	4.297LysAsp: 4.297 ± 0.057	5.077LysGlu: 5.077 ± 0.072	2.959LysPhe: 2.959 ± 0.05	4.747LysGly: 4.747 ± 0.059	1.366LysHis: 1.366 ± 0.035	5.8LysIle: 5.8 ± 0.069	5.902LysLys: 5.902 ± 0.084	6.802LysLeu: 6.802 ± 0.088	1.987LysMet: 1.987 ± 0.04	4.75LysAsn: 4.75 ± 0.063	2.825LysPro: 2.825 ± 0.047	2.911LysGln: 2.911 ± 0.05	2.857LysArg: 2.857 ± 0.05	4.236LysSer: 4.236 ± 0.053	4.426LysThr: 4.426 ± 0.063	4.862LysVal: 4.862 ± 0.065	0.848LysTrp: 0.848 ± 0.025	2.966LysTyr: 2.966 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.491LeuAla: 7.491 ± 0.088	0.766LeuCys: 0.766 ± 0.023	4.538LeuAsp: 4.538 ± 0.071	4.716LeuGlu: 4.716 ± 0.068	4.848LeuPhe: 4.848 ± 0.074	5.95LeuGly: 5.95 ± 0.072	1.573LeuHis: 1.573 ± 0.037	7.082LeuIle: 7.082 ± 0.087	7.891LeuLys: 7.891 ± 0.082	9.298LeuLeu: 9.298 ± 0.1	2.208LeuMet: 2.208 ± 0.044	6.11LeuAsn: 6.11 ± 0.088	3.952LeuPro: 3.952 ± 0.055	3.432LeuGln: 3.432 ± 0.051	3.465LeuArg: 3.465 ± 0.061	7.074LeuSer: 7.074 ± 0.069	5.984LeuThr: 5.984 ± 0.072	5.574LeuVal: 5.574 ± 0.078	0.92LeuTrp: 0.92 ± 0.027	3.316LeuTyr: 3.316 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.723MetAla: 1.723 ± 0.04	0.13MetCys: 0.13 ± 0.009	1.186MetAsp: 1.186 ± 0.031	1.374MetGlu: 1.374 ± 0.037	0.839MetPhe: 0.839 ± 0.025	1.638MetGly: 1.638 ± 0.036	0.404MetHis: 0.404 ± 0.017	1.557MetIle: 1.557 ± 0.039	2.025MetLys: 2.025 ± 0.041	2.151MetLeu: 2.151 ± 0.041	0.635MetMet: 0.635 ± 0.023	1.336MetAsn: 1.336 ± 0.031	1.049MetPro: 1.049 ± 0.031	0.948MetGln: 0.948 ± 0.028	0.961MetArg: 0.961 ± 0.028	1.37MetSer: 1.37 ± 0.035	1.033MetThr: 1.033 ± 0.025	1.482MetVal: 1.482 ± 0.035	0.185MetTrp: 0.185 ± 0.012	0.687MetTyr: 0.687 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.475AsnAla: 4.475 ± 0.066	0.41AsnCys: 0.41 ± 0.017	2.877AsnAsp: 2.877 ± 0.048	3.345AsnGlu: 3.345 ± 0.05	3.129AsnPhe: 3.129 ± 0.059	4.402AsnGly: 4.402 ± 0.073	1.04AsnHis: 1.04 ± 0.028	4.353AsnIle: 4.353 ± 0.056	4.016AsnLys: 4.016 ± 0.051	5.746AsnLeu: 5.746 ± 0.068	1.277AsnMet: 1.277 ± 0.029	3.517AsnAsn: 3.517 ± 0.064	2.807AsnPro: 2.807 ± 0.049	2.192AsnGln: 2.192 ± 0.045	2.364AsnArg: 2.364 ± 0.048	3.648AsnSer: 3.648 ± 0.062	3.379AsnThr: 3.379 ± 0.057	3.398AsnVal: 3.398 ± 0.058	0.779AsnTrp: 0.779 ± 0.027	2.953AsnTyr: 2.953 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.77ProAla: 2.77 ± 0.054	0.22ProCys: 0.22 ± 0.013	2.119ProAsp: 2.119 ± 0.043	2.476ProGlu: 2.476 ± 0.044	1.928ProPhe: 1.928 ± 0.038	2.357ProGly: 2.357 ± 0.041	0.633ProHis: 0.633 ± 0.022	2.776ProIle: 2.776 ± 0.043	2.531ProLys: 2.531 ± 0.051	3.301ProLeu: 3.301 ± 0.055	0.791ProMet: 0.791 ± 0.024	2.247ProAsn: 2.247 ± 0.039	0.96ProPro: 0.96 ± 0.036	1.307ProGln: 1.307 ± 0.03	1.017ProArg: 1.017 ± 0.026	2.283ProSer: 2.283 ± 0.042	2.181ProThr: 2.181 ± 0.041	2.72ProVal: 2.72 ± 0.044	0.358ProTrp: 0.358 ± 0.018	1.468ProTyr: 1.468 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.537GlnAla: 2.537 ± 0.041	0.179GlnCys: 0.179 ± 0.013	1.543GlnAsp: 1.543 ± 0.032	2.05GlnGlu: 2.05 ± 0.038	1.717GlnPhe: 1.717 ± 0.038	1.962GlnGly: 1.962 ± 0.039	0.747GlnHis: 0.747 ± 0.022	2.681GlnIle: 2.681 ± 0.039	2.86GlnLys: 2.86 ± 0.052	3.895GlnLeu: 3.895 ± 0.054	0.882GlnMet: 0.882 ± 0.027	2.162GlnAsn: 2.162 ± 0.045	1.234GlnPro: 1.234 ± 0.031	1.854GlnGln: 1.854 ± 0.044	1.478GlnArg: 1.478 ± 0.035	2.151GlnSer: 2.151 ± 0.045	2.21GlnThr: 2.21 ± 0.04	2.155GlnVal: 2.155 ± 0.041	0.4GlnTrp: 0.4 ± 0.016	1.401GlnTyr: 1.401 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.406ArgAla: 2.406 ± 0.042	0.206ArgCys: 0.206 ± 0.013	1.85ArgAsp: 1.85 ± 0.044	2.117ArgGlu: 2.117 ± 0.039	1.975ArgPhe: 1.975 ± 0.035	2.138ArgGly: 2.138 ± 0.041	0.607ArgHis: 0.607 ± 0.021	2.985ArgIle: 2.985 ± 0.047	2.872ArgLys: 2.872 ± 0.047	3.712ArgLeu: 3.712 ± 0.057	0.967ArgMet: 0.967 ± 0.026	2.311ArgAsn: 2.311 ± 0.046	1.293ArgPro: 1.293 ± 0.034	1.227ArgGln: 1.227 ± 0.03	1.442ArgArg: 1.442 ± 0.036	2.176ArgSer: 2.176 ± 0.037	2.051ArgThr: 2.051 ± 0.039	2.173ArgVal: 2.173 ± 0.047	0.464ArgTrp: 0.464 ± 0.019	1.744ArgTyr: 1.744 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.624SerAla: 4.624 ± 0.061	0.572SerCys: 0.572 ± 0.02	2.974SerAsp: 2.974 ± 0.048	3.084SerGlu: 3.084 ± 0.051	3.809SerPhe: 3.809 ± 0.054	4.537SerGly: 4.537 ± 0.073	1.093SerHis: 1.093 ± 0.03	4.925SerIle: 4.925 ± 0.065	4.274SerLys: 4.274 ± 0.054	6.453SerLeu: 6.453 ± 0.082	1.324SerMet: 1.324 ± 0.034	3.464SerAsn: 3.464 ± 0.054	2.345SerPro: 2.345 ± 0.039	1.961SerGln: 1.961 ± 0.04	2.259SerArg: 2.259 ± 0.04	4.287SerSer: 4.287 ± 0.059	3.658SerThr: 3.658 ± 0.063	3.862SerVal: 3.862 ± 0.059	0.736SerTrp: 0.736 ± 0.023	2.972SerTyr: 2.972 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.651ThrAla: 4.651 ± 0.065	0.347ThrCys: 0.347 ± 0.018	3.064ThrAsp: 3.064 ± 0.053	3.034ThrGlu: 3.034 ± 0.061	2.861ThrPhe: 2.861 ± 0.049	4.521ThrGly: 4.521 ± 0.065	1.0ThrHis: 1.0 ± 0.027	4.501ThrIle: 4.501 ± 0.065	3.766ThrLys: 3.766 ± 0.057	5.74ThrLeu: 5.74 ± 0.064	1.039ThrMet: 1.039 ± 0.028	3.234ThrAsn: 3.234 ± 0.057	2.424ThrPro: 2.424 ± 0.048	1.937ThrGln: 1.937 ± 0.035	1.72ThrArg: 1.72 ± 0.039	3.592ThrSer: 3.592 ± 0.06	3.603ThrThr: 3.603 ± 0.071	3.772ThrVal: 3.772 ± 0.064	0.648ThrTrp: 0.648 ± 0.026	2.461ThrTyr: 2.461 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.618ValAla: 4.618 ± 0.065	0.502ValCys: 0.502 ± 0.021	3.373ValAsp: 3.373 ± 0.051	3.364ValGlu: 3.364 ± 0.055	3.091ValPhe: 3.091 ± 0.05	3.901ValGly: 3.901 ± 0.055	0.95ValHis: 0.95 ± 0.028	4.647ValIle: 4.647 ± 0.062	4.923ValLys: 4.923 ± 0.065	5.978ValLeu: 5.978 ± 0.084	1.473ValMet: 1.473 ± 0.038	3.973ValAsn: 3.973 ± 0.057	2.268ValPro: 2.268 ± 0.045	1.889ValGln: 1.889 ± 0.037	2.188ValArg: 2.188 ± 0.042	4.279ValSer: 4.279 ± 0.062	3.469ValThr: 3.469 ± 0.055	4.111ValVal: 4.111 ± 0.068	0.658ValTrp: 0.658 ± 0.022	2.357ValTyr: 2.357 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.775TrpAla: 0.775 ± 0.03	0.117TrpCys: 0.117 ± 0.008	0.589TrpAsp: 0.589 ± 0.019	0.641TrpGlu: 0.641 ± 0.023	0.59TrpPhe: 0.59 ± 0.025	0.788TrpGly: 0.788 ± 0.026	0.23TrpHis: 0.23 ± 0.014	0.742TrpIle: 0.742 ± 0.024	0.845TrpLys: 0.845 ± 0.027	1.156TrpLeu: 1.156 ± 0.034	0.315TrpMet: 0.315 ± 0.018	0.684TrpAsn: 0.684 ± 0.022	0.331TrpPro: 0.331 ± 0.018	0.486TrpGln: 0.486 ± 0.017	0.46TrpArg: 0.46 ± 0.016	0.65TrpSer: 0.65 ± 0.022	0.593TrpThr: 0.593 ± 0.018	0.708TrpVal: 0.708 ± 0.025	0.171TrpTrp: 0.171 ± 0.013	0.472TrpTyr: 0.472 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.958TyrAla: 2.958 ± 0.046	0.309TyrCys: 0.309 ± 0.016	2.176TyrAsp: 2.176 ± 0.049	2.07TyrGlu: 2.07 ± 0.045	2.422TyrPhe: 2.422 ± 0.045	2.768TyrGly: 2.768 ± 0.049	0.866TyrHis: 0.866 ± 0.027	2.505TyrIle: 2.505 ± 0.045	2.785TyrLys: 2.785 ± 0.045	4.027TyrLeu: 4.027 ± 0.055	0.744TyrMet: 0.744 ± 0.023	2.511TyrAsn: 2.511 ± 0.055	1.666TyrPro: 1.666 ± 0.039	1.871TyrGln: 1.871 ± 0.039	1.844TyrArg: 1.844 ± 0.037	2.561TyrSer: 2.561 ± 0.051	2.461TyrThr: 2.461 ± 0.048	2.127TyrVal: 2.127 ± 0.037	0.501TyrTrp: 0.501 ± 0.022	1.824TyrTyr: 1.824 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3767 proteins (1348508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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