Amino acid dipepetide frequency for Hubei leech virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.403AlaAla: 9.403 ± 0.569
0.409AlaCys: 0.409 ± 0.398
4.088AlaAsp: 4.088 ± 0.915
2.453AlaGlu: 2.453 ± 0.065
3.271AlaPhe: 3.271 ± 1.11
6.95AlaGly: 6.95 ± 2.476
2.044AlaHis: 2.044 ± 0.764
5.315AlaIle: 5.315 ± 1.496
3.679AlaLys: 3.679 ± 1.94
8.994AlaLeu: 8.994 ± 1.671
1.635AlaMet: 1.635 ± 0.248
3.679AlaAsn: 3.679 ± 0.098
5.724AlaPro: 5.724 ± 1.281
4.906AlaGln: 4.906 ± 1.098
3.271AlaArg: 3.271 ± 0.732
7.359AlaSer: 7.359 ± 1.033
6.132AlaThr: 6.132 ± 1.679
4.088AlaVal: 4.088 ± 0.301
0.409AlaTrp: 0.409 ± 0.216
4.088AlaTyr: 4.088 ± 1.541
0.0AlaXaa: 0.0 ± 0.0
Cys
2.044CysAla: 2.044 ± 0.764
0.0CysCys: 0.0 ± 0.0
0.818CysAsp: 0.818 ± 0.183
0.409CysGlu: 0.409 ± 0.216
0.0CysPhe: 0.0 ± 0.0
1.635CysGly: 1.635 ± 0.862
0.0CysHis: 0.0 ± 0.0
1.226CysIle: 1.226 ± 0.647
2.044CysLys: 2.044 ± 0.464
0.818CysLeu: 0.818 ± 0.431
0.409CysMet: 0.409 ± 0.216
0.0CysAsn: 0.0 ± 0.0
0.818CysPro: 0.818 ± 0.431
0.0CysGln: 0.0 ± 0.0
0.818CysArg: 0.818 ± 0.183
0.409CysSer: 0.409 ± 0.216
0.0CysThr: 0.0 ± 0.0
2.044CysVal: 2.044 ± 1.078
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.635AspAla: 1.635 ± 0.862
0.409AspCys: 0.409 ± 0.216
4.088AspAsp: 4.088 ± 0.927
5.315AspGlu: 5.315 ± 0.346
3.271AspPhe: 3.271 ± 0.118
2.044AspGly: 2.044 ± 0.15
1.635AspHis: 1.635 ± 0.248
6.132AspIle: 6.132 ± 1.065
2.862AspLys: 2.862 ± 1.509
6.541AspLeu: 6.541 ± 0.236
1.635AspMet: 1.635 ± 0.366
2.453AspAsn: 2.453 ± 0.549
2.453AspPro: 2.453 ± 0.549
1.635AspGln: 1.635 ± 0.248
1.635AspArg: 1.635 ± 0.862
3.271AspSer: 3.271 ± 1.96
5.724AspThr: 5.724 ± 1.175
5.724AspVal: 5.724 ± 0.667
0.409AspTrp: 0.409 ± 0.216
1.635AspTyr: 1.635 ± 0.366
0.0AspXaa: 0.0 ± 0.0
Glu
6.132GluAla: 6.132 ± 1.391
1.635GluCys: 1.635 ± 0.862
3.679GluAsp: 3.679 ± 0.516
2.044GluGlu: 2.044 ± 1.078
2.044GluPhe: 2.044 ± 0.464
4.088GluGly: 4.088 ± 0.915
1.635GluHis: 1.635 ± 0.862
3.679GluIle: 3.679 ± 0.098
0.818GluLys: 0.818 ± 0.183
3.271GluLeu: 3.271 ± 0.732
2.862GluMet: 2.862 ± 0.281
2.453GluAsn: 2.453 ± 0.679
1.226GluPro: 1.226 ± 0.581
1.635GluGln: 1.635 ± 0.862
2.453GluArg: 2.453 ± 0.679
2.862GluSer: 2.862 ± 0.281
2.453GluThr: 2.453 ± 0.679
2.862GluVal: 2.862 ± 0.895
2.044GluTrp: 2.044 ± 0.464
1.635GluTyr: 1.635 ± 0.862
0.0GluXaa: 0.0 ± 0.0
Phe
4.906PheAla: 4.906 ± 1.098
0.0PheCys: 0.0 ± 0.0
3.271PheAsp: 3.271 ± 1.11
2.453PheGlu: 2.453 ± 0.679
2.044PhePhe: 2.044 ± 0.764
2.453PheGly: 2.453 ± 0.549
2.044PheHis: 2.044 ± 1.078
2.044PheIle: 2.044 ± 0.15
4.088PheLys: 4.088 ± 0.301
1.635PheLeu: 1.635 ± 0.366
0.409PheMet: 0.409 ± 0.216
2.862PheAsn: 2.862 ± 0.895
1.635PhePro: 1.635 ± 0.862
1.635PheGln: 1.635 ± 0.248
2.453PheArg: 2.453 ± 0.065
3.271PheSer: 3.271 ± 0.496
4.088PheThr: 4.088 ± 0.915
3.271PheVal: 3.271 ± 1.11
1.226PheTrp: 1.226 ± 0.647
2.862PheTyr: 2.862 ± 0.947
0.0PheXaa: 0.0 ± 0.0
Gly
4.906GlyAla: 4.906 ± 0.484
0.818GlyCys: 0.818 ± 0.183
5.724GlyAsp: 5.724 ± 0.561
5.315GlyGlu: 5.315 ± 0.882
3.679GlyPhe: 3.679 ± 0.516
2.862GlyGly: 2.862 ± 0.333
0.409GlyHis: 0.409 ± 0.216
2.453GlyIle: 2.453 ± 0.679
4.497GlyLys: 4.497 ± 1.143
3.679GlyLeu: 3.679 ± 0.098
2.044GlyMet: 2.044 ± 0.15
2.862GlyAsn: 2.862 ± 0.947
3.679GlyPro: 3.679 ± 1.744
0.818GlyGln: 0.818 ± 0.183
2.453GlyArg: 2.453 ± 0.065
4.497GlySer: 4.497 ± 1.927
4.906GlyThr: 4.906 ± 0.13
7.359GlyVal: 7.359 ± 1.033
0.818GlyTrp: 0.818 ± 0.183
0.818GlyTyr: 0.818 ± 0.183
0.0GlyXaa: 0.0 ± 0.0
His
1.635HisAla: 1.635 ± 0.366
0.0HisCys: 0.0 ± 0.0
0.818HisAsp: 0.818 ± 0.183
0.409HisGlu: 0.409 ± 0.216
0.818HisPhe: 0.818 ± 0.183
1.635HisGly: 1.635 ± 0.862
0.409HisHis: 0.409 ± 0.216
2.044HisIle: 2.044 ± 1.078
0.818HisLys: 0.818 ± 0.431
1.226HisLeu: 1.226 ± 0.581
0.409HisMet: 0.409 ± 0.216
0.818HisAsn: 0.818 ± 0.183
1.635HisPro: 1.635 ± 0.248
0.818HisGln: 0.818 ± 0.183
1.635HisArg: 1.635 ± 0.366
2.453HisSer: 2.453 ± 0.065
1.226HisThr: 1.226 ± 0.033
0.818HisVal: 0.818 ± 0.431
0.409HisTrp: 0.409 ± 0.216
0.818HisTyr: 0.818 ± 0.183
0.0HisXaa: 0.0 ± 0.0
Ile
5.315IleAla: 5.315 ± 0.346
1.226IleCys: 1.226 ± 0.647
4.497IleAsp: 4.497 ± 0.529
2.862IleGlu: 2.862 ± 0.895
2.453IlePhe: 2.453 ± 0.679
1.226IleGly: 1.226 ± 0.033
2.044IleHis: 2.044 ± 0.464
2.044IleIle: 2.044 ± 1.078
1.226IleLys: 1.226 ± 0.647
6.132IleLeu: 6.132 ± 1.391
2.862IleMet: 2.862 ± 0.333
3.271IleAsn: 3.271 ± 0.732
2.862IlePro: 2.862 ± 0.333
1.635IleGln: 1.635 ± 0.366
0.818IleArg: 0.818 ± 0.797
4.088IleSer: 4.088 ± 0.915
5.724IleThr: 5.724 ± 1.895
2.862IleVal: 2.862 ± 0.281
1.226IleTrp: 1.226 ± 0.581
2.044IleTyr: 2.044 ± 0.764
0.0IleXaa: 0.0 ± 0.0
Lys
5.315LysAla: 5.315 ± 0.96
0.409LysCys: 0.409 ± 0.216
2.044LysAsp: 2.044 ± 1.078
3.679LysGlu: 3.679 ± 1.94
2.862LysPhe: 2.862 ± 0.281
3.271LysGly: 3.271 ± 1.11
0.818LysHis: 0.818 ± 0.431
2.453LysIle: 2.453 ± 0.065
2.862LysLys: 2.862 ± 0.281
5.315LysLeu: 5.315 ± 0.96
1.226LysMet: 1.226 ± 0.56
2.044LysAsn: 2.044 ± 0.15
1.635LysPro: 1.635 ± 0.366
2.044LysGln: 2.044 ± 0.464
2.453LysArg: 2.453 ± 0.679
2.044LysSer: 2.044 ± 0.464
4.088LysThr: 4.088 ± 1.541
2.453LysVal: 2.453 ± 1.293
0.409LysTrp: 0.409 ± 0.216
2.453LysTyr: 2.453 ± 0.679
0.0LysXaa: 0.0 ± 0.0
Leu
6.132LeuAla: 6.132 ± 1.679
1.635LeuCys: 1.635 ± 0.366
7.359LeuAsp: 7.359 ± 0.809
6.95LeuGlu: 6.95 ± 1.208
3.271LeuPhe: 3.271 ± 0.118
3.679LeuGly: 3.679 ± 1.326
2.044LeuHis: 2.044 ± 0.464
3.271LeuIle: 3.271 ± 0.496
3.271LeuLys: 3.271 ± 0.496
4.906LeuLeu: 4.906 ± 2.586
1.226LeuMet: 1.226 ± 0.647
2.862LeuAsn: 2.862 ± 0.947
4.088LeuPro: 4.088 ± 0.915
3.679LeuGln: 3.679 ± 0.098
2.862LeuArg: 2.862 ± 0.333
6.132LeuSer: 6.132 ± 0.451
8.994LeuThr: 8.994 ± 0.171
6.132LeuVal: 6.132 ± 0.451
0.818LeuTrp: 0.818 ± 0.183
2.862LeuTyr: 2.862 ± 1.509
0.0LeuXaa: 0.0 ± 0.0
Met
4.088MetAla: 4.088 ± 0.301
0.0MetCys: 0.0 ± 0.0
0.818MetAsp: 0.818 ± 0.431
2.453MetGlu: 2.453 ± 0.679
1.226MetPhe: 1.226 ± 0.033
2.453MetGly: 2.453 ± 0.549
0.818MetHis: 0.818 ± 0.797
0.818MetIle: 0.818 ± 0.183
2.044MetLys: 2.044 ± 0.464
3.679MetLeu: 3.679 ± 0.712
0.818MetMet: 0.818 ± 0.431
0.0MetAsn: 0.0 ± 0.0
1.226MetPro: 1.226 ± 0.033
1.226MetGln: 1.226 ± 0.647
3.271MetArg: 3.271 ± 0.496
2.453MetSer: 2.453 ± 1.293
0.409MetThr: 0.409 ± 0.216
2.044MetVal: 2.044 ± 0.15
0.409MetTrp: 0.409 ± 0.216
1.635MetTyr: 1.635 ± 0.366
0.0MetXaa: 0.0 ± 0.0
Asn
2.453AsnAla: 2.453 ± 0.065
1.226AsnCys: 1.226 ± 0.033
1.635AsnAsp: 1.635 ± 0.366
1.635AsnGlu: 1.635 ± 0.98
4.088AsnPhe: 4.088 ± 0.915
4.906AsnGly: 4.906 ± 2.326
0.818AsnHis: 0.818 ± 0.183
2.862AsnIle: 2.862 ± 0.333
2.044AsnLys: 2.044 ± 1.078
4.906AsnLeu: 4.906 ± 2.326
1.226AsnMet: 1.226 ± 0.033
2.044AsnAsn: 2.044 ± 0.764
2.453AsnPro: 2.453 ± 0.679
1.635AsnGln: 1.635 ± 0.248
1.226AsnArg: 1.226 ± 0.033
1.635AsnSer: 1.635 ± 0.248
2.862AsnThr: 2.862 ± 0.333
2.862AsnVal: 2.862 ± 0.281
0.818AsnTrp: 0.818 ± 0.797
1.635AsnTyr: 1.635 ± 0.248
0.0AsnXaa: 0.0 ± 0.0
Pro
4.497ProAla: 4.497 ± 0.699
1.635ProCys: 1.635 ± 0.248
2.044ProAsp: 2.044 ± 0.464
2.453ProGlu: 2.453 ± 0.679
4.497ProPhe: 4.497 ± 0.085
2.044ProGly: 2.044 ± 0.15
0.818ProHis: 0.818 ± 0.183
2.044ProIle: 2.044 ± 0.764
1.635ProLys: 1.635 ± 0.248
5.724ProLeu: 5.724 ± 0.667
1.635ProMet: 1.635 ± 0.248
2.453ProAsn: 2.453 ± 1.163
0.409ProPro: 0.409 ± 0.398
1.226ProGln: 1.226 ± 0.581
3.271ProArg: 3.271 ± 0.496
2.044ProSer: 2.044 ± 0.764
2.453ProThr: 2.453 ± 0.549
3.679ProVal: 3.679 ± 1.744
0.818ProTrp: 0.818 ± 0.183
2.044ProTyr: 2.044 ± 0.464
0.0ProXaa: 0.0 ± 0.0
Gln
4.088GlnAla: 4.088 ± 1.529
0.818GlnCys: 0.818 ± 0.431
0.818GlnAsp: 0.818 ± 0.797
1.635GlnGlu: 1.635 ± 0.98
1.226GlnPhe: 1.226 ± 0.647
1.635GlnGly: 1.635 ± 0.862
0.409GlnHis: 0.409 ± 0.216
2.044GlnIle: 2.044 ± 0.15
1.635GlnLys: 1.635 ± 0.248
2.453GlnLeu: 2.453 ± 0.549
1.635GlnMet: 1.635 ± 0.366
0.0GlnAsn: 0.0 ± 0.0
1.226GlnPro: 1.226 ± 0.033
3.271GlnGln: 3.271 ± 0.496
3.271GlnArg: 3.271 ± 0.732
4.088GlnSer: 4.088 ± 0.301
0.818GlnThr: 0.818 ± 0.431
2.453GlnVal: 2.453 ± 0.065
0.0GlnTrp: 0.0 ± 0.0
2.044GlnTyr: 2.044 ± 1.378
0.0GlnXaa: 0.0 ± 0.0
Arg
3.679ArgAla: 3.679 ± 0.098
0.0ArgCys: 0.0 ± 0.0
2.453ArgAsp: 2.453 ± 0.065
2.862ArgGlu: 2.862 ± 0.895
3.271ArgPhe: 3.271 ± 0.732
3.271ArgGly: 3.271 ± 1.96
0.409ArgHis: 0.409 ± 0.216
4.088ArgIle: 4.088 ± 0.927
2.453ArgLys: 2.453 ± 0.679
1.635ArgLeu: 1.635 ± 0.248
2.044ArgMet: 2.044 ± 0.464
2.044ArgAsn: 2.044 ± 1.078
0.818ArgPro: 0.818 ± 0.183
1.226ArgGln: 1.226 ± 1.195
2.044ArgArg: 2.044 ± 0.764
6.132ArgSer: 6.132 ± 0.451
1.635ArgThr: 1.635 ± 0.248
3.679ArgVal: 3.679 ± 1.13
0.818ArgTrp: 0.818 ± 0.183
2.044ArgTyr: 2.044 ± 0.15
0.0ArgXaa: 0.0 ± 0.0
Ser
4.906SerAla: 4.906 ± 1.712
0.409SerCys: 0.409 ± 0.216
5.724SerAsp: 5.724 ± 1.895
2.862SerGlu: 2.862 ± 0.281
4.088SerPhe: 4.088 ± 1.541
5.315SerGly: 5.315 ± 1.496
0.818SerHis: 0.818 ± 0.183
4.088SerIle: 4.088 ± 0.927
3.271SerLys: 3.271 ± 1.11
4.497SerLeu: 4.497 ± 1.313
2.044SerMet: 2.044 ± 0.764
3.271SerAsn: 3.271 ± 0.732
4.088SerPro: 4.088 ± 0.301
2.044SerGln: 2.044 ± 1.378
3.271SerArg: 3.271 ± 0.118
4.906SerSer: 4.906 ± 1.098
4.906SerThr: 4.906 ± 0.13
4.497SerVal: 4.497 ± 0.529
1.226SerTrp: 1.226 ± 0.033
1.226SerTyr: 1.226 ± 0.581
0.0SerXaa: 0.0 ± 0.0
Thr
4.906ThrAla: 4.906 ± 1.358
0.409ThrCys: 0.409 ± 0.216
3.271ThrAsp: 3.271 ± 0.118
2.044ThrGlu: 2.044 ± 0.464
4.088ThrPhe: 4.088 ± 0.301
4.497ThrGly: 4.497 ± 0.699
1.635ThrHis: 1.635 ± 0.248
4.088ThrIle: 4.088 ± 1.529
3.271ThrLys: 3.271 ± 1.11
4.906ThrLeu: 4.906 ± 1.358
1.226ThrMet: 1.226 ± 0.226
5.315ThrAsn: 5.315 ± 1.496
6.132ThrPro: 6.132 ± 0.777
2.453ThrGln: 2.453 ± 1.163
2.862ThrArg: 2.862 ± 0.947
4.088ThrSer: 4.088 ± 0.301
4.088ThrThr: 4.088 ± 0.927
4.088ThrVal: 4.088 ± 0.915
2.044ThrTrp: 2.044 ± 0.764
2.862ThrTyr: 2.862 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
6.95ValAla: 6.95 ± 1.248
0.818ValCys: 0.818 ± 0.431
4.497ValAsp: 4.497 ± 0.699
1.635ValGlu: 1.635 ± 0.248
1.226ValPhe: 1.226 ± 0.647
7.359ValGly: 7.359 ± 0.195
1.226ValHis: 1.226 ± 0.581
3.679ValIle: 3.679 ± 0.098
4.497ValLys: 4.497 ± 0.529
5.315ValLeu: 5.315 ± 1.574
2.453ValMet: 2.453 ± 0.679
5.315ValAsn: 5.315 ± 0.268
3.679ValPro: 3.679 ± 1.13
2.453ValGln: 2.453 ± 0.549
4.088ValArg: 4.088 ± 0.313
3.271ValSer: 3.271 ± 0.496
3.679ValThr: 3.679 ± 1.13
4.088ValVal: 4.088 ± 0.313
0.818ValTrp: 0.818 ± 0.431
1.635ValTyr: 1.635 ± 0.366
0.0ValXaa: 0.0 ± 0.0
Trp
0.409TrpAla: 0.409 ± 0.216
0.818TrpCys: 0.818 ± 0.431
1.635TrpAsp: 1.635 ± 0.248
1.226TrpGlu: 1.226 ± 0.033
0.818TrpPhe: 0.818 ± 0.431
0.818TrpGly: 0.818 ± 0.431
0.0TrpHis: 0.0 ± 0.0
0.409TrpIle: 0.409 ± 0.398
0.409TrpLys: 0.409 ± 0.216
2.862TrpLeu: 2.862 ± 0.947
1.635TrpMet: 1.635 ± 0.862
0.409TrpAsn: 0.409 ± 0.398
0.0TrpPro: 0.0 ± 0.0
0.409TrpGln: 0.409 ± 0.216
1.226TrpArg: 1.226 ± 0.033
0.818TrpSer: 0.818 ± 0.797
1.226TrpThr: 1.226 ± 1.195
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.818TrpTyr: 0.818 ± 0.431
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.497TyrAla: 4.497 ± 0.699
0.818TyrCys: 0.818 ± 0.431
1.226TyrAsp: 1.226 ± 0.033
0.818TyrGlu: 0.818 ± 0.431
0.409TyrPhe: 0.409 ± 0.216
2.453TyrGly: 2.453 ± 0.065
0.818TyrHis: 0.818 ± 0.183
1.635TyrIle: 1.635 ± 0.248
2.453TyrLys: 2.453 ± 0.679
3.679TyrLeu: 3.679 ± 0.712
2.044TyrMet: 2.044 ± 0.464
0.818TyrAsn: 0.818 ± 0.797
1.635TyrPro: 1.635 ± 0.366
0.818TyrGln: 0.818 ± 0.183
1.226TyrArg: 1.226 ± 0.581
1.635TyrSer: 1.635 ± 0.366
3.271TyrThr: 3.271 ± 0.496
3.679TyrVal: 3.679 ± 0.098
1.226TyrTrp: 1.226 ± 0.033
2.044TyrTyr: 2.044 ± 0.464
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski