Amino acid dipepetide frequency for Klebsiella phage ST512-KPC3phi13.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.766AlaAla: 11.766 ± 2.259
0.917AlaCys: 0.917 ± 0.305
5.883AlaAsp: 5.883 ± 0.671
8.328AlaGlu: 8.328 ± 1.0
2.216AlaPhe: 2.216 ± 0.355
7.334AlaGly: 7.334 ± 0.89
1.146AlaHis: 1.146 ± 0.355
5.119AlaIle: 5.119 ± 0.605
7.334AlaLys: 7.334 ± 0.957
9.015AlaLeu: 9.015 ± 0.931
3.362AlaMet: 3.362 ± 0.402
4.66AlaAsn: 4.66 ± 0.743
2.368AlaPro: 2.368 ± 0.432
4.966AlaGln: 4.966 ± 0.916
5.883AlaArg: 5.883 ± 0.757
6.57AlaSer: 6.57 ± 0.972
6.57AlaThr: 6.57 ± 0.874
4.813AlaVal: 4.813 ± 0.665
2.139AlaTrp: 2.139 ± 0.419
2.598AlaTyr: 2.598 ± 0.512
0.0AlaXaa: 0.0 ± 0.0
Cys
1.375CysAla: 1.375 ± 0.386
0.382CysCys: 0.382 ± 0.201
0.993CysAsp: 0.993 ± 0.292
0.84CysGlu: 0.84 ± 0.263
0.229CysPhe: 0.229 ± 0.129
0.688CysGly: 0.688 ± 0.266
0.382CysHis: 0.382 ± 0.191
0.535CysIle: 0.535 ± 0.195
0.535CysLys: 0.535 ± 0.18
1.222CysLeu: 1.222 ± 0.348
0.458CysMet: 0.458 ± 0.199
0.382CysAsn: 0.382 ± 0.188
0.688CysPro: 0.688 ± 0.251
0.535CysGln: 0.535 ± 0.221
0.993CysArg: 0.993 ± 0.268
0.993CysSer: 0.993 ± 0.277
0.611CysThr: 0.611 ± 0.254
0.458CysVal: 0.458 ± 0.195
0.458CysTrp: 0.458 ± 0.172
0.382CysTyr: 0.382 ± 0.179
0.0CysXaa: 0.0 ± 0.0
Asp
5.959AspAla: 5.959 ± 0.67
0.917AspCys: 0.917 ± 0.322
4.126AspAsp: 4.126 ± 0.704
3.896AspGlu: 3.896 ± 0.585
2.445AspPhe: 2.445 ± 0.435
4.355AspGly: 4.355 ± 0.632
0.688AspHis: 0.688 ± 0.198
2.368AspIle: 2.368 ± 0.439
3.132AspLys: 3.132 ± 0.607
3.667AspLeu: 3.667 ± 0.552
1.91AspMet: 1.91 ± 0.33
2.827AspAsn: 2.827 ± 0.532
1.986AspPro: 1.986 ± 0.373
2.368AspGln: 2.368 ± 0.447
2.75AspArg: 2.75 ± 0.482
2.75AspSer: 2.75 ± 0.584
3.438AspThr: 3.438 ± 0.438
3.591AspVal: 3.591 ± 0.712
1.986AspTrp: 1.986 ± 0.375
2.98AspTyr: 2.98 ± 0.531
0.0AspXaa: 0.0 ± 0.0
Glu
6.647GluAla: 6.647 ± 0.88
0.917GluCys: 0.917 ± 0.271
2.521GluAsp: 2.521 ± 0.346
3.973GluGlu: 3.973 ± 0.759
2.98GluPhe: 2.98 ± 0.516
3.896GluGly: 3.896 ± 0.669
0.917GluHis: 0.917 ± 0.247
3.591GluIle: 3.591 ± 0.565
4.966GluLys: 4.966 ± 0.608
6.341GluLeu: 6.341 ± 0.839
2.292GluMet: 2.292 ± 0.463
2.827GluAsn: 2.827 ± 0.455
2.063GluPro: 2.063 ± 0.511
3.591GluGln: 3.591 ± 0.624
4.737GluArg: 4.737 ± 0.621
3.667GluSer: 3.667 ± 0.629
2.292GluThr: 2.292 ± 0.468
4.278GluVal: 4.278 ± 0.489
1.07GluTrp: 1.07 ± 0.273
2.827GluTyr: 2.827 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
3.438PheAla: 3.438 ± 0.5
0.153PheCys: 0.153 ± 0.1
2.598PheAsp: 2.598 ± 0.497
1.91PheGlu: 1.91 ± 0.423
1.299PhePhe: 1.299 ± 0.395
2.292PheGly: 2.292 ± 0.368
0.84PheHis: 0.84 ± 0.268
1.986PheIle: 1.986 ± 0.387
1.222PheLys: 1.222 ± 0.311
1.91PheLeu: 1.91 ± 0.397
0.917PheMet: 0.917 ± 0.293
1.222PheAsn: 1.222 ± 0.305
0.917PhePro: 0.917 ± 0.275
0.84PheGln: 0.84 ± 0.281
2.368PheArg: 2.368 ± 0.495
2.445PheSer: 2.445 ± 0.379
2.521PheThr: 2.521 ± 0.46
2.139PheVal: 2.139 ± 0.331
0.611PheTrp: 0.611 ± 0.264
1.681PheTyr: 1.681 ± 0.352
0.0PheXaa: 0.0 ± 0.0
Gly
6.418GlyAla: 6.418 ± 0.738
1.757GlyCys: 1.757 ± 0.349
4.813GlyAsp: 4.813 ± 0.624
4.66GlyGlu: 4.66 ± 0.529
2.521GlyPhe: 2.521 ± 0.429
4.584GlyGly: 4.584 ± 0.641
0.535GlyHis: 0.535 ± 0.212
5.348GlyIle: 5.348 ± 0.514
5.272GlyLys: 5.272 ± 0.674
5.195GlyLeu: 5.195 ± 0.708
1.757GlyMet: 1.757 ± 0.332
2.445GlyAsn: 2.445 ± 0.429
1.604GlyPro: 1.604 ± 0.287
2.98GlyGln: 2.98 ± 0.504
3.896GlyArg: 3.896 ± 0.526
2.75GlySer: 2.75 ± 0.647
2.98GlyThr: 2.98 ± 0.48
4.431GlyVal: 4.431 ± 0.529
0.764GlyTrp: 0.764 ± 0.265
2.903GlyTyr: 2.903 ± 0.546
0.0GlyXaa: 0.0 ± 0.0
His
0.993HisAla: 0.993 ± 0.232
0.382HisCys: 0.382 ± 0.188
0.917HisAsp: 0.917 ± 0.246
0.993HisGlu: 0.993 ± 0.281
0.917HisPhe: 0.917 ± 0.28
1.222HisGly: 1.222 ± 0.299
0.458HisHis: 0.458 ± 0.175
0.993HisIle: 0.993 ± 0.32
0.84HisLys: 0.84 ± 0.215
1.681HisLeu: 1.681 ± 0.448
0.153HisMet: 0.153 ± 0.113
0.688HisAsn: 0.688 ± 0.235
0.993HisPro: 0.993 ± 0.354
0.535HisGln: 0.535 ± 0.194
1.146HisArg: 1.146 ± 0.277
0.84HisSer: 0.84 ± 0.246
0.917HisThr: 0.917 ± 0.295
1.375HisVal: 1.375 ± 0.368
0.611HisTrp: 0.611 ± 0.202
0.535HisTyr: 0.535 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
6.112IleAla: 6.112 ± 0.771
0.84IleCys: 0.84 ± 0.263
3.285IleAsp: 3.285 ± 0.5
3.514IleGlu: 3.514 ± 0.64
1.834IlePhe: 1.834 ± 0.359
4.049IleGly: 4.049 ± 0.627
1.222IleHis: 1.222 ± 0.337
2.674IleIle: 2.674 ± 0.371
3.285IleLys: 3.285 ± 0.415
3.056IleLeu: 3.056 ± 0.648
0.535IleMet: 0.535 ± 0.231
2.216IleAsn: 2.216 ± 0.449
1.757IlePro: 1.757 ± 0.347
1.375IleGln: 1.375 ± 0.305
2.674IleArg: 2.674 ± 0.491
4.89IleSer: 4.89 ± 0.519
4.813IleThr: 4.813 ± 0.487
3.132IleVal: 3.132 ± 0.401
0.917IleTrp: 0.917 ± 0.259
2.139IleTyr: 2.139 ± 0.391
0.0IleXaa: 0.0 ± 0.0
Lys
6.8LysAla: 6.8 ± 0.736
1.07LysCys: 1.07 ± 0.321
3.056LysAsp: 3.056 ± 0.678
3.591LysGlu: 3.591 ± 0.437
1.757LysPhe: 1.757 ± 0.333
3.209LysGly: 3.209 ± 0.502
1.375LysHis: 1.375 ± 0.415
2.827LysIle: 2.827 ± 0.536
3.744LysLys: 3.744 ± 0.599
4.278LysLeu: 4.278 ± 0.592
1.757LysMet: 1.757 ± 0.407
1.986LysAsn: 1.986 ± 0.388
2.827LysPro: 2.827 ± 0.545
2.98LysGln: 2.98 ± 0.383
4.508LysArg: 4.508 ± 0.68
4.049LysSer: 4.049 ± 0.623
3.973LysThr: 3.973 ± 0.637
3.667LysVal: 3.667 ± 0.431
0.764LysTrp: 0.764 ± 0.261
1.146LysTyr: 1.146 ± 0.25
0.0LysXaa: 0.0 ± 0.0
Leu
9.321LeuAla: 9.321 ± 1.233
0.993LeuCys: 0.993 ± 0.276
3.514LeuAsp: 3.514 ± 0.47
4.584LeuGlu: 4.584 ± 0.834
2.216LeuPhe: 2.216 ± 0.458
4.737LeuGly: 4.737 ± 0.505
1.452LeuHis: 1.452 ± 0.342
4.966LeuIle: 4.966 ± 0.588
4.584LeuLys: 4.584 ± 0.501
5.654LeuLeu: 5.654 ± 0.827
1.91LeuMet: 1.91 ± 0.355
3.896LeuAsn: 3.896 ± 0.529
3.438LeuPro: 3.438 ± 0.636
3.056LeuGln: 3.056 ± 0.422
5.73LeuArg: 5.73 ± 0.844
5.119LeuSer: 5.119 ± 0.616
4.355LeuThr: 4.355 ± 0.542
4.278LeuVal: 4.278 ± 0.634
0.764LeuTrp: 0.764 ± 0.246
2.445LeuTyr: 2.445 ± 0.363
0.0LeuXaa: 0.0 ± 0.0
Met
2.368MetAla: 2.368 ± 0.443
0.0MetCys: 0.0 ± 0.0
1.146MetAsp: 1.146 ± 0.351
1.222MetGlu: 1.222 ± 0.328
0.611MetPhe: 0.611 ± 0.201
1.375MetGly: 1.375 ± 0.418
0.458MetHis: 0.458 ± 0.215
0.993MetIle: 0.993 ± 0.309
2.139MetLys: 2.139 ± 0.458
0.993MetLeu: 0.993 ± 0.315
0.688MetMet: 0.688 ± 0.326
1.375MetAsn: 1.375 ± 0.298
1.681MetPro: 1.681 ± 0.486
1.07MetGln: 1.07 ± 0.295
1.757MetArg: 1.757 ± 0.346
2.445MetSer: 2.445 ± 0.347
2.521MetThr: 2.521 ± 0.513
2.139MetVal: 2.139 ± 0.392
0.535MetTrp: 0.535 ± 0.173
0.688MetTyr: 0.688 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
4.66AsnAla: 4.66 ± 0.719
0.611AsnCys: 0.611 ± 0.24
2.368AsnAsp: 2.368 ± 0.56
2.445AsnGlu: 2.445 ± 0.423
0.993AsnPhe: 0.993 ± 0.27
4.202AsnGly: 4.202 ± 0.474
0.764AsnHis: 0.764 ± 0.289
2.75AsnIle: 2.75 ± 0.447
2.292AsnLys: 2.292 ± 0.342
2.75AsnLeu: 2.75 ± 0.39
1.146AsnMet: 1.146 ± 0.304
2.598AsnAsn: 2.598 ± 0.386
2.216AsnPro: 2.216 ± 0.446
2.216AsnGln: 2.216 ± 0.513
2.521AsnArg: 2.521 ± 0.478
3.209AsnSer: 3.209 ± 0.491
1.834AsnThr: 1.834 ± 0.405
2.827AsnVal: 2.827 ± 0.529
0.458AsnTrp: 0.458 ± 0.168
1.375AsnTyr: 1.375 ± 0.271
0.0AsnXaa: 0.0 ± 0.0
Pro
3.82ProAla: 3.82 ± 0.546
0.306ProCys: 0.306 ± 0.142
2.827ProAsp: 2.827 ± 0.464
3.209ProGlu: 3.209 ± 0.528
0.84ProPhe: 0.84 ± 0.255
2.598ProGly: 2.598 ± 0.565
0.84ProHis: 0.84 ± 0.279
1.528ProIle: 1.528 ± 0.345
1.528ProLys: 1.528 ± 0.321
3.438ProLeu: 3.438 ± 0.585
0.84ProMet: 0.84 ± 0.289
1.375ProAsn: 1.375 ± 0.373
1.604ProPro: 1.604 ± 0.431
1.681ProGln: 1.681 ± 0.33
1.681ProArg: 1.681 ± 0.363
2.063ProSer: 2.063 ± 0.377
2.063ProThr: 2.063 ± 0.47
3.82ProVal: 3.82 ± 0.526
0.382ProTrp: 0.382 ± 0.186
0.688ProTyr: 0.688 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
5.042GlnAla: 5.042 ± 1.325
0.688GlnCys: 0.688 ± 0.233
1.375GlnAsp: 1.375 ± 0.289
2.139GlnGlu: 2.139 ± 0.453
1.681GlnPhe: 1.681 ± 0.343
2.674GlnGly: 2.674 ± 0.754
0.688GlnHis: 0.688 ± 0.233
2.063GlnIle: 2.063 ± 0.439
2.827GlnLys: 2.827 ± 0.52
3.591GlnLeu: 3.591 ± 0.536
1.452GlnMet: 1.452 ± 0.309
1.146GlnAsn: 1.146 ± 0.242
1.222GlnPro: 1.222 ± 0.378
3.209GlnGln: 3.209 ± 1.003
2.521GlnArg: 2.521 ± 0.466
3.056GlnSer: 3.056 ± 0.699
2.598GlnThr: 2.598 ± 0.625
3.591GlnVal: 3.591 ± 0.689
0.611GlnTrp: 0.611 ± 0.182
1.452GlnTyr: 1.452 ± 0.407
0.0GlnXaa: 0.0 ± 0.0
Arg
5.119ArgAla: 5.119 ± 0.6
0.688ArgCys: 0.688 ± 0.254
4.278ArgAsp: 4.278 ± 0.564
5.424ArgGlu: 5.424 ± 0.8
1.528ArgPhe: 1.528 ± 0.281
4.049ArgGly: 4.049 ± 0.565
1.299ArgHis: 1.299 ± 0.296
3.285ArgIle: 3.285 ± 0.529
3.973ArgLys: 3.973 ± 0.668
4.966ArgLeu: 4.966 ± 0.639
1.452ArgMet: 1.452 ± 0.363
2.75ArgAsn: 2.75 ± 0.364
2.139ArgPro: 2.139 ± 0.456
2.827ArgGln: 2.827 ± 0.429
4.355ArgArg: 4.355 ± 0.801
3.896ArgSer: 3.896 ± 0.547
2.674ArgThr: 2.674 ± 0.539
3.896ArgVal: 3.896 ± 0.538
1.834ArgTrp: 1.834 ± 0.387
1.91ArgTyr: 1.91 ± 0.469
0.0ArgXaa: 0.0 ± 0.0
Ser
6.418SerAla: 6.418 ± 0.696
0.611SerCys: 0.611 ± 0.228
3.896SerAsp: 3.896 ± 0.634
4.737SerGlu: 4.737 ± 0.663
2.75SerPhe: 2.75 ± 0.439
4.508SerGly: 4.508 ± 0.538
0.917SerHis: 0.917 ± 0.289
3.285SerIle: 3.285 ± 0.457
3.285SerLys: 3.285 ± 0.578
5.348SerLeu: 5.348 ± 0.682
1.757SerMet: 1.757 ± 0.412
3.132SerAsn: 3.132 ± 0.711
2.139SerPro: 2.139 ± 0.439
2.445SerGln: 2.445 ± 0.629
3.973SerArg: 3.973 ± 0.468
3.82SerSer: 3.82 ± 0.593
3.744SerThr: 3.744 ± 0.544
4.431SerVal: 4.431 ± 0.794
0.993SerTrp: 0.993 ± 0.262
1.299SerTyr: 1.299 ± 0.317
0.0SerXaa: 0.0 ± 0.0
Thr
6.494ThrAla: 6.494 ± 0.771
0.382ThrCys: 0.382 ± 0.191
3.209ThrAsp: 3.209 ± 0.518
4.202ThrGlu: 4.202 ± 0.484
1.986ThrPhe: 1.986 ± 0.361
5.424ThrGly: 5.424 ± 0.626
0.993ThrHis: 0.993 ± 0.307
3.514ThrIle: 3.514 ± 0.615
2.063ThrLys: 2.063 ± 0.369
4.966ThrLeu: 4.966 ± 0.627
0.993ThrMet: 0.993 ± 0.268
2.75ThrAsn: 2.75 ± 0.491
2.674ThrPro: 2.674 ± 0.432
2.445ThrGln: 2.445 ± 0.626
2.674ThrArg: 2.674 ± 0.44
3.667ThrSer: 3.667 ± 0.472
3.591ThrThr: 3.591 ± 0.657
4.431ThrVal: 4.431 ± 0.644
1.299ThrTrp: 1.299 ± 0.383
1.07ThrTyr: 1.07 ± 0.316
0.0ThrXaa: 0.0 ± 0.0
Val
6.112ValAla: 6.112 ± 0.748
0.611ValCys: 0.611 ± 0.222
4.126ValAsp: 4.126 ± 0.578
3.438ValGlu: 3.438 ± 0.57
2.368ValPhe: 2.368 ± 0.567
3.438ValGly: 3.438 ± 0.529
0.993ValHis: 0.993 ± 0.284
4.737ValIle: 4.737 ± 0.583
4.355ValLys: 4.355 ± 0.57
4.202ValLeu: 4.202 ± 0.549
1.604ValMet: 1.604 ± 0.308
3.667ValAsn: 3.667 ± 0.565
2.75ValPro: 2.75 ± 0.427
2.292ValGln: 2.292 ± 0.482
4.049ValArg: 4.049 ± 0.596
4.202ValSer: 4.202 ± 0.585
4.584ValThr: 4.584 ± 0.678
4.278ValVal: 4.278 ± 0.54
1.146ValTrp: 1.146 ± 0.275
1.91ValTyr: 1.91 ± 0.375
0.0ValXaa: 0.0 ± 0.0
Trp
1.07TrpAla: 1.07 ± 0.277
0.229TrpCys: 0.229 ± 0.139
0.917TrpAsp: 0.917 ± 0.208
1.375TrpGlu: 1.375 ± 0.379
0.611TrpPhe: 0.611 ± 0.238
0.84TrpGly: 0.84 ± 0.255
0.688TrpHis: 0.688 ± 0.253
0.611TrpIle: 0.611 ± 0.228
1.146TrpLys: 1.146 ± 0.305
2.674TrpLeu: 2.674 ± 0.552
0.382TrpMet: 0.382 ± 0.189
0.611TrpAsn: 0.611 ± 0.204
0.458TrpPro: 0.458 ± 0.218
0.764TrpGln: 0.764 ± 0.239
1.681TrpArg: 1.681 ± 0.343
1.07TrpSer: 1.07 ± 0.252
0.917TrpThr: 0.917 ± 0.288
1.299TrpVal: 1.299 ± 0.3
0.076TrpTrp: 0.076 ± 0.066
0.611TrpTyr: 0.611 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.056TyrAla: 3.056 ± 0.376
0.688TyrCys: 0.688 ± 0.237
2.292TyrAsp: 2.292 ± 0.496
1.91TyrGlu: 1.91 ± 0.358
1.528TyrPhe: 1.528 ± 0.582
2.139TyrGly: 2.139 ± 0.353
0.535TyrHis: 0.535 ± 0.191
1.222TyrIle: 1.222 ± 0.398
0.84TyrLys: 0.84 ± 0.238
2.063TyrLeu: 2.063 ± 0.35
0.764TyrMet: 0.764 ± 0.32
1.681TyrAsn: 1.681 ± 0.407
1.604TyrPro: 1.604 ± 0.421
1.452TyrGln: 1.452 ± 0.341
2.445TyrArg: 2.445 ± 0.422
1.986TyrSer: 1.986 ± 0.445
1.834TyrThr: 1.834 ± 0.406
1.986TyrVal: 1.986 ± 0.396
0.611TyrTrp: 0.611 ± 0.238
1.146TyrTyr: 1.146 ± 0.353
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (13090 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski