Amino acid dipepetide frequency for Aureococcus anophagefferens virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.459AlaAla: 1.459 ± 0.149
0.52AlaCys: 0.52 ± 0.061
1.979AlaAsp: 1.979 ± 0.122
2.639AlaGlu: 2.639 ± 0.215
1.886AlaPhe: 1.886 ± 0.148
1.487AlaGly: 1.487 ± 0.132
0.548AlaHis: 0.548 ± 0.083
3.122AlaIle: 3.122 ± 0.185
3.522AlaLys: 3.522 ± 0.215
2.89AlaLeu: 2.89 ± 0.151
0.901AlaMet: 0.901 ± 0.083
2.277AlaAsn: 2.277 ± 0.157
1.069AlaPro: 1.069 ± 0.118
0.688AlaGln: 0.688 ± 0.083
1.227AlaArg: 1.227 ± 0.123
2.509AlaSer: 2.509 ± 0.201
1.645AlaThr: 1.645 ± 0.123
2.035AlaVal: 2.035 ± 0.117
0.381AlaTrp: 0.381 ± 0.056
1.608AlaTyr: 1.608 ± 0.128
0.0AlaXaa: 0.0 ± 0.0
Cys
0.771CysAla: 0.771 ± 0.095
0.418CysCys: 0.418 ± 0.069
0.976CysAsp: 0.976 ± 0.102
0.892CysGlu: 0.892 ± 0.077
0.957CysPhe: 0.957 ± 0.109
0.883CysGly: 0.883 ± 0.109
0.455CysHis: 0.455 ± 0.066
1.134CysIle: 1.134 ± 0.11
1.682CysLys: 1.682 ± 0.154
1.236CysLeu: 1.236 ± 0.117
0.548CysMet: 0.548 ± 0.096
1.134CysAsn: 1.134 ± 0.103
0.585CysPro: 0.585 ± 0.07
0.381CysGln: 0.381 ± 0.06
0.455CysArg: 0.455 ± 0.06
1.106CysSer: 1.106 ± 0.132
0.697CysThr: 0.697 ± 0.086
0.79CysVal: 0.79 ± 0.101
0.139CysTrp: 0.139 ± 0.033
0.465CysTyr: 0.465 ± 0.066
0.0CysXaa: 0.0 ± 0.0
Asp
2.565AspAla: 2.565 ± 0.175
0.818AspCys: 0.818 ± 0.094
6.514AspAsp: 6.514 ± 0.696
5.678AspGlu: 5.678 ± 0.35
3.596AspPhe: 3.596 ± 0.195
2.676AspGly: 2.676 ± 0.199
0.725AspHis: 0.725 ± 0.076
6.96AspIle: 6.96 ± 0.262
5.882AspLys: 5.882 ± 0.307
4.693AspLeu: 4.693 ± 0.214
2.463AspMet: 2.463 ± 0.21
5.046AspAsn: 5.046 ± 0.222
1.069AspPro: 1.069 ± 0.104
1.338AspGln: 1.338 ± 0.112
1.756AspArg: 1.756 ± 0.127
4.024AspSer: 4.024 ± 0.227
4.098AspThr: 4.098 ± 0.249
4.173AspVal: 4.173 ± 0.219
1.124AspTrp: 1.124 ± 0.146
3.132AspTyr: 3.132 ± 0.174
0.0AspXaa: 0.0 ± 0.0
Glu
2.137GluAla: 2.137 ± 0.159
0.994GluCys: 0.994 ± 0.109
5.334GluAsp: 5.334 ± 0.302
6.078GluGlu: 6.078 ± 0.461
4.042GluPhe: 4.042 ± 0.181
2.314GluGly: 2.314 ± 0.171
1.069GluHis: 1.069 ± 0.104
7.546GluIle: 7.546 ± 0.339
7.732GluLys: 7.732 ± 0.369
5.26GluLeu: 5.26 ± 0.217
1.505GluMet: 1.505 ± 0.125
6.83GluAsn: 6.83 ± 0.234
3.987GluPro: 3.987 ± 1.257
1.84GluGln: 1.84 ± 0.129
2.23GluArg: 2.23 ± 0.134
4.665GluSer: 4.665 ± 0.254
3.922GluThr: 3.922 ± 0.286
2.825GluVal: 2.825 ± 0.184
0.948GluTrp: 0.948 ± 0.123
2.918GluTyr: 2.918 ± 0.155
0.0GluXaa: 0.0 ± 0.0
Phe
2.017PheAla: 2.017 ± 0.154
1.106PheCys: 1.106 ± 0.111
4.619PheAsp: 4.619 ± 0.241
4.275PheGlu: 4.275 ± 0.188
2.258PhePhe: 2.258 ± 0.198
2.258PheGly: 2.258 ± 0.164
1.124PheHis: 1.124 ± 0.108
4.656PheIle: 4.656 ± 0.227
5.566PheLys: 5.566 ± 0.265
4.089PheLeu: 4.089 ± 0.217
1.255PheMet: 1.255 ± 0.106
7.425PheAsn: 7.425 ± 0.441
1.487PhePro: 1.487 ± 0.105
1.487PheGln: 1.487 ± 0.107
1.413PheArg: 1.413 ± 0.105
3.652PheSer: 3.652 ± 0.201
2.444PheThr: 2.444 ± 0.147
2.509PheVal: 2.509 ± 0.146
0.539PheTrp: 0.539 ± 0.074
2.797PheTyr: 2.797 ± 0.172
0.0PheXaa: 0.0 ± 0.0
Gly
1.914GlyAla: 1.914 ± 0.154
0.781GlyCys: 0.781 ± 0.081
2.881GlyAsp: 2.881 ± 0.2
2.853GlyGlu: 2.853 ± 0.231
2.175GlyPhe: 2.175 ± 0.148
2.453GlyGly: 2.453 ± 0.249
0.651GlyHis: 0.651 ± 0.078
3.243GlyIle: 3.243 ± 0.185
4.646GlyLys: 4.646 ± 0.217
3.085GlyLeu: 3.085 ± 0.23
1.106GlyMet: 1.106 ± 0.142
2.5GlyAsn: 2.5 ± 0.174
0.455GlyPro: 0.455 ± 0.074
0.864GlyGln: 0.864 ± 0.102
1.236GlyArg: 1.236 ± 0.126
2.686GlySer: 2.686 ± 0.198
1.868GlyThr: 1.868 ± 0.166
2.574GlyVal: 2.574 ± 0.373
0.613GlyTrp: 0.613 ± 0.088
1.654GlyTyr: 1.654 ± 0.143
0.0GlyXaa: 0.0 ± 0.0
His
0.762HisAla: 0.762 ± 0.106
0.446HisCys: 0.446 ± 0.067
0.901HisAsp: 0.901 ± 0.092
0.892HisGlu: 0.892 ± 0.1
1.106HisPhe: 1.106 ± 0.119
0.623HisGly: 0.623 ± 0.08
0.493HisHis: 0.493 ± 0.062
1.728HisIle: 1.728 ± 0.146
1.636HisLys: 1.636 ± 0.134
1.44HisLeu: 1.44 ± 0.134
0.39HisMet: 0.39 ± 0.056
1.32HisAsn: 1.32 ± 0.107
0.455HisPro: 0.455 ± 0.067
0.418HisGln: 0.418 ± 0.071
0.446HisArg: 0.446 ± 0.06
1.255HisSer: 1.255 ± 0.117
0.762HisThr: 0.762 ± 0.095
0.836HisVal: 0.836 ± 0.093
0.167HisTrp: 0.167 ± 0.038
0.66HisTyr: 0.66 ± 0.099
0.0HisXaa: 0.0 ± 0.0
Ile
3.178IleAla: 3.178 ± 0.189
1.71IleCys: 1.71 ± 0.163
7.035IleAsp: 7.035 ± 0.301
8.122IleGlu: 8.122 ± 0.276
4.702IlePhe: 4.702 ± 0.226
4.814IleGly: 4.814 ± 0.301
1.784IleHis: 1.784 ± 0.134
8.122IleIle: 8.122 ± 0.368
8.512IleLys: 8.512 ± 0.342
6.821IleLeu: 6.821 ± 0.311
1.673IleMet: 1.673 ± 0.126
6.877IleAsn: 6.877 ± 0.311
3.16IlePro: 3.16 ± 0.158
2.676IleGln: 2.676 ± 0.146
3.615IleArg: 3.615 ± 0.166
6.747IleSer: 6.747 ± 0.255
4.275IleThr: 4.275 ± 0.237
4.451IleVal: 4.451 ± 0.208
0.576IleTrp: 0.576 ± 0.059
3.41IleTyr: 3.41 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
3.048LysAla: 3.048 ± 0.21
1.784LysCys: 1.784 ± 0.184
6.328LysAsp: 6.328 ± 0.306
6.97LysGlu: 6.97 ± 0.326
5.752LysPhe: 5.752 ± 0.246
3.104LysGly: 3.104 ± 0.192
1.821LysHis: 1.821 ± 0.142
10.018LysIle: 10.018 ± 0.367
13.354LysLys: 13.354 ± 0.609
7.379LysLeu: 7.379 ± 0.275
2.49LysMet: 2.49 ± 0.153
8.865LysAsn: 8.865 ± 0.406
2.528LysPro: 2.528 ± 0.186
3.095LysGln: 3.095 ± 0.183
3.15LysArg: 3.15 ± 0.182
6.626LysSer: 6.626 ± 0.314
5.687LysThr: 5.687 ± 0.248
4.814LysVal: 4.814 ± 0.238
1.71LysTrp: 1.71 ± 0.192
5.297LysTyr: 5.297 ± 0.201
0.0LysXaa: 0.0 ± 0.0
Leu
2.333LeuAla: 2.333 ± 0.169
1.124LeuCys: 1.124 ± 0.101
4.135LeuAsp: 4.135 ± 0.167
5.065LeuGlu: 5.065 ± 0.184
4.08LeuPhe: 4.08 ± 0.164
2.36LeuGly: 2.36 ± 0.18
1.347LeuHis: 1.347 ± 0.102
6.802LeuIle: 6.802 ± 0.297
9.228LeuLys: 9.228 ± 0.453
5.734LeuLeu: 5.734 ± 0.274
1.849LeuMet: 1.849 ± 0.143
6.551LeuAsn: 6.551 ± 0.264
2.314LeuPro: 2.314 ± 0.158
1.989LeuGln: 1.989 ± 0.153
2.342LeuArg: 2.342 ± 0.15
5.176LeuSer: 5.176 ± 0.248
3.829LeuThr: 3.829 ± 0.207
3.141LeuVal: 3.141 ± 0.163
0.493LeuTrp: 0.493 ± 0.07
3.364LeuTyr: 3.364 ± 0.186
0.0LeuXaa: 0.0 ± 0.0
Met
0.743MetAla: 0.743 ± 0.08
0.446MetCys: 0.446 ± 0.065
1.013MetAsp: 1.013 ± 0.097
1.478MetGlu: 1.478 ± 0.127
3.671MetPhe: 3.671 ± 0.404
0.706MetGly: 0.706 ± 0.09
0.344MetHis: 0.344 ± 0.053
1.886MetIle: 1.886 ± 0.127
2.611MetLys: 2.611 ± 0.174
1.645MetLeu: 1.645 ± 0.141
0.669MetMet: 0.669 ± 0.09
2.128MetAsn: 2.128 ± 0.161
0.585MetPro: 0.585 ± 0.072
0.651MetGln: 0.651 ± 0.083
0.753MetArg: 0.753 ± 0.093
2.5MetSer: 2.5 ± 0.196
1.292MetThr: 1.292 ± 0.106
0.725MetVal: 0.725 ± 0.089
0.084MetTrp: 0.084 ± 0.029
0.939MetTyr: 0.939 ± 0.105
0.0MetXaa: 0.0 ± 0.0
Asn
3.327AsnAla: 3.327 ± 0.191
1.329AsnCys: 1.329 ± 0.119
5.353AsnAsp: 5.353 ± 0.26
5.78AsnGlu: 5.78 ± 0.222
5.195AsnPhe: 5.195 ± 0.236
2.76AsnGly: 2.76 ± 0.223
1.143AsnHis: 1.143 ± 0.116
7.648AsnIle: 7.648 ± 0.361
7.76AsnLys: 7.76 ± 0.357
6.617AsnLeu: 6.617 ± 0.319
3.308AsnMet: 3.308 ± 0.274
6.254AsnAsn: 6.254 ± 0.313
2.063AsnPro: 2.063 ± 0.141
4.646AsnGln: 4.646 ± 0.351
2.388AsnArg: 2.388 ± 0.151
4.516AsnSer: 4.516 ± 0.238
4.99AsnThr: 4.99 ± 0.247
6.04AsnVal: 6.04 ± 0.296
1.199AsnTrp: 1.199 ± 0.156
3.503AsnTyr: 3.503 ± 0.193
0.0AsnXaa: 0.0 ± 0.0
Pro
0.855ProAla: 0.855 ± 0.116
0.325ProCys: 0.325 ± 0.054
1.496ProAsp: 1.496 ± 0.121
4.777ProGlu: 4.777 ± 1.272
1.338ProPhe: 1.338 ± 0.094
0.725ProGly: 0.725 ± 0.095
0.465ProHis: 0.465 ± 0.061
3.708ProIle: 3.708 ± 0.258
2.425ProLys: 2.425 ± 0.19
1.924ProLeu: 1.924 ± 0.128
0.511ProMet: 0.511 ± 0.076
2.1ProAsn: 2.1 ± 0.148
0.939ProPro: 0.939 ± 0.133
0.716ProGln: 0.716 ± 0.105
0.53ProArg: 0.53 ± 0.068
1.942ProSer: 1.942 ± 0.151
1.329ProThr: 1.329 ± 0.104
1.227ProVal: 1.227 ± 0.179
0.372ProTrp: 0.372 ± 0.063
1.663ProTyr: 1.663 ± 0.123
0.0ProXaa: 0.0 ± 0.0
Gln
0.706GlnAla: 0.706 ± 0.078
0.269GlnCys: 0.269 ± 0.043
1.775GlnAsp: 1.775 ± 0.141
1.803GlnGlu: 1.803 ± 0.144
1.255GlnPhe: 1.255 ± 0.112
1.106GlnGly: 1.106 ± 0.109
0.558GlnHis: 0.558 ± 0.082
2.565GlnIle: 2.565 ± 0.147
3.15GlnLys: 3.15 ± 0.187
1.961GlnLeu: 1.961 ± 0.135
0.651GlnMet: 0.651 ± 0.07
2.518GlnAsn: 2.518 ± 0.151
2.137GlnPro: 2.137 ± 0.219
0.66GlnGln: 0.66 ± 0.071
0.966GlnArg: 0.966 ± 0.103
1.71GlnSer: 1.71 ± 0.138
1.245GlnThr: 1.245 ± 0.11
1.208GlnVal: 1.208 ± 0.108
0.223GlnTrp: 0.223 ± 0.044
1.097GlnTyr: 1.097 ± 0.104
0.0GlnXaa: 0.0 ± 0.0
Arg
1.134ArgAla: 1.134 ± 0.108
0.511ArgCys: 0.511 ± 0.073
1.738ArgAsp: 1.738 ± 0.142
1.896ArgGlu: 1.896 ± 0.148
1.84ArgPhe: 1.84 ± 0.146
1.245ArgGly: 1.245 ± 0.108
0.613ArgHis: 0.613 ± 0.081
3.076ArgIle: 3.076 ± 0.178
3.42ArgLys: 3.42 ± 0.192
2.444ArgLeu: 2.444 ± 0.137
0.762ArgMet: 0.762 ± 0.093
2.658ArgAsn: 2.658 ± 0.154
0.781ArgPro: 0.781 ± 0.085
0.799ArgGln: 0.799 ± 0.088
1.273ArgArg: 1.273 ± 0.131
1.589ArgSer: 1.589 ± 0.113
1.347ArgThr: 1.347 ± 0.112
1.589ArgVal: 1.589 ± 0.134
0.307ArgTrp: 0.307 ± 0.058
1.626ArgTyr: 1.626 ± 0.118
0.0ArgXaa: 0.0 ± 0.0
Ser
2.184SerAla: 2.184 ± 0.14
0.901SerCys: 0.901 ± 0.097
4.228SerAsp: 4.228 ± 0.223
4.442SerGlu: 4.442 ± 0.257
4.554SerPhe: 4.554 ± 0.24
3.243SerGly: 3.243 ± 0.228
0.994SerHis: 0.994 ± 0.109
6.486SerIle: 6.486 ± 0.257
8.475SerLys: 8.475 ± 0.331
4.609SerLeu: 4.609 ± 0.211
1.654SerMet: 1.654 ± 0.143
7.629SerAsn: 7.629 ± 0.307
1.403SerPro: 1.403 ± 0.144
1.589SerGln: 1.589 ± 0.111
2.026SerArg: 2.026 ± 0.128
4.944SerSer: 4.944 ± 0.31
2.76SerThr: 2.76 ± 0.236
3.606SerVal: 3.606 ± 0.304
0.558SerTrp: 0.558 ± 0.066
2.964SerTyr: 2.964 ± 0.165
0.0SerXaa: 0.0 ± 0.0
Thr
1.459ThrAla: 1.459 ± 0.147
0.623ThrCys: 0.623 ± 0.078
3.857ThrAsp: 3.857 ± 0.24
3.206ThrGlu: 3.206 ± 0.204
2.751ThrPhe: 2.751 ± 0.196
2.221ThrGly: 2.221 ± 0.142
0.883ThrHis: 0.883 ± 0.099
4.042ThrIle: 4.042 ± 0.167
4.925ThrLys: 4.925 ± 0.263
3.959ThrLeu: 3.959 ± 0.197
0.994ThrMet: 0.994 ± 0.104
5.139ThrAsn: 5.139 ± 0.268
1.645ThrPro: 1.645 ± 0.158
1.255ThrGln: 1.255 ± 0.092
1.747ThrArg: 1.747 ± 0.128
5.446ThrSer: 5.446 ± 0.334
2.844ThrThr: 2.844 ± 0.199
2.147ThrVal: 2.147 ± 0.145
0.427ThrTrp: 0.427 ± 0.063
2.24ThrTyr: 2.24 ± 0.161
0.0ThrXaa: 0.0 ± 0.0
Val
2.165ValAla: 2.165 ± 0.146
0.604ValCys: 0.604 ± 0.075
2.667ValAsp: 2.667 ± 0.165
3.262ValGlu: 3.262 ± 0.244
2.676ValPhe: 2.676 ± 0.16
2.546ValGly: 2.546 ± 0.425
0.818ValHis: 0.818 ± 0.096
4.758ValIle: 4.758 ± 0.215
4.275ValLys: 4.275 ± 0.222
3.661ValLeu: 3.661 ± 0.191
0.994ValMet: 0.994 ± 0.093
3.234ValAsn: 3.234 ± 0.168
1.71ValPro: 1.71 ± 0.162
1.171ValGln: 1.171 ± 0.106
1.496ValArg: 1.496 ± 0.118
4.842ValSer: 4.842 ± 0.27
4.433ValThr: 4.433 ± 0.346
2.444ValVal: 2.444 ± 0.204
0.353ValTrp: 0.353 ± 0.054
1.859ValTyr: 1.859 ± 0.145
0.0ValXaa: 0.0 ± 0.0
Trp
0.242TrpAla: 0.242 ± 0.046
0.186TrpCys: 0.186 ± 0.045
2.147TrpAsp: 2.147 ± 0.297
0.316TrpGlu: 0.316 ± 0.062
0.558TrpPhe: 0.558 ± 0.076
0.353TrpGly: 0.353 ± 0.052
0.149TrpHis: 0.149 ± 0.045
0.678TrpIle: 0.678 ± 0.074
0.892TrpLys: 0.892 ± 0.105
0.52TrpLeu: 0.52 ± 0.061
0.158TrpMet: 0.158 ± 0.036
1.97TrpAsn: 1.97 ± 0.189
0.102TrpPro: 0.102 ± 0.031
0.195TrpGln: 0.195 ± 0.042
0.307TrpArg: 0.307 ± 0.047
0.381TrpSer: 0.381 ± 0.052
0.427TrpThr: 0.427 ± 0.065
0.474TrpVal: 0.474 ± 0.067
0.056TrpTrp: 0.056 ± 0.025
0.558TrpTyr: 0.558 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.394TyrAla: 1.394 ± 0.118
0.808TyrCys: 0.808 ± 0.101
3.355TyrAsp: 3.355 ± 0.175
3.754TyrGlu: 3.754 ± 0.169
2.583TyrPhe: 2.583 ± 0.178
2.36TyrGly: 2.36 ± 0.133
0.753TyrHis: 0.753 ± 0.09
4.08TyrIle: 4.08 ± 0.211
4.135TyrLys: 4.135 ± 0.223
3.29TyrLeu: 3.29 ± 0.177
0.976TyrMet: 0.976 ± 0.121
3.364TyrAsn: 3.364 ± 0.181
0.892TyrPro: 0.892 ± 0.098
1.106TyrGln: 1.106 ± 0.109
1.292TyrArg: 1.292 ± 0.111
2.937TyrSer: 2.937 ± 0.161
1.914TyrThr: 1.914 ± 0.129
2.36TyrVal: 2.36 ± 0.115
0.4TyrTrp: 0.4 ± 0.051
2.398TyrTyr: 2.398 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 376 proteins (107610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski